CCNA2

Gene Information

Official Symbol: CCNA2
Official Name: cyclin A2
Aliases and Previous Symbols: N/A
Entrez ID: 890
UniProt: P20248
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M. [provided by RefSeq, Aug 2016].
UniProt Summary: Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. {ECO:0000269|PubMed:1312467}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BI-6727 0.04μM R03 exp98	-2.58
Doxorubicin 0.02μM R08 exp478	-2.55
BI-2536 0.02μM R03 exp96	-2.31
6-Thio-2-deoxyguanosine 2μM R06 exp259	-2.29
BI-D1870 3.15μM R02 exp66	-2.13
Oligomycin-A 20μM R00 exp26	-1.99
BVD-523 15μM R02 exp67	-1.84
Vinblastine 0.015μM R05 exp208	-1.83
Atovaquone 15μM R08 exp451	-1.82
Pimelic-diphenylamide-106 5μM R00 exp28	-1.79
Lead acetate 2000μM R08 exp498 no dilution day6	-1.73
RO-3307 4.7μM R02 exp80	-1.7
Nicotinamide 2000μM R01 exp50	1.7
Asunaprenir 3μM R07 exp336	1.71
Losmapimod 1μM R07 exp376	1.74
Betulinic acid 10 to 15μM on day4 R05 exp222	1.77
Selumetinib 20μM R02 exp81	1.78
UM131593 0.1μM R01 exp58	1.78
Dynasore 10μM R04 exp180	1.79
Thapsigargin 0.005μM R07 exp407	1.81
UM0130462 0.025 to 0.035μM day4 R05 exp247	1.81
FK-506 5μM R07 exp358	1.85
Methotrexate 0.01μM R08 exp501	1.85
IU1-47 25μM R04 exp182	1.86
THZ531 0.11μM R07 exp409	1.87
Chlorpromazine 10μM R07 exp344	1.88
Colchicine 0.009μM R05 exp215	1.88
Wiskostatin 3μM R07 exp422	1.91
BN82002 4μM R07 exp340	1.94
LB-100 2μM R05 exp210	1.97
GSK-LSD1 10μM R03 exp123	1.98
2-Methoxyestradiol 0.2μM R01 exp40	1.99
GSK626616 14μM R08 exp485	1.99
HMS-I1 1μM R01 exp46	2.01
NN-Diethyl-meta-toluamide 500μM R08 exp438	2.06
Zebularine 20μM R07 exp423	2.17
Alda-1 10μM R06 exp262	2.18
NFN1 0.1μM R01 exp49	2.25
EPZ-5676 30μM R05 exp233	2.4
Ribavirin 10μM R01 exp52	2.73
CB-839 10μM R05 exp224	2.86
MK-1775 0.32μM R02 exp75	4

