NDUFB11

Gene Information

Official Symbol: NDUFB11
Official Name: N/ADH:ubiquinone oxidoreductase subunit B11
Aliases and Previous Symbols: N/A
Entrez ID: 54539
UniProt: Q9NX14
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is located at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to ubiquinone. Mutations in the human gene are associated with linear skin defects with multiple congenital anomalies 3 and mitochondrial complex I deficiency. [provided by RefSeq, Dec 2016].
UniProt Summary: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MKC9989 10μM R03 exp133	-1.72
Hydroxychloroquine 30μM R08 exp490	1.74
iCRT14 30μM R08 exp492	1.74
Azithromycin 100μM R08 exp452	1.75
Vemurafenib 6.6μM R02 exp89	1.77
BML-284 0.09μM R08 exp460	1.79
HMS-I1 1μM R01 exp46	1.82
Palbociclib 1μM R07 exp382	1.82
Tubacin 1.6μM R07 exp416	1.82
Aphidicolin 0.4μM R08 exp440	1.83
Cannabidiol 20μM R08 exp466	1.83
Chloroquine 32μM R08 exp470	1.84
Arsenate 40μM R06 exp264	1.85
Olaparib 4μM R08 exp512	1.86
AICAR 240μM R03 exp116	1.9
CFI-400945 25μM R08 exp469	1.9
GSK-J4 1.5μM R08 exp441	1.92
UM0129480 7μM R02 exp85	1.93
Vinblastine 0.002μM R01 exp60	1.99
Doxorubicin 0.02μM R08 exp478	2.02
Mubritinib 0.2μM R01 exp48	2.11
AICAR 240μM R05 exp211	2.22
Tanespimycin 14μM R08 exp527	2.27
UMK57 1μM R01 exp59	2.4
Q15 2.7μM R02 exp79	2.42
Ammonium tetrathiomolybdate 10μM R08 exp448	2.53
Vemurafenib 6.6μM R08 exp434	2.54
Mitomycin-C 0.06μM R08 exp503	2.58
BI-D1870 3.15μM R02 exp66	2.6
Thimerosal 0.85μM R08 exp529	2.62
UM0125461 0.74μM R02 exp84	2.62
Hydroxyurea 100μM R07 exp329	2.69
Ribavirin 10μM R01 exp52	2.74
Genistein 15μM R07 exp360	2.88
Atovaquone 15μM R08 exp451	3.11
HMS-I2 10μM R06 exp288	3.15
Calcium Ionophore 0.4μM R07 exp342	3.43
Artemisinin 50μM R08 exp450	3.81
Oligomycin-A 2μM R00 exp25	3.99

