SRP14
Gene Information
- Official Symbol: SRP14
- Official Name: signal recognition particle 14
- Aliases and Previous Symbols: N/A
- Entrez ID: 6727
- UniProt: P37108
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
Pfam Domains GO Terms
Pfam Domains
| SRP14 |
GO Terms
| endoplasmic reticulum signal peptide binding |
| signal recognition particle, endoplasmic reticulum targeting |
| 7S RNA binding |
| SRP-dependent cotranslational protein targeting to membrane |
| cotranslational protein targeting to membrane |
| protein targeting to ER |
| establishment of protein localization to endoplasmic reticulum |
| secretory granule lumen |
| ficolin-1-rich granule lumen |
| protein localization to endoplasmic reticulum |
| protein targeting to membrane |
| establishment of protein localization to membrane |
| protein targeting |
| establishment of protein localization to organelle |
| protein localization to membrane |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| myeloid leukocyte activation |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulated exocytosis |
| protein localization to organelle |
| leukocyte mediated immunity |
| exocytosis |
| leukocyte activation |
| intracellular protein transport |
| secretion by cell |
| response to drug |
| export from cell |
| cell activation |
| immune effector process |
| secretion |
| RNA binding |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| establishment of localization in cell |
| nitrogen compound transport |
| immune response |
| extracellular region |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| THG1L | 0.671 |
| PMM2 | 0.641 |
| DPAGT1 | 0.637 |
| TRIAP1 | 0.634 |
| ALG1 | 0.631 |
| GMPPB | 0.607 |
| RTCB | 0.602 |
| ATXN10 | 0.597 |
| RPE | 0.593 |
| UAP1 | 0.593 |
| CRLS1 | 0.576 |
| GTF3C4 | 0.575 |
| ADSL | 0.574 |
| DHRSX | 0.572 |
| RABGGTB | 0.57 |
| RPTOR | 0.569 |
| GFPT1 | 0.567 |
| ROMO1 | 0.564 |
| HARS | 0.564 |
| DOHH | 0.564 |
| GEMIN8 | 0.561 |
| RNMT | 0.56 |
| TEN1 | 0.559 |
| SLC25A26 | 0.556 |
| TAZ | 0.556 |
| PPA2 | 0.554 |
| PPP2R3C | 0.553 |
| RPIA | 0.552 |
| GTF3C3 | 0.551 |
| GTF3C6 | 0.55 |
| ALG13 | 0.55 |
| ALG6 | 0.549 |
| UHRF1 | 0.547 |
| NAE1 | 0.544 |
| DHPS | 0.544 |
| GTF3C2 | 0.543 |
| LSM10 | 0.543 |
| TKT | 0.543 |
| PPCS | 0.533 |
| ATP2A2 | 0.532 |
| AASDHPPT | 0.531 |
| CHCHD4 | 0.53 |
| TSEN54 | 0.527 |
| CEP57 | 0.527 |
| UTP23 | 0.521 |
| DAD1 | 0.521 |
| BAP1 | 0.521 |
| VEZT | 0.518 |
| EXOC4 | 0.517 |
| PIK3R4 | 0.516 |
| ATIC | 0.514 |
| UBE2G2 | 0.514 |
| HSPD1 | 0.513 |
| GNB1L | 0.512 |
| EIF3F | 0.511 |
| DR1 | 0.511 |
| APAF1 | 0.51 |
| FH | 0.51 |
| ENO1 | 0.509 |
| RPP21 | 0.508 |
| BAK1 | 0.503 |
| DNLZ | 0.5 |
| CBFB | 0.5 |
| URM1 | 0.5 |
| TPI1 | 0.5 |
| HCCS | 0.5 |
| NSMCE1 | 0.499 |
| TAMM41 | 0.499 |
| PELO | 0.499 |
| C14orf80 | 0.498 |
| KDSR | 0.498 |
| ALG5 | 0.497 |
| MBTPS2 | 0.497 |
| SRD5A3 | 0.495 |
| SEC62 | 0.494 |
| MTOR | 0.494 |
| MED16 | 0.494 |
| TBCA | 0.494 |
| ELP3 | 0.494 |
| SNAPC5 | 0.491 |
| AARS | 0.491 |
| PGGT1B | 0.491 |
| TRMT5 | 0.49 |
| SLC25A19 | 0.49 |
