DDTL

Gene Information

Official Symbol: DDTL
Official Name: D-dopachrome tautomerase like
Aliases and Previous Symbols: N/A
Entrez ID: 100037417
UniProt: A6NHG4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: N/A

Function Summary

Entrez Summary: N/A
UniProt Summary: May have lyase activity. {ECO:0000305}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
PU-H71 1μM R08 exp515	-1.96
ONC212 0.15μM R08 exp513	-1.91
42°C R08 exp539	-1.89
CHIR-124 0.04μM R06 exp272	1.82
UM131593 0.1μM R01 exp58	1.84
proTAME 5μM R04 exp187	1.86
GSK2606414 1μM R05 exp236	1.98
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	3.04

Gene	Correlation
TCEB3CL2	0.618
PSMD11	0.609
PSMA6	0.597
CHD4	0.584
RPS12	0.58
TBC1D3H	0.57
TCEB3C	0.568
PSMD1	0.567
TBC1D3G	0.566
KCTD17	0.558
TCEB3CL	0.556
HIVEP3	0.543
CBWD3	0.542
LRR1	0.541
C1QTNF9B	0.541
ZFAND5	0.539
SLC6A17	0.53
TBC1D3C	0.528
SSH2	0.522
MT1E	0.521
NUPL1	0.519
PSMA7	0.518
TFIP11	0.516
GOLGA6L6	0.514
COPG1	0.514
TBC1D3F	0.514
AAAS	0.513
TOP1MT	0.512
VASN	0.512
CBWD5	0.511
LAD1	0.51
RNPC3	0.509
CTAGE4	0.509
SYT9	0.508
TBC1D3I	0.507
TBC1D3E	0.506
TBC1D3K	0.506
TBC1D3L	0.505
PSMB4	0.504
DTL	0.504
TP53TG3B	0.503
RPL35	0.502
TP53TG3	0.502
TP53TG3C	0.501
SLC4A1	0.5
CACTIN	0.498
PCF11	0.498
PSMD2	0.496
HAP1	0.494
INTS5	0.494
GOLGA8O	0.494
TWISTNB	0.492
COPA	0.492
ATXN1	0.492
DISP2	0.492
CDCA3	0.491
PSMD14	0.491
PSMC2	0.491
RBM39	0.491
PSMD3	0.49
FAM160A1	0.489
RBBP5	0.488
MADCAM1	0.487
NOP16	0.487
ATP13A1	0.486
CBWD6	0.486
UPF1	0.485
SLC38A7	0.484
MYH7B	0.484
ORC1	0.483
C14orf93	0.483
ZNF541	0.483
BCL2L1	0.482
SEC13	0.482
SLC5A5	0.48
COPE	0.479
ANKLE1	0.479
SEL1L	0.479
SMG7	0.479
RPL34	0.479
AKAP1	0.478
FCN2	0.478
DHX38	0.478
NOL8	0.478
NARFL	0.477
SUPT6H	0.477
RPS2	0.477
ANKLE2	0.475
ACSF2	0.475
TICRR	0.475
NUP54	0.475
AKIRIN2	0.473
IK	0.473
CDC73	0.473
RFC1	0.473
POLA1	0.472
RRP15	0.471
PSMC1	0.471
OR10G3	0.471
XAB2	0.471
S1PR4	0.47
CCNA2	0.469
NBPF10	0.468
TBC1D3	0.468
PAF1	0.467
RAD21	0.465
MCOLN1	0.464
RRN3	0.464
PAN3	0.463
PAN2	0.463
AQR	0.463
HIST2H3D	0.462
SMG1	0.462
CTR9	0.459
ZNF830	0.459
POLA2	0.458
NPIPB5	0.458
PSMB1	0.458
CDT1	0.456
PWP2	0.456
WDR43	0.456
UQCRH	0.455
CDC45	0.454
SF3A1	0.454
RPS19	0.453
WDR87	0.452
GOLGA8J	0.452
IGFN1	0.452
ALDH1B1	0.452
RPS28	0.452
DNM2	0.452
PSMB2	0.451
NBPF16	0.451
BYSL	0.451
RFPL3	0.45
FAM25B	0.45
DOCK6	0.45
WDR75	0.45
UTP3	0.45
COPB1	0.449
RRP7A	0.448
RANBP2	0.448
CCDC64B	0.448
SNRPA1	0.448
RPS9	0.448
MYT1L	0.447
DDX56	0.447
KIF3C	0.447
CHMP2A	0.447
PSMD7	0.446
ORC6	0.446
RNF113A	0.446
AAMP	0.444
MYO1H	0.444
TP53TG3D	0.444
PSMD13	0.443
ZNF106	0.443
NUP205	0.443
ISCU	0.443
RFXANK	0.443
POLR2D	0.442
CASC3	0.442
PSMC6	0.441
PBXIP1	0.441
POLR2F	0.441
RPSA	0.44
POLE	0.439
MED17	0.439
AATF	0.438
TOPBP1	0.438
SUPT5H	0.438
UTP18	0.438
PSMB3	0.437
RPL6	0.437
SULT1A3	0.436
CCDC116	0.436
XYLT2	0.436
ESF1	0.435
PPFIA4	0.435
SULT1A4	0.435
SNIP1	0.434
OGFR	0.434
AHCTF1	0.433
TRAIP	0.433
ARCN1	0.431
COL2A1	0.431
HAUS4	0.431
PLA2G4F	0.429
STIL	0.428
NFATC4	0.428
SF3A3	0.427
LRRC56	0.426
SAP30BP	0.426
CLN6	0.426
KPNB1	0.425
CMYA5	0.425
PLK4	0.424
NUP153	0.424
HIST1H2BE	0.424
SH3BP1	0.424
SRRT	0.423
RPS19BP1	0.422
ATP6V1C1	0.422
PDCD11	0.422
EXOSC3	0.422
EXOSC9	0.421
SCAF1	0.421
CHAF1A	0.421
C2orf27B	0.42
EBNA1BP2	0.42
EXOSC6	0.42
PSMD6	0.42
NOL12	0.42
RPL30	0.419
NUP160	0.418
GAR1	0.418
MAP7D1	0.417
ZNF655	0.416
MFSD12	0.416
MYB	0.416
HIST2H3C	0.416
HIST2H3A	0.416
RILPL2	0.415
SMC2	0.415
DNTTIP2	0.415
GOLGA6L3	0.415
PLK1	0.414
CCDC94	0.414
SFPQ	0.414
HNRNPA1	0.413
MED14	0.413
NKD2	0.413
BRIX1	0.412
TSPY8	0.412
CTAGE9	0.412
EIF4A3	0.411
KRT2	0.411
NUP43	0.41
GID4	0.41
VPS54	0.41
MYH2	0.41
MAT2A	0.409
NAPA	0.409
NUP107	0.409
ATP6V1A	0.408
HNRNPC	0.408
LOC643669	0.408
CKAP5	0.408
NSF	0.408
TSG101	0.407
HINFP	0.406
GPRIN2	0.406
ATP6V0B	0.406
CEP192	0.406
VPS28	0.406
POP1	0.405
APC2	0.405
SMG5	0.404
POLR1A	0.404
RAD51	0.404
SPECC1L	0.404
TTYH1	0.403
FOXD4L2	0.403
EGR2	0.402
DHFR	0.402
TUBA8	0.402
CWC22	0.402
NOL10	0.402
VPS52	0.401
CHMP4B	0.4
RRP1	0.4

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1687
Expression level (log2 read counts): 3.58

Expression Distribution