TARS2

Gene Information

Official Symbol: TARS2
Official Name: threonyl-tRNA synthetase 2, mitochondrial
Aliases and Previous Symbols: N/A
Entrez ID: 80222
UniProt: Q9BW92
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the class-II aminoacyl-tRNA synthetase family. The encoded protein is a mitochondrial aminoacyl-tRNA synthetase. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 4. [provided by RefSeq, Dec 2012].
UniProt Summary: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain. {ECO:0000269|PubMed:26811336}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
iCRT14 30μM R08 exp492	1.7
Oligomycin-A 2μM R00 exp25	1.7
Trimetrexate 0.03μM R08 exp535	1.7
AICAR 240μM R05 exp211	1.73
Salinomycin 3.5μM R08 exp521	1.73
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	1.75
Arsenate 40μM R06 exp264	1.75
Milciclib 2μM R08 exp502	1.79
Dorsomorphin 5μM R07 exp357	1.8
BI-D1870 3.15μM R02 exp66	1.81
Vemurafenib 6.6μM R02 exp89	1.84
CoCl2 18μM R07 exp346	1.85
ABT-702 5μM plus CoCl2 18μM R07 exp320	1.91
Cannabidiol 20μM R08 exp466	1.99
Hydroxyurea 100μM R07 exp329	2.01
Torin1 0.08μM R02 exp82	2.02
Bafilomycin-A1 0.009μM R08 exp454	2.03
Vemurafenib 6.6μM R08 exp434	2.04
CI-1040 9.5μM R08 exp472	2.06
Deferoxamine 11μM R07 exp350	2.07
QNZ 0.01μM R08 exp439	2.12
Mubritinib 0.2μM R01 exp48	2.19
GSK-J4 1.5μM R08 exp441	2.22
Trientine 500μM R08 exp534	2.22
UM0125461 0.74μM R02 exp84	2.76
Thimerosal 0.85μM R08 exp529	3.24

