PET117

Gene Information

Official Symbol: PET117
Official Name: PET117 cytochrome c oxidase chaperone
Aliases and Previous Symbols: N/A
Entrez ID: 100303755
UniProt: Q6UWS5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Quercetin 20μM R08 exp517	1.8
Torin1 0.08μM R02 exp82	1.84
Genistein 15μM R07 exp360	1.86
MK-1775 0.32μM R02 exp75	1.89
Ibrutinib 10μM R08 exp442	1.9
Hippuristanol 0.12μM R08 exp488	1.92
Mubritinib 0.2μM R01 exp48	1.95
Calcium Ionophore 0.4μM R07 exp342	2.02
LLY-283 2.6μM R06 exp290	2.02
Thimerosal 0.85μM R08 exp529	2.07
UM0129480 7μM R02 exp85	2.07
Azithromycin 100μM R08 exp452	2.09
UMK57 1μM R01 exp59	2.09
Q15 2.7μM R02 exp79	2.12
Chloroquine 32μM R08 exp470	2.15
HMS-I1 1μM R01 exp46	2.17
QNZ 0.01μM R05 exp241	2.18
QNZ 0.01μM R08 exp439	2.23
Vemurafenib 6.6μM R02 exp89	2.25
Hydroxyurea 100μM R07 exp329	2.28
BI-D1870 3.15μM R02 exp66	2.39
Tubacin 1.6μM R07 exp416	2.51
Arsenate 40μM R06 exp264	2.54
iCRT14 30μM R08 exp492	2.77
Ribavirin 10 to 15μM on day4 R04 exp160	2.78
UM0125461 0.74μM R02 exp84	3.16
Ribavirin 10μM R01 exp52	3.18
Pterostilbene 16μM R02 exp78	3.36
Oligomycin-A 2μM R00 exp25	3.91

Gene	Correlation
COA3	0.724
NARS2	0.67
SELRC1	0.668
PET112	0.649
METTL17	0.633
LARS2	0.627
COX11	0.627
QRSL1	0.622
EARS2	0.621
COA6	0.621
CARS2	0.612
MALSU1	0.607
AARS2	0.606
HSD17B10	0.602
SCO2	0.6
NDUFA2	0.59
NDUFB11	0.589
TFB1M	0.588
MRPS27	0.586
WARS2	0.585
DDX28	0.58
ACAD9	0.579
MRPL45	0.576
MRPS21	0.575
NDUFAF7	0.575
COX18	0.574
NDUFS2	0.567
GTPBP10	0.567
DAP3	0.566
MRPL21	0.565
TARS2	0.563
MRPS25	0.56
MTO1	0.559
FTSJ2	0.558
PARS2	0.557
ERAL1	0.556
MRPS6	0.556
MRPL47	0.554
MRPS16	0.553
MRPL49	0.553
MTIF2	0.552
XPNPEP3	0.55
FASTKD2	0.547
GRSF1	0.546
RPUSD3	0.545
COX15	0.544
MRPS34	0.544
RMND1	0.543
DARS2	0.543
NDUFAF3	0.542
NUBPL	0.542
POLG2	0.542
COX20	0.54
RARS2	0.539
MCAT	0.538
FASTKD5	0.537
MRPL17	0.536
PTCD3	0.531
MRPS12	0.529
MTRF1L	0.526
MTG1	0.525
NDUFA1	0.524
CHCHD1	0.519
PREPL	0.518
POLRMT	0.518
C1QBP	0.517
CLPP	0.516
NDUFA3	0.516
YARS2	0.514
RBFA	0.512
TIMMDC1	0.512
LRPPRC	0.511
RPUSD4	0.511
MRPS26	0.51
NSUN4	0.51
MRPL3	0.51
MRPS35	0.509
GFM1	0.509
MTG2	0.509
NDUFB10	0.508
GFM2	0.507
COQ2	0.507
MRPS18B	0.506
VARS2	0.504
GTPBP8	0.504
UQCC1	0.504
COX16	0.502
COX6B1	0.501
SCO1	0.5
MPV17L2	0.5
MRPL43	0.498
NDUFAF6	0.498
MRPL28	0.498
C12orf65	0.497
SSBP1	0.497
MRPL2	0.497
MRPS24	0.496
MRPS5	0.496
BCS1L	0.493
COX6A1	0.492
MRPL4	0.491
MRP63	0.49
HIGD2A	0.489
MRPL22	0.489
MRPL23	0.487
POLG	0.487
SLC31A1	0.486
MRPL44	0.486
NDUFS5	0.485
WBSCR16	0.484
MRPL11	0.484
NDUFA8	0.482
MRPS10	0.481
MRPL53	0.481
NDUFB2	0.479
AIFM1	0.479
MARS2	0.478
COX7B	0.478
MRPL1	0.477
ECSIT	0.474
NDUFC1	0.473
NDUFC2	0.473
FARS2	0.472
NDUFB9	0.47
COX19	0.47
MRPL18	0.47
MRPL35	0.47
MRPL39	0.469
NDUFA11	0.469
RTN4IP1	0.467
NDUFV1	0.467
HMGXB3	0.467
MTERFD1	0.465
MRPL37	0.463
PDSS2	0.461
MRPL20	0.46
MRPS22	0.459
NDUFA6	0.457
RNASEH1	0.456
PDE12	0.455
NDUFB6	0.454
NDUFB4	0.454
MTIF3	0.453
HARS2	0.453
MRPS14	0.451
NDUFS8	0.451
CLUH	0.449
TACO1	0.447
NDUFV2	0.446
MTERFD2	0.446
TRUB2	0.446
RNMTL1	0.444
SLC25A51	0.444
TRIT1	0.444
MTRF1	0.443
COX17	0.443
TOMM20	0.441
MRPS18A	0.438
SLC25A3	0.437
YBEY	0.437
FASTKD1	0.436
MRRF	0.435
PNPT1	0.435
MTPAP	0.434
GTPBP6	0.434
MRPS23	0.433
GATC	0.429
PTCD2	0.428
COQ7	0.428
MRPS2	0.428
NDUFAF5	0.426
MRPL55	0.425
C10orf2	0.42
MIPEP	0.42
TMEM261	0.418
MRPS9	0.418
NDUFA4	0.417
OMA1	0.416
MRPL9	0.415
TSFM	0.414
SURF1	0.414
MRPL48	0.413
MRPL51	0.412
NDUFA10	0.411
MRPL33	0.411
MRPS7	0.41
TOMM6	0.409
SLIRP	0.408
MDH2	0.408
COX7C	0.407
MRPL30	0.404
COQ4	0.404
ATP5C1	0.403
MRPL42	0.402
IBA57	0.402
PET100	0.402
MRPL12	0.401
NOA1	0.4

Global Fraction of Cell Lines Where Essential: 68/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	9/28
bone	1/26
breast	5/33
central nervous system	1/56
cervix	0/4
colorectal	3/17
esophagus	3/13
fibroblast	0/1
gastric	1/16
kidney	2/21
liver	2/20
lung	4/75
lymphocyte	1/16
ovary	0/26
pancreas	3/24
peripheral nervous system	0/16
plasma cell	5/15
prostate	0/1
skin	2/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	2/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 565
Expression level (log2 read counts): 3.0

Expression Distribution

mitochondrial respiratory chain complex IV assembly
respiratory chain complex IV assembly
cytochrome complex assembly
mitochondrial respiratory chain complex assembly
mitochondrion organization
cellular protein-containing complex assembly
mitochondrion
protein-containing complex assembly
protein-containing complex subunit organization