PDSS1

Gene Information

Official Symbol: PDSS1
Official Name: decaprenyl diphosphate synthase subunit 1
Aliases and Previous Symbols: N/A
Entrez ID: 23590
UniProt: Q5T2R2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is an enzyme that elongates the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. The protein may be peripherally associated with the inner mitochondrial membrane, though no transit peptide has been definitively identified to date. Defects in this gene are a cause of coenzyme Q10 deficiency. [provided by RefSeq, Jul 2008].
UniProt Summary: Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10. {ECO:0000269|PubMed:16262699}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
SGC2043 10μM R03 exp152	-2.67
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	-2.64
Geldanamycin 0.01μM R05 exp235	-2.63
Salubrinal 20μM R07 exp399	-2.46
Rifampicin 30μM R08 exp430	-2.42
ZLN024 50μM R08 exp538	-2.4
Citral 50μM R06 exp274	-2.07
Daidzin 10μM R06 exp280	-2.06
CB-839 10μM R05 exp224	-1.89
Methotrexate 0.01μM R08 exp501	-1.84
VE-822 0.04μM R06 exp300	-1.75
BH1 1μM R04 exp169	-1.74
Aphidicolin 0.04μM R06 exp263	-1.72
UM0011500 5μM R05 exp245	-1.72
Deguelin 0.15μM R05 exp209	-1.7
Arsenate 40μM R06 exp264	1.77
Dorsomorphin 5μM R07 exp357	1.84
R-DABN 8μM R03 exp111	1.85
Rucaparib 6.5μM R08 exp520	1.85
TIC10 10μM R08 exp532	1.86
CAY10603 0.55μM R08 exp467	1.88
Etoposide 1μM R00 exp19	1.89
Hydroxyurea 100μM R07 exp329	1.9
Bleomycin 5μM R08 exp459	1.93
AICAR 240μM R05 exp211	1.97
GSK461364A 0.1μM R03 exp126	1.99
Arsenic trioxide 60μM R08 exp449	2
Tanespimycin 14μM R08 exp527	2
JQ1 0.8μM R08 exp435	2.03
WNT3A 44ng/ml R08 exp537	2.14
Tubastatin-A 2.5μM R07 exp417	2.18
PU-H71 1μM R08 exp515	2.2
UM131593 0.2μM R03 exp106	2.22
GSK-J4 1.5μM R08 exp441	2.24
UM0125461 0.74μM R02 exp84	2.24
Vinblastine 0.2μM R03 exp108	2.3
BI-6727 0.04μM R03 exp98	2.38
Nutlin-3A 1.6μM R06 exp294	2.64
BI-6727 0.0125μM R03 exp97	2.65
Quercetin 20μM R08 exp517	2.78
Atovaquone 15μM R08 exp451	2.81
Ammonium tetrathiomolybdate 10μM R08 exp448	3.8

