PSMD11

Gene Information

Official Symbol: PSMD11
Official Name: proteasome 26S subunit, non-ATPase 11
Aliases and Previous Symbols: N/A
Entrez ID: 5717
UniProt: O00231
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:22972301}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Tozasertib 0.1μM R07 exp414	-2.28
Tanespimycin 14μM R08 exp527	-2.13
Nutlin-3A 1.6μM R06 exp294	-2
PU-H71 1μM R08 exp515	-1.93
42°C R08 exp539	-1.9
Doxorubicin 0.02μM R08 exp478	-1.88
Sulforaphane 9μM R08 exp525	-1.85
iCRT14 30μM R08 exp492	-1.82
Artemisinin 50μM R08 exp450	-1.81
JQ1 0.8μM R08 exp435	-1.78
Staurosporine 0.02μM R08 exp524	-1.76
Salinomycin 3.5μM R08 exp521	-1.73
MK-1775 0.32μM R02 exp75	1.73
Mdivi-1 15μM R05 exp217	1.76
5-Fluorouracil 2μM R00 exp1	1.81
Nifurtimox 1μM R03 exp141	1.81
Chloramphenicol 20μM R00 exp13	1.83
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	1.87
CB-839 10μM R05 exp224	2.06
DABN 2μM R00 exp16	2.1
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	2.15
Nicotinamide 1000μM R03 exp101	2.15
Vinorelbine 0.001μM R05 exp249	2.2
Colchicine 0.009μM R05 exp215	2.21
Geldanamycin 0.01μM R05 exp235	2.26
A-769662 20μM R07 exp331	2.34
CHIR-124 0.04μM R06 exp272	2.56
Rapamycin 1μM R00 exp29	3.01

Gene	Correlation
DDTL	0.609
PSMD1	0.573
CHD4	0.565
PAN2	0.564
SMG1	0.559
VASN	0.559
MT1E	0.552
PSMA6	0.55
PAN3	0.548
ZFAND5	0.548
RPS28	0.545
PSMD3	0.538
PSMC6	0.535
PSMC1	0.534
LRR1	0.525
TERF2	0.524
TCEB3CL2	0.524
CDC73	0.524
PSMD13	0.523
SCAF1	0.519
PSMD14	0.519
COPA	0.519
C14orf93	0.518
SMG7	0.518
ATXN1	0.516
MYO1H	0.515
BCL2L1	0.511
PSMB4	0.508
COPE	0.508
RPS12	0.508
COPG1	0.506
KPNB1	0.505
RFC1	0.504
UBAP1	0.502
CCNA2	0.501
TCEB3C	0.499
TOP1MT	0.497
AAMP	0.496
TBC1D3G	0.496
NOP16	0.492
ZNF106	0.49
PSMC2	0.489
POLA2	0.489
DDT	0.488
RANBP2	0.487
GID4	0.485
TBC1D3H	0.484
TWISTNB	0.484
MYB	0.482
NPIPB5	0.48
HAP1	0.479
SSH2	0.479
RBM39	0.477
WDR43	0.476
POLE	0.476
PSMB2	0.474
KCTD17	0.474
PSMA7	0.474
C1QTNF9B	0.474
ORC1	0.473
DTL	0.473
SUPT6H	0.472
ATP13A1	0.471
ZNF830	0.471
ISCU	0.471
RPS14	0.47
TCEB3CL	0.47
PCF11	0.467
CDT1	0.466
ADRM1	0.466
CBWD3	0.464
RPS19	0.464
RPSA	0.464
NUPL1	0.463
OR10G3	0.463
POLR2F	0.463
ORC6	0.462
PWP2	0.462
CASC3	0.46
TBC1D3F	0.46
PSMB1	0.46
CBWD5	0.459
COL2A1	0.459
PSMD7	0.459
TFIP11	0.458
NAPA	0.457
SFPQ	0.456
GOLGA8O	0.456
AHCTF1	0.456
NBPF10	0.456
DDX56	0.455
RBBP5	0.454
NOL10	0.454
PSMC4	0.453
TBC1D3E	0.453
CGB2	0.453
TBC1D3I	0.453
TBC1D3K	0.452
CCDC94	0.452
TBC1D3L	0.452
PLCG2	0.452
MED12	0.451
SYT9	0.45
PLK4	0.448
PSMC3	0.448
RPL35	0.448
PAF1	0.448
RPS2	0.446
AKIRIN2	0.446
SF3A1	0.446
UPF1	0.446
DNM2	0.446
CCDC64B	0.446
ABT1	0.446
COPB2	0.445
DISP2	0.445
XYLT2	0.443
CDCA3	0.442
RRN3	0.442
AQR	0.442
FAM160A1	0.441
RAD21	0.441
NBPF16	0.441
PSMD6	0.44
TSG101	0.439
CACNA1A	0.439
GGA3	0.439
RPS3A	0.439
ANKLE2	0.438
HIST1H2BE	0.438
PDCD11	0.438
CBWD6	0.437
TBC1D3	0.437
PSMC5	0.436
SNRPA1	0.435
NUP93	0.435
DNTTIP2	0.435
PRKCZ	0.434
MYH7B	0.434
DHX38	0.433
PSMD2	0.432
POLA1	0.432
NUP54	0.432
CTR9	0.432
TRAIP	0.431
SF3A3	0.431
XPO1	0.431
TTYH1	0.43
TERF1	0.43
UTP3	0.43
BRD2	0.43
CHMP2A	0.429
NUP160	0.429
SULT1A4	0.429
SULT1A3	0.428
RPS7	0.428
CWC22	0.427
CDC45	0.427
UTP20	0.426
RRP15	0.426
OGFR	0.426
HIST2H2BF	0.426
TRA2B	0.426
NUP133	0.426
RPL30	0.425
NFE2L1	0.425
TBC1D3C	0.424
TOPBP1	0.423
KIF3C	0.421
MED14	0.42
CHCHD3	0.42
RFPL3	0.419
USP36	0.419
RPL14	0.418
BYSL	0.418
TICRR	0.418
CMYA5	0.417
SLC6A17	0.417
TGM5	0.417
NDC1	0.415
RPL8	0.415
SLC38A7	0.415
AATF	0.414
NOL8	0.414
LAD1	0.414
BRIX1	0.414
MDM2	0.413
DOCK6	0.412
SNIP1	0.411
RPS9	0.41
PLA2G4F	0.409
WDR87	0.409
GAR1	0.409
SSRP1	0.409
GPRIN2	0.408
ACSF2	0.408
EXOSC5	0.407
ZFYVE16	0.407
SLC4A1	0.407
ACBD4	0.407
ANKLE1	0.406
RNF121	0.406
IGFN1	0.406
S1PR4	0.405
KLHL1	0.405
KRT36	0.405
EXOSC9	0.404
IK	0.404
GOLGA6L3	0.404
MYT1L	0.404
NOP14	0.404
MYO18A	0.403
LIPE	0.401
DDX21	0.401
TRIM52	0.401
WDR75	0.401
CHAF1A	0.4
PSMD12	0.4
KRT78	0.4
CLPTM1	0.4

