NDUFAF7
Gene Information
- Official Symbol: NDUFAF7
- Official Name: N/ADH:ubiquinone oxidoreductase complex assembly factor 7
- Aliases and Previous Symbols: N/A
- Entrez ID: 55471
- UniProt: Q7L592
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes an assembly factor protein which helps in the assembly and stabilization of Complex I, a large multi-subunit enzyme in the mitochondrial respiratory chain. Complex I is involved in several physiological activities in the cell, including metabolite transport and ATP synthesis. The encoded protein is a methyltransferase which methylates Arg85 of a subunit of Complex I in the early stages of its assembly. A pseudogene related to this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016].
- UniProt Summary: Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (PubMed:20406883, PubMed:24089531, PubMed:24838397). Acts by mediating symmetric dimethylation of 'Arg-118' of NDUFS2 after it assembles into the complex I, stabilizing the early intermediate complex (PubMed:24089531). {ECO:0000269|PubMed:20406883, ECO:0000269|PubMed:24089531, ECO:0000269|PubMed:24838397}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 1827
- Expression level (log2 read counts): 5.55
NDUFAF7 Expression in NALM6 Cells: 5.55
