ATP5B

Gene Information

Official Symbol: ATP5F1B
Official Name: ATP synthase F1 subunit beta
Aliases and Previous Symbols: N/A
Entrez ID: 506
UniProt: P06576
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
2-Deoxy-D-glucose 800μM R05 exp214	-2.46
Thioridazine 5μM R08 exp530	-2.02
TNF-alpha 44ng/ml R08 exp533	-1.86
GSK-J4 1μM R07 exp362	-1.77
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-1.72
Mubritinib 0.2μM R02 exp65	1.7
Mubritinib 0.2μM R01 exp48	1.72
VER-155008 3.9μM R06 exp301	1.72
Rotenone 0.07μM R08 exp431	1.73
Vinblastine 0.2μM R03 exp108	1.82
Benzoate 20000μM R08 exp456	1.84
TIC10 10μM R08 exp532	1.86
Tanespimycin 14μM R08 exp527	1.88
Etoposide 0.3μM R05 exp199	1.89
Etoposide 1μM R00 exp19	1.96
Cannabidiol 13μM R08 exp465	1.97
Dimethyl-Sulfoxide 1pc R03 exp120	2
Hippuristanol 0.12μM R08 exp488	2.01
Dorsomorphin 5μM R07 exp357	2.02
LLY-283 2.6μM R06 exp290	2.02
MLN-4924 2μM R00 exp22	2.02
Aphidicolin 0.4μM R08 exp440	2.03
Hinokiflavone 12μM R08 exp487	2.06
5-Fluorouracil 20μM R00 exp2	2.07
Cannabidiol 20μM R08 exp466	2.07
Chloramphenicol 20μM R00 exp13	2.09
42°C R08 exp539	2.13
DABN racemic mixture R03 exp93	2.15
Olaparib 4μM R08 exp512	2.17
Pimelic-diphenylamide-106 5μM R00 exp28	2.19
Actinomycin-D 0.001μM R00 exp3	2.2
Senexin-A 25μM R07 exp400	2.21
BI-2536 0.02μM R03 exp96	2.23
GSK591 2.6μM R03 exp128	2.25
iCRT14 30μM R08 exp492	2.26
MS023 7μM R03 exp135	2.28
BI-6727 0.04μM R03 exp98	2.31
R-DABN 8μM R03 exp111	2.38
Bleomycin 5μM R08 exp459	2.39
CFI-400945 25μM R08 exp469	2.4
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.4
THZ1 0.06μM R08 exp531	2.51
QNZ 0.01μM R08 exp439	2.57
Citral 75μM R06 exp275	2.58
Phenformin 20μM R05 exp212	2.69
NMS-873 0.07μM R07 exp380	2.7
GSK461364A 0.1μM R03 exp126	2.77
Mitomycin-C 0.06μM R08 exp503	2.77
UM131593 0.2μM R03 exp106	2.79
CI-1040 9.5μM R08 exp472	2.84
Oligomycin-A 2μM R00 exp25	2.88
QNZ 0.01μM R05 exp241	2.96
Doxorubicin 0.02μM R08 exp478	3.08
Atovaquone 15μM R08 exp451	3.17

