PARS2

Gene Information

Official Symbol: PARS2
Official Name: prolyl-tRNA synthetase 2, mitochondrial
Aliases and Previous Symbols: N/A
Entrez ID: 25973
UniProt: Q7L3T8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of proline to tRNA molecules. Mutations have been found in this gene in some patients with Alpers syndrome. [provided by RefSeq, Mar 2015].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK343 3μM R03 exp124	-1.76
HMS-I2 1μM R06 exp286	-1.75
Rotenone 0.07μM R08 exp431	1.76
Ribavirin 10μM R01 exp52	1.8
Hydroxyurea 100μM R07 exp329	1.86
Tanespimycin 14μM R08 exp527	1.86
Oligomycin-A 2μM R00 exp25	1.87
QNZ 0.01μM R08 exp439	1.9
Trientine 500μM R08 exp534	1.95
UM0125461 0.74μM R02 exp84	1.97
Doxorubicin 0.02μM R08 exp478	1.98
Mubritinib 0.2μM R01 exp48	2.02
LLY-283 2.6μM R06 exp290	2.15
Mubritinib 0.2μM R02 exp65	2.31
Thimerosal 0.85μM R08 exp529	2.82

Gene	Correlation
HSD17B10	0.744
TARS2	0.738
YARS2	0.735
DAP3	0.725
NARS2	0.722
SELRC1	0.714
MRPS6	0.711
MRPL23	0.709
LARS2	0.691
MRPL21	0.676
EARS2	0.674
QRSL1	0.666
SCO2	0.665
MRPS34	0.662
MRPS21	0.658
MRPS16	0.657
GFM1	0.657
VARS2	0.654
RPUSD4	0.649
RARS2	0.649
HARS2	0.647
MRPS14	0.641
DARS2	0.639
WBSCR16	0.634
GATC	0.63
MRPS25	0.628
KIAA0391	0.626
MTG2	0.623
MARS2	0.621
FASTKD5	0.621
C10orf2	0.62
MRPS5	0.619
NDUFB11	0.616
AARS2	0.615
MRP63	0.611
MRPS26	0.611
PET112	0.609
GTPBP10	0.609
MRPL47	0.606
FTSJ2	0.604
MRPL3	0.603
COX16	0.6
RBFA	0.599
BCS1L	0.599
METTL17	0.599
MRPS10	0.597
MRPL53	0.596
GFM2	0.592
COA3	0.592
POLRMT	0.592
POLG2	0.591
MRPS2	0.591
SARS2	0.585
DNLZ	0.58
MRPL12	0.578
RNASEH1	0.573
POLG	0.57
MRPL20	0.57
COX11	0.568
NDUFAF7	0.564
MRPS18A	0.563
MRPS24	0.561
COA6	0.56
NDUFA3	0.558
PET117	0.557
PGM3	0.556
MRPS12	0.555
RPUSD3	0.553
MRPS9	0.551
SUPV3L1	0.551
WARS2	0.548
MRPS35	0.547
FARS2	0.545
MRPL45	0.545
MRPL15	0.542
TEFM	0.542
MRPS33	0.54
MRPL4	0.539
ATP5D	0.539
MRPL42	0.538
DHRSX	0.536
PMVK	0.535
PNPT1	0.535
ATP5C1	0.535
MRPS23	0.534
MTG1	0.534
TRMT61A	0.534
ATP5A1	0.533
MTRF1L	0.53
MRPL44	0.529
SLC25A26	0.529
COX15	0.525
TUFM	0.524
MRPS7	0.523
C12orf65	0.52
COX7B	0.519
MALSU1	0.519
MRPL22	0.518
AIFM1	0.517
CARS2	0.514
MRPS11	0.51
TRUB2	0.509
NDUFA2	0.508
RNMTL1	0.508
HMGXB3	0.504
MRPL2	0.504
MRPL18	0.502
TMEM242	0.501
COX17	0.5
MRPL43	0.5
MRPL34	0.5
MRPL39	0.499
NDUFB6	0.494
MRPL11	0.494
GTPBP6	0.493
MTERFD2	0.492
NDUFA1	0.491
LSM10	0.491
MRPS27	0.49
NDUFAF3	0.488
