RPS2
Gene Information
- Official Symbol: RPS2
- Official Name: ribosomal protein S2
- Aliases and Previous Symbols: N/A
- Entrez ID: 6187
- UniProt: P15880
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Ribosomal S5 |
| Ribosomal S5 C |
GO Terms
| fibroblast growth factor binding |
| positive regulation of ubiquitin-protein transferase activity |
| cytosolic small ribosomal subunit |
| regulation of ubiquitin-protein transferase activity |
| SRP-dependent cotranslational protein targeting to membrane |
| cotranslational protein targeting to membrane |
| protein targeting to ER |
| establishment of protein localization to endoplasmic reticulum |
| viral transcription |
| positive regulation of protein ubiquitination |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| viral gene expression |
| positive regulation of protein modification by small protein conjugation or removal |
| protein localization to endoplasmic reticulum |
| translational initiation |
| protein targeting to membrane |
| mRNA binding |
| structural constituent of ribosome |
| nuclear-transcribed mRNA catabolic process |
| regulation of protein ubiquitination |
| rRNA processing |
| mRNA catabolic process |
| rRNA metabolic process |
| regulation of protein modification by small protein conjugation or removal |
| RNA catabolic process |
| establishment of protein localization to membrane |
| ribosome biogenesis |
| cadherin binding |
| enzyme binding |
| protein targeting |
| nucleobase-containing compound catabolic process |
| translation |
| ncRNA processing |
| peptide biosynthetic process |
| focal adhesion |
| establishment of protein localization to organelle |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| aromatic compound catabolic process |
| ribonucleoprotein complex biogenesis |
| ncRNA metabolic process |
| organic cyclic compound catabolic process |
| protein localization to membrane |
| amide biosynthetic process |
| peptide metabolic process |
| positive regulation of transferase activity |
| mRNA metabolic process |
| viral process |
| protein localization to organelle |
| symbiotic process |
| cellular amide metabolic process |
| interspecies interaction between organisms |
| nucleolus |
| RNA processing |
| cellular macromolecule catabolic process |
| regulation of transferase activity |
| intracellular protein transport |
| macromolecule catabolic process |
| positive regulation of protein modification process |
| RNA binding |
| organonitrogen compound biosynthetic process |
| positive regulation of catalytic activity |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| cellular nitrogen compound biosynthetic process |
| RNA metabolic process |
| positive regulation of protein metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| macromolecule biosynthetic process |
| organic substance catabolic process |
| positive regulation of molecular function |
| cellular catabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
| regulation of protein modification process |
| membrane |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| TBC1D3H | 0.629 |
| TCEB3CL2 | 0.613 |
| TBC1D3F | 0.607 |
