ALG5

Gene Information

Official Symbol: ALG5
Official Name: ALG5 dolichyl-phosphate beta-glucosyltransferase
Aliases and Previous Symbols: N/A
Entrez ID: 29880
UniProt: Q9Y673
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Thapsigargin 0.005μM R07 exp407	-2.55
Pifithrin-alpha 20μM R07 exp390	-2.43
Bisphenol S 100μM R08 exp458	-2.37
A-366 10μM R03 exp115	-2.2
Bortezomib 0.005μM R00 exp6	-2.13
Salubrinal 20μM R07 exp399	-2.07
IWR1 50μM R08 exp495	-2.01
A-395N 10μM R05 exp219	-1.98
GSK343 3μM R03 exp124	-1.98
Ethanol 0.01 R05 exp234	-1.96
GW501516 25μM R06 exp285	-1.96
Zebularine 20μM R07 exp423	-1.96
GSK-J4 1μM R07 exp362	-1.93
Lapatinib 5μM R01 exp47	-1.92
Asunaprenir 3μM R07 exp336	-1.89
UNC1999 2μM R03 exp155	-1.88
Benzoate 10000μM R08 exp455	-1.87
BS-181 20μM R08 exp461	-1.87
ZLN024 50μM R08 exp538	-1.87
All-trans-Retinoic-Acid 8μM R07 exp333	-1.85
Lead acetate 2000μM R08 exp497	-1.85
YM155 0.0002μM R01 exp61	-1.85
DKK1 89ng/ml R08 exp477	-1.84
Cannabidiol 13μM R08 exp465	-1.83
CB-839 10μM R05 exp224	-1.81
Isoniazid 100μM R08 exp494	-1.8
Cryptotanshinone 12μM R05 exp227	-1.78
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	-1.76
UM0130462 0.025 to 0.035μM day4 R05 exp247	-1.76
Cerivastatin 0.15μM R05 exp226	-1.75
proTAME 5μM R04 exp187	-1.72
Disulfiram 4.3μM R06 exp281	-1.71
OICR-9429 10μM R03 exp142	-1.7
Actinomycin-D 0.01μM R00 exp4	1.7
Salinomycin 3.5μM R08 exp521	1.71
DABN racemic mixture R03 exp93	1.72
Actinomycin-D 0.001μM R00 exp3	1.77
Mitomycin-C 0.06μM R08 exp503	1.79
Rotenone 20μM R00 exp34	1.79
PU-H71 1μM R08 exp515	1.87
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.91
Bortezomib 0.05μM R00 exp7	1.99
Hinokiflavone 12μM R08 exp487	1.99
BI-2536 0.02μM R03 exp96	2
DABN 20μM R00 exp17	2
Palbociclib 1μM R07 exp382	2.02
6-Thio-2-deoxyguanosine 2μM R06 exp259	2.1
Pimelic-diphenylamide-106 5μM R00 exp28	2.15
THZ1 0.06μM R08 exp531	2.18
Senexin-A 25μM R07 exp400	2.33
Oligomycin-A 20μM R00 exp26	2.45
Arsenate 40μM R06 exp264	2.47
Nocodazole 0.2μM R02 exp64	2.47
Etoposide 1μM R00 exp19	2.68
Deferoxamine 11μM R07 exp350	2.95
42°C R08 exp539	3.06

