LARS2

Gene Information

Official Symbol: LARS2
Official Name: leucyl-tRNA synthetase 2, mitochondrial
Aliases and Previous Symbols: N/A
Entrez ID: 23395
UniProt: Q15031
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
proTAME 5μM R04 exp187	-1.72
ABT-702 5μM plus CoCl2 18μM R07 exp320	1.7
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	1.73
CI-1040 9.5μM R08 exp472	1.74
Q15 2.7μM R02 exp79	1.75
UM131593 0.2μM R03 exp106	1.77
iCRT14 30μM R08 exp492	1.78
GSK-J4 1.5μM R08 exp441	1.79
TIC10 10μM R08 exp532	1.79
Rapamycin 1μM R00 exp29	1.81
Amiloride 100μM R08 exp447	1.84
Calcium Ionophore 0.4μM R07 exp342	1.86
BI-D1870 3.15μM R02 exp66	1.87
Chloramphenicol 20μM R00 exp13	1.9
Genistein 15μM R07 exp360	1.9
CoCl2 18μM R07 exp346	1.93
Vemurafenib 6.6μM R02 exp89	2
Tubacin 1.6μM R07 exp416	2.02
Hydroxyurea 100μM R07 exp329	2.04
Milciclib 2μM R08 exp502	2.05
UM0125461 0.74μM R02 exp84	2.08
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	2.11
ONC212 0.15μM R08 exp513	2.11
LLY-283 2.6μM R06 exp290	2.15
∆-9-Tetrahydrocannabinol 30μM R08 exp445	2.2
QNZ 0.01μM R05 exp241	2.26
FK-506 30μM R07 exp359	2.27
Pterostilbene 16μM R02 exp78	2.27
Rotenone 0.07μM R08 exp431	2.27
Vemurafenib 6.6μM R08 exp434	2.28
Phenformin 20μM R05 exp212	2.32
Mubritinib 0.2μM R02 exp65	2.36
Rapamycin 10μM R00 exp30	2.37
Arsenate 40μM R06 exp264	2.54
Thimerosal 0.85μM R08 exp529	2.75
Trientine 500μM R08 exp534	2.82
Oligomycin-A 2μM R00 exp25	3.36

