MRPS34

Gene Information

Official Symbol: MRPS34
Official Name: mitochondrial ribosomal protein S34
Aliases and Previous Symbols: N/A
Entrez ID: 65993
UniProt: P82930
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation. {ECO:0000250|UniProtKB:Q9JIK9}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CR131-b 0.005μM R08 exp474	1.73
Ribavirin 10μM R01 exp52	1.73
VER-155008 3.9μM R06 exp301	1.75
GSK-J4 1.5μM R08 exp441	1.77
Tanespimycin 14μM R08 exp527	1.82
TIC10 10μM R08 exp532	1.84
Aphidicolin 0.4μM R08 exp440	1.87
Monensin 0.3μM R08 exp507	1.88
CFI-400945 25μM R08 exp469	1.97
PU-H71 1μM R08 exp515	1.98
Vemurafenib 6.6μM R02 exp89	2.04
Deferoxamine 11μM R07 exp350	2.17
AICAR 240μM R05 exp211	2.18
ONC212 0.15μM R08 exp513	2.33
Hydroxyurea 100μM R07 exp329	2.41
Thimerosal 0.85μM R08 exp529	2.52
Pterostilbene 16μM R02 exp78	2.69
UM0125461 0.74μM R02 exp84	2.78

Gene	Correlation
HSD17B10	0.757
YARS2	0.727
TARS2	0.721
MRPL47	0.72
MRPL21	0.717
MRPS14	0.707
QRSL1	0.7
MRPL23	0.697
MRPS6	0.697
MRPS16	0.689
MRPS5	0.688
MRPS18A	0.684
EARS2	0.676
SCO2	0.673
KIAA0391	0.672
DAP3	0.671
GFM1	0.666
SELRC1	0.665
VARS2	0.664
PARS2	0.662
MRPS26	0.662
RPUSD4	0.661
DARS2	0.658
MRPL53	0.658
MRPS21	0.655
RBFA	0.653
NARS2	0.653
MRP63	0.65
SUPV3L1	0.649
GTPBP10	0.648
MRPS2	0.64
MRPS9	0.637
C12orf65	0.637
MTG2	0.637
COX16	0.636
WBSCR16	0.631
GFM2	0.63
LARS2	0.627
FASTKD5	0.627
SARS2	0.625
RARS2	0.618
BCS1L	0.615
HARS2	0.615
MRPL55	0.613
TRUB2	0.612
SLC25A26	0.612
MARS2	0.612
NDUFA3	0.609
TUFM	0.609
MRPS24	0.608
AARS2	0.607
MRPL20	0.603
MRPS25	0.602
COA3	0.593
MRPS12	0.593
NDUFB11	0.588
MRPL15	0.588
GATC	0.587
MTPAP	0.587
AIFM1	0.587
POLRMT	0.587
FARS2	0.586
RNASEH1	0.584
PET112	0.582
COA6	0.58
TEFM	0.578
FTSJ2	0.577
NDUFAF7	0.577
MRPL12	0.573
PNPT1	0.573
MRPL42	0.571
MRPL3	0.569
RPUSD3	0.564
COQ2	0.563
MTG1	0.562
TOMM20	0.562
CHCHD4	0.56
MIPEP	0.558
MRPL4	0.557
TRIAP1	0.556
POLG	0.556
MRPS11	0.551
TMEM242	0.551
DNLZ	0.551
MRPL45	0.55
MRPS10	0.545
PET117	0.544
MRPL33	0.543
PDSS1	0.539
C17orf89	0.538
IBA57	0.538
UQCR10	0.536
C10orf2	0.534
METTL17	0.534
MRPL44	0.533
MRPL34	0.532
MRPS22	0.532
LSM10	0.531
CHCHD1	0.531
NDUFA2	0.531
NDUFB5	0.53
UQCRQ	0.527
MRPL11	0.526
MRPL39	0.525
MRPS33	0.524
TRMT61A	0.523
DHRSX	0.523
COX17	0.52
MRPS35	0.52
MTRF1L	0.519
ELAC2	0.519
PGM3	0.518
UQCRC2	0.517
COX6C	0.517
TOMM40	0.516
TIMM8B	0.516
MRPL9	0.513
WARS2	0.512
MRPL22	0.512
COX15	0.508
ATP5D	0.508
MRPL36	0.507
NDUFC2	0.506
POLG2	0.505
MRPS23	0.504
MRPL41	0.503
MRPS27	0.501
HCCS	0.501
COX7B	0.5
DHX30	0.5
