FASTKD5

Gene Information

Official Symbol: FASTKD5
Official Name: FAST kinase domains 5
Aliases and Previous Symbols: N/A
Entrez ID: 60493
UniProt: Q7L8L6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Plays an important role in the processing of non- canonical mitochondrial mRNA precursors (PubMed:25683715). {ECO:0000269|PubMed:25683715}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Hypoxia 5%O2 R04 exp191	-3.05
HMS-I2 10μM R06 exp288	-2.47
Nicotinamide 1000μM R03 exp101	-2.32
ABT-702 5μM R06 exp261	-2.03
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-1.95
A-196 10μM R03 exp114	-1.93
Ethanol 0.003 R08 exp437	-1.93
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	-1.92
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	-1.88
Benzoate 10000μM R08 exp455	-1.87
Q15 1 to 2μM on day4 R04 exp164	-1.86
Nicotinate 1000μM R03 exp140	-1.83
TNF-alpha 44ng/ml R08 exp533	-1.81
IU1-47 25μM R04 exp182	-1.76
HMS-I2 5μM R06 exp287	-1.7
Bafilomycin-A1 0.009μM R08 exp454	1.72
Dorsomorphin 5μM R07 exp357	1.77
Hinokiflavone 12μM R08 exp487	1.79
Vitamin-D3 40μM R08 exp536	2.08
LLY-283 2.6μM R06 exp290	2.12
Salinomycin 3.5μM R08 exp521	2.12
TIC10 10μM R08 exp532	2.32
ONC212 0.15μM R08 exp513	2.49
CB-5083 0.4μM R08 exp468	2.5
Hydroxyurea 100μM R07 exp329	2.78
Vemurafenib 6.6μM R08 exp434	2.82
Rotenone 0.07μM R08 exp431	3.1

Gene	Correlation
SELRC1	0.718
MRPL23	0.694
YARS2	0.676
MRPL21	0.674
MRPS21	0.674
MRPS6	0.668
HSD17B10	0.667
EARS2	0.663
COX16	0.663
DAP3	0.66
SCO2	0.659
MRPS5	0.657
RPUSD4	0.654
NARS2	0.651
TARS2	0.649
COA3	0.645
MRPS16	0.643
QRSL1	0.641
VARS2	0.634
MRPL47	0.632
MRPS34	0.627
MRPS18A	0.624
PARS2	0.621
MRPS2	0.617
GATC	0.615
MRPL53	0.613
COA6	0.609
MRPS14	0.608
RARS2	0.607
MTG2	0.605
BCS1L	0.603
COX15	0.601
RBFA	0.601
SARS2	0.6
PET112	0.599
COX7B	0.596
C10orf2	0.595
GFM1	0.595
MRP63	0.588
HARS2	0.586
LARS2	0.58
RNASEH1	0.577
C12orf65	0.576
MRPS10	0.576
MRPS26	0.575
MRPS24	0.57
MTPAP	0.569
GTPBP10	0.567
DARS2	0.567
TUFM	0.566
AARS2	0.561
PDSS1	0.561
MRPL12	0.561
MTG1	0.556
TMEM242	0.553
COX11	0.552
MARS2	0.55
TEFM	0.547
KIAA0391	0.544
TRUB2	0.544
PGM3	0.543
FTSJ2	0.542
MRPS25	0.542
WBSCR16	0.539
COX6C	0.537
MRPL45	0.537
SUPV3L1	0.537
PET117	0.537
LSM10	0.536
COX17	0.534
MTERFD2	0.533
MRPS9	0.531
DHRSX	0.531
MRPS12	0.53
GFM2	0.526
MRPL55	0.526
PET100	0.524
POLG2	0.523
MRPL34	0.521
MRPL43	0.52
MRPS35	0.519
CHCHD4	0.519
COA5	0.518
MRPL3	0.517
MRPL15	0.513
FARS2	0.512
NDUFAF7	0.512
PNPT1	0.511
ATP5D	0.51
NDUFB11	0.508
MTRF1L	0.505
LRPPRC	0.505
NDUFA3	0.503
SLC25A26	0.501
MRPL18	0.5
MRPL4	0.498
MRPL20	0.496
COQ2	0.495
METTL17	0.494
ATP5C1	0.494
POLG	0.494
MRPL44	0.485
COQ4	0.485
MRPL11	0.484
COX6B1	0.484
DHX30	0.483
MRPS33	0.481
UQCRC2	0.481
MIPEP	0.476
MRPL22	0.476
MRPS23	0.474
ATP5A1	0.474
UQCR10	0.473
DNLZ	0.472
NDUFA2	0.471
RPUSD3	0.471
MRPS11	0.471
TBRG4	0.468
CHCHD1	0.465
WARS2	0.464
C17orf89	0.463
MTIF3	0.463
COQ7	0.46
POLRMT	0.459
UQCC2	0.458
MRPL2	0.458
NDUFAF4	0.455
TRIAP1	0.455
CYCS	0.454
OPA1	0.453
NDUFC2	0.452
MRPL42	0.451
CARS2	0.451
NDUFB3	0.451
SSBP1	0.449
TIMM8B	0.449
ATP5B	0.449
NDUFB5	0.448
COX20	0.448
TOMM20	0.448
MRPL1	0.446
CLPP	0.446
TOMM22	0.446
DDX28	0.446
NDUFA1	0.444
NDUFS7	0.444
MRPL49	0.444
MRPS7	0.443
UQCRC1	0.443
MCAT	0.443
HCCS	0.44
AIFM1	0.44
MRPL36	0.44
RPIA	0.439
MRPS22	0.438
NDUFV1	0.438
COQ3	0.437
ALG8	0.436
MRPL46	0.435
NDUFS2	0.435
COX19	0.435
COX5A	0.434
MRPL41	0.434
ATP5SL	0.434
TAMM41	0.434
FH	0.433
RTN4IP1	0.432
MRPS17	0.432
MRPL33	0.43
MRPS28	0.428
HMGXB3	0.428
MRPL13	0.425
AASDHPPT	0.422
PTPMT1	0.421
PTCD3	0.419
MTO1	0.418
PGS1	0.418
ELAC2	0.418
HIGD2A	0.416
MRPS27	0.415
GARS	0.415
MRPL39	0.414
ECSIT	0.413
PMVK	0.413
ACAD9	0.412
TFAM	0.412
IBA57	0.412
MRPL37	0.411
MALSU1	0.41
GEMIN7	0.41
FASTKD2	0.406
UQCRQ	0.406
TAZ	0.406
MINOS1	0.405
MRPL51	0.403
NDUFB6	0.403
C11orf57	0.402
MTIF2	0.402
TOMM40	0.4
BRWD1	0.4
ATP5H	0.4

Global Fraction of Cell Lines Where Essential: 23/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	1/28
bone	1/26
breast	0/33
central nervous system	0/56
cervix	1/4
colorectal	1/17
esophagus	2/13
fibroblast	0/1
gastric	1/16
kidney	1/21
liver	0/20
lung	3/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1660
Expression level (log2 read counts): 5.42

Expression Distribution

FAST 2
RAP
FAST 1

ribonucleoprotein granule
mitochondrial RNA processing
rRNA binding
mitochondrial RNA metabolic process
mitochondrial nucleoid
mitochondrial gene expression
cellular respiration
energy derivation by oxidation of organic compounds
protein kinase activity
generation of precursor metabolites and energy
mRNA processing
mRNA metabolic process
RNA processing
oxidation-reduction process
protein phosphorylation
mitochondrion
phosphorylation
RNA binding
RNA metabolic process
gene expression