COQ2	0.488
PTPMT1	0.486
PDSS1	0.485
ELAC2	0.484
TFB1M	0.482
MCAT	0.479
ATP5B	0.477
NDUFC2	0.477
MTPAP	0.476
MRPL51	0.476
ACAD9	0.475
MTIF2	0.475
RPIA	0.475
NDUFB5	0.474
MTERFD1	0.473
DDX28	0.473
OPA1	0.472
CHCHD1	0.472
SSBP1	0.472
RTN4IP1	0.469
SRD5A3	0.468
FH	0.468
C17orf89	0.468
GTPBP8	0.467
TOMM20	0.467
NDUFS2	0.466
RFT1	0.466
MRPL55	0.465
ALG8	0.464
ERAL1	0.464
MRPL17	0.464
COX20	0.462
SLC25A3	0.458
UQCRC2	0.457
COQ7	0.456
ALDH18A1	0.455
ATP5SL	0.454
MRPL36	0.454
IBA57	0.453
DHX30	0.452
MTIF3	0.452
TIMM8B	0.45
ALG6	0.449
COQ3	0.448
TMEM261	0.447
MRPL13	0.446
TFAM	0.446
MINOS1	0.445
PPCDC	0.445
PTCD3	0.443
TOMM6	0.443
TFB2M	0.443
UQCR10	0.443
COX5A	0.442
TRIAP1	0.442
COA5	0.442
CHCHD4	0.44
MRPL52	0.439
PTCD1	0.439
ATP5H	0.439
ROMO1	0.438
PPCS	0.435
COX19	0.433
TPK1	0.433
NDUFAF4	0.433
NDUFA11	0.432
PET100	0.432
MRPL46	0.431
MRPL33	0.431
SEC62	0.431
COX6C	0.43
PITRM1	0.43
G6PD	0.43
MRPS22	0.43
CRLS1	0.429
ATP5E	0.429
FASTKD2	0.429
MRPS17	0.429
PGS1	0.425
MIPEP	0.425
NDUFB9	0.425
MRPL37	0.424
KDSR	0.422
MRPL28	0.422
GRSF1	0.422
SLC25A52	0.422
PPA2	0.422
DOLK	0.422
SSB	0.421
NDUFC1	0.419
NSUN4	0.419
ATP5L	0.418
HIGD2A	0.418
TAZ	0.414
COX6B1	0.414
FASTKD1	0.412
SLC25A51	0.411
ECSIT	0.411
MRPL41	0.409
UQCC2	0.409
NUBPL	0.408
COQ6	0.408
NDUFAF5	0.406
ATP5O	0.405
METTL1	0.405
NDUFS7	0.404
MRPL35	0.404
LRPPRC	0.404
MRPS28	0.403
NDUFA10	0.402
COQ5	0.401

Global Fraction of Cell Lines Where Essential: 37/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	3/28
bone	1/26
breast	2/33
central nervous system	1/56
cervix	1/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	2/21
liver	2/20
lung	4/75
lymphocyte	2/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	2/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1030
Expression level (log2 read counts): 2.31

Expression Distribution

tRNA-synt 2b
HGTP anticodon

proline-tRNA ligase activity
prolyl-tRNA aminoacylation
tRNA aminoacylation for protein translation
tRNA aminoacylation
amino acid activation
tRNA metabolic process
cellular amino acid metabolic process
mitochondrial matrix
translation
peptide biosynthetic process
ncRNA metabolic process
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
mitochondrion
organonitrogen compound biosynthetic process
ATP binding
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
small molecule metabolic process
macromolecule biosynthetic process
gene expression