SUPT6H
Gene Information
- Official Symbol: SUPT6H
- Official Name: SPT6 homolog, histone chaperone and transcription elongation factor
- Aliases and Previous Symbols: N/A
- Entrez ID: 6830
- UniProt: Q7KZ85
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| S1 |
GO Terms
| chromatin maintenance |
| negative regulation of histone H3-K27 methylation |
| regulation of mRNA export from nucleus |
| regulation of ribonucleoprotein complex localization |
| regulation of histone H3-K27 methylation |
| regulation of RNA export from nucleus |
| regulation of nucleobase-containing compound transport |
| positive regulation of transcription elongation from RNA polymerase II promoter |
| mRNA transcription by RNA polymerase II |
| negative regulation of histone methylation |
| transcriptionally active chromatin |
| mRNA transcription |
| transcription elongation factor complex |
| nucleosome binding |
| regulation of transcription elongation from RNA polymerase II promoter |
| positive regulation of DNA-templated transcription, elongation |
| regulation of isotype switching |
| blastocyst formation |
| regulation of protein export from nucleus |
| negative regulation of histone modification |
| cellular component maintenance |
| regulation of DNA-templated transcription, elongation |
| regulation of B cell mediated immunity |
| regulation of immunoglobulin mediated immune response |
| negative regulation of chromatin organization |
| regulation of immunoglobulin production |
| regulation of histone methylation |
| transcription elongation from RNA polymerase II promoter |
| DNA-templated transcription, elongation |
| blastocyst development |
| regulation of DNA recombination |
| regulation of nucleocytoplasmic transport |
| histone binding |
| negative regulation of chromosome organization |
| regulation of mRNA processing |
| regulation of production of molecular mediator of immune response |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| regulation of histone modification |
| regulation of lymphocyte mediated immunity |
| regulation of muscle cell differentiation |
| mRNA transport |
| nucleosome organization |
| regulation of adaptive immune response |
| chromatin remodeling |
| regulation of chromatin organization |
| RNA transport |
| nucleic acid transport |
| establishment of RNA localization |
| regulation of leukocyte mediated immunity |
| regulation of B cell activation |
| RNA localization |
| regulation of intracellular protein transport |
| nucleobase-containing compound transport |
| protein-DNA complex subunit organization |
| regulation of mRNA metabolic process |
| regulation of chromosome organization |
| regulation of intracellular transport |
| regulation of DNA metabolic process |
| negative regulation of organelle organization |
| in utero embryonic development |
| RNA splicing |
| regulation of immune effector process |
| mRNA processing |
| transcription by RNA polymerase II |
| regulation of lymphocyte activation |
| regulation of cellular protein localization |
| negative regulation of protein modification process |
| regulation of leukocyte activation |
| chordate embryonic development |
| regulation of cell activation |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| embryo development ending in birth or egg hatching |