| TCEB3CL | 0.607 |
| TCEB3C | 0.605 |
| PSMB4 | 0.604 |
| CBWD3 | 0.598 |
| TBC1D3G | 0.596 |
| CHD4 | 0.591 |
| CBWD5 | 0.586 |
| TBC1D3 | 0.578 |
| TBC1D3C | 0.577 |
| NPIPB5 | 0.573 |
| CCNA2 | 0.566 |
| RPS12 | 0.563 |
| CBWD6 | 0.562 |
| TBC1D3E | 0.561 |
| TBC1D3I | 0.561 |
| TBC1D3K | 0.56 |
| TBC1D3L | 0.56 |
| C1QTNF9B | 0.559 |
| VASN | 0.552 |
| ORC1 | 0.55 |
| ORC6 | 0.54 |
| NUPL1 | 0.536 |
| PSMB2 | 0.53 |
| RBBP5 | 0.524 |
| RPS5 | 0.523 |
| NOP16 | 0.522 |
| PSMA6 | 0.521 |
| RPL35 | 0.52 |
| DTL | 0.519 |
| MED14 | 0.519 |
| CACTIN | 0.518 |
| SCAF1 | 0.516 |
| PSMD3 | 0.512 |
| C14orf93 | 0.512 |
| KCTD17 | 0.51 |
| CDC73 | 0.51 |
| MYO1H | 0.51 |
| MT1E | 0.509 |
| TFIP11 | 0.509 |
| MYB | 0.509 |
| AAMP | 0.506 |
| TWISTNB | 0.505 |
| EXOSC5 | 0.504 |
| PSMD1 | 0.501 |
| LRR1 | 0.498 |
| HIST2H3C | 0.498 |
| HIST2H3A | 0.497 |
| CDC6 | 0.495 |
| RRP7A | 0.495 |
| SF3A1 | 0.495 |
| UTP3 | 0.494 |
| ANKLE2 | 0.492 |
| NSF | 0.492 |
| TIMELESS | 0.49 |
| POLA2 | 0.49 |
| PSMC2 | 0.488 |
| SEC13 | 0.488 |
| MYT1L | 0.486 |
| GOLGA8O | 0.486 |
| COL2A1 | 0.485 |
| UPF1 | 0.485 |
| NFATC4 | 0.484 |
| RNF113A | 0.484 |
| NARFL | 0.484 |
| PSMA7 | 0.483 |
| RPS19BP1 | 0.483 |
| POLA1 | 0.48 |
| CMYA5 | 0.48 |
| POLE | 0.48 |
| POLR2J3 | 0.48 |
| CCDC64B | 0.48 |
| WDR87 | 0.478 |
| TSPY1 | 0.478 |
| SLC4A1 | 0.478 |
| DDTL | 0.477 |
| PWP2 | 0.477 |
| DHX38 | 0.477 |
| PCF11 | 0.477 |
| BYSL | 0.476 |
| RPL6 | 0.476 |
| RPS3A | 0.475 |
| IGFN1 | 0.475 |
| RPS20 | 0.474 |
| PSMB1 | 0.474 |
| FAM25B | 0.473 |
| ATP6AP1 | 0.473 |
| RPS28 | 0.472 |
| HIVEP3 | 0.471 |
| RANBP2 | 0.471 |
| TSG101 | 0.47 |
| PSMD2 | 0.469 |
| TICRR | 0.469 |
| TYMS | 0.466 |
| PAF1 | 0.466 |
| RRM1 | 0.466 |
| SUPT5H | 0.466 |
| CDT1 | 0.465 |
| PSAP | 0.464 |
| NUP160 | 0.464 |
| CHMP2A | 0.464 |
| MADCAM1 | 0.464 |
| MED17 | 0.462 |
| RAD51 | 0.462 |
| FBXO5 | 0.461 |
| SF3A3 | 0.461 |
| CDC45 | 0.461 |
| EXOSC6 | 0.461 |
| ZNF106 | 0.46 |
| SSH2 | 0.46 |
| GOLGA6B | 0.46 |
| SNRPA1 | 0.459 |
| EGR2 | 0.459 |
| PDE4DIP | 0.459 |
| PSMD6 | 0.459 |
| FAM86B2 | 0.459 |
| PSMC1 | 0.459 |
| GOLGA6L1 | 0.458 |
| HAP1 | 0.458 |
| PSMC6 | 0.458 |
| RPS9 | 0.457 |
| SLC38A7 | 0.457 |
| ART5 | 0.456 |
| KIF3C | 0.456 |
| ZFAND5 | 0.455 |
| CDCA3 | 0.454 |
| NOL12 | 0.454 |
| MCM7 | 0.454 |
| NDC80 | 0.454 |
| RIOK2 | 0.453 |
| RRN3 | 0.453 |
| AKT1S1 | 0.453 |
| AATF | 0.451 |
| NUP62 | 0.451 |
| TSPY8 | 0.451 |
| PRPF3 | 0.451 |
| HIST1H2BE | 0.45 |
| RPS21 | 0.45 |
| RPS7 | 0.45 |
| PPFIA4 | 0.45 |
| SAP30BP | 0.45 |
| AQR | 0.45 |
| ZNF655 | 0.449 |
| ISCU | 0.449 |
| COPE | 0.448 |
| INTS5 | 0.448 |
| AKIRIN2 | 0.448 |
| RRP15 | 0.448 |
| OR10G3 | 0.448 |
| NOP14 | 0.447 |
| PSMD11 | 0.446 |
| ZNF830 | 0.446 |
| NPIPB8 | 0.446 |
| NUP133 | 0.446 |
| MDM2 | 0.445 |
| NUP85 | 0.445 |
| COPB1 | 0.445 |
| EIF3G | 0.444 |
| PRPF8 | 0.444 |
| PSMD14 | 0.444 |
| RBM39 | 0.443 |
| COPG1 | 0.443 |
| S1PR4 | 0.443 |
| ELMOD3 | 0.443 |
| UTP20 | 0.443 |
| NOL10 | 0.443 |
| LAD1 | 0.442 |
| CKAP5 | 0.442 |
| HIST2H3D | 0.442 |
| SLC6A17 | 0.442 |
| XYLT2 | 0.442 |
| MCOLN1 | 0.441 |
| PSMC5 | 0.44 |
| WDR75 | 0.44 |
| NAPA | 0.44 |
