LRR1

Gene Information

Official Symbol: LRR1
Official Name: leucine rich repeat protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 122769
UniProt: Q96L50
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. Probable substrate recognition subunit of an ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269|PubMed:15601820}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
SNS-032 25μM R07 exp401	-2.41
Tozasertib 0.1μM R07 exp414	-2.24
Atovaquone 15μM R08 exp451	-2.09
GSK-J4 1.5μM R08 exp441	-2.06
SNS-032 15μM R08 exp443	-2.06
CB-5083 0.4μM R08 exp468	-2.05
CFI-400945 25μM R08 exp469	-2.05
BI-6727 0.04μM R03 exp98	-1.99
Brefeldin A 0.02μM R00 exp8	-1.99
BI-2536 0.02μM R03 exp96	-1.9
MLN-4924 2μM R00 exp22	-1.89
Doxorubicin 0.02μM R08 exp478	-1.79
Centrinone 0.5μM R07 exp343	-1.78
Bortezomib 0.05μM R00 exp7	-1.74
Thapsigargin 0.005μM R07 exp407	1.7
Rifampicin 1μM R00 exp31	1.71
Zebularine 20μM R07 exp423	1.73
35°C R06 exp302	1.76
Rapamycin 1μM R00 exp29	1.8
Alda-1 10μM R06 exp262	1.81
Losmapimod 1μM R07 exp376	1.83
Cyclosporin-A 3μM R07 exp348	1.84
Aphidicolin 0.04μM R06 exp263	1.85
Pimelic-diphenylamide-106 0.5μM R00 exp27	1.86
IU1-47 25μM R04 exp182	1.88
Alpha-Amanitin 0.5μM R00 exp5	1.91
3-Bromopyruvate 7μM R04 exp175	1.95
Cryptotanshinone 12μM R05 exp227	2.03
Vinblastine 0.002μM R01 exp60	2.03
Chloramphenicol 2μM R00 exp12	2.13
Citral 50μM R06 exp274	2.14
Ibrutinib 1μM R07 exp372	2.17
Talazoparib 0.006μM R06 exp299	2.17
D-Fructose 10000μM R06 exp279	2.19
MSC2530818 10μM R07 exp379	2.2
Vemurafenib 6.6μM R02 exp89	2.2
EPZ-5676 30μM R05 exp233	2.25
Celastrol 0.12μM R05 exp225	2.26
CCCP 1μM R00 exp11	2.27
CVT-10216 0.1μM R06 exp278	2.57
MK-1775 0.32μM R02 exp75	2.8