| RNA biosynthetic process |
| DNA-binding transcription factor activity |
| mRNA metabolic process |
| chromatin organization |
| viral process |
| negative regulation of cellular component organization |
| regulation of protein transport |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| symbiotic process |
| interspecies interaction between organisms |
| RNA processing |
| anatomical structure formation involved in morphogenesis |
| regulation of cellular localization |
| embryo development |
| regulation of protein localization |
| negative regulation of cellular protein metabolic process |
| chromosome organization |
| nucleobase-containing compound biosynthetic process |
| negative regulation of protein metabolic process |
| regulation of immune response |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| positive regulation of transcription by RNA polymerase II |
| regulation of organelle organization |
| organic cyclic compound biosynthetic process |
| RNA binding |
| DNA binding |
| positive regulation of transcription, DNA-templated |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| regulation of immune system process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| macromolecule biosynthetic process |
| regulation of cell differentiation |
| regulation of protein modification process |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| POLR2J3 | 0.579 |
| PAN2 | 0.555 |
| TBC1D3C | 0.552 |
| TBC1D3G | 0.549 |
| VASN | 0.548 |
| DTL | 0.546 |
| ZFAND5 | 0.542 |
| CBWD3 | 0.541 |
| PSMD3 | 0.54 |
| ANKLE2 | 0.539 |
| SSH2 | 0.538 |
| TCEB3C | 0.535 |
| TCEB3CL2 | 0.535 |
| ORC1 | 0.533 |
| SUPT5H | 0.532 |
| COPE | 0.532 |
| TICRR | 0.531 |
| PAN3 | 0.529 |
| CBWD5 | 0.528 |
| PSMB4 | 0.527 |
| NUP205 | 0.525 |
| RBM39 | 0.524 |
| PSMC6 | 0.523 |
| PCF11 | 0.523 |
| MED17 | 0.52 |
| TBC1D3H | 0.517 |
| NOL10 | 0.517 |
| RPL14 | 0.515 |
| ZNF655 | 0.515 |
| C14orf93 | 0.514 |
| ZNF106 | 0.513 |
| RAD21 | 0.512 |
| CLASP1 | 0.511 |
| TCEB3CL | 0.51 |
| POLA2 | 0.509 |
| ORC6 | 0.508 |
| RPL35 | 0.508 |
| COPB2 | 0.507 |
| HIST1H2BE | 0.505 |
| PSMA6 | 0.504 |
| PSMD1 | 0.503 |
| DDX56 | 0.503 |
| CDCA3 | 0.501 |
| NUPL1 | 0.498 |
| COPG1 | 0.496 |
| CCNA2 | 0.496 |
| PSMB1 | 0.495 |
| HIST2H2BF | 0.492 |
| RRP15 | 0.492 |
| SFPQ | 0.491 |
| COPB1 | 0.491 |
| SMG7 | 0.491 |
| NPIPB5 | 0.49 |
| SYT9 | 0.49 |
| VPS54 | 0.49 |
| C1QTNF9B | 0.489 |
| ATP6V0C | 0.489 |
| MYB | 0.488 |
| SULT2B1 | 0.488 |
| TBC1D3E | 0.487 |
| TBC1D3K | 0.487 |
| TBC1D3I | 0.487 |
| TBC1D3L | 0.486 |
| CBWD6 | 0.486 |
| MT1E | 0.486 |
| RAD51 | 0.484 |
| NOP16 | 0.482 |
| UPF1 | 0.481 |
| KRT78 | 0.481 |
| OGFR | 0.48 |
| CHD4 | 0.48 |
| PSMC1 | 0.48 |
| UBAP1 | 0.48 |
| GOLGA6L6 | 0.479 |
| POLR1A | 0.479 |
| ARCN1 | 0.478 |
| DDTL | 0.477 |
| MDM2 | 0.476 |
| NBPF10 | 0.476 |
| AAMP | 0.476 |
| POLA1 | 0.476 |
| PSMC2 | 0.476 |
| PSMC4 | 0.475 |
| ATXN1 | 0.474 |
| PSMD6 | 0.474 |
| PSMD11 | 0.472 |
| POLR2D | 0.471 |
| SCAF1 | 0.47 |
| FBXO5 | 0.469 |
| WDR43 | 0.469 |
| MED14 | 0.469 |
| SF3A3 | 0.468 |
| RNPC3 | 0.467 |
| KPNB1 | 0.467 |
| SLC38A7 | 0.466 |
| CGB2 | 0.466 |
| TWISTNB | 0.466 |
| WDR75 | 0.466 |
| RIOK2 | 0.464 |
| GOLGA6A | 0.463 |
| TOP1MT | 0.461 |
| ATP6V0B | 0.461 |
| GOSR2 | 0.461 |
| FBXW9 | 0.461 |
| RPS7 | 0.461 |