Gene	Correlation
MRPS21	0.604
MRPS5	0.603
SLC25A26	0.582
RPUSD4	0.582
HSD17B10	0.568
C17orf89	0.567
SARS2	0.566
MRPL21	0.566
YARS2	0.565
SELRC1	0.565
MRPS16	0.564
SUPV3L1	0.563
C12orf65	0.562
MRPL23	0.561
FASTKD5	0.561
COX16	0.558
MRPL53	0.552
GTPBP10	0.548
GATC	0.547
MRPS6	0.546
MRPS34	0.539
COQ2	0.535
TEFM	0.535
MRPS18A	0.534
NDUFB3	0.53
MRP63	0.529
TRIAP1	0.527
DAP3	0.525
BCS1L	0.522
ATP5D	0.521
COX6C	0.52
CHCHD4	0.52
NDUFAF4	0.519
AASDHPPT	0.516
QRSL1	0.516
RARS2	0.515
GFM1	0.515
TUFM	0.51
MRPS14	0.509
KIAA0391	0.508
MRPL15	0.506
DARS2	0.506
ATP5SL	0.506
NDUFB5	0.505
MRPL12	0.505
MTG2	0.503
VARS2	0.501
HARS2	0.497
TMEM242	0.496
MRPS9	0.495
MTPAP	0.494
MRPL47	0.494
EARS2	0.487
COQ7	0.487
COX7B	0.486
NDUFB11	0.485
PARS2	0.485
RTN4IP1	0.484
RNASEH1	0.482
TARS2	0.482
MRPS25	0.482
SCO2	0.482
UQCRC2	0.481
MRPS26	0.479
PMM2	0.478
RBFA	0.478
MRPL55	0.477
ATP5B	0.477
GFM2	0.477
WBSCR16	0.476
RPIA	0.476
C10orf2	0.475
TRMT10A	0.474
COQ4	0.474
NDUFAF7	0.473
CRLS1	0.472
NDUFC2	0.472
NARS2	0.47
COX17	0.47
MTIF3	0.47
MRPS33	0.469
COQ3	0.469
NDUFA3	0.465
TAZ	0.465
MRPS12	0.465
MRPS24	0.464
ALG6	0.463
CEP57	0.463
ROMO1	0.46
LARS2	0.459
TRUB2	0.458
TMEM126B	0.458
RPUSD3	0.457
TRNT1	0.457
ATP5O	0.456
TIMM8B	0.453
TPK1	0.453
TMEM261	0.453
COQ6	0.453
TOMM22	0.452
DPAGT1	0.452
ATP5A1	0.45
MRPL18	0.45
FH	0.45
TOMM40	0.449
THG1L	0.449
MTRF1L	0.449
PNPT1	0.449
UQCR10	0.448
NDUFA2	0.441
RNMTL1	0.438
COA6	0.437
COX6B1	0.437
MRPL34	0.435
MRPS2	0.435
DNLZ	0.433
LSM10	0.432
COA5	0.432
MRPS23	0.432
NDUFB9	0.431
NDUFS7	0.43
ALG13	0.43
ADSL	0.429
AIFM1	0.427
MRPL36	0.427
RPE	0.427
MRPS17	0.427
MRPS10	0.427
NDUFB1	0.427
PGM3	0.426
NDUFA11	0.424
FTSJ2	0.423
ALG1	0.422
FARS2	0.422
NDUFB6	0.422
UQCRQ	0.421
MRPS7	0.421
ATP5J	0.421
MINOS1	0.419
ATP5C1	0.419
ELAC2	0.418
COX5A	0.417
COA3	0.417
NDUFA1	0.416
MRPL27	0.416
MRPL22	0.415
PPCS	0.415
TAMM41	0.414
HCCS	0.411
NDUFAF3	0.408
MRPL44	0.408
ATXN10	0.408
DHX30	0.407
OPA1	0.406
MRPL45	0.406
ATP5H	0.405
POLG	0.404
ECSIT	0.404
MRPS22	0.403
MARS2	0.402
GLRX5	0.402
COX10	0.402
GEMIN7	0.402
PDSS2	0.401
COQ5	0.401
MTG1	0.4
NDUFB7	0.4
UQCC2	0.4

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3289
Expression level (log2 read counts): 5.34

Expression Distribution

trans-hexaprenyltranstransferase activity
trans-octaprenyltranstransferase activity
transferase complex
quinone biosynthetic process
ubiquinone biosynthetic process
ubiquinone metabolic process
isoprenoid biosynthetic process
ketone biosynthetic process
quinone metabolic process
protein heterotetramerization
oxidoreduction coenzyme metabolic process
cellular ketone metabolic process
protein heterooligomerization
coenzyme biosynthetic process
isoprenoid metabolic process
protein tetramerization
cofactor biosynthetic process
coenzyme metabolic process
mitochondrial matrix
cofactor metabolic process
protein heterodimerization activity
protein complex oligomerization
lipid biosynthetic process
small molecule biosynthetic process
cellular lipid metabolic process
lipid metabolic process
protein-containing complex assembly
small molecule metabolic process
protein-containing complex subunit organization