RPL35

Gene Information

Official Symbol: RPL35
Official Name: ribosomal protein L35
Aliases and Previous Symbols: N/A
Entrez ID: 11224
UniProt: P42766
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Component of the large ribosomal subunit. {ECO:0000305|PubMed:12962325}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bortezomib 0.05μM R00 exp7	-2.49
Rotenone 20μM R00 exp34	-2.44
Etoposide 10μM R00 exp20	-2.2
BRD2 inhibitor II 20μM R07 exp341	1.73
Rifampicin 10μM R00 exp32	1.73
Fluvastatin 2.2μM R06 exp282	1.81
Menadione 5μM R06 exp292	1.83
Golgicide-A 4μM R03 exp122	1.88
UM0130462 0.025 to 0.035μM day4 R05 exp247	1.93

Gene	Correlation
PSMB4	0.625
POLR2J3	0.606
TCEB3C	0.589
SUPT5H	0.574
CACTIN	0.572
EXOSC9	0.564
TCEB3CL2	0.559
TCEB3CL	0.554
PSMB2	0.552
RAD51	0.549
COX7A2L	0.548
VPS28	0.544
RPL6	0.537
CHD4	0.537
PSMA6	0.535
RRP7A	0.534
TBC1D3C	0.532
C14orf93	0.532
RPS12	0.528
IGFN1	0.528
CBWD6	0.527
EBNA1BP2	0.527
TBC1D3H	0.527
DTL	0.525
NARFL	0.523
RPS7	0.522
UTP20	0.522
PSMA7	0.522
GOLGA8J	0.52
RPS2	0.52
DDX56	0.52
RPS9	0.52
PSMD2	0.52
KIAA0947	0.518
TBC1D3G	0.517
NOL10	0.517
MDM2	0.515
ORC1	0.515
DNTTIP2	0.514
SART1	0.514
IK	0.513
PAN3	0.512
WDR75	0.511
TBC1D3F	0.511
RPS5	0.51
TSPY2	0.51
C1QTNF9B	0.509
SUPT6H	0.508
RPL34	0.507
POLA1	0.506
PSMC1	0.505
SF3A1	0.504
BYSL	0.504
CBWD3	0.503
LAD1	0.503
DDTL	0.502
POLE	0.502
POLA2	0.501
PRIM1	0.501
NUP160	0.5
TBC1D3I	0.5
TBC1D3K	0.5
TBC1D3E	0.5
TBC1D3L	0.5
CBWD5	0.499
SLC4A1	0.497
ATP6V1B2	0.496
EXOSC8	0.495
RANBP2	0.494
TSPY1	0.493
LRR1	0.49
RPS19BP1	0.49
ORC6	0.489
PSMB1	0.489
NPIPB5	0.488
COL2A1	0.487
PWP2	0.486
RRN3	0.486
SF3A3	0.485
AQR	0.485
ZNF574	0.485
RPS3A	0.485
CCNA2	0.485
HAP1	0.484
RPL38	0.481
VASN	0.481
RBBP5	0.48
RNF113A	0.479
COPE	0.479
CCDC116	0.479
COPB1	0.478
SNRPA1	0.478
PSMC6	0.477
ZNF655	0.476
PSMB3	0.476
KRT78	0.475
PSMC5	0.474
TBC1D3	0.474
MFSD12	0.474
GOLGA6L1	0.474
PSMD3	0.473
CHAF1A	0.473
ACSF2	0.472
CTAGE4	0.472
COPG1	0.472
PSMD14	0.472
RPS11	0.472
ZFAND5	0.472
CDC6	0.471
HIST2H3A	0.471
SLC6A17	0.471
HIST2H3C	0.471
OR10G3	0.47
NPIPB11	0.469
WDR43	0.469
CDT1	0.468
SSH2	0.468
NFATC4	0.467
POLR2D	0.467
CDC73	0.467
PSMD1	0.467
TSPY8	0.467
AATF	0.466
EXOSC1	0.465
CEBPZ	0.465
TICRR	0.464
TFIP11	0.463
GOLGA6L6	0.463
APC2	0.462
SLC38A7	0.46
KPNB1	0.46
SMG7	0.46
ATP6V1C1	0.46
KCTD17	0.459
ART5	0.458
EXOSC6	0.458
PPFIA4	0.458
MPHOSPH10	0.457
PSMC2	0.457
POLR1A	0.457
RPL8	0.456
DHFR	0.455
NOL12	0.455
DIDO1	0.455
RNPC3	0.454
CEP192	0.454
GOLGA6L3	0.454
BRD2	0.454
UQCRH	0.453
ISCU	0.453
C19orf53	0.453
POP5	0.452
BRIX1	0.452
RRP15	0.451
MT1E	0.451
CLN6	0.451
MTCH2	0.451
SF3B1	0.45
ZNF830	0.45
TAF1	0.449
NUPL1	0.449
TWISTNB	0.449
RBM39	0.449
CDH24	0.448
PSMD11	0.448
PPM1D	0.447
DDX21	0.447
CHCHD3	0.447
FAM160A1	0.446
MRS2	0.446
MBTD1	0.445
EXOSC3	0.445
UTP3	0.444
SF3A2	0.443
RPL12	0.442
RPL17	0.442
CDC45	0.442
RRP9	0.442
PAF1	0.442
PLK1	0.441
RBM48	0.441
SYT9	0.441
HINFP	0.44
ATP6V1A	0.44
MKI67IP	0.44
TIMELESS	0.44
HIST1H2BE	0.44
PCF11	0.44
RPA2	0.44
RIOK2	0.439
XYLT2	0.438
RAD21	0.437
POLR2A	0.437
GOLGA6L4	0.436
POLR2F	0.435
LOC643669	0.435
SNIP1	0.435
ATP6V0C	0.434
MYB	0.433
ATP6V0B	0.433
IMP3	0.433
GOLGA8O	0.433
NOL9	0.433
UPF1	0.432
NOP16	0.432
FBXW9	0.432
INTS5	0.431
GPX4	0.43
AAMP	0.43
MED14	0.429
TPX2	0.429
HGC6.3	0.428
NPIPB8	0.427
RPL9	0.427
NSF	0.427
AHCTF1	0.426
S1PR4	0.425
PDE4DIP	0.425
DHX38	0.425
ANKLE2	0.425
TP53TG3D	0.425
CGB2	0.424
COPB2	0.424
FAM86B2	0.424
RPS3	0.424
POLR2I	0.424
CTR9	0.423
ATP6AP1	0.423
INTS6	0.423
RRP12	0.422
NUP133	0.422
ATP13A1	0.422
NBPF10	0.422
ARCN1	0.422
GID4	0.421
PRPF3	0.421
CHMP4B	0.421
RILPL2	0.421
SMC2	0.42
RSL1D1	0.42
DIMT1	0.42
BMS1	0.419
TYMS	0.419
ZNF541	0.419
OSBP	0.419
WDR46	0.419
RPS28	0.419
XAB2	0.418
EFTUD2	0.418
CDCA5	0.418
TP53TG3B	0.418
PPIE	0.418
ANKLE1	0.417
TP53TG3	0.417
PLA2G4F	0.417
TP53TG3C	0.417
MYO18A	0.417
SAP30BP	0.417
PRPF8	0.417
RPL7L1	0.416
NGDN	0.415
STIL	0.415
EIF3G	0.415
AKIRIN2	0.414
CCDC64B	0.414
AKT1S1	0.414
EIF4A3	0.413
DNM2	0.413
COPZ1	0.413
HIVEP3	0.411
MFAP1	0.411
POLR2L	0.411
TERF1	0.411
DDX47	0.411
TRAIP	0.411
NUP205	0.41
NUP153	0.409
NUP43	0.409
NAPA	0.409
HIST2H2AA3	0.409
CHMP2A	0.409
RPL14	0.408
HIST2H2AA4	0.408
STRN	0.408
CTAGE9	0.408
MED17	0.408
SNRNP70	0.407
NELFCD	0.407
YTHDC1	0.407
AKAP1	0.406
GOLGA8K	0.405
CCDC94	0.405
HEATR1	0.405
MYO1H	0.405
SMG1	0.404
TSG101	0.404
DIEXF	0.404
MCOLN1	0.404
CACNA1A	0.404
FAM25B	0.404
TERF2	0.403
OGFR	0.403
CDCA3	0.403
PSAP	0.402
CWC22	0.402
GOLGA6B	0.401
TAF15	0.4
DISP2	0.4
PLEKHA4	0.4