Gene	Correlation
NDUFA1	0.741
NDUFB9	0.736
NDUFS2	0.733
NDUFAF7	0.727
NDUFAF3	0.724
NDUFA2	0.72
NDUFA3	0.719
GRSF1	0.706
NDUFB6	0.689
ACAD9	0.687
NDUFA11	0.671
MRPS21	0.67
ECSIT	0.668
TARS2	0.665
NUBPL	0.661
FTSJ2	0.65
MTO1	0.645
NDUFC2	0.642
HSD17B10	0.641
YARS2	0.64
QRSL1	0.638
NDUFC1	0.633
DAP3	0.633
NARS2	0.63
GFM1	0.627
MRPL21	0.625
NDUFB5	0.625
NDUFS7	0.624
NDUFA8	0.624
NDUFS5	0.619
LARS2	0.618
GTPBP10	0.618
MTRF1L	0.617
PARS2	0.616
GFM2	0.613
TIMMDC1	0.609
RNASEH1	0.607
ATP5SL	0.607
NDUFV1	0.605
MRPS5	0.604
C12orf65	0.601
NDUFAF6	0.599
MRPS25	0.599
MRPL23	0.597
EARS2	0.597
C17orf89	0.592
NDUFB7	0.59
PET117	0.589
NDUFA10	0.589
MRPS34	0.588
RBFA	0.586
SELRC1	0.586
MRP63	0.585
RPUSD3	0.584
CHCHD1	0.583
DARS2	0.582
TEFM	0.582
MRPS6	0.581
POLG	0.58
NFU1	0.58
POLG2	0.579
PET112	0.579
IBA57	0.578
WBSCR16	0.578
GATC	0.578
MRPL47	0.577
RTN4IP1	0.577
METTL17	0.576
NDUFB2	0.576
RPUSD4	0.575
MRPS14	0.574
MRPS16	0.574
TMEM261	0.574
C10orf2	0.572
MTG1	0.572
VARS2	0.572
BCS1L	0.571
MRPL53	0.57
NDUFAF1	0.569
NDUFA6	0.569
NDUFS8	0.561
MRPL15	0.559
NDUFAF4	0.559
NDUFB10	0.559
TUFM	0.556
MRPS33	0.555
MRPL45	0.553
NDUFV2	0.553
NDUFS3	0.553
SCO2	0.552
MARS2	0.552
FOXRED1	0.551
FASTKD2	0.55
NDUFAF5	0.55
POLRMT	0.55
MTG2	0.546
MRPL12	0.545
MRPS27	0.545
COQ7	0.544
COA3	0.544
SARS2	0.541
MIPEP	0.537
MRPS26	0.537
MRPL3	0.536
MALSU1	0.533
AARS2	0.532
NDUFB4	0.532
SSBP1	0.532
MRPL44	0.531
NDUFS1	0.531
TFB1M	0.531
COQ2	0.528
MRPS9	0.526
SUPV3L1	0.525
MRPS18A	0.525
NDUFA13	0.525
MCAT	0.524
GLRX5	0.524
RARS2	0.519
HMGXB3	0.518
MRPS2	0.517
MRPS12	0.517
TRUB2	0.516
TOMM20	0.515
WARS2	0.514
MRPL17	0.513
PNPT1	0.513
DDX28	0.512
SLC25A26	0.512
HARS2	0.512
GTPBP8	0.51
AIFM1	0.51
C1QBP	0.509
MRPL43	0.508
MRPS24	0.508
FARS2	0.508
MRPL55	0.508
FASTKD5	0.508
CARS2	0.507
MRPS10	0.507
MRPL13	0.506
KIAA0391	0.505
MTERFD1	0.504
MRPL22	0.499
COX16	0.494
MRPS17	0.494
MTIF2	0.493
COX7B	0.491
NDUFA5	0.491
COX15	0.489
GTPBP6	0.489
PTCD3	0.488
COX11	0.488
PDSS1	0.485
MRPS11	0.48
NDUFB3	0.48
MRPL2	0.479
SLC25A3	0.478
MRPS23	0.477
MRPL42	0.476
TFAM	0.475
MRPL11	0.475
RNMTL1	0.472
SLC25A19	0.471
COA6	0.471
ERAL1	0.47
ATP5C1	0.47
COQ3	0.469
NDUFA9	0.469
MTERFD2	0.468
MRPL41	0.468
MRPL20	0.467
SLC25A51	0.466
COX17	0.459
ATP5D	0.459
TPK1	0.458
SLC25A52	0.457
NDUFB1	0.457
MRPS35	0.455
NSUN4	0.453
MRPL4	0.452
TMEM242	0.452
TRMT10C	0.449
TOMM6	0.448
MRPL28	0.447
MTPAP	0.447
MRPL18	0.446
MRPL46	0.445
MRPL34	0.445
UQCRC2	0.443
UQCR10	0.443
MRPS7	0.443
NOA1	0.442
TIMM21	0.441
FASTKD1	0.438
ELAC2	0.437
ALAS1	0.435
MRPS22	0.434
FH	0.433
COX5A	0.43
COX6C	0.43
ICT1	0.428
ISCA2	0.428
TMEM126B	0.428
MRPL1	0.427
AASDHPPT	0.425
UQCRC1	0.424
ATP5A1	0.422
MRPS18B	0.421
MTIF3	0.419
MRPL49	0.417
PITRM1	0.416
LRPPRC	0.415
CLPP	0.415
PDSS2	0.415
MRPL39	0.414
PDE12	0.414
MINOS1	0.412
ATP5E	0.411
TIMM8B	0.411
NDUFB8	0.411
RPIA	0.41
MRPL33	0.409
SFXN4	0.405
RMND1	0.405
DHX30	0.402
COX6B1	0.401
PTCD1	0.401

Global Fraction of Cell Lines Where Essential: 24/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	0/26
bone	0/26
breast	2/30
central nervous system	0/49
cervix	0/4
colorectal	1/17
esophagus	0/11
fibroblast	0/1
gastric	1/14
kidney	2/18
liver	1/19
lung	4/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	2/20
soft tissue	1/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	2/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 759
Expression level (log2 read counts): 5.23

Expression Distribution