NARS2

Gene Information

Official Symbol: N/ARS2
Official Name: asparaginyl-tRNA synthetase 2, mitochondrial
Aliases and Previous Symbols: N/A
Entrez ID: 79731
UniProt: Q96I59
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of asparagine to tRNA molecules. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency 24 (COXPD24). [provided by RefSeq, Mar 2015].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
HMS-I2 10μM R06 exp288	-1.75
Aphidicolin 0.4μM R08 exp440	1.74
Artemisinin 50μM R08 exp450	1.78
Mubritinib 0.2μM R02 exp65	1.78
Phenformin 20μM R05 exp212	1.78
Epothilone-B 0.0015μM R05 exp231	1.79
BI-D1870 3.15μM R02 exp66	1.8
Olaparib 4μM R08 exp512	1.81
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	1.86
ABT-702 5μM plus CoCl2 18μM R07 exp320	1.89
CR131-b 0.005μM R08 exp474	1.93
LLY-283 2.6μM R06 exp290	1.94
TIC10 10μM R08 exp532	1.94
Torin1 0.08μM R02 exp82	2.08
Vemurafenib 6.6μM R08 exp434	2.2
Hydroxyurea 100μM R07 exp329	2.25
ONC212 0.15μM R08 exp513	2.25
iCRT14 30μM R08 exp492	2.31
Arsenate 40μM R06 exp264	2.41
Amiloride 100μM R08 exp447	2.45
QNZ 0.01μM R08 exp439	2.51
UM0125461 0.74μM R02 exp84	2.52
Genistein 15μM R07 exp360	2.53
Thimerosal 0.85μM R08 exp529	2.77
Oligomycin-A 2μM R00 exp25	3.04