Gene	Correlation
HSD17B10	0.782
YARS2	0.761
NARS2	0.749
PARS2	0.738
SELRC1	0.733
GFM1	0.732
SCO2	0.726
MRPS34	0.721
MRPS6	0.72
DAP3	0.718
MRPS16	0.707
VARS2	0.705
MRPL23	0.699
MTG2	0.698
RPUSD4	0.697
MRPL21	0.697
EARS2	0.695
MRPS21	0.692
MRPL53	0.674
RBFA	0.672
MRPS14	0.671
MRPS5	0.666
COX16	0.665
NDUFB11	0.665
QRSL1	0.664
LARS2	0.663
DARS2	0.652
FASTKD5	0.649
MRPS18A	0.647
MRPS2	0.642
BCS1L	0.642
AARS2	0.641
MRP63	0.64
RNASEH1	0.639
MRPL12	0.638
GATC	0.636
MARS2	0.635
MRPS25	0.627
MRPS26	0.627
SARS2	0.625
RARS2	0.625
GTPBP10	0.624
KIAA0391	0.619
MRPL47	0.618
C10orf2	0.618
COA3	0.616
HARS2	0.615
WBSCR16	0.613
POLG2	0.611
COA6	0.608
SUPV3L1	0.608
MRPL3	0.608
NDUFAF7	0.607
PET112	0.606
NDUFA3	0.605
PNPT1	0.603
MRPS24	0.602
MRPS10	0.596
C12orf65	0.596
GFM2	0.595
TEFM	0.591
FTSJ2	0.59
TUFM	0.588
COX11	0.583
MRPL45	0.581
POLG	0.58
MRPS9	0.572
MRPL20	0.571
MTG1	0.57
MRPL15	0.568
MRPL34	0.566
POLRMT	0.566
PET117	0.563
FARS2	0.559
COX15	0.556
TOMM20	0.554
COX17	0.552
WARS2	0.551
MTPAP	0.551
MRPS33	0.548
MRPS12	0.547
MRPS11	0.546
PGM3	0.544
MRPS35	0.542
METTL17	0.542
NDUFB5	0.541
MTRF1L	0.54
MRPS23	0.538
MRPL11	0.536
NDUFAF3	0.535
MRPL36	0.532
AIFM1	0.532
TMEM242	0.529
MRPL43	0.528
MRPL55	0.527
NDUFA2	0.527
TFAM	0.526
MRPS27	0.525
COX7B	0.524
COQ2	0.523
C17orf89	0.522
MRPL44	0.521
SLC25A26	0.52
NDUFA1	0.519
ELAC2	0.518
NDUFB6	0.518
UQCRC2	0.517
CARS2	0.516
COX6C	0.514
DNLZ	0.514
TRUB2	0.514
MRPL4	0.511
ATP5A1	0.509
ATP5C1	0.506
MALSU1	0.505
MIPEP	0.503
MRPS7	0.503
MRPL42	0.501
ATP5D	0.5
ECSIT	0.498
DHRSX	0.496
MRPL39	0.495
MTERFD2	0.493
MRPL2	0.493
RPUSD3	0.492
FH	0.492
IBA57	0.492
MRPL52	0.492
RPIA	0.489
NDUFC2	0.489
COX5A	0.488
LSM10	0.487
CHCHD4	0.487
LRPPRC	0.486
NDUFS2	0.483
COX20	0.483
PDSS1	0.482
UQCRQ	0.48
ATP5SL	0.479
COQ3	0.477
CHCHD1	0.476
RNMTL1	0.474
TFB1M	0.47
MRPS22	0.47
MRPL18	0.469
MRPL33	0.468
GRSF1	0.464
MRPL37	0.463
DHX30	0.461
NDUFAF4	0.459
PPA2	0.458
RTN4IP1	0.458
NDUFS7	0.458
MRPL41	0.456
MRPL32	0.455
HMGXB3	0.454
TMEM261	0.454
NDUFB9	0.453
MTIF3	0.452
TPK1	0.452
SSBP1	0.452
TRMT61A	0.45
PTCD1	0.449
TMEM126B	0.449
G6PD	0.449
MTERFD1	0.448
TRIAP1	0.448
ALDH18A1	0.447
NDUFS8	0.446
MRPL22	0.446
MRPL17	0.446
PMVK	0.445
C1QBP	0.445
GTPBP6	0.445
MRPL46	0.445
ACAD9	0.444
COA5	0.444
NDUFV1	0.443
MRPL49	0.443
OPA1	0.44
NDUFB1	0.44
MRPL35	0.44
MTIF2	0.439
ATP5B	0.439
NDUFA10	0.438
MRPL13	0.437
SLC25A3	0.435
ALAS1	0.434
TOMM40	0.434
FASTKD1	0.432
UQCC2	0.43
PET100	0.429
SLC25A19	0.429
SSB	0.429
NDUFA11	0.428
UQCR10	0.428
COQ7	0.427
PPCS	0.426
GTPBP8	0.426
TIMM8B	0.425
PTCD3	0.423
NDUFC1	0.423
FASTKD2	0.422
ATP5H	0.422
MRPS28	0.422
MCAT	0.42
COX4I1	0.42
MTO1	0.42
NSUN4	0.419
ALG6	0.419
PITRM1	0.418
DDX28	0.417
PMM2	0.413
TFB2M	0.412
TAMM41	0.411
NDUFS5	0.41
NDUFB3	0.41
MRPS18B	0.41
PTPMT1	0.41
TOMM6	0.41
NUBPL	0.409
GARS	0.408
ERAL1	0.407
MRPL38	0.407
TEN1	0.407
HIGD2A	0.406
ALG8	0.406
PTDSS1	0.404
MRPL27	0.404
COQ6	0.403
AURKAIP1	0.4
HCCS	0.4
METTL1	0.4

Global Fraction of Cell Lines Where Essential: 378/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	17/28
blood	11/28
bone	10/26
breast	22/33
central nervous system	20/56
cervix	2/4
colorectal	11/17
esophagus	11/13
fibroblast	1/1
gastric	11/16
kidney	7/21
liver	9/20
lung	46/75
lymphocyte	4/16
ovary	4/26
pancreas	11/24
peripheral nervous system	6/16
plasma cell	9/15
prostate	0/1
skin	12/24
soft tissue	5/9
thyroid	0/2
upper aerodigestive	14/22
urinary tract	20/29
uterus	2/5

Essentiality in NALM6

Essentiality Rank: 245
Expression level (log2 read counts): 5.89

Expression Distribution

TGS
tRNA-synt 2b
tRNA SAD
HGTP anticodon

mitochondrial threonyl-tRNA aminoacylation
threonyl-tRNA aminoacylation
threonine-tRNA ligase activity
tRNA aminoacylation for mitochondrial protein translation
aminoacyl-tRNA metabolism involved in translational fidelity
aminoacyl-tRNA editing activity
regulation of translational fidelity
mitochondrial RNA metabolic process
tRNA aminoacylation for protein translation
tRNA aminoacylation
amino acid activation
mitochondrial translation
mitochondrial gene expression
tRNA metabolic process
cellular amino acid metabolic process
mitochondrial matrix
translation
peptide biosynthetic process
cellular component
ncRNA metabolic process
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
protein homodimerization activity
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
organonitrogen compound biosynthetic process
ATP binding
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
small molecule metabolic process
macromolecule biosynthetic process
gene expression