Gene	Correlation
ATP5O	0.844
ATP5A1	0.782
ATP5D	0.767
ATP5C1	0.693
ATP5F1	0.633
ATP5J	0.628
ATP5L	0.614
ATP5E	0.602
ATP5H	0.599
ATP5I	0.586
TRIAP1	0.584
TMEM242	0.568
THG1L	0.561
BCS1L	0.56
SLC25A26	0.554
DPAGT1	0.552
COX16	0.551
MRPL21	0.549
HSPD1	0.548
FH	0.545
DOHH	0.543
PMM2	0.531
HCCS	0.53
HSD17B10	0.53
GFPT1	0.53
ATP5J2	0.53
DARS2	0.529
UBE2G2	0.527
SUPV3L1	0.523
PPA2	0.52
ELAC2	0.518
ZRSR2	0.507
DAP3	0.504
TRNT1	0.504
UAP1	0.503
MRPS14	0.503
DOLK	0.499
YARS2	0.499
WBSCR16	0.495
ATXN10	0.494
MED16	0.494
ADSL	0.493
SELRC1	0.493
MRPS16	0.492
GMPPB	0.491
ALG1	0.489
KIAA0391	0.488
COX7B	0.488
MRPS26	0.488
RARS2	0.487
ALG6	0.486
MBTPS2	0.485
RNMT	0.482
ALG13	0.479
MRPS6	0.478
HARS2	0.478
VEZT	0.478
PARS2	0.477
PDSS1	0.477
MRPL20	0.475
RPP21	0.474
SSB	0.474
ENY2	0.471
PNPT1	0.47
RTCB	0.47
MRPS21	0.47
OPA1	0.47
UBA5	0.469
CASP9	0.469
TUFM	0.469
DHPS	0.468
CYCS	0.468
MRP63	0.467
NDUFAF4	0.466
ROMO1	0.465
RPTOR	0.463
C10orf2	0.462
GFM1	0.462
TMEM41B	0.46
RPUSD4	0.459
TEFM	0.459
TAMM41	0.458
PPP6C	0.457
GATC	0.456
SCO2	0.456
LSM10	0.455
ALG5	0.455
MRPL47	0.455
TAZ	0.452
GTF3C6	0.452
GTF3C4	0.452
SARS2	0.449
CBFB	0.449
FASTKD5	0.449
BAP1	0.444
MRPL23	0.444
VARS2	0.443
TRMT5	0.443
LARS2	0.442
UQCRC2	0.442
ZBTB11	0.441
MRPS34	0.44
KDSR	0.44
C17orf89	0.44
TARS2	0.439
C1orf27	0.436
NDUFC2	0.434
MRPS18A	0.433
MARS2	0.432
NDUFB3	0.431
MRPS11	0.43
MRPS33	0.429
NARS2	0.428
PLAA	0.427
WDR59	0.427
DHRSX	0.427
URM1	0.426
NAE1	0.424
CRLS1	0.423
HIST1H2BK	0.423
MRPS9	0.423
DR1	0.422
MRPS5	0.422
AARS	0.42
RTN4IP1	0.419
DNLZ	0.418
SDHA	0.417
CHCHD4	0.417
DNAJC3	0.417
UHRF1	0.416
NDUFB5	0.415
ALG2	0.415
EARS2	0.415
COX15	0.414
EGLN1	0.414
FAF2	0.412
MRPS2	0.412
SLC25A19	0.412
GFM2	0.411
TRMT10A	0.411
PPCS	0.41
DDX1	0.41
BAK1	0.409
GNB1L	0.408
SERF2	0.407
SLC35B1	0.407
APAF1	0.407
LAMTOR5	0.407
TIMM13	0.407
EXOC4	0.405
RFT1	0.405
TXNL4B	0.405
UQCR10	0.405
MRPS25	0.404
MRPS23	0.404
GTF3C3	0.404
NDUFA3	0.403
SLC25A52	0.403
GTPBP10	0.402
SEC62	0.402
COX5A	0.402
PGGT1B	0.401
TTI1	0.4

Global Fraction of Cell Lines Where Essential: 227/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	8/28
blood	8/28
bone	8/26
breast	14/33
central nervous system	14/56
cervix	3/4
colorectal	7/17
esophagus	5/13
fibroblast	0/1
gastric	6/16
kidney	7/21
liver	9/20
lung	27/75
lymphocyte	1/16
ovary	3/26
pancreas	6/24
peripheral nervous system	2/16
plasma cell	4/15
prostate	0/1
skin	8/24
soft tissue	5/9
thyroid	0/2
upper aerodigestive	6/22
urinary tract	7/29
uterus	2/5

Essentiality in NALM6

Essentiality Rank: 865
Expression level (log2 read counts): 9.6

Expression Distribution

ATP-synt ab
ATP-synt ab C
ATP-synt ab N

proton-transporting ATP synthase complex, catalytic core F(1)
mitochondrial proton-transporting ATP synthase, catalytic core
proton-transporting ATP synthase complex
angiostatin binding
negative regulation of cell adhesion involved in substrate-bound cell migration
mitochondrial proton-transporting ATP synthase complex
proton-transporting ATP synthase activity, rotational mechanism
MHC class I protein binding
mitochondrial ATP synthesis coupled proton transport
proton-transporting ATPase activity, rotational mechanism
ATP synthesis coupled proton transport
energy coupled proton transport, down electrochemical gradient
substrate-dependent cell migration
response to interleukin-7
cellular response to interleukin-7
cristae formation
ATP biosynthetic process
mitochondrial nucleoid
inner mitochondrial membrane organization
purine ribonucleoside triphosphate biosynthetic process
purine nucleoside triphosphate biosynthetic process
ribonucleoside triphosphate biosynthetic process
positive regulation of blood vessel endothelial cell migration
purine ribonucleoside triphosphate metabolic process
transmembrane transporter activity
nucleoside triphosphate biosynthetic process
ribonucleoside triphosphate metabolic process
purine nucleoside triphosphate metabolic process
regulation of intracellular pH
regulation of blood vessel endothelial cell migration
regulation of cellular pH
nucleoside triphosphate metabolic process
mitochondrial transmembrane transport
regulation of pH
positive regulation of endothelial cell migration
mitochondrial membrane
cellular monovalent inorganic cation homeostasis
oxidative phosphorylation
osteoblast differentiation
mitochondrial membrane organization