Gene	Correlation
LARS2	0.763
DAP3	0.76
SELRC1	0.756
YARS2	0.756
TARS2	0.749
RARS2	0.742
MRPS6	0.742
QRSL1	0.736
GFM1	0.731
HSD17B10	0.73
EARS2	0.728
MRPL21	0.725
MRPS21	0.723
PARS2	0.722
PET112	0.71
SCO2	0.704
COA3	0.695
RPUSD4	0.689
FTSJ2	0.688
MRPS16	0.685
DARS2	0.685
MRPS14	0.683
AARS2	0.68
VARS2	0.677
MRPL23	0.675
RBFA	0.673
PET117	0.67
HARS2	0.668
MRPL45	0.665
MRPS34	0.653
FASTKD5	0.651
MARS2	0.646
BCS1L	0.643
MRPL3	0.643
WBSCR16	0.642
TEFM	0.642
POLG2	0.636
MTG2	0.636
GATC	0.635
COX11	0.633
NDUFB11	0.63
COX16	0.63
MRP63	0.629
GTPBP10	0.629
MRPL12	0.626
MRPS5	0.626
MRPL53	0.621
MRPL47	0.618
CARS2	0.616
WARS2	0.616
POLG	0.614
NDUFAF7	0.61
METTL17	0.608
MRPS25	0.608
RPUSD3	0.603
KIAA0391	0.601
C10orf2	0.6
MRPS18A	0.6
TFB1M	0.598
COX15	0.598
MRPS26	0.597
GFM2	0.593
MTRF1L	0.593
COA6	0.587
MRPL20	0.583
RNASEH1	0.582
MRPS10	0.578
MRPL42	0.576
NDUFA1	0.576
MTERFD1	0.573
MRPS22	0.572
PNPT1	0.571
POLRMT	0.571
COX7B	0.569
MTERFD2	0.568
MRPL43	0.564
MRPS12	0.562
MRPL4	0.562
MTG1	0.562
NDUFA3	0.561
COX20	0.561
MALSU1	0.56
DDX28	0.559
MRPS27	0.559
FARS2	0.555
SUPV3L1	0.554
NDUFC2	0.553
PGM3	0.549
MRPS35	0.548
MRPS9	0.546
MIPEP	0.546
GTPBP6	0.546
SSBP1	0.545
MTIF2	0.543
NDUFS2	0.543
MRPS24	0.541
ATP5SL	0.541
MRPS2	0.538
TMEM242	0.536
ACAD9	0.536
CLPP	0.535
HMGXB3	0.534
TUFM	0.532
TFAM	0.531
NDUFB6	0.528
TRUB2	0.528
ATP5C1	0.527
NDUFA2	0.527
C12orf65	0.527
MRPS23	0.524
MRPL39	0.524
DNLZ	0.523
MRPL35	0.523
SARS2	0.519
MRPL18	0.519
NSUN4	0.518
SLC25A26	0.517
TOMM20	0.517
MRPL44	0.517
ERAL1	0.516
NDUFB9	0.515
MRPL2	0.515
NDUFAF3	0.515
MRPS7	0.514
MRPS33	0.511
DHRSX	0.509
RTN4IP1	0.509
GRSF1	0.508
MRPL33	0.506
MRPL49	0.505
MRPL15	0.505
COQ7	0.505
HIGD2A	0.502
RNMTL1	0.502
AIFM1	0.502
LRPPRC	0.501
PMVK	0.5
MRPL11	0.498
PTCD3	0.497
COX17	0.497
NDUFB5	0.496
CHCHD1	0.495
MRPS28	0.491
NDUFA11	0.491
FASTKD2	0.49
MTO1	0.49
MRPS18B	0.488
IBA57	0.488
COX19	0.484
NDUFS5	0.484
MRPL51	0.484
MRPL17	0.483
FH	0.483
NDUFV1	0.482
COQ2	0.482
MRPL37	0.48
MTPAP	0.48
MRPS11	0.48
MTRF1	0.477
NUBPL	0.476
MRPL28	0.475
SLC25A3	0.475
NDUFAF5	0.474
MRPL13	0.473
TRMT10C	0.472
NDUFA8	0.47
ALAS1	0.47
PDSS1	0.47
MRPS17	0.469
LSM10	0.466
MRPL52	0.466
MRPL22	0.465
MRPL1	0.465
TIMMDC1	0.462
METTL1	0.462
MRPL38	0.461
ICT1	0.461
TFB2M	0.46
NDUFS1	0.457
MCAT	0.457
C1QBP	0.456
ATP5A1	0.456
TMEM261	0.454
NDUFAF1	0.454
ELAC2	0.454
NDUFC1	0.454
GTPBP8	0.453
NDUFS7	0.452
PPCDC	0.452
ATP5D	0.451
MRPL36	0.451
MRPL55	0.451
UQCR10	0.451
UQCRC2	0.448
TOMM7	0.447
COQ3	0.446
DHX30	0.446
ECSIT	0.445
PTPMT1	0.445
ALDH18A1	0.443
NDUFB3	0.443
MRPL46	0.44
COQ6	0.439
COX6C	0.437
PET100	0.437
COQ4	0.436
SCO1	0.434
TOMM22	0.433
COX6B1	0.433
COQ5	0.433
FASTKD1	0.432
ADAT2	0.429
ATP5B	0.428
OPA1	0.428
TRMT61A	0.428
SLC25A51	0.428
SLC7A1	0.427
NDUFA10	0.426
NDUFAF4	0.423
PTCD1	0.421
RPIA	0.418
MRPL24	0.418
ALG6	0.418
SLC25A52	0.416
MRPL34	0.415
UQCRC1	0.414
MRPL32	0.414
MRPL27	0.412
XPNPEP3	0.411
MTIF3	0.41
MRPL41	0.409
PDSS2	0.409
PTRHD1	0.408
PITRM1	0.406
ALG8	0.406
NDUFAF6	0.404
C17orf89	0.404
SSB	0.403
PREPL	0.403
FECH	0.403
NDUFB10	0.402
SLC31A1	0.402
NDUFB7	0.402
TOMM6	0.402
COX5A	0.4

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 391
Expression level (log2 read counts): 4.68

Expression Distribution