Gene	Correlation
NARS2	0.763
EARS2	0.711
YARS2	0.711
DAP3	0.695
SELRC1	0.692
PARS2	0.691
MRPL21	0.691
QRSL1	0.685
HSD17B10	0.685
MRPS21	0.683
FTSJ2	0.673
AARS2	0.669
GFM1	0.666
TARS2	0.663
MRPS16	0.663
MRPS6	0.656
NDUFAF7	0.641
SCO2	0.638
MRPL45	0.636
RPUSD4	0.633
DARS2	0.633
VARS2	0.632
PET112	0.63
PET117	0.627
MRPS34	0.627
HARS2	0.622
NDUFB11	0.618
MRPS25	0.615
RARS2	0.615
CARS2	0.615
MARS2	0.614
RPUSD3	0.612
MRPL23	0.611
MRPS26	0.609
MRPS14	0.608
GFM2	0.607
NDUFC2	0.605
TFB1M	0.599
MTRF1L	0.59
COX16	0.589
MRPS10	0.589
POLG2	0.587
NDUFA1	0.587
MRPL47	0.587
COX11	0.586
GTPBP10	0.585
MRPS5	0.584
MRPL20	0.584
NDUFA3	0.583
TEFM	0.582
WARS2	0.58
COA3	0.58
KIAA0391	0.58
FASTKD5	0.58
MRPL53	0.574
WBSCR16	0.573
MTIF2	0.571
METTL17	0.57
NDUFS2	0.57
GATC	0.568
C10orf2	0.568
MRP63	0.565
NDUFAF5	0.563
BCS1L	0.563
C12orf65	0.562
MTG2	0.561
SSBP1	0.559
MALSU1	0.553
FASTKD2	0.552
RTN4IP1	0.552
NDUFA2	0.552
COA6	0.552
RBFA	0.547
MRPS24	0.542
AIFM1	0.541
ATP5C1	0.541
GRSF1	0.539
RNASEH1	0.538
COX15	0.537
ACAD9	0.536
MRPL3	0.535
NDUFS5	0.534
MRPL43	0.533
GTPBP6	0.532
POLG	0.532
MRPL12	0.53
MTG1	0.527
ERAL1	0.527
DDX28	0.526
ATP5SL	0.526
MRPS33	0.52
MTERFD1	0.52
NDUFB6	0.518
FARS2	0.518
SARS2	0.518
MRPL49	0.518
MRPL42	0.516
NDUFB5	0.513
MRPL39	0.511
MRPS27	0.511
COQ7	0.509
POLRMT	0.507
MRPS23	0.507
MRPL4	0.507
HMGXB3	0.506
TRUB2	0.506
COX20	0.506
NDUFAF3	0.505
MTERFD2	0.504
PNPT1	0.504
ECSIT	0.503
MRPS12	0.502
MCAT	0.501
NDUFA11	0.5
RNMTL1	0.499
CLPP	0.497
NDUFAF6	0.495
COQ2	0.494
TOMM7	0.494
MRPL44	0.494
NDUFAF4	0.491
NDUFV1	0.491
MRPS35	0.49
TOMM20	0.489
MRPS18A	0.489
SUPV3L1	0.489
NSUN4	0.487
MIPEP	0.487
TMEM242	0.486
MRPS9	0.484
COX19	0.484
NDUFC1	0.482
DHRSX	0.482
GTPBP8	0.48
FH	0.48
MRPL22	0.479
TMEM261	0.479
MRPS7	0.478
TUFM	0.478
PMVK	0.478
MTO1	0.476
MRPL52	0.476
MRPS28	0.476
NDUFAF1	0.476
MRPS2	0.474
NUBPL	0.474
NDUFB9	0.473
MRPL33	0.473
PGM3	0.473
SLC25A26	0.473
MRPL28	0.473
C17orf89	0.472
COX7B	0.472
MTIF3	0.471
NDUFS1	0.47
TIMMDC1	0.47
MRPS17	0.467
PET100	0.465
MINOS1	0.465
MRPS22	0.464
CHCHD1	0.464
ADAT2	0.461
ALDH18A1	0.46
MRPS11	0.46
PDSS1	0.459
MRPL11	0.458
PTCD1	0.458
IBA57	0.457
MTRF1	0.454
TRMT61A	0.453
ATP5D	0.453
TOMM6	0.453
SCO1	0.453
COX17	0.452
COQ4	0.452
TFAM	0.452
NDUFA10	0.45
NDUFA8	0.449
MRPL15	0.446
MRPL18	0.445
ALG6	0.444
NDUFB3	0.443
ATP5B	0.442
MRPL46	0.442
MRPL35	0.442
SLC25A3	0.441
MTPAP	0.44
MRPL36	0.438
ATP5A1	0.437
DNLZ	0.437
UQCR10	0.436
ELAC2	0.436
UQCRC2	0.436
C1QBP	0.435
MRPL55	0.435
MRPS18B	0.434
NDUFS3	0.431
MRPL13	0.43
SLC25A51	0.429
PPCDC	0.427
PITRM1	0.426
RMND1	0.426
HIGD2A	0.425
COQ3	0.423
LRPPRC	0.423
PTCD3	0.423
MRPL1	0.422
MRPL17	0.421
ICT1	0.421
NOA1	0.42
SLC25A52	0.419
TIMM8B	0.418
DHX30	0.417
PTPMT1	0.417
METTL1	0.416
TFB2M	0.415
SRD5A3	0.414
MRPL2	0.414
MRPL51	0.413
FOXRED1	0.411
TOMM22	0.409
NDUFB7	0.406
MRPL38	0.404
COQ6	0.404
TSFM	0.403
ALG8	0.402
ATP5E	0.402
COQ5	0.401
RPIA	0.4
NDUFB10	0.4

Global Fraction of Cell Lines Where Essential: 97/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	3/28
blood	2/28
bone	4/26
breast	9/33
central nervous system	4/56
cervix	1/4
colorectal	3/17
esophagus	5/13
fibroblast	0/1
gastric	3/16
kidney	5/21
liver	3/20
lung	15/75
lymphocyte	2/16
ovary	0/26
pancreas	1/24
peripheral nervous system	1/16
plasma cell	1/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	7/22
urinary tract	4/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 360
Expression level (log2 read counts): 6.23

Expression Distribution

Anticodon 1
tRNA-synt 1
tRNA-synt 1g

leucyl-tRNA aminoacylation
leucine-tRNA ligase activity
aminoacyl-tRNA editing activity
aminoacyl-tRNA metabolism involved in translational fidelity
regulation of translational fidelity
tRNA aminoacylation for protein translation
tRNA aminoacylation
amino acid activation
mitochondrial translation
mitochondrial gene expression
tRNA metabolic process
cellular amino acid metabolic process
mitochondrial matrix
translation
peptide biosynthetic process
ncRNA metabolic process
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
mitochondrion
organonitrogen compound biosynthetic process
ATP binding
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
small molecule metabolic process
macromolecule biosynthetic process
gene expression