MRPS6

Gene Information

Official Symbol: MRPS6
Official Name: mitochondrial ribosomal protein S6
Aliases and Previous Symbols: N/A
Entrez ID: 64968
UniProt: P82932
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
39°C R06 exp303	-1.93
Genistein 15μM R07 exp360	1.73
Oligomycin-A 2μM R00 exp25	1.75
BI-D1870 3.15μM R02 exp66	1.77
UM0125461 0.74μM R02 exp84	1.79
SNS-032 15μM R08 exp443	1.81
Nicotine 3000μM R08 exp510	1.9
Q15 2.7μM R02 exp79	1.93
Vemurafenib 6.6μM R08 exp434	1.94
CR131-b 0.005μM R08 exp474	1.96
TIC10 10μM R08 exp532	2
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	2.04
Tanespimycin 14μM R08 exp527	2.13
CoCl2 18μM R07 exp346	2.14
Hydroxyurea 100μM R07 exp329	2.21
Thimerosal 0.85μM R08 exp529	2.32
Salinomycin 3.5μM R08 exp521	2.45
Hinokiflavone 12μM R08 exp487	2.46
iCRT14 30μM R08 exp492	2.51
GSK-J4 1.5μM R08 exp441	2.52
LLY-283 2.6μM R06 exp290	2.56
ONC212 0.15μM R08 exp513	2.72

