BCS1L

Gene Information

Official Symbol: BCS1L
Official Name: BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone
Aliases and Previous Symbols: N/A
Entrez ID: 617
UniProt: Q9Y276
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a homolog of the S. cerevisiae bcs1 protein which is involved in the assembly of complex III of the mitochondrial respiratory chain. The encoded protein does not contain a mitochondrial targeting sequence but experimental studies confirm that it is imported into mitochondria. Mutations in this gene are associated with mitochondrial complex III deficiency and the GRACILE syndrome. Several alternatively spliced transcripts encoding two different isoforms have been described. [provided by RefSeq, Jan 2016].
UniProt Summary: Chaperone necessary for the assembly of mitochondrial respiratory chain complex III. Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. {ECO:0000269|PubMed:18628306}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Alda-1 10μM R06 exp262	-1.72
CR131-b 0.005μM R08 exp474	1.79
QNZ 0.01μM R08 exp439	1.85
Rotenone 0.07μM R08 exp431	1.85
Hydroxyurea 100μM R07 exp329	1.87
Ribavirin 10 to 15μM on day4 R04 exp160	1.88
Tanespimycin 14μM R08 exp527	1.88
ONC212 0.15μM R08 exp513	1.89
MK2206 4μM R08 exp504	1.9
Mitomycin-C 0.06μM R08 exp503	1.95
BI-D1870 3.15μM R02 exp66	2.01
Thimerosal 0.85μM R08 exp529	2.02
iCRT14 30μM R08 exp492	2.26
LLY-283 2.6μM R06 exp290	2.3
UM0125461 0.74μM R02 exp84	2.3
TIC10 10μM R08 exp532	2.38
Ammonium tetrathiomolybdate 10μM R08 exp448	3.74