| DOLK | 0.489 |
| PPP4C | 0.488 |
| PPP6C | 0.488 |
| PGM3 | 0.487 |
| TPRKB | 0.486 |
| TPK1 | 0.486 |
| GEMIN7 | 0.486 |
| ENY2 | 0.484 |
| GEMIN6 | 0.483 |
| EXOC3 | 0.483 |
| EPRS | 0.479 |
| TTI1 | 0.478 |
| DDX20 | 0.477 |
| TRMT10A | 0.476 |
| EIF4E | 0.474 |
| GTF2A2 | 0.474 |
| TUBD1 | 0.473 |
| N6AMT1 | 0.472 |
| C15orf41 | 0.472 |
| TAF1A | 0.472 |
| LSM11 | 0.469 |
| RAD1 | 0.468 |
| RFT1 | 0.467 |
| SRP9 | 0.467 |
| DDOST | 0.467 |
| BCS1L | 0.466 |
| TTI2 | 0.465 |
| WDR24 | 0.465 |
| KCTD5 | 0.464 |
| CDIPT | 0.461 |
| FAF2 | 0.46 |
| NBN | 0.459 |
| PDAP1 | 0.459 |
| CCT7 | 0.458 |
| HAUS8 | 0.458 |
| OSGEP | 0.457 |
| ATP5J | 0.456 |
| UBA5 | 0.455 |
| ALG2 | 0.455 |
| TRMT61A | 0.453 |
| TIMM13 | 0.452 |
| PGK1 | 0.452 |
| CTC1 | 0.451 |
| UBE2M | 0.45 |
| RAD50 | 0.45 |
| PLAA | 0.45 |
| OPA1 | 0.45 |
| SUPV3L1 | 0.45 |
| SSB | 0.448 |
| GEMIN5 | 0.447 |
| CASP9 | 0.447 |
| BUB3 | 0.445 |
| TTC4 | 0.445 |
| TRNT1 | 0.444 |
| DDX55 | 0.443 |
| UBA3 | 0.443 |
| TMEM41B | 0.44 |
| ORAOV1 | 0.439 |
| CMTR1 | 0.439 |
| UXT | 0.439 |
| ALG8 | 0.438 |
| MED4 | 0.437 |
| PKM | 0.437 |
| POLR3H | 0.437 |
| ALG14 | 0.436 |
| TMED10 | 0.436 |
| PDPK1 | 0.435 |
| MRPS33 | 0.435 |
| FGFR1OP | 0.434 |
| DPF2 | 0.433 |
| SEC63 | 0.432 |
| TBP | 0.431 |
| TRMT6 | 0.43 |
| ZRSR2 | 0.43 |
| MRPS5 | 0.43 |
| SARS2 | 0.43 |
| CCDC101 | 0.43 |
| TBCB | 0.429 |
| TELO2 | 0.429 |
| CTDNEP1 | 0.429 |
| TIMM22 | 0.427 |
| LAMTOR4 | 0.426 |
| DUSP12 | 0.424 |
| NAA20 | 0.424 |
| DDX42 | 0.424 |
| CYCS | 0.423 |
| DDX1 | 0.423 |
| RBMX2 | 0.423 |
| SNF8 | 0.423 |
| PAM16 | 0.423 |
| PPCDC | 0.422 |
| CSNK2B | 0.422 |
| SEC61G | 0.422 |
| GGPS1 | 0.421 |
| FNTA | 0.42 |
| RBFA | 0.419 |
| TUBE1 | 0.418 |
| CIAO1 | 0.418 |
| VDAC2 | 0.418 |
| C1D | 0.416 |
| YARS2 | 0.416 |
| PGS1 | 0.416 |
| SRPRB | 0.415 |
| PTAR1 | 0.415 |
| VRK1 | 0.415 |
| TXNL4B | 0.414 |
| PSMG4 | 0.414 |
| GTF3A | 0.413 |
| ELAC2 | 0.412 |
| WDR92 | 0.412 |
| C16orf59 | 0.411 |
| ZNHIT1 | 0.411 |
| ATP5A1 | 0.411 |
| NCOR1 | 0.411 |
| DHDDS | 0.409 |
| TGS1 | 0.409 |
| CEPT1 | 0.408 |
| EEF1E1 | 0.408 |
| MRPS6 | 0.407 |
| TOMM40 | 0.406 |
| RFK | 0.406 |
| HSD17B10 | 0.405 |
| UBE2K | 0.404 |
| ERCC2 | 0.403 |
| SDHA | 0.402 |
| WDR1 | 0.402 |
| TMA16 | 0.401 |
| LMO2 | 0.401 |
| UBE2J1 | 0.4 |
| GATC | 0.4 |
| ELP2 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 690/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 26/28 |
| blood | 25/28 |
| bone | 25/26 |
| breast | 30/33 |
| central nervous system | 52/56 |
| cervix | 4/4 |
| colorectal | 16/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 20/21 |
| liver | 20/20 |
| lung | 69/75 |
| lymphocyte | 14/16 |
| ovary | 25/26 |
| pancreas | 23/24 |
| peripheral nervous system | 15/16 |
| plasma cell | 13/15 |
| prostate | 0/1 |
| skin | 23/24 |
| soft tissue | 8/9 |
| thyroid | 2/2 |
| upper aerodigestive | 20/22 |
| urinary tract | 28/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 3781
- Expression level (log2 read counts): 7.01
Expression Distribution
SRP14 Expression in NALM6 Cells: 7.01
