CDC73

Gene Information

Official Symbol: CDC73
Official Name: cell division cycle 73
Aliases and Previous Symbols: N/A
Entrez ID: 79577
UniProt: Q6P1J9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma. [provided by RefSeq, Jul 2009].
UniProt Summary: Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling. Involved in polyadenylation of mRNA precursors. {ECO:0000269|PubMed:15580289, ECO:0000269|PubMed:15632063, ECO:0000269|PubMed:15923622, ECO:0000269|PubMed:16630820, ECO:0000269|PubMed:16989776, ECO:0000269|PubMed:19136632, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:20541477, ECO:0000269|PubMed:21329879}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
SNS-032 15μM R08 exp443	-2.77
MS023 7μM R03 exp135	-2.66
Aminopterin 0.005μM R07 exp335	-2.55
JQ1 0.8μM R08 exp435	-2.43
RO-3307 4.7μM R02 exp80	-2.33
SNS-032 25μM R07 exp401	-2.33
Artemisinin 50μM R08 exp450	-2.32
SB743921 0.001μM R05 exp244	-2.32
TIC10 10μM R08 exp532	-2.3
Ammonium tetrathiomolybdate 10μM R08 exp448	-2.27
Nocodazole 0.1μM R03 exp94	-2.2
PU-H71 1μM R08 exp515	-2.19
THZ1 0.06μM R08 exp531	-2.17
CR131-b 0.005μM R08 exp474	-2.16
Monensin 0.3μM R08 exp507	-2.06
Atovaquone 15μM R08 exp451	-2.03
UM131593 0.2μM R03 exp106	-2.01
DABN racemic mixture R03 exp93	-1.98
Staurosporine 0.02μM R08 exp524	-1.89
Mitomycin-C 0.06μM R08 exp503	-1.84
Benzoate 20000μM R08 exp456	-1.8
BI-6727 0.04μM R03 exp98	-1.74
ONC212 0.15μM R08 exp513	-1.7
Rotenone 2μM R00 exp33	-1.7
Trametinib 10μM R02 exp83	1.76
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	1.78
Nifuroxazide 1μM R01 exp51	1.78
ABT-702 5μM R07 exp318	1.8
RO-3306 3 to 4μM on day4 R04 exp165	1.81
Calcium Ionophore 0.4μM R07 exp342	1.88
Dinaciclib 0.007μM R07 exp355	1.88
PF-06409577 20μM R07 exp389	1.9
Pomalidomide 20μM R07 exp391	1.94
Doxycycline 10μM R00 exp18	2.05
Ibrutinib 1μM R07 exp372	2.07
VHL-ligand-1 20μM R07 exp421	2.08
Deguelin 0.05μM R02 exp69	2.11
BRD2 inhibitor II 20μM R07 exp341	2.13
FBS-Wisent 0.1 R07 exp426	2.13
GSK-J4 1μM R07 exp362	2.17
Zebularine 20μM R07 exp423	2.23
Fluvastatin 2.2μM R06 exp282	2.26
Erlotinib 10μM R05 exp216	2.28
GSK2606414 1μM R05 exp236	2.41
Parthenolide 2.5μM R05 exp238	2.45
Betulinic acid 10 to 15μM on day4 R05 exp222	2.46
Lapatinib 5μM R01 exp47	2.65
TRAIL 5ng/ml R00 exp35	2.75

