RPS12

Gene Information

Official Symbol: RPS12
Official Name: ribosomal protein S12
Aliases and Previous Symbols: N/A
Entrez ID: 6206
UniProt: P25398
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
SNS-032 25μM R07 exp401	-2.34
Palbociclib 1μM R07 exp382	-1.88
Cycloheximide 0.02μM R00 exp14	1.7
BI-6727 0.001μM R01 exp42	1.72
RO-3306 3 to 4μM on day4 R04 exp165	1.72
Temozolomide 200μM R04 exp189	1.74
Metformin 100 to 150μM on day4 R04 exp170	1.79
Erlotinib 10μM R05 exp216	2.43
Vemurafenib 6.6μM R02 exp89	2.55
Chloramphenicol 2μM R00 exp12	2.75

Gene	Correlation
DDTL	0.58
TCEB3CL2	0.574
TCEB3C	0.571
RPS2	0.563
TBC1D3G	0.562
TFIP11	0.56
TBC1D3F	0.558
NOL10	0.556
TCEB3CL	0.554
PSMA6	0.552
TBC1D3H	0.549
RPS19	0.542
CHD4	0.541
RPS5	0.535
RBM39	0.53
TSPY8	0.53
RPL35	0.528
RPS28	0.528
VASN	0.526
RPS3A	0.521
CDC73	0.518
DTL	0.516
PSMB4	0.515
RBBP5	0.514
KCTD17	0.511
PCF11	0.511
NUPL1	0.509
RPL6	0.508
PSMD11	0.508
SYT9	0.505
FAM25B	0.504
NOL12	0.503
CCNA2	0.503
TERF2	0.502
PSMC6	0.5
TBC1D3C	0.499
RPS7	0.499
RPS3	0.499
KIF3C	0.498
TBC1D3	0.498
RPS27A	0.498
ORC1	0.498
KRT2	0.497
PSMB1	0.497
NARFL	0.496
S1PR4	0.496
NUP133	0.496
PSMA7	0.494
PSMD1	0.492
PSMB2	0.491
TWISTNB	0.491
TERF1	0.49
PPFIA4	0.489
XAB2	0.488
PSMD3	0.488
AATF	0.486
HIVEP3	0.485
ZNF106	0.485
EIF3G	0.485
SLC6A17	0.485
ZNF830	0.485
RPL30	0.485
OGFR	0.484
IK	0.483
RPLP1	0.483
CBWD5	0.482
MT1E	0.479
DDT	0.479
CDC45	0.479
AKIRIN2	0.478
GOLGA8O	0.478
POLA1	0.478
CHCHD3	0.477
C1QTNF9B	0.477
COPG1	0.476
PLA2G4F	0.475
NFATC4	0.475
TBC1D3L	0.475
ZFAND5	0.475
TBC1D3I	0.475
RRP7A	0.475
TBC1D3K	0.475
TBC1D3E	0.475
NOP16	0.473
AQR	0.472
AKT1S1	0.471
CBWD3	0.47
SH3BP1	0.47
CACTIN	0.47
C14orf93	0.469
XYLT2	0.468
BYSL	0.468
CDCA3	0.467
POLR2F	0.467
CDC6	0.466
PSMC2	0.466
TOP1MT	0.466
RPS10	0.465
DIMT1	0.464
SNIP1	0.464
ISCU	0.463
SCAF1	0.462
UTP20	0.462
RPL34	0.462
WDR87	0.462
COPE	0.461
CCDC116	0.461
RNPC3	0.461
ORC6	0.46
POLR2D	0.46
NPIPB5	0.46
NUP54	0.459
MADCAM1	0.459
GOLGA6L1	0.459
CKAP5	0.458
PSMC5	0.457
HAP1	0.457
GOLGA8J	0.456
MSH5	0.456
RPS19BP1	0.455
PSMD2	0.453
RPS11	0.452
TIMELESS	0.45
TICRR	0.45
CWC22	0.449
EBNA1BP2	0.448
ATP6V1C1	0.448
MFSD12	0.448
DISP2	0.448
TP53TG3B	0.447
DNTTIP2	0.447
TP53TG3	0.446
NSF	0.446
MYB	0.445
TP53TG3C	0.445
CMYA5	0.445
WDR75	0.445
SF3A3	0.445
SSH2	0.445
LRR1	0.444
SNRPA1	0.444
WDR43	0.444
CLN6	0.444
HNRNPC	0.444
CDT1	0.443
CTAGE4	0.443
POLE2	0.442
SUPT5H	0.441
PSMD14	0.441
RRP1	0.441
PLK4	0.441
TRAIP	0.44
RPS9	0.44
SEC13	0.44
IGFN1	0.44
PSMC1	0.439
RFC1	0.439
MCOLN1	0.439
CEP192	0.438
POLE	0.437
NPIPB8	0.437
GOLGA6L6	0.436
PLEKHA4	0.434
POLR2L	0.434
HGC6.3	0.433
MYO1H	0.433
RPS14	0.433
EIF3A	0.433
RRP12	0.433
NBPF10	0.433
NUP98	0.433
CBWD6	0.432
USP36	0.432
GAR1	0.431
PAF1	0.43
NAPA	0.43
SF3A1	0.43
ACSF2	0.429
ANKLE1	0.429
RPS16	0.429
SUPT6H	0.428
MYT1L	0.428
EXD1	0.428
POLA2	0.427
GGA3	0.427
CCDC64B	0.426
CHAF1A	0.426
DDX56	0.426
DIEXF	0.425
ZNF574	0.425
SFPQ	0.425
PRPF8	0.425
RNF113A	0.424
UPF1	0.424
AHCTF1	0.423
RANBP2	0.423
RILPL2	0.422
CASC3	0.422
NOP14	0.421
FAM160A1	0.42
MED12	0.42
ELMOD3	0.419
EXOSC3	0.419
TAF12	0.419
SMG1	0.419
MDM2	0.419
C2orf27B	0.419
PDCD11	0.419
UTP3	0.419
PPAN	0.418
PRIM1	0.418
MKI67IP	0.418
VPS28	0.417
SLC4A1	0.417
TYMS	0.417
RPLP2	0.416
COL2A1	0.415
POLR2H	0.415
TAF1	0.415
MYH7B	0.414
TTK	0.414
SRRM2	0.414
ACBD4	0.413
GOSR2	0.413
EXOSC9	0.413
GOLGA6L3	0.412
PPM1D	0.412
SAP30BP	0.412
TGM5	0.412
RPSA	0.412
BRIX1	0.412
RFFL	0.412
CYB561A3	0.412
RFXANK	0.411
EIF2AK4	0.411
RPL14	0.41
HIST1H2BE	0.41
RAD21	0.41
AAMP	0.41
ATXN1	0.409
NUP153	0.409
FBXW9	0.409
NIP7	0.408
NBPF16	0.408
SLC38A7	0.408
RIOK2	0.408
TUBA8	0.408
EIF4B	0.408
GOLGA6B	0.407
GOLGA8K	0.407
FOXD4L2	0.407
CTR9	0.407
INTS5	0.406
RIOK1	0.406
EGR2	0.406
RPL9	0.405
MYT1	0.405
GOLGA6A	0.405
TPX2	0.405
RPL8	0.404
COPA	0.403
ADRM1	0.403
GID4	0.402
PWP2	0.402
FCN2	0.402
PRPF3	0.401
MFAP1	0.401
POLR2J3	0.4
DHX38	0.4
UBAP1	0.4
AAAS	0.4
BRD2	0.4