Gene	Correlation
PSMB4	0.581
TCEB3C	0.577
CHD4	0.575
RPS2	0.566
LRR1	0.564
TCEB3CL2	0.558
GOLGA6L1	0.552
TBC1D3H	0.551
PSMD2	0.55
COPG1	0.549
TBC1D3F	0.549
NPIPB5	0.548
TCEB3CL	0.548
PSMA6	0.547
UTP3	0.546
VASN	0.544
HIVEP3	0.541
CDC45	0.541
UPF1	0.538
MT1E	0.533
NUPL1	0.531
HGC6.3	0.53
RRP7A	0.529
CHAF1A	0.528
CBWD5	0.527
CBWD3	0.525
AQR	0.523
ORC6	0.519
EXOSC5	0.519
SNIP1	0.518
AATF	0.517
PSMD3	0.515
RPS19BP1	0.513
TSG101	0.511
SLC6A17	0.511
TFIP11	0.511
PSMA7	0.51
TBC1D3G	0.51
C14orf93	0.508
CDCA3	0.507
DTL	0.506
RPS12	0.503
PSMD1	0.503
TYMS	0.502
CLN6	0.502
TBC1D3	0.501
PSMD11	0.501
PSMC2	0.5
C1QTNF9B	0.5
POLR2D	0.5
CTAGE4	0.498
POLA1	0.497
EIF4A3	0.496
DISP2	0.496
EXOSC9	0.496
SUPT6H	0.496
TSPY8	0.495
CBWD6	0.494
MYO1H	0.494
RPS5	0.493
DDX56	0.491
POLE	0.491
SSH2	0.49
ACSF2	0.49
PSMD7	0.488
VPS28	0.488
CCDC64B	0.486
RAD51	0.486
ATP6V1C1	0.486
KCTD17	0.486
RPL35	0.485
RFC1	0.485
ATP6AP1	0.485
NSF	0.484
SNRPA1	0.484
CMYA5	0.483
SLC4A1	0.483
KRT78	0.483
SUPT5H	0.482
BYSL	0.482
ZFAND5	0.481
POLR2J3	0.481
PSMB2	0.479
TICRR	0.478
PAN3	0.478
MYT1L	0.477
NOL12	0.477
NUFIP2	0.476
ANKLE2	0.476
RAD21	0.475
MMS22L	0.475
ZNF830	0.475
NUP133	0.473
PSMC1	0.472
PSMC6	0.469
NOP16	0.469
DDTL	0.469
IK	0.468
SEC13	0.468
EXOSC4	0.468
RPS20	0.468
HIST2H2BF	0.468
HAP1	0.466
DIDO1	0.466
FAM25B	0.466
SYT9	0.466
PSMC5	0.466
PDE4DIP	0.465
MED14	0.464
XYLT2	0.464
FAM231C	0.464
EXOSC6	0.464
FAM231A	0.463
PSMA1	0.461
OGFR	0.46
PAN2	0.46
ORC1	0.46
POLR2A	0.46
RNPC3	0.459
RPS9	0.459
PAF1	0.458
TWISTNB	0.457
CDT1	0.456
LAD1	0.456
NFATC4	0.455
NUP160	0.455
AAMP	0.454
TBC1D3I	0.451
NOL10	0.45
TBC1D3E	0.45
COPE	0.449
TBC1D3L	0.449
TBC1D3K	0.449
SMG7	0.448
NUP54	0.448
TTK	0.447
SAP30BP	0.445
STIL	0.444
CCDC116	0.444
CDC6	0.443
PLK4	0.443
ISCU	0.443
EXD1	0.443
MYO18A	0.442
DOCK6	0.441
CCDC94	0.44
RRN3	0.44
SLC38A7	0.44
MAT2A	0.44
COL2A1	0.439
MYB	0.439
RPS10	0.439
ART5	0.439
TTC1	0.438
RRP15	0.438
NUP85	0.437
RBBP5	0.437
NAPA	0.436
RPS28	0.436
TBC1D3C	0.436
PSMB3	0.436
PHF2	0.435
IGFN1	0.435
MDM2	0.435
UQCRH	0.434
GOLGA6A	0.434
HMGCR	0.434
C2orf27B	0.433
GOLGA8O	0.432
CRNKL1	0.432
RANBP2	0.432
MYLK3	0.431
SART1	0.431
RPLP1	0.431
HIST2H3C	0.431
HIST2H3A	0.431
HIST1H2BE	0.429
TPX2	0.429
RPS7	0.428
PSMB1	0.428
ATP6V0C	0.428
CHMP2A	0.428
COPB1	0.428
ARCN1	0.427
ANKLE1	0.427
WAPAL	0.426
NAALADL1	0.426
UTP20	0.426
RPS14	0.425
S1PR4	0.425
EGR2	0.424
CEP192	0.424
ZNF655	0.424
ZNF541	0.424
COPZ1	0.424
CDC73	0.423
KIF3C	0.422
NPIPB8	0.422
GID4	0.422
TERF2	0.421
TONSL	0.419
GOLGA6B	0.419
RPSA	0.419
XAB2	0.419
NUP205	0.418
OSBP	0.418
RPL26	0.418
OR10G3	0.417
FAM86B2	0.416
WDR87	0.416
PSMD8	0.416
COPB2	0.416
RPS3A	0.415
PWP2	0.414
PLA2G4F	0.414
PSMD14	0.414
RPL14	0.414
DHX38	0.413
EBNA1BP2	0.413
GAR1	0.413
MTCH2	0.413
PRSS8	0.412
RPS19	0.412
CGB2	0.412
TIMELESS	0.412
MCM7	0.411
PSMC3	0.41
ADRM1	0.41
ATP6V1B2	0.408
TRIM52	0.408
ZNF675	0.408
MED28	0.408
PCF11	0.408
ATP13A1	0.407
PSMD6	0.407
GPX4	0.407
ATP6V1A	0.407
CTAGE9	0.407
TP53TG3B	0.407
NDC80	0.407
TP53TG3	0.406
TP53TG3C	0.406
MED17	0.406
GOSR2	0.405
AHCTF1	0.405
RNF113A	0.404
SCGB1C1	0.404
COPA	0.403
BRIX1	0.402
PNO1	0.402
VPS52	0.402
KPNB1	0.402
GLTSCR2	0.402
WDR75	0.402
POLR2F	0.402
NUMA1	0.401
TRAIP	0.401
POLD1	0.401
CHCHD3	0.401
EXOSC3	0.401
MBTD1	0.4
TSPY1	0.4
ZNF106	0.4

Global Fraction of Cell Lines Where Essential: 709/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	27/28
bone	24/26
breast	33/33
central nervous system	53/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	14/16
kidney	20/21
liver	19/20
lung	73/75
lymphocyte	16/16
ovary	25/26
pancreas	23/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	22/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	28/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 666
Expression level (log2 read counts): 7.29

Expression Distribution

Cyclin C
Cyclin N

cellular response to cocaine
cyclin A2-CDK2 complex
cyclin-dependent protein kinase activity
cellular response to luteinizing hormone stimulus
response to luteinizing hormone
male pronucleus
cellular response to insulin-like growth factor stimulus
female pronucleus
cellular response to nitric oxide
cellular response to leptin stimulus
cellular response to gonadotropin stimulus
cellular response to reactive nitrogen species
response to nitric oxide
cellular response to platelet-derived growth factor stimulus
response to platelet-derived growth factor
response to leptin
response to gonadotropin
histone phosphorylation
cyclin-dependent protein kinase holoenzyme complex
cyclin-dependent protein serine/threonine kinase regulator activity
cellular response to alkaloid
response to glucagon
cellular response to estradiol stimulus
positive regulation of fibroblast proliferation
response to bronchodilator
cochlea development
response to cocaine
animal organ regeneration
response to anesthetic
regulation of fibroblast proliferation
regulation of cyclin-dependent protein serine/threonine kinase activity
regulation of cyclin-dependent protein kinase activity
regulation of DNA replication
response to alkaloid
cell cycle G1/S phase transition
cellular response to ammonium ion
G2/M transition of mitotic cell cycle
cellular response to reactive oxygen species
cell cycle G2/M phase transition
response to estradiol