| RPS9 | 0.46 |
| SMG1 | 0.46 |
| RPL26 | 0.46 |
| POLR2J | 0.46 |
| NUP155 | 0.459 |
| SLC6A17 | 0.459 |
| EXOSC5 | 0.459 |
| RPS3A | 0.457 |
| HAP1 | 0.456 |
| LAD1 | 0.454 |
| CEP192 | 0.454 |
| HIST1H4B | 0.454 |
| YTHDC1 | 0.454 |
| TBC1D3F | 0.454 |
| CDC73 | 0.453 |
| NUP43 | 0.453 |
| TSPY8 | 0.453 |
| MYO1H | 0.453 |
| COPZ1 | 0.451 |
| ISCU | 0.451 |
| AQR | 0.451 |
| CDC45 | 0.451 |
| SLC4A1 | 0.448 |
| CDC6 | 0.448 |
| TFIP11 | 0.446 |
| PSMD14 | 0.446 |
| KMT2A | 0.446 |
| SNRPA1 | 0.445 |
| PSAP | 0.445 |
| PAF1 | 0.445 |
| RNF121 | 0.444 |
| CTAGE4 | 0.443 |
| CWC22 | 0.442 |
| HMGCR | 0.441 |
| TBC1D3 | 0.441 |
| UQCRH | 0.439 |
| RANBP2 | 0.438 |
| IGFN1 | 0.438 |
| PSMB3 | 0.438 |
| TRAIP | 0.437 |
| AKIRIN2 | 0.437 |
| DNM2 | 0.436 |
| NUP153 | 0.436 |
| RPL30 | 0.435 |
| NOL12 | 0.435 |
| RPS2 | 0.435 |
| CCDC94 | 0.434 |
| IK | 0.434 |
| TIMELESS | 0.433 |
| DNTTIP2 | 0.432 |
| RRM1 | 0.432 |
| DISP2 | 0.432 |
| SEC13 | 0.431 |
| STIL | 0.431 |
| OSBP | 0.431 |
| RPS14 | 0.43 |
| TP53TG3B | 0.429 |
| TTC31 | 0.429 |
| PRIM1 | 0.429 |
| SSFA2 | 0.429 |
| PLK1 | 0.429 |
| ZNF830 | 0.428 |
| RPS12 | 0.428 |
| TP53TG3 | 0.427 |
| HIST2H3A | 0.426 |
| SNIP1 | 0.426 |
| TP53TG3C | 0.426 |
| S1PR4 | 0.426 |
| RPS5 | 0.426 |
| AATF | 0.425 |
| EXOSC9 | 0.425 |
| HIVEP3 | 0.425 |
| HIST2H3C | 0.425 |
| CTAGE9 | 0.425 |
| RFXANK | 0.424 |
| RPS19BP1 | 0.423 |
| AHCTF1 | 0.422 |
| MAP7D1 | 0.422 |
| GOLGA8J | 0.422 |
| TSPY1 | 0.422 |
| MFSD12 | 0.422 |
| PBXIP1 | 0.422 |
| RBBP5 | 0.421 |
| KCTD17 | 0.421 |
| GOLGA8O | 0.421 |
| RPL34 | 0.421 |
| SH3BP1 | 0.421 |
| LRR1 | 0.42 |
| ATP6V1A | 0.419 |
| RPL6 | 0.419 |
| PSMD7 | 0.419 |
| RUVBL2 | 0.419 |
| POLR2A | 0.419 |
| RPS28 | 0.419 |
| DYNC1I2 | 0.417 |
| POLR2G | 0.417 |
| TAF15 | 0.417 |
| NCKAP1L | 0.416 |
| GPRIN2 | 0.415 |
| KRT2 | 0.414 |
| OR10G3 | 0.413 |
| ACO2 | 0.413 |
| CACNA1A | 0.413 |
| EXD1 | 0.412 |
| VPS52 | 0.411 |
| HINFP | 0.411 |
| RRP1 | 0.411 |
| ZNF513 | 0.411 |
| NUP54 | 0.411 |
| TAF1 | 0.41 |
| PIGS | 0.41 |
| CDT1 | 0.41 |
| PSMA7 | 0.41 |
| COX8A | 0.409 |
| TSG101 | 0.409 |
| RRN3 | 0.408 |
| FAM160A1 | 0.408 |
| CHMP2A | 0.407 |
| NUP214 | 0.406 |
| RFPL3 | 0.406 |
| UTP3 | 0.406 |
| UTP20 | 0.406 |
| EIF4A3 | 0.406 |
| CHMP4B | 0.405 |
| SEMA6B | 0.405 |
| CKAP5 | 0.404 |
| PSMB2 | 0.404 |
| NARFL | 0.404 |
| PDE4DIP | 0.404 |
| RFFL | 0.404 |
| RPL9 | 0.403 |
| BCL2L1 | 0.402 |
| RPL7L1 | 0.402 |
| CLN6 | 0.401 |
| MED29 | 0.401 |
| MYH2 | 0.401 |
| DGCR14 | 0.401 |
| FBL | 0.401 |
| ATP6V1C1 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 723/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 27/28 |
| blood | 28/28 |
| bone | 25/25 |
| breast | 33/33 |
| central nervous system | 55/56 |
| cervix | 4/4 |
| colorectal | 16/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 15/15 |
| kidney | 21/21 |
| liver | 20/20 |
| lung | 75/75 |
| lymphocyte | 14/14 |
| ovary | 26/26 |
| pancreas | 24/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 15/15 |
| prostate | 1/1 |
| skin | 24/24 |
| soft tissue | 7/7 |
| thyroid | 2/2 |
| upper aerodigestive | 22/22 |
| urinary tract | 29/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 93
- Expression level (log2 read counts): 7.64
Expression Distribution
SUPT6H Expression in NALM6 Cells: 7.64