Global Fraction of Cell Lines Where Essential: 533/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	20/28
blood	22/28
bone	18/26
breast	28/33
central nervous system	37/56
cervix	2/4
colorectal	8/17
esophagus	6/13
fibroblast	1/1
gastric	12/16
kidney	16/21
liver	16/20
lung	51/75
lymphocyte	14/16
ovary	22/26
pancreas	15/24
peripheral nervous system	13/16
plasma cell	14/15
prostate	0/1
skin	17/24
soft tissue	7/9
thyroid	2/2
upper aerodigestive	10/22
urinary tract	20/29
uterus	4/5

Essentiality in NALM6

Essentiality Rank: 243
Expression level (log2 read counts): 6.65

Expression Distribution

proteasome regulatory particle, lid subcomplex
proteasome assembly
proteasome accessory complex
proteasome complex
regulation of cellular amino acid metabolic process
regulation of hematopoietic stem cell differentiation
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
regulation of transcription from RNA polymerase II promoter in response to hypoxia
antigen processing and presentation of exogenous peptide antigen via MHC class I
NIK/NF-kappaB signaling
regulation of cellular amine metabolic process
anaphase-promoting complex-dependent catabolic process
regulation of hematopoietic progenitor cell differentiation
negative regulation of G2/M transition of mitotic cell cycle
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
interleukin-1-mediated signaling pathway
Wnt signaling pathway, planar cell polarity pathway
antigen processing and presentation of peptide antigen via MHC class I
negative regulation of cell cycle G2/M phase transition
regulation of establishment of planar polarity
stimulatory C-type lectin receptor signaling pathway
secretory granule lumen
innate immune response activating cell surface receptor signaling pathway
regulation of stem cell differentiation
tumor necrosis factor-mediated signaling pathway
regulation of transcription from RNA polymerase II promoter in response to stress
ficolin-1-rich granule lumen
regulation of DNA-templated transcription in response to stress
non-canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
stem cell differentiation
regulation of cellular ketone metabolic process
Fc-epsilon receptor signaling pathway
cellular response to interleukin-1
negative regulation of canonical Wnt signaling pathway
T cell receptor signaling pathway
antigen processing and presentation of exogenous peptide antigen
positive regulation of Wnt signaling pathway
regulation of mRNA stability
regulation of morphogenesis of an epithelium