ENY2

Gene Information

Official Symbol: ENY2
Official Name: ENY2 transcription and export complex 2 subunit
Aliases and Previous Symbols: N/A
Entrez ID: 56943
UniProt: Q9NPA8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. {ECO:0000269|PubMed:18206972, ECO:0000269|PubMed:21746879}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	-2.55
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	-2.32
YM155 0.0002μM R01 exp61	-2.19
Tunicamycin 0.04μM R07 exp418	-1.98
Ibrutinib 10μM R08 exp442	-1.86
proTAME 5μM R04 exp187	-1.83
Calcipotriol 5μM R08 exp464	-1.82
Lenalidomide 20μM R07 exp375	-1.81
Taxol 0.002μM R01 exp54	-1.77
Bisphenol A 100μM R06 exp269	-1.74
Mdivi-1 15μM R05 exp217	-1.71
Citral 75μM R06 exp275	1.7
DABN 20μM R00 exp17	1.7
Hinokiflavone 12μM R08 exp487	1.71
BI-2536 0.02μM R03 exp96	1.75
LY2090314 0.003μM R08 exp500 no dilution day6	1.77
TRAIL 5ng/ml R00 exp35	1.79
Amiloride 100μM R08 exp447	1.8
Doxorubicin 0.02μM R08 exp478	1.83
Nocodazole 0.2μM R00 exp24	1.89
Latrunculin-B 10μM R07 exp374	1.94
Cytochalasin-B 5μM R07 exp349	1.96
UM131593 0.2μM R03 exp106	2
Nocodazole 0.1μM R03 exp94	2.02
Sulforaphane 9μM R08 exp526 no dilution day6	2.06
Etoposide 10μM R00 exp20	2.13
MLN-4924 0.2μM R00 exp21	2.16
Staurosporine 0.02μM R08 exp524	2.2
GSK461364A 0.005μM R03 exp125	2.22
Pimelic-diphenylamide-106 5μM R00 exp28	2.31
GSK461364A 0.1μM R03 exp126	2.34
TIC10 10μM R08 exp532	2.37
Mubritinib 0.2μM R02 exp65	2.42
Benzoate 20000μM R08 exp456	2.45
GSK-J4 1.5μM R08 exp441	2.47
Diepoxybutane 3μM R07 exp354	2.52
Rotenone 0.07μM R08 exp431	2.52
AICAR 240μM R03 exp116	2.58
Tanespimycin 14μM R08 exp527	2.7
I-BRD9 4μM R07 exp365	2.75
Deferoxamine 11μM R07 exp350	2.76
CI-1040 9.5μM R08 exp472	2.79
RO-3307 4.7μM R02 exp80	2.99
AICAR 240μM R05 exp211	3
Etoposide 0.3μM R05 exp199	3.05
Bortezomib 0.05μM R00 exp7	3.06
6-Thio-2-deoxyguanosine 2μM R06 exp259	3.11
MLN-4924 2μM R00 exp22	3.11
Monensin 0.3μM R08 exp507	3.15
Actinomycin-D 0.01μM R00 exp4	3.17
MS023 7μM R03 exp135	3.21
Q15 2.7μM R02 exp79	3.21
UM0129480 7μM R02 exp85	3.31
Artemisinin 50μM R08 exp450	3.45
Olaparib 4μM R08 exp512	3.56
BI-D1870 3.15μM R02 exp66	3.57
Etoposide 1μM R00 exp19	3.58
Bleomycin 5μM R08 exp459	3.62
Mitomycin-C 0.06μM R08 exp503	3.95
Rotenone 20μM R00 exp34	4.72
5-Fluorouracil 20μM R00 exp2	6.31
Actinomycin-D 0.001μM R00 exp3	6.4

