VARS2

Gene Information

Official Symbol: VARS2
Official Name: valyl-tRNA synthetase 2, mitochondrial
Aliases and Previous Symbols: N/A
Entrez ID: 57176
UniProt: Q5ST30
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a mitochondrial aminoacyl-tRNA synthetase, which catalyzes the attachment of valine to tRNA(Val) for mitochondrial translation. Mutations in this gene cause combined oxidative phosphorylation deficiency-20, and are also associated with early-onset mitochondrial encephalopathies. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2014].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-1.88
2-Deoxy-D-glucose 800μM R05 exp214	-1.77
TRAIL 5ng/ml R00 exp35	-1.74
Mitomycin-C 0.06μM R08 exp503	1.75
GSK-J4 1.5μM R08 exp441	1.76
PU-H71 1μM R08 exp515	1.76
Ammonium tetrathiomolybdate 10μM R08 exp448	1.79
Mdivi-1 15μM R05 exp217	1.79
ONC212 0.15μM R08 exp513	1.8
Hinokiflavone 12μM R08 exp487	1.85
BI-D1870 3.15μM R02 exp66	1.9
Vemurafenib 6.6μM R08 exp434	1.96
Aphidicolin 0.4μM R08 exp440	1.99
LLY-283 2.6μM R06 exp290	2.07
Deferoxamine 11μM R07 exp350	2.14
42°C R08 exp539	2.16
Amiloride 100μM R08 exp447	2.18
Hydroxyurea 100μM R07 exp329	2.2
UM0125461 0.74μM R02 exp84	2.26
Monensin 0.3μM R08 exp507	2.37
CoCl2 18μM R07 exp346	2.39
Phenformin 20μM R05 exp212	2.56
Thimerosal 0.85μM R08 exp529	2.63