Gene	Correlation
PMM2	0.642
DPAGT1	0.61
ALG6	0.608
GFPT1	0.604
ALG1	0.595
DNAJC3	0.593
TRIAP1	0.59
RNMT	0.589
UAP1	0.579
GTF3C4	0.577
ENY2	0.57
HARS	0.563
GMPPB	0.561
UBE2J1	0.556
GTF3C2	0.551
MANF	0.55
TMED10	0.55
CBFB	0.547
UBE2G2	0.544
PGGT1B	0.541
DNAJB11	0.538
MAPK14	0.536
CTDNEP1	0.533
RPTOR	0.532
AARS	0.529
DERL1	0.529
RPE	0.527
SEC62	0.526
DOHH	0.522
ATP5J	0.522
ALG2	0.521
HSPD1	0.519
PPA2	0.519
MBTPS2	0.517
CCDC101	0.515
UBA5	0.514
ATXN10	0.514
SEC63	0.51
RTCB	0.509
CRLS1	0.508
THG1L	0.507
TRMT5	0.505
TMEM41B	0.505
VMP1	0.503
TIMM13	0.5
DAD1	0.5
USO1	0.5
DERL2	0.499
SRP14	0.497
BAP1	0.493
ROMO1	0.491
ALG9	0.491
SEC61B	0.489
DOLK	0.487
CSNK2B	0.487
PPP2R3C	0.486
DPF2	0.486
ATP5A1	0.483
TRMT10A	0.481
TAZ	0.48
UHRF1	0.478
PAM16	0.478
UTP23	0.476
SRP68	0.476
EIF4E	0.474
UBE2K	0.473
IRF2BP2	0.472
MEAF6	0.471
NXT1	0.47
SLC25A26	0.47
OPA1	0.47
SRD5A3	0.469
ORAOV1	0.469
ATP5O	0.469
DHPS	0.469
UFM1	0.465
SDHA	0.464
TAMM41	0.464
DPM3	0.463
SEC16A	0.462
EXOC4	0.461
VEZT	0.461
ALG13	0.46
THOC6	0.459
GNB1L	0.459
ALG14	0.458
VRK1	0.456
WDR24	0.455
ATP5B	0.455
TSEN54	0.454
MRPS33	0.451
HAUS8	0.451
TTI2	0.45
MED25	0.45
XPO6	0.448
PELO	0.448
OTUD5	0.448
MED16	0.446
NSMCE1	0.446
POLR3H	0.446
CYCS	0.443
STT3A	0.442
MARS	0.441
RAD1	0.441
NAE1	0.44
FLVCR1	0.439
PISD	0.439
NUPL2	0.438
LSM10	0.437
C14orf2	0.437
DHRSX	0.436
MLLT1	0.436
SLC35B1	0.435
CBX3	0.435
ALG3	0.434
DDX5	0.433
MBTPS1	0.432
ATP2A2	0.432
CDIPT	0.432
C1orf27	0.428
MRPL15	0.427
KDSR	0.427
TTI1	0.427
MTOR	0.427
OST4	0.427
TBCA	0.427
UFSP2	0.426
HCCS	0.426
SUPV3L1	0.426
ZFX	0.426
NARS	0.425
ALG8	0.425
CEPT1	0.425
ADSL	0.425
GTF3C6	0.425
GTF3C3	0.424
ELAC2	0.423
TBP	0.422
KCMF1	0.422
RPN1	0.421
LSMD1	0.421
DHDDS	0.421
DCAF5	0.419
SRP72	0.419
APAF1	0.418
CASP9	0.415
RPP21	0.415
SEC61G	0.414
RCE1	0.414
MRPL23	0.413
PPCS	0.413
LAMTOR4	0.412
UXT	0.412
UFC1	0.411
EIF1	0.409
MRPS14	0.409
DDOST	0.407
SSB	0.407
MRPS6	0.406
UBE3A	0.404
HSD17B10	0.403
TRNT1	0.402
TXNL4B	0.402
SPCS2	0.402
EIF2B3	0.401
ATP5D	0.4
FAF2	0.4

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3939
Expression level (log2 read counts): 5.33

Expression Distribution

dolichyl-phosphate beta-glucosyltransferase activity
oligosaccharyl transferase activity
protein N-linked glycosylation via asparagine
peptidyl-asparagine modification
protein N-linked glycosylation
determination of left/right symmetry
determination of bilateral symmetry
specification of symmetry
macromolecule glycosylation
protein glycosylation
glycosylation
glycoprotein biosynthetic process
glycoprotein metabolic process
pattern specification process
carbohydrate derivative biosynthetic process
peptidyl-amino acid modification
endoplasmic reticulum membrane
carbohydrate derivative metabolic process
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
membrane