Gene	Correlation
DARS2	0.712
SCO2	0.71
HSD17B10	0.706
YARS2	0.697
SELRC1	0.692
GFM1	0.677
MRPL21	0.674
COX16	0.665
NARS2	0.643
TARS2	0.642
MRPS14	0.639
SARS2	0.637
DAP3	0.631
MRPS5	0.629
SLC25A26	0.623
VARS2	0.621
RPUSD4	0.619
MRPS6	0.617
MRPS26	0.616
MRPS34	0.615
COX7B	0.615
EARS2	0.612
KIAA0391	0.61
RNASEH1	0.607
SUPV3L1	0.607
QRSL1	0.607
MRP63	0.604
FASTKD5	0.603
PARS2	0.599
TUFM	0.598
GFM2	0.597
MRPS16	0.595
MRPL47	0.595
MRPL23	0.588
WBSCR16	0.588
ATP5D	0.587
MRPL53	0.583
MRPS21	0.58
RBFA	0.579
PNPT1	0.577
MTPAP	0.575
AASDHPPT	0.574
UQCRC2	0.573
TMEM242	0.572
NDUFB11	0.571
UQCR10	0.57
FARS2	0.57
COA3	0.569
ATP5A1	0.568
C10orf2	0.567
LARS2	0.563
NDUFAF7	0.562
GTPBP10	0.56
COX11	0.56
ATP5B	0.56
DHRSX	0.559
FH	0.557
COX15	0.556
C17orf89	0.555
HARS2	0.553
MRPS2	0.552
RARS2	0.552
GATC	0.55
NDUFA3	0.545
PGM3	0.542
ATP5O	0.54
C12orf65	0.54
MRPS9	0.539
MRPL20	0.536
TEFM	0.535
LSM10	0.535
MARS2	0.535
ATP5C1	0.534
COX6C	0.533
NDUFB5	0.531
MTG2	0.531
COX17	0.528
MRPL15	0.526
MRPS23	0.525
MTRF1L	0.524
PDSS1	0.522
THG1L	0.521
TRIAP1	0.52
MRPS18A	0.519
COA6	0.516
FTSJ2	0.516
ATIC	0.516
ATP5J	0.515
MRPS24	0.514
MRPS25	0.513
POLG	0.509
CHCHD4	0.508
ATXN10	0.507
POLG2	0.504
MRPL12	0.503
AARS2	0.501
DOHH	0.499
RPE	0.499
COQ2	0.498
MRPS33	0.497
UQCRC1	0.495
NDUFB3	0.495
MRPL45	0.494
SLC25A19	0.494
PET117	0.493
UAP1	0.489
NDUFA1	0.488
MRPL44	0.488
ATP5E	0.488
MRPS12	0.487
UQCC2	0.487
HCCS	0.486
DNLZ	0.486
MRPS11	0.486
MTG1	0.484
RPIA	0.482
C11orf57	0.48
TPK1	0.478
ATP5F1	0.478
VEZT	0.477
DPAGT1	0.477
URM1	0.477
NDUFA2	0.476
PET100	0.476
METTL17	0.475
WARS2	0.474
NDUFC2	0.473
UQCRQ	0.472
COQ7	0.471
ELAC2	0.47
MRPL55	0.47
MRPL18	0.469
MRPS10	0.468
TFAM	0.467
SRP14	0.466
DHX30	0.466
PMM2	0.465
TRMT61A	0.465
PPA2	0.464
TMEM126B	0.464
MRPL27	0.464
COA5	0.463
NDUFS7	0.462
ALDH18A1	0.459
ALG6	0.459
ATP5H	0.459
NDUFS2	0.458
PPCS	0.458
RTN4IP1	0.458
ATP5L	0.457
NDUFAF3	0.457
SSB	0.456
KDSR	0.456
NDUFV1	0.455
NDUFAF4	0.455
SDHA	0.453
POLRMT	0.452
TRUB2	0.452
PET112	0.451
TOMM20	0.45
ALG13	0.45
COX5A	0.449
MTIF3	0.448
NDUFB9	0.446
MRPL11	0.446
COQ4	0.445
NFU1	0.443
TKT	0.443
ALAS1	0.442
SLC25A3	0.441
MRPL34	0.44
MRPL36	0.44
HIGD2A	0.439
TOMM40	0.438
CYCS	0.437
MRPL42	0.436
DOLK	0.435
GTF3C6	0.435
MRPL39	0.434
TEN1	0.434
PTDSS1	0.434
CARS2	0.432
MTERFD1	0.432
UBE2G2	0.432
MRPL3	0.432
MIPEP	0.431
FASTKD1	0.43
GEMIN7	0.43
COQ3	0.43
RBMX2	0.429
EIF3F	0.429
SLC25A52	0.428
ROMO1	0.428
NDUFB1	0.428
COX6B1	0.427
NDUFB6	0.427
MTERFD2	0.426
MRPL43	0.426
IBA57	0.423
MRPL33	0.422
EXOC4	0.422
COQ5	0.422
SEC62	0.421
CEPT1	0.421
GFPT1	0.421
CRLS1	0.421
OPA1	0.421
SRD5A3	0.42
RPUSD3	0.42
ECSIT	0.419
AIFM1	0.417
ZCRB1	0.415
TRMT10A	0.415
MRPL38	0.414
TIMM8B	0.413
MOCS3	0.412
TRNT1	0.412
ATP5SL	0.412
TAMM41	0.411
MRPL22	0.411
GMPPB	0.41
MRPS22	0.41
TOMM6	0.41
MSTO1	0.41
MRPL4	0.409
PGS1	0.409
COX20	0.408
ADSL	0.408
ALG8	0.408
LAMTOR3	0.407
PMVK	0.407
NDUFS5	0.406
N6AMT1	0.405
PPP6C	0.404
COQ6	0.404
TAZ	0.403
TXNL4B	0.403
UHRF1	0.402
PDCD5	0.401
UBA5	0.401
TIMMDC1	0.4
RPP21	0.4

Global Fraction of Cell Lines Where Essential: 32/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	3/28
blood	0/28
bone	1/26
breast	3/33
central nervous system	3/56
cervix	1/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	2/16
kidney	1/21
liver	3/20
lung	2/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	1/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 670
Expression level (log2 read counts): 5.86

Expression Distribution

AAA
BCS1 N

respiratory chain complex III assembly
mitochondrial respiratory chain complex III assembly
mitochondrial respiratory chain complex III
mitochondrial respiratory chain complex IV assembly
respiratory chain complex IV assembly
cytochrome complex assembly
NADH dehydrogenase complex assembly
mitochondrial respiratory chain complex I assembly
mitochondrial respiratory chain complex assembly
mitochondrion organization
cellular protein-containing complex assembly
mitochondrion
ATP binding
protein-containing complex assembly
protein-containing complex subunit organization