Gene	Correlation
CTR9	0.581
VASN	0.575
PSMA6	0.562
PSMB4	0.56
RBM39	0.558
CKAP5	0.551
RRN3	0.547
TCEB3C	0.542
AHCTF1	0.54
MYO1H	0.54
NUP160	0.534
PAF1	0.533
TCEB3CL2	0.527
COPE	0.526
CGB2	0.525
PSMD11	0.524
HAP1	0.518
RPS12	0.518
CNOT1	0.516
PSMD1	0.512
PSMA7	0.512
TFIP11	0.512
RPS2	0.51
PSMD3	0.51
TCEB3CL	0.51
RPSA	0.509
CDC6	0.509
MT1E	0.506
PSMC1	0.506
TBC1D3H	0.506
CDCA3	0.505
TBC1D3I	0.504
TBC1D3E	0.503
DTL	0.503
TBC1D3L	0.502
TBC1D3K	0.502
TBC1D3C	0.501
ZNF106	0.501
POLD1	0.5
TBC1D3F	0.499
PSMC6	0.499
C14orf93	0.498
NARFL	0.498
TICRR	0.497
RPA2	0.497
PSMD14	0.496
ORC1	0.496
ZFAND5	0.495
SNRPA1	0.494
TBC1D3G	0.493
COL2A1	0.493
ORC6	0.491
POLA2	0.49
HIST1H2BE	0.49
PSMB3	0.488
S1PR4	0.488
MSH5	0.487
RBBP5	0.486
TBC1D3	0.484
TRIM52	0.482
RPS3	0.48
ANKLE2	0.48
ZNF830	0.479
C2orf27B	0.477
WDR61	0.476
PSMC5	0.476
AKIRIN2	0.474
CDK8	0.473
DDTL	0.473
RPS28	0.473
COPG1	0.472
RPL14	0.47
NDC80	0.469
RPS9	0.469
CHD4	0.467
KCTD17	0.467
PSMB1	0.467
RPL35	0.467
NUPL1	0.467
GAR1	0.466
INTS6	0.465
AQR	0.464
SCAF1	0.463
NUFIP2	0.462
INTS5	0.462
AAAS	0.461
TPX2	0.46
C1QTNF9B	0.459
ZNF148	0.459
RPL6	0.457
PSMB2	0.457
SNRNP70	0.455
WDR87	0.455
SF3A1	0.455
PAN3	0.454
ATP6AP1	0.454
RPS5	0.453
SUPT6H	0.453
SEC13	0.452
CWC22	0.451
RPS3A	0.449
TWISTNB	0.449
GOLGA8O	0.448
PWP2	0.447
SMG7	0.447
CACTIN	0.446
LRR1	0.446
CEP192	0.446
TERF2	0.446
ILF2	0.446
SSH2	0.446
DOCK6	0.445
FANCM	0.444
FAM160A1	0.443
SUPT5H	0.443
PPM1D	0.442
ACSF2	0.442
SF3A3	0.441
DIDO1	0.441
RFC1	0.441
RPL7L1	0.441
ARCN1	0.441
RRP15	0.44
NBPF10	0.44
BCL2L1	0.44
PSMD2	0.44
HIST2H2BF	0.44
RPS14	0.439
EXOSC3	0.439
SMG1	0.438
CMYA5	0.438
CRNKL1	0.438
PPFIA4	0.437
FAM86B2	0.437
GON4L	0.437
COPA	0.437
CBWD6	0.437
NPIPB8	0.436
CBWD5	0.436
SRSF1	0.436
HIST2H3A	0.436
HIST2H3C	0.435
XYLT2	0.434
ATXN1	0.434
POLR1A	0.434
POLE	0.433
RPL38	0.433
BOD1L1	0.433
EXOSC5	0.431
PSMD7	0.431
BMS1	0.43
PRPF3	0.43
SF3B2	0.43
RPLP1	0.43
CHMP2A	0.43
CENPP	0.429
PSAP	0.429
CCDC64B	0.429
TAGLN	0.427
NCAPG	0.427
GOLGA8H	0.427
CHAF1A	0.426
RAD21	0.426
DDX51	0.426
TUBA8	0.425
MADCAM1	0.424
EXOSC9	0.424
CDT1	0.424
CCNA2	0.423
RNF113A	0.423
ISCU	0.423
SYT9	0.423
DNTTIP2	0.423
RPL8	0.422
NUP85	0.422
RPRD2	0.421
WDR75	0.421
ATP6V1C1	0.42
CBWD3	0.42
KRT78	0.419
INTS1	0.419
PLK1	0.418
DDX56	0.418
NOP16	0.417
RPL34	0.417
PSMC2	0.415
PITPNM3	0.415
RAD51	0.415
TAF15	0.414
TSG101	0.414
TOPBP1	0.414
HIST1H2AJ	0.414
NUF2	0.414
NAPA	0.414
IK	0.413
PPAN	0.413
PRKCZ	0.413
MDM2	0.413
PLA2G4F	0.412
PSMA1	0.412
NOL10	0.412
OR10G3	0.412
RILPL1	0.411
GOLGA6L3	0.411
SLC4A1	0.411
PAN2	0.411
PSMC4	0.411
GOLGA8J	0.408
NDC1	0.408
EIF4A3	0.408
PRPF19	0.407
GPX4	0.407
UBAP1	0.406
NFATC4	0.406
CCDC94	0.404
NUP133	0.404
PSMC3	0.403
MKI67IP	0.403
NIP7	0.402
IGFN1	0.402
EIF3G	0.402
TBC1D7	0.402
CYB561A3	0.402
POLR2F	0.401
FAM20A	0.401
ELMOD3	0.4
WDR46	0.4
PLK4	0.4

Global Fraction of Cell Lines Where Essential: 281/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	10/28
blood	13/28
bone	16/25
breast	11/33
central nervous system	24/56
cervix	0/4
colorectal	6/17
esophagus	1/13
fibroblast	1/1
gastric	6/15
kidney	8/21
liver	4/20
lung	25/75
lymphocyte	7/14
ovary	9/26
pancreas	4/24
peripheral nervous system	7/16
plasma cell	5/15
prostate	1/1
skin	9/24
soft tissue	4/7
thyroid	1/2
upper aerodigestive	13/22
urinary tract	12/29
uterus	3/5

Essentiality in NALM6

Essentiality Rank: 749
Expression level (log2 read counts): 5.4

Expression Distribution