Global Fraction of Cell Lines Where Essential: 625/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	26/28
blood	21/28
bone	23/26
breast	28/33
central nervous system	52/56
cervix	4/4
colorectal	14/17
esophagus	10/13
fibroblast	0/1
gastric	11/16
kidney	16/21
liver	16/20
lung	63/75
lymphocyte	13/16
ovary	24/26
pancreas	21/24
peripheral nervous system	14/16
plasma cell	14/15
prostate	1/1
skin	23/24
soft tissue	7/9
thyroid	2/2
upper aerodigestive	13/22
urinary tract	24/29
uterus	4/5

Essentiality in NALM6

Essentiality Rank: 651
Expression level (log2 read counts): 8.92

Expression Distribution

cytosolic small ribosomal subunit
SRP-dependent cotranslational protein targeting to membrane
cotranslational protein targeting to membrane
protein targeting to ER
establishment of protein localization to endoplasmic reticulum
viral transcription
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
viral gene expression
protein localization to endoplasmic reticulum
translational initiation
protein targeting to membrane
structural constituent of ribosome
nuclear-transcribed mRNA catabolic process
mRNA catabolic process
RNA catabolic process
establishment of protein localization to membrane
protein targeting
nucleobase-containing compound catabolic process
translation
peptide biosynthetic process
establishment of protein localization to organelle
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
protein localization to membrane
organic cyclic compound catabolic process
amide biosynthetic process
peptide metabolic process
intracellular membrane-bounded organelle
mRNA metabolic process
viral process
protein localization to organelle
symbiotic process
cellular amide metabolic process
interspecies interaction between organisms
cellular macromolecule catabolic process
Golgi apparatus
intracellular protein transport
macromolecule catabolic process
RNA binding