PSMB2

Gene Information

Official Symbol: PSMB2
Official Name: proteasome 20S subunit beta 2
Aliases and Previous Symbols: N/A
Entrez ID: 5690
UniProt: P49721
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MLN-4924 2μM R00 exp22	-2.64
Bortezomib 0.05μM R00 exp7	-2.35
R-DABN 8μM R03 exp111	-2
Ammonium tetrathiomolybdate 10μM R08 exp448	-1.93
Bortezomib 0.005μM R00 exp6	-1.9
Staurosporine 0.02μM R08 exp524	-1.82
Oligomycin-A 20μM R00 exp26	-1.8
Pimelic-diphenylamide-106 5μM R00 exp28	-1.72
Vinblastine 0.002μM R01 exp60	1.73
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	1.78
GSK-J4 1-1.25μM to day4 R07 exp363	1.8
Adefovir 20μM R07 exp332	1.81
Dimethyloxaloylglycine 11μM R07 exp314	1.83
LB-100 2μM R05 exp210	1.85
2-Methoxyestradiol 0.55μM R07 exp310	1.93
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	2.04
Taxol 0.002μM R01 exp54	2.43
Cidofovir 10μM R07 exp345	2.54

Gene	Correlation
TCEB3C	0.618
TCEB3CL2	0.609
TCEB3CL	0.601
RRP7A	0.585
PSMB4	0.58
PRIM1	0.577
COPG1	0.567
DNTTIP2	0.563
PSMA6	0.554
RPL35	0.552
POLE	0.548
GOLGA6L4	0.544
CBWD3	0.543
PSMB1	0.54
GOLGA6L3	0.539
TYMS	0.538
UTP20	0.534
PSMD3	0.532
TBC1D3F	0.532
RPS2	0.53
MED17	0.524
TBC1D3H	0.522
AQR	0.521
EXOSC9	0.518
C14orf93	0.518
INTS5	0.517
SLC4A1	0.517
TBC1D3	0.516
PSMA7	0.515
CHAF1A	0.514
LRR1	0.511
CBWD5	0.511
TBC1D3G	0.51
MT1E	0.51
VASN	0.509
NUPL1	0.505
PSMD2	0.505
NPIPB5	0.505
WDR75	0.504
CHD4	0.501
CBWD6	0.501
PSMD6	0.501
DTL	0.5
ATP13A1	0.5
PDE4DIP	0.499
RPS5	0.499
UPF1	0.497
PSMD14	0.495
SLC6A17	0.494
TWISTNB	0.494
ATP6V0B	0.493
UTP3	0.492
PSMC5	0.492
COL2A1	0.492
RPS12	0.491
PWP2	0.49
COPE	0.49
BYSL	0.488
PSMC2	0.488
C1QTNF9B	0.486
RRN3	0.486
SH3BP1	0.484
SUPT5H	0.484
AATF	0.484
CACTIN	0.483
NUP160	0.481
CCNA2	0.479
RPS7	0.479
KRT78	0.479
MYO18A	0.479
ZNF830	0.479
CLN6	0.477
KCTD17	0.477
ATP6V1C1	0.477
TICRR	0.476
POLR2J3	0.476
SF3A3	0.476
PHF2	0.475
PSMD11	0.474
TP53TG3C	0.472
TP53TG3	0.472
TP53TG3B	0.472
MYB	0.471
TRAIP	0.47
SLC38A7	0.47
EXOSC5	0.469
XAB2	0.469
COX7A2L	0.469
ATP6V1A	0.468
ORC1	0.467
VPS28	0.467
POLR1A	0.467
TSPY1	0.466
PSMC6	0.466
PDCD11	0.465
TBC1D3I	0.464
TBC1D3E	0.464
TBC1D3L	0.463
POLR2F	0.463
COPB2	0.463
TBC1D3K	0.463
ISY1	0.463
RAD21	0.461
CDC45	0.461
PLK1	0.461
ORC6	0.461
PSMB3	0.46
HIST2H3C	0.459
HIST2H3A	0.459
TSG101	0.458
IGFN1	0.458
CDC73	0.457
EXOSC6	0.457
TSPY2	0.457
TBC1D3C	0.457
TPX2	0.455
AHCTF1	0.455
SEC13	0.454
DHX38	0.453
POLR2D	0.453
SNRPA1	0.453
PAN2	0.452
PSMA1	0.452
