POLE

Gene Information

Official Symbol: POLE
Official Name: DNA polymerase epsilon, catalytic subunit
Aliases and Previous Symbols: N/A
Entrez ID: 5426
UniProt: Q07864
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes the catalytic subunit of DNA polymerase epsilon. The enzyme is involved in DNA repair and chromosomal DNA replication. Mutations in this gene have been associated with colorectal cancer 12 and facial dysmorphism, immunodeficiency, livedo, and short stature. [provided by RefSeq, Sep 2013].
UniProt Summary: Participates in DNA repair and in chromosomal DNA replication.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MLN-4924 2μM R00 exp22	-2.53
Monensin 0.3μM R08 exp507	-2.38
Rotenone 2μM R00 exp33	-2.34
ONC212 0.15μM R08 exp513	-2.08
Artemisinin 50μM R08 exp450	-1.95
Bortezomib 0.05μM R00 exp7	-1.9
UM131593 0.2μM R03 exp106	-1.9
DABN racemic mixture R03 exp93	-1.89
Nocodazole 0.2μM R00 exp24	-1.86
BI-2536 0.02μM R03 exp96	-1.85
Vitamin-D3 40μM R08 exp536	-1.85
Tanespimycin 14μM R08 exp527	-1.8
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	1.73
Rapamycin 2μM plus FK-506 5μM R07 exp308	1.73
UM0011500 5μM R05 exp245	1.73
Pyrazinamide 100μM R08 exp516	1.77
Hydroxychloroquine 30μM R08 exp490	1.78
Taxol 0.002μM R01 exp54	1.79
Cyclosporin-A 3μM R07 exp348	1.83
Losmapimod 1μM R07 exp376	1.84
ABT-702 0.1μM R06 exp260	1.85
BI-6727 0.001μM R01 exp42	1.86
Alpha-Amanitin 0.5μM R00 exp5	1.97
Daidzin 10μM R06 exp280	1.98
Dynasore 10μM R04 exp180	1.98
UM0130462 0.025 to 0.035μM day4 R05 exp247	2.04
IL-3 9ng/ml R08 exp493	2.05
Isoniazid 100μM R08 exp494	2.14
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	2.19
Rifampicin 1μM R00 exp31	2.19
Rapamycin 0.001μM R08 exp429	2.2
Resminostat 0.5μM R07 exp393	2.21
Cidofovir 10μM R07 exp345	2.26
2-Methoxyestradiol 0.2μM R01 exp40	2.3
Beta-Estradiol 0.55μM R07 exp425	2.32
Cannabidiol 13μM R08 exp465	2.36
TNF-alpha 44ng/ml R08 exp533	2.41
Chlorpromazine 10μM R07 exp344	2.44
Cycloheximide 0.02μM R00 exp14	2.5
Cyclosporin-A 0.8μM R07 exp347	2.56
Pimelic-diphenylamide-106 0.5μM R00 exp27	2.79
Dimethyloxaloylglycine 11μM R07 exp314	3