Gene	Correlation
YARS2	0.73
HSD17B10	0.705
TARS2	0.705
DAP3	0.694
MRPS14	0.69
MRPS21	0.688
GFM1	0.686
MRPL53	0.684
SELRC1	0.682
NARS2	0.677
RPUSD4	0.675
MRPL23	0.675
MRPS16	0.672
SCO2	0.668
MRPS34	0.664
MRP63	0.663
DARS2	0.661
QRSL1	0.657
MRPS18A	0.657
PARS2	0.654
MARS2	0.65
MRPL21	0.648
MRPS6	0.647
MRPS26	0.647
MRPS5	0.639
EARS2	0.639
COX16	0.638
FASTKD5	0.634
LARS2	0.632
MRPL47	0.628
C10orf2	0.626
SARS2	0.625
COA3	0.623
BCS1L	0.621
FTSJ2	0.621
AARS2	0.611
KIAA0391	0.61
COX15	0.606
MRPS24	0.604
MRPL3	0.603
RARS2	0.603
HARS2	0.601
SUPV3L1	0.599
RBFA	0.597
MRPS2	0.597
MRPS12	0.596
FARS2	0.594
COA6	0.593
PET112	0.592
MRPS9	0.59
MRPL20	0.586
MRPS10	0.582
MRPL12	0.581
MRPS25	0.58
COX7B	0.578
TEFM	0.576
TUFM	0.574
PNPT1	0.574
NDUFB11	0.572
POLG2	0.572
MRPL33	0.571
TFAM	0.571
NDUFA3	0.57
MRPS23	0.568
GATC	0.567
MRPL45	0.564
TOMM20	0.562
TRUB2	0.56
NDUFAF7	0.56
SLC25A26	0.557
RNASEH1	0.557
GFM2	0.557
C12orf65	0.555
MRPL55	0.55
COQ2	0.549
WBSCR16	0.548
UQCRC2	0.547
MTG2	0.546
MRPL18	0.541
MTRF1L	0.541
GTPBP10	0.54
MRPL15	0.539
COX11	0.538
MRPS7	0.527
MTPAP	0.526
AIFM1	0.518
MRPL52	0.515
MRPS27	0.514
MRPS11	0.512
MRPS35	0.512
MRPS33	0.511
METTL17	0.507
MRPL44	0.505
MRPS17	0.505
CARS2	0.505
PET117	0.504
MRPL39	0.504
COX6C	0.503
TMEM242	0.503
MRPL4	0.502
PGM3	0.501
PDSS1	0.501
RPUSD3	0.501
UQCR10	0.499
MRPL43	0.496
RNMTL1	0.496
MRPL34	0.496
NDUFV1	0.496
MRPL13	0.495
C17orf89	0.492
COA5	0.491
MALSU1	0.491
MRPL42	0.49
POLRMT	0.489
MTERFD2	0.489
MRPL36	0.489
ATP5D	0.488
RTN4IP1	0.488
WARS2	0.487
NDUFA1	0.485
ATP5A1	0.484
OPA1	0.484
MTIF3	0.484
COX17	0.482
COQ3	0.481
LRPPRC	0.48
MRPS22	0.479
ATP5C1	0.478
TIMM8B	0.476
DNLZ	0.476
ELAC2	0.474
NDUFAF4	0.473
NDUFS7	0.467
ERAL1	0.467
NDUFC2	0.467
DHRSX	0.466
DHX30	0.464
NDUFA2	0.464
TFB1M	0.463
MRPL28	0.463
POLG	0.463
MTG1	0.461
ECSIT	0.46
UQCC2	0.46
NDUFAF3	0.459
TFB2M	0.459
MRPL35	0.458
MIPEP	0.457
TRIAP1	0.456
HCCS	0.455
MRPL46	0.455
NDUFB5	0.454
GTPBP6	0.452
DDX28	0.451
NDUFS2	0.45
NDUFB3	0.45
PTCD3	0.45
MRPL17	0.449
NDUFB6	0.449
HIGD2A	0.448
MRPL22	0.448
TRMT10C	0.445
COX6B1	0.443
ATP5B	0.443
ALDH18A1	0.443
COQ4	0.441
UQCRQ	0.441
TMEM126B	0.441
UQCRC1	0.437
TOMM7	0.434
MRPL11	0.434
CRLS1	0.434
CHCHD1	0.433
CHCHD4	0.432
COX5A	0.432
IBA57	0.431
MTERFD1	0.429
MRPL1	0.427
MRPL38	0.427
MRPS28	0.425
ACAD9	0.425
NDUFB1	0.424
TRMT61A	0.424
COX10	0.423
MRPL32	0.423
MCAT	0.422
COQ7	0.421
LSM10	0.421
FH	0.419
COQ6	0.419
SLC25A3	0.418
MRPL54	0.417
PPCS	0.417
NDUFS5	0.415
PRKRIR	0.414
TAMM41	0.413
TIMMDC1	0.413
MRPL2	0.413
MRPL10	0.412
TPK1	0.412
TOMM6	0.412
SLC31A1	0.409
GTPBP8	0.409
MRPL49	0.409
ATP5SL	0.409
ATP5J	0.409
MRPL37	0.408
TAZ	0.406
COX20	0.406
COX7C	0.406
MTIF2	0.406
MRPL27	0.405
ATP5O	0.405
TOMM40	0.405
PGGT1B	0.404
NDUFAF5	0.403
GRSF1	0.403
NDUFA8	0.403
HMGXB3	0.402
TRMT10A	0.402
TOMM22	0.401
ALG8	0.4

Global Fraction of Cell Lines Where Essential: 60/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	1/28
bone	2/26
breast	4/33
central nervous system	4/56
cervix	1/4
colorectal	3/17
esophagus	1/13
fibroblast	0/1
gastric	3/16
kidney	3/21
liver	4/20
lung	7/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	5/22
urinary tract	2/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 479
Expression level (log2 read counts): 5.71

Expression Distribution

tRNA-synt 1g
tRNA-synt 1
Anticodon 1

valyl-tRNA aminoacylation
valine-tRNA ligase activity
aminoacyl-tRNA editing activity
aminoacyl-tRNA metabolism involved in translational fidelity
regulation of translational fidelity
tRNA aminoacylation for protein translation
tRNA aminoacylation
amino acid activation
tRNA metabolic process
cellular amino acid metabolic process
translation
peptide biosynthetic process
ncRNA metabolic process
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
mitochondrion
organonitrogen compound biosynthetic process
ATP binding
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
small molecule metabolic process
macromolecule biosynthetic process
gene expression