Gene	Correlation
TCEB3C	0.57
CCNA2	0.564
PSMA6	0.555
PWP2	0.55
PSMD3	0.549
TBC1D3F	0.548
CHD4	0.548
TBC1D3G	0.547
DDTL	0.541
TBC1D3H	0.54
MT1E	0.54
TBC1D3	0.538
AKIRIN2	0.533
TCEB3CL	0.527
NUPL1	0.527
CBWD3	0.527
TCEB3CL2	0.526
PSMD11	0.525
PSMD1	0.524
CBWD5	0.519
BYSL	0.517
PSMB2	0.511
TBC1D3E	0.51
TBC1D3I	0.509
VASN	0.509
TBC1D3L	0.509
TBC1D3K	0.509
ZNF830	0.508
RFC1	0.506
RPS2	0.498
PSMA7	0.497
PSMD2	0.497
UPF1	0.495
DNTTIP2	0.493
NUP160	0.492
PSMD14	0.491
MED17	0.491
RPL35	0.49
TFIP11	0.49
ORC1	0.489
PAN2	0.489
PSMB4	0.486
IK	0.485
HIVEP3	0.485
PAN3	0.484
CBWD6	0.484
TSG101	0.483
LAD1	0.478
GOLGA6L6	0.477
EIF4A3	0.476
NUP54	0.476
C1QTNF9B	0.475
SLC6A17	0.475
OR10G3	0.474
RPSA	0.474
KCTD17	0.474
NUP205	0.473
TSPY8	0.473
XYLT2	0.472
CDC45	0.471
NPIPB5	0.47
C14orf93	0.469
TBC1D3C	0.466
COPE	0.466
SNIP1	0.466
RPS7	0.465
ATP6V1C1	0.464
SUPT5H	0.464
C2orf27B	0.463
HAP1	0.463
CACTIN	0.461
RRP7A	0.461
DTL	0.46
CHAF1A	0.46
EXOSC5	0.459
CDCA3	0.457
SF3A3	0.457
COPB1	0.457
RRN3	0.456
KPNB1	0.456
AQR	0.455
HIST1H2BE	0.454
PSMD7	0.453
PSMC3	0.452
RPS19	0.451
COL2A1	0.451
SF3A1	0.451
HK1	0.449
TWISTNB	0.449
RPS3A	0.449
CTAGE4	0.449
GID4	0.448
POLE	0.448
CCDC94	0.448
RPS5	0.448
HINFP	0.448
ANKLE2	0.448
PCF11	0.447
TPX2	0.447
PAF1	0.446
CDC73	0.446
RAD21	0.446
LOC643669	0.446
DHX38	0.446
UTP20	0.444
RPS12	0.444
AAMP	0.443
GAR1	0.443
MYO1H	0.442
SLC4A1	0.441
DDX56	0.441
EXOSC9	0.44
PSMC1	0.438
RAD51	0.437
ANKLE1	0.436
RPS14	0.436
FAM160A1	0.436
RPS9	0.436
NUP133	0.436
PLA2G4F	0.435
SLC38A7	0.435
ELMOD3	0.435
ATP13A1	0.434
ARCN1	0.434
DDT	0.434
NARFL	0.434
WDR87	0.434
TP53TG3	0.433
ORC6	0.433
TP53TG3B	0.433
TP53TG3C	0.432
OSBP	0.432
PRPF8	0.431
POLR2F	0.43
TERF2	0.429
ACSF2	0.429
HMGCR	0.428
PDE4DIP	0.428
OR11H6	0.427
CLN6	0.427
TP53TG3D	0.427
ZNF106	0.426
WDR75	0.426
MED14	0.426
POLA1	0.425
NPIPB8	0.424
HCFC1	0.424
ZFAND5	0.424
PSMC2	0.423
EXOSC8	0.423
GOLGA6A	0.423
PLK1	0.422
PBXIP1	0.422
C3	0.422
HIST2H3C	0.422
HIST2H3A	0.422
PSMC5	0.421
SEC13	0.42
NDC1	0.42
FCN2	0.42
CKAP5	0.42
SUPT6H	0.42
POP1	0.419
IGFN1	0.419
SYT9	0.418
CDC6	0.418
CCDC116	0.417
GOLGA8O	0.417
FAM231C	0.416
FAM231A	0.416
CHMP2A	0.415
NOP16	0.415
DDX21	0.414
SSH2	0.414
SNRPA1	0.414
FAM25B	0.413
UTP3	0.413
PSMA1	0.413
RPL6	0.412
CEP192	0.412
RPS28	0.412
MFSD12	0.411
ADRA1D	0.411
RFFL	0.411
PIGS	0.41
AAAS	0.41
EXOSC3	0.41
MADCAM1	0.41
NOL8	0.41
ISY1	0.409
PDE12	0.409
PDCD11	0.409
AATF	0.409
CGB2	0.409
ATP6V0C	0.408
NOC4L	0.407
RPL15	0.407
CLPTM1	0.407
DHFR	0.406
SH3BP1	0.406
ATP6AP1	0.406
TICRR	0.406
TYMS	0.406
POLR2A	0.405
KRT78	0.405
GOLGA8H	0.405
PPFIA4	0.405
SART1	0.405
ACBD4	0.404
RNF113A	0.403
C3orf17	0.403
RPL14	0.403
RPS3	0.403
GON4L	0.402
CHST3	0.402
ABT1	0.401
NUP43	0.401
COPZ1	0.401
RPS11	0.4
XAB2	0.4
MYO18A	0.4

Global Fraction of Cell Lines Where Essential: 738/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	12/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 397
Expression level (log2 read counts): 5.06

Expression Distribution

post-translational protein modification
protein ubiquitination
protein modification by small protein conjugation
protein modification by small protein conjugation or removal