NDUFA1	0.497
MRPL46	0.497
RPIA	0.494
COQ3	0.493
COX6B1	0.492
MRPL17	0.492
MRPL43	0.492
AASDHPPT	0.488
PTRHD1	0.485
MRPL18	0.484
COX5A	0.483
ATP5C1	0.483
ATP5SL	0.482
TFAM	0.481
MRPL52	0.481
NDUFAF3	0.48
COQ5	0.478
COX11	0.477
OPA1	0.477
HMGXB3	0.476
NDUFB6	0.476
LRPPRC	0.476
MTERFD2	0.474
TOMM6	0.474
DDX28	0.474
NDUFB9	0.473
MRPS7	0.472
COQ4	0.471
ISCA2	0.471
TEN1	0.469
NDUFS2	0.468
MALSU1	0.468
NDUFAF4	0.465
NDUFV1	0.465
PMM2	0.465
PTCD3	0.464
MRPL2	0.464
MRPS17	0.464
PPCS	0.463
ATP5A1	0.461
ROMO1	0.46
MCAT	0.459
GTPBP6	0.459
VEZT	0.458
PPA2	0.458
THG1L	0.456
MRPL28	0.455
UHRF1	0.454
MRPL35	0.453
COQ7	0.453
CARS2	0.452
ATIC	0.451
TPK1	0.451
UQCC2	0.449
FH	0.448
MRPL37	0.445
COA5	0.445
ECSIT	0.445
PITRM1	0.441
ACAD9	0.44
NDUFB3	0.44
ATP5B	0.44
CRLS1	0.438
HIGD2A	0.438
TAMM41	0.437
GLRX5	0.437
SLC25A19	0.437
TAZ	0.436
RTN4IP1	0.435
NFU1	0.435
TOMM22	0.435
TBRG4	0.434
MTIF3	0.432
TMEM126B	0.428
TMEM261	0.428
PTCD1	0.428
RPE	0.427
ERAL1	0.426
SDHA	0.424
MTERFD1	0.423
RNMTL1	0.423
UAP1	0.423
TFB2M	0.422
ATP5J	0.422
CLPP	0.422
ALG1	0.421
ATP5H	0.421
GTPBP8	0.42
FASTKD1	0.42
PGGT1B	0.419
COX20	0.419
NDUFAF5	0.417
COQ6	0.417
MRPL13	0.416
SLC25A3	0.416
COX19	0.415
UQCRFS1	0.414
MRPL49	0.414
MRPL27	0.414
ATXN10	0.412
NDUFS7	0.411
NDUFB1	0.411
ATP5O	0.408
SLC31A1	0.407
FASTKD2	0.407
MTO1	0.407
DOHH	0.404
PMVK	0.404
MRPL51	0.402
DPAGT1	0.4
RFT1	0.4

Global Fraction of Cell Lines Where Essential: 107/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	4/28
blood	2/28
bone	2/26
breast	6/33
central nervous system	5/56
cervix	2/4
colorectal	2/17
esophagus	3/13
fibroblast	0/1
gastric	3/16
kidney	3/21
liver	4/20
lung	14/75
lymphocyte	1/16
ovary	4/26
pancreas	4/24
peripheral nervous system	4/16
plasma cell	3/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	3/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 1347
Expression level (log2 read counts): 6.36

Expression Distribution

mitochondrial small ribosomal subunit
mitochondrial translational termination
mitochondrial translational elongation
translational termination
mitochondrial translation
translational elongation
cellular protein complex disassembly
mitochondrial gene expression
structural constituent of ribosome
protein-containing complex disassembly
translation
mitochondrial inner membrane
cellular component disassembly
peptide biosynthetic process
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
mitochondrion
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
protein-containing complex subunit organization
gene expression