Global Fraction of Cell Lines Where Essential: 659/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	24/28
blood	27/28
bone	22/26
breast	30/33
central nervous system	49/56
cervix	3/4
colorectal	13/17
esophagus	11/13
fibroblast	1/1
gastric	14/16
kidney	19/21
liver	18/20
lung	69/75
lymphocyte	15/16
ovary	24/26
pancreas	21/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	23/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	18/22
urinary tract	26/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 734
Expression level (log2 read counts): 8.3

Expression Distribution

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
maturation of LSU-rRNA
cytosolic large ribosomal subunit
ribosomal large subunit biogenesis
SRP-dependent cotranslational protein targeting to membrane
cotranslational protein targeting to membrane
protein targeting to ER
establishment of protein localization to endoplasmic reticulum
viral transcription
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
viral gene expression
protein localization to endoplasmic reticulum
translational initiation
protein targeting to membrane
mRNA binding
structural constituent of ribosome
nuclear-transcribed mRNA catabolic process
rRNA processing
mRNA catabolic process
rRNA metabolic process
RNA catabolic process
establishment of protein localization to membrane
ribosome biogenesis
protein targeting
nucleobase-containing compound catabolic process
translation
ncRNA processing
peptide biosynthetic process
establishment of protein localization to organelle
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
ribonucleoprotein complex biogenesis
ncRNA metabolic process
organic cyclic compound catabolic process
protein localization to membrane
amide biosynthetic process
peptide metabolic process
mRNA metabolic process
viral process