Gene	Correlation
YARS2	0.756
HSD17B10	0.754
NARS2	0.742
DAP3	0.741
MRPS21	0.731
MRPL21	0.73
TARS2	0.72
GFM1	0.712
PARS2	0.711
SELRC1	0.71
MRPS16	0.705
MRPS34	0.697
MRPL23	0.692
RPUSD4	0.69
SCO2	0.689
EARS2	0.686
MRPS26	0.682
MRPS5	0.682
QRSL1	0.679
MRPS18A	0.672
RARS2	0.669
FASTKD5	0.668
MRP63	0.663
LARS2	0.656
WBSCR16	0.655
RBFA	0.654
COX16	0.652
KIAA0391	0.65
SUPV3L1	0.647
VARS2	0.647
MRPS14	0.646
MRPL47	0.644
DARS2	0.643
SARS2	0.642
HARS2	0.642
MRPL53	0.634
COA3	0.632
MTG2	0.629
MARS2	0.627
MRPS9	0.617
BCS1L	0.617
MRPS25	0.616
COX15	0.612
RNASEH1	0.605
COX17	0.6
GFM2	0.598
MRPS33	0.597
MRPS2	0.596
GATC	0.596
NDUFAF7	0.594
C10orf2	0.593
TEFM	0.591
GTPBP10	0.589
TRUB2	0.588
PET112	0.587
COX7B	0.585
FTSJ2	0.585
PNPT1	0.583
NDUFB11	0.581
MRPL15	0.58
POLRMT	0.58
MRPL42	0.578
METTL17	0.573
FARS2	0.572
MRPL12	0.571
AIFM1	0.568
MRPL3	0.568
SLC25A26	0.567
MRPS10	0.567
NDUFA3	0.562
C12orf65	0.562
COA6	0.562
MRPS35	0.562
MRPL44	0.562
PGM3	0.559
PET117	0.556
MRPL20	0.552
MRPS22	0.551
TUFM	0.551
MRPS12	0.551
MRPS23	0.551
AARS2	0.55
MTPAP	0.548
PDSS1	0.546
MRPL36	0.544
MRPL4	0.542
MRPL18	0.538
MRPS24	0.536
POLG	0.536
DHRSX	0.536
NDUFC2	0.536
MRPL45	0.535
MTRF1L	0.53
MRPL33	0.529
MRPS11	0.529
ELAC2	0.528
UQCRC2	0.528
POLG2	0.528
WARS2	0.526
ATP5A1	0.526
MRPL11	0.526
COX11	0.522
C17orf89	0.52
TOMM20	0.518
NDUFAF4	0.517
MRPL55	0.515
ATP5SL	0.514
MRPL43	0.513
MTG1	0.512
NDUFA1	0.511
CARS2	0.508
MTERFD1	0.507
MTERFD2	0.506
MRPL34	0.505
TIMM8B	0.505
NDUFB5	0.505
MRPL22	0.505
DNLZ	0.505
TRIAP1	0.503
HIGD2A	0.502
CHCHD4	0.502
MRPL39	0.501
LRPPRC	0.498
NDUFA2	0.498
TFAM	0.498
MRPL52	0.498
DHX30	0.497
FH	0.497
CRLS1	0.496
ALG6	0.496
RPUSD3	0.496
TOMM22	0.494
ATP5D	0.492
COA5	0.492
LSM10	0.49
ACAD9	0.488
ALG8	0.486
NDUFB6	0.485
ATP5C1	0.485
NDUFAF3	0.484
RTN4IP1	0.484
COQ2	0.484
RNMTL1	0.481
CHCHD1	0.481
ATP5B	0.478
MRPL41	0.478
HMGXB3	0.478
TFB1M	0.477
MALSU1	0.477
MRPS7	0.476
COX6C	0.473
MRPS27	0.473
MRPL35	0.473
NDUFS2	0.471
SRD5A3	0.468
MIPEP	0.468
COX6B1	0.467
ATXN10	0.466
PTCD3	0.466
PPA2	0.465
MRPL27	0.465
PITRM1	0.464
NDUFB9	0.464
CLPP	0.463
MRPL2	0.463
TMEM242	0.462
ROMO1	0.462
MRPL46	0.461
HCCS	0.461
NDUFA11	0.459
UQCR10	0.458
OPA1	0.458
RPIA	0.458
FASTKD1	0.456
ALDH18A1	0.455
TIMM17A	0.452
MRPL51	0.452
TPK1	0.452
TAMM41	0.451
ECSIT	0.451
PMM2	0.449
PMVK	0.448
SEC62	0.448
NDUFV1	0.446
COQ7	0.446
MRPL1	0.445
MTIF2	0.445
MRPL17	0.444
TMEM126B	0.443
ATP5J	0.443
DDX28	0.442
MRPL13	0.442
GTPBP6	0.439
DPAGT1	0.439
COX5A	0.437
NDUFAF1	0.437
PTDSS1	0.436
COX20	0.436
MRPL28	0.435
TOMM40	0.435
IBA57	0.435
COQ3	0.433
COQ4	0.433
SSBP1	0.432
FASTKD2	0.431
ALAS1	0.431
AASDHPPT	0.429
MRPL37	0.428
MCAT	0.428
CYCS	0.427
ATP5H	0.427
PET100	0.427
USO1	0.425
MTIF3	0.424
SCO1	0.423
TOMM7	0.423
TRMT61A	0.422
ATIC	0.421
UQCRQ	0.421
NDUFA10	0.419
PPCS	0.418
UAP1	0.418
TOMM6	0.417
SLC25A3	0.417
MRPL32	0.417
DOLK	0.415
NDUFS7	0.414
TMEM261	0.414
MBTPS2	0.413
TFB2M	0.413
MRPS17	0.412
SSB	0.412
GLRX5	0.412
TAZ	0.411
PGS1	0.411
PPCDC	0.409
NDUFB3	0.408
COQ6	0.407
SRP14	0.407
THG1L	0.406
NDUFC1	0.406
NDUFA8	0.406
ALG5	0.406
ALG3	0.405
PGGT1B	0.405
UQCC2	0.405
RPE	0.404
MRPS28	0.403
UQCRC1	0.403

Global Fraction of Cell Lines Where Essential: 176/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	6/28
blood	3/28
bone	5/26
breast	10/33
central nervous system	7/56
cervix	1/4
colorectal	7/17
esophagus	7/13
fibroblast	0/1
gastric	6/16
kidney	4/21
liver	6/20
lung	18/75
lymphocyte	1/16
ovary	2/26
pancreas	4/24
peripheral nervous system	1/16
plasma cell	4/15
prostate	0/1
skin	7/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	9/22
urinary tract	9/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 737
Expression level (log2 read counts): 4.64

Expression Distribution

small ribosomal subunit rRNA binding
small ribosomal subunit
mitochondrial small ribosomal subunit
mitochondrial translational termination
mitochondrial translational elongation
translational termination
mitochondrial translation
translational elongation
cellular protein complex disassembly
mitochondrial gene expression
structural constituent of ribosome
protein-containing complex disassembly
translation
mitochondrial inner membrane
cellular component disassembly
peptide biosynthetic process
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
protein-containing complex subunit organization
gene expression