Gene	Correlation
NXT1	0.642
GFPT1	0.623
RPTOR	0.623
HARS	0.622
HSPD1	0.618
PMM2	0.603
GMPPB	0.603
DPAGT1	0.602
CASP9	0.593
PLAA	0.586
APAF1	0.584
MEAF6	0.584
THG1L	0.583
CSNK2B	0.579
PPP2R3C	0.578
UAP1	0.572
ALG5	0.57
HCCS	0.568
TRIAP1	0.564
ALG1	0.558
RNMT	0.557
ATP5J	0.556
CYCS	0.554
UBQLN1	0.553
BAP1	0.542
DOHH	0.539
BAK1	0.539
NUPL2	0.535
RTCB	0.534
FAF2	0.526
UBE2G2	0.524
ADSL	0.523
UTP23	0.523
WDR24	0.52
THOC6	0.518
ATXN10	0.514
MARCH5	0.513
UBE2K	0.51
CTDNEP1	0.506
DIABLO	0.505
MTOR	0.504
ALG2	0.503
GABPA	0.503
DNAJC3	0.502
VHL	0.502
GTF3A	0.5
LAMTOR5	0.498
EIF4E	0.495
MFN1	0.495
GTF3C3	0.493
TGS1	0.485
UBA3	0.484
SRP14	0.484
UHRF1	0.483
VDAC2	0.483
MAPK14	0.481
TRMT5	0.48
UBE2J1	0.479
PELO	0.479
RPE	0.478
ATP5O	0.476
GTF3C2	0.475
KDSR	0.475
NAE1	0.474
DPF2	0.474
CCDC101	0.473
SERF2	0.472
ATP5B	0.471
ATP5I	0.471
FGFR1OP	0.47
TBP	0.469
SSB	0.469
TLE4	0.469
DAD1	0.468
DERL2	0.468
TMED10	0.468
WDR59	0.466
SDHA	0.465
EPRS	0.463
ALG6	0.462
DHPS	0.461
KCTD5	0.461
CCT7	0.46
THOC3	0.458
VEZT	0.458
DDHD2	0.457
MED16	0.455
ROMO1	0.455
ALG13	0.454
RPP21	0.452
SEH1L	0.452
NARS	0.452
CBFB	0.452
SEC16A	0.449
ABCF3	0.448
PAX5	0.446
PAM16	0.446
ID3	0.446
MRPS33	0.446
GTF3C6	0.445
DR1	0.445
DOLK	0.444
TMEM41B	0.444
BTAF1	0.443
OSGEP	0.443
ATP5A1	0.443
MANF	0.442
AARS	0.44
TXNRD1	0.438
EIF3F	0.438
NSD1	0.438
MARS	0.438
UBA5	0.437
HAUS8	0.436
ATP5F1	0.434
ORAOV1	0.434
SPCS2	0.434
CARS	0.433
PCBP2	0.433
SUV420H1	0.433
USO1	0.43
TSEN54	0.429
TP53	0.428
DERL1	0.427
CRLS1	0.427
MBTPS2	0.427
SEC61G	0.426
OTUD5	0.426
PPA2	0.425
SRP68	0.424
LAMTOR4	0.424
SEC62	0.424
RAD23B	0.423
FBXO11	0.421
NSMCE1	0.42
GTF3C4	0.419
MED4	0.418
ALG14	0.418
SLC25A26	0.417
TTI2	0.417
TBCA	0.417
GFER	0.415
ATP2A2	0.414
DHDDS	0.414
THOC7	0.412
ALG3	0.412
NUP50	0.411
LSMD1	0.411
MIOS	0.409
TIMM13	0.408
YARS	0.408
PRKRIR	0.407
SLC35B1	0.407
ATAD1	0.407
VRK1	0.407
DARS2	0.405
TTI1	0.405
MRPS14	0.403
SUPV3L1	0.403
URM1	0.402
GEMIN5	0.401

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3515
Expression level (log2 read counts): 5.68

Expression Distribution

DUBm complex
transcription export complex 2
negative regulation of insulin secretion involved in cellular response to glucose stimulus
nuclear pore nuclear basket
SAGA complex
poly(A)+ mRNA export from nucleus
histone deubiquitination
negative regulation of insulin secretion
negative regulation of peptide hormone secretion
regulation of insulin secretion involved in cellular response to glucose stimulus
negative regulation of hormone secretion
nuclear receptor transcription coactivator activity
transcription elongation from RNA polymerase II promoter
DNA-templated transcription, elongation
mRNA-containing ribonucleoprotein complex export from nucleus
mRNA export from nucleus
ribonucleoprotein complex export from nucleus
ribonucleoprotein complex localization
RNA export from nucleus
negative regulation of protein secretion
negative regulation of peptide secretion
protein export from nucleus
mRNA transport
nuclear export
regulation of insulin secretion
negative regulation of protein transport
negative regulation of establishment of protein localization
RNA transport
nucleic acid transport
establishment of RNA localization
negative regulation of secretion by cell
regulation of peptide hormone secretion
RNA localization
negative regulation of secretion
nucleobase-containing compound transport
protein-containing complex localization
nucleocytoplasmic transport
nuclear transport
regulation of hormone secretion
protein deubiquitination