| CEP192 | 0.439 |
| RPS14 | 0.438 |
| ZNF541 | 0.438 |
| MED29 | 0.438 |
| NCL | 0.437 |
| GOLGA6L6 | 0.437 |
| ATP6V1C1 | 0.435 |
| SUPT6H | 0.435 |
| GOLGA6L3 | 0.434 |
| RPL38 | 0.434 |
| SF3B3 | 0.434 |
| AAAS | 0.433 |
| STIL | 0.432 |
| CHAF1A | 0.432 |
| DDX56 | 0.432 |
| PSMB3 | 0.431 |
| C2orf27B | 0.431 |
| KPNB1 | 0.431 |
| PLA2G4F | 0.43 |
| COPA | 0.43 |
| FAM160A1 | 0.429 |
| SULT1A4 | 0.429 |
| OGFR | 0.429 |
| GPRIN2 | 0.429 |
| PSMC4 | 0.429 |
| CCDC116 | 0.429 |
| SULT1A3 | 0.429 |
| KRT2 | 0.428 |
| GOSR2 | 0.428 |
| VPS28 | 0.428 |
| SMG7 | 0.428 |
| RPL34 | 0.428 |
| KRT78 | 0.427 |
| SULT2B1 | 0.427 |
| NUP54 | 0.427 |
| CTAGE4 | 0.427 |
| RPS19 | 0.427 |
| RPL12 | 0.426 |
| ATP6V0C | 0.426 |
| POLR2A | 0.426 |
| PARP3 | 0.426 |
| TRAIP | 0.426 |
| GOLGA6A | 0.426 |
| ACSF2 | 0.426 |
| PLK4 | 0.425 |
| DISP2 | 0.425 |
| RPSA | 0.425 |
| POLR1A | 0.424 |
| DOCK6 | 0.424 |
| GOLGA8J | 0.424 |
| AHCTF1 | 0.424 |
| PLRG1 | 0.423 |
| COPZ1 | 0.423 |
| IK | 0.423 |
| EXOSC9 | 0.423 |
| TRIM52 | 0.422 |
| RRP1 | 0.422 |
| PRIM1 | 0.422 |
| FCN2 | 0.422 |
| TSPY2 | 0.421 |
| ANKLE1 | 0.421 |
| GOLGA8K | 0.421 |
| TUBA8 | 0.42 |
| GOLGA6L4 | 0.42 |
| POLR2F | 0.42 |
| UQCRH | 0.42 |
| GGA3 | 0.419 |
| KIAA0947 | 0.419 |
| HIST2H2BF | 0.418 |
| NBPF16 | 0.417 |
| RPL9 | 0.416 |
| RPL14 | 0.416 |
| TERF1 | 0.416 |
| ESF1 | 0.416 |
| PLK1 | 0.415 |
| NOL7 | 0.415 |
| RPS11 | 0.415 |
| SYT9 | 0.414 |
| TPX2 | 0.414 |
| CLCN6 | 0.414 |
| RPS3 | 0.414 |
| PLEKHA4 | 0.414 |
| EXD1 | 0.414 |
| ATP6V0B | 0.413 |
| EXOSC8 | 0.413 |
| SFPQ | 0.413 |
| ARCN1 | 0.413 |
| TOP1MT | 0.413 |
| DDX21 | 0.413 |
| DIMT1 | 0.413 |
| RPS10 | 0.412 |
| CASC3 | 0.412 |
| DDX47 | 0.411 |
| RNF4 | 0.411 |
| PAN3 | 0.411 |
| CLN6 | 0.411 |
| CHCHD3 | 0.41 |
| CACNA1A | 0.41 |
| SART1 | 0.41 |
| SRGAP2C | 0.409 |
| CTR9 | 0.409 |
| C3orf17 | 0.409 |
| SMG1 | 0.409 |
| RNPC3 | 0.408 |
| NUP43 | 0.408 |
| NBPF10 | 0.407 |
| EIF4A3 | 0.407 |
| HNRNPC | 0.407 |
| CGB2 | 0.404 |
| ATXN1 | 0.404 |
| BID | 0.404 |
| CCDC94 | 0.404 |
| POLR2D | 0.404 |
| OSBP | 0.404 |
| NUP98 | 0.404 |
| RPL15 | 0.404 |
| BAGE3 | 0.403 |
| TERF2 | 0.403 |
| SCGB1C1 | 0.403 |
| ARHGEF15 | 0.403 |
| SNIP1 | 0.403 |
| BAGE5 | 0.402 |
| BAGE2 | 0.402 |
| RPL30 | 0.402 |
| RAD21 | 0.402 |
| BAGE4 | 0.402 |
| BAGE | 0.402 |
| DDX41 | 0.401 |
| PAN2 | 0.401 |
| SNRNP70 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 584/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 24/28 |
| blood | 25/28 |
| bone | 24/26 |
| breast | 27/33 |
| central nervous system | 40/56 |
| cervix | 4/4 |
| colorectal | 14/17 |
| esophagus | 11/13 |
| fibroblast | 1/1 |
| gastric | 15/16 |
| kidney | 17/21 |
| liver | 18/20 |
| lung | 58/75 |
| lymphocyte | 12/16 |
| ovary | 20/26 |
| pancreas | 16/24 |
| peripheral nervous system | 11/16 |
| plasma cell | 13/15 |
| prostate | 1/1 |
| skin | 20/24 |
| soft tissue | 7/9 |
| thyroid | 1/2 |
| upper aerodigestive | 14/22 |
| urinary tract | 21/29 |
| uterus | 2/5 |
Essentiality in NALM6
- Essentiality Rank: 364
- Expression level (log2 read counts): 10.52
Expression Distribution
RPS2 Expression in NALM6 Cells: 10.52