POLA1	0.451
DDTL	0.451
EIF4A3	0.451
RANBP2	0.45
RANGAP1	0.45
CGB2	0.449
SEL1L	0.449
FCN2	0.449
PIGS	0.449
TUBA8	0.449
ZFAND5	0.449
MTCH2	0.449
CEP192	0.448
AAMP	0.448
NUP85	0.448
EXOSC3	0.448
RRP15	0.448
PPFIA4	0.447
PSMD1	0.447
PLA2G4F	0.447
NUP54	0.446
COPB1	0.445
NELFCD	0.445
LAD1	0.444
TP53TG3D	0.444
FBXW9	0.443
ATP6V1B2	0.443
AKT1S1	0.443
CHMP2A	0.443
CGB1	0.441
EBNA1BP2	0.439
PAN3	0.439
CDC6	0.439
IK	0.439
SKIV2L2	0.438
NBPF10	0.438
MFSD12	0.438
RPS19	0.437
PRPF3	0.437
POLR2L	0.437
SART1	0.436
CKAP5	0.436
POLR2A	0.436
C2orf27B	0.435
DIMT1	0.435
RPS3	0.434
AKIRIN2	0.434
PSAP	0.434
PSMC1	0.434
NAPA	0.433
POLR2H	0.433
RPS9	0.432
FTSJ3	0.432
MED14	0.432
NFATC4	0.431
GAR1	0.431
OSBP	0.431
NSF	0.431
ATP6AP1	0.43
COPA	0.43
BRD2	0.43
PSMD7	0.43
KRT2	0.43
PAF1	0.429
POLA2	0.428
WDR43	0.428
NOL10	0.428
CHCHD3	0.428
ACSF2	0.428
POLD1	0.427
DDT	0.427
CDH24	0.427
NARFL	0.426
MCOLN1	0.426
SULT1A4	0.425
ARCN1	0.425
SULT1A3	0.425
SRRT	0.425
ART5	0.424
DDX21	0.424
CDCA3	0.423
RUVBL2	0.423
ACD	0.423
DDX47	0.422
FAM25B	0.422
TFIP11	0.421
HIVEP3	0.42
CCDC116	0.42
NUP62	0.419
SMG1	0.419
APC2	0.418
MDM2	0.418
TIMELESS	0.417
TONSL	0.417
NPIPB8	0.417
NUP153	0.417
ITGAX	0.417
BRIX1	0.416
GOLGA6A	0.415
RNF113A	0.415
DDX56	0.415
MYH7B	0.415
EGR2	0.415
RPS3A	0.415
PRPF8	0.414
FAM160A1	0.413
GOLGA8O	0.411
GRAMD1A	0.411
RAD51	0.411
PPIE	0.411
PLEKHA4	0.411
PSMA5	0.411
VPS51	0.41
MPHOSPH10	0.41
RPS11	0.41
CCDC64B	0.41
KIAA0947	0.409
MYO1H	0.409
NUP98	0.409
WDR87	0.408
RPS19BP1	0.408
RIOK2	0.408
ZNF219	0.408
PLXNB3	0.408
CTAGE4	0.408
ATP6V0C	0.408
GOLGA8J	0.407
ANKLE2	0.407
SF3A1	0.407
FAM231C	0.407
FAM231A	0.407
VPS52	0.406
RPL34	0.406
RPS28	0.406
PBXIP1	0.405
SYT9	0.405
FBL	0.405
C3orf17	0.404
SUPT6H	0.404
MYLK3	0.404
CWC22	0.403
GPX4	0.403
IL2RB	0.403
CDCA5	0.403
PNO1	0.403
GOLGA6L1	0.402
TAF1	0.402
KPNB1	0.401
NGDN	0.401
RNPC3	0.401
POP7	0.401
EXOSC8	0.401
CRNKL1	0.4

Global Fraction of Cell Lines Where Essential: 685/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	28/28
bone	20/26
breast	33/33
central nervous system	53/56
cervix	4/4
colorectal	15/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	20/21
liver	16/20
lung	71/75
lymphocyte	15/16
ovary	26/26
pancreas	21/24
peripheral nervous system	16/16
plasma cell	14/15
prostate	1/1
skin	18/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	26/29
uterus	4/5

Essentiality in NALM6

Essentiality Rank: 510
Expression level (log2 read counts): 7.02

Expression Distribution