Gene	Correlation
PSMD3	0.566
CHD4	0.562
PSMB2	0.548
PRIM1	0.54
TCEB3C	0.537
PSMB4	0.527
TCEB3CL	0.526
PAN3	0.519
NUPL1	0.518
PSMA6	0.511
POLR2J3	0.51
PSMD2	0.508
PDE4DIP	0.507
NUP160	0.507
TCEB3CL2	0.505
SUPT5H	0.505
C1QTNF9B	0.504
SLC4A1	0.503
SART1	0.503
RPL35	0.502
PSMA7	0.501
CBWD6	0.501
PSMD7	0.5
ATP6V1C1	0.499
PSMD1	0.498
CBWD5	0.497
CDCA3	0.496
DOCK6	0.494
AATF	0.493
RAD51	0.491
CBWD3	0.491
CCNA2	0.491
RRP15	0.489
MDM2	0.488
GOLGA6L3	0.487
COPE	0.484
NHP2L1	0.484
NPIPB5	0.483
ZNF830	0.482
ORC6	0.481
GOLGA6L1	0.48
RPS2	0.48
TBC1D3H	0.48
UPF1	0.479
CDC45	0.477
TICRR	0.476
PSMD11	0.476
TBC1D3F	0.475
MT1E	0.474
KCTD17	0.473
IK	0.472
AAMP	0.472
PAF1	0.471
ORC1	0.471
RRP7A	0.471
PWP2	0.47
DTL	0.47
GOLGA6A	0.469
COL2A1	0.467
WDR75	0.467
OSBP	0.466
POLR2F	0.466
RPS19BP1	0.464
SNRPA1	0.463
KRT78	0.463
CCDC64B	0.462
IGFN1	0.461
CGB2	0.461
LAD1	0.459
TYMS	0.458
TBC1D3	0.455
NARFL	0.454
C14orf93	0.453
STIL	0.452
ISCU	0.45
PSMC1	0.449
TSG101	0.449
RPS9	0.448
MPHOSPH10	0.448
RAD21	0.448
EBNA1BP2	0.448
LRR1	0.448
HIST2H3A	0.447
CHAF1A	0.447
HIST2H3C	0.447
RRP1	0.446
TBC1D3C	0.446
TFIP11	0.445
TIMELESS	0.445
TBC1D3G	0.444
COPB1	0.443
BYSL	0.442
MCOLN1	0.442
GOLGA8O	0.442
NAPA	0.441
COPG1	0.441
WDR43	0.441
RPS4X	0.44
PSMC2	0.44
ATP6V1A	0.44
ACSF2	0.44
SAP30BP	0.44
ZFAND5	0.439
DDTL	0.439
GID4	0.439
DNTTIP2	0.437
RPS12	0.437
EXOSC5	0.436
COPB2	0.436
EXOSC9	0.435
S1PR4	0.434
INCENP	0.434
XYLT2	0.434
CDC73	0.433
VASN	0.433
SF3A1	0.433
C3orf17	0.433
FAM231C	0.432
PSMC6	0.431
NUP205	0.431
FAM231A	0.431
SLC6A17	0.431
TSPY8	0.431
PARP3	0.429
TBC1D3I	0.429
TBC1D3E	0.429
ATP13A1	0.429
TBC1D3L	0.428
NFATC4	0.428
TBC1D3K	0.428
SLC7A6OS	0.427
RIOK2	0.427
GPX4	0.426
DDX56	0.426
TP53TG3B	0.424
POLA1	0.424
COX7A2L	0.424
MMS22L	0.424
NOL10	0.424
NPIPB11	0.423
NOP16	0.423
NUP153	0.423
TP53TG3	0.423
ZNF574	0.423
TP53TG3C	0.423
AQR	0.423
UQCRH	0.422
CHCHD3	0.421
CKAP5	0.42
DISP2	0.42
PPFIA4	0.42
CACTIN	0.42
SSH2	0.419
VPS28	0.419
RPSA	0.419
NOL12	0.419
EXOSC6	0.419
UTP20	0.418
CACNA1A	0.418
TWISTNB	0.418
CROCC	0.417
PDCD11	0.417
CDC6	0.417
PSMB1	0.416
KIAA0947	0.416
FTSJ3	0.416
MYLK3	0.416
KIAA1211	0.415
INTS5	0.415
ZNF687	0.415
BAGE2	0.414
ANKLE2	0.414
BAGE	0.414
PNO1	0.414
FAM25B	0.414
BAGE3	0.414
HIVEP3	0.413
ADRM1	0.413
BAGE4	0.413
BAGE5	0.413
UTP3	0.413
RRN3	0.412
GOLGA6L4	0.412
PSMD8	0.412
DHX38	0.412
RPL7L1	0.412
AKIRIN2	0.411
MYT1L	0.411
ZNF541	0.411
XAB2	0.411
TP53TG3D	0.409
SMG1	0.409
WDR46	0.409
DNM2	0.409
SH3BP1	0.409
PAN2	0.408
CEBPZ	0.408
ZNF655	0.408
PLEKHA4	0.408
PSMC5	0.407
RPS5	0.407
RPS3	0.406
CDH24	0.406
DDX21	0.405
ACD	0.405
RANBP2	0.404
MYH7B	0.404
SCMH1	0.403
FBXW9	0.403
NPIPB8	0.402
MYO18A	0.402
AHCTF1	0.401
POLA2	0.4
PIGS	0.4
POLR2L	0.4

Global Fraction of Cell Lines Where Essential: 735/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	27/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	16/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	74/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 434
Expression level (log2 read counts): 8.79

Expression Distribution

DNA pol B exo2
DNA pol B
DUF1744
DNA pol B exo1

DNA replication proofreading
leading strand elongation
epsilon DNA polymerase complex
base-excision repair, gap-filling
single-stranded DNA 3-5 exodeoxyribonuclease activity
DNA strand elongation involved in DNA replication
DNA strand elongation
nucleotide-excision repair, DNA gap filling
telomere maintenance via semi-conservative replication
DNA-directed DNA polymerase activity
DNA replication initiation
base-excision repair
DNA-dependent DNA replication maintenance of fidelity
4 iron, 4 sulfur cluster binding
nuclear DNA replication
cell cycle DNA replication
DNA synthesis involved in DNA repair
nucleotide binding
telomere maintenance
telomere organization
DNA biosynthetic process
nucleotide-excision repair
G1/S transition of mitotic cell cycle
DNA-dependent DNA replication
cell cycle G1/S phase transition
DNA replication
mitotic cell cycle phase transition
cell cycle phase transition
nucleic acid phosphodiester bond hydrolysis
anatomical structure homeostasis
chromatin binding
embryonic organ development
DNA repair
mitotic cell cycle process
mitotic cell cycle
DNA metabolic process
cellular response to DNA damage stimulus
zinc ion binding
cellular homeostasis
embryo development