SELRC1

Gene Information

Official Symbol: COA7
Official Name: cytochrome c oxidase assembly factor 7 (putative)
Aliases and Previous Symbols: N/A
Entrez ID: 65260
UniProt: Q96BR5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Required for assembly of mitochondrial respiratory chain complex I and complex IV. {ECO:0000269|PubMed:24333015}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
HMS-I2 10μM R06 exp288	-2.31
Oligomycin-A 2μM R00 exp25	1.73
CFI-400945 25μM R08 exp469	1.74
Genistein 15μM R07 exp360	1.77
Pterostilbene 16μM R02 exp78	1.77
BI-D1870 3.15μM R02 exp66	1.82
QNZ 0.01μM R05 exp241	1.85
TIC10 10μM R08 exp532	1.86
Tubacin 1.6μM R07 exp416	1.87
Phenformin 20μM R03 exp143	1.88
Hydroxyurea 100μM R07 exp329	1.89
GSK-J4 1.5μM R08 exp441	1.92
Bafilomycin-A1 0.009μM R08 exp454	1.94
ONC212 0.15μM R08 exp513	1.96
Arsenic trioxide 60μM R08 exp449	1.98
Milciclib 2μM R08 exp502	1.98
Monensin 0.3μM R08 exp507	1.98
Rotenone 0.07μM R08 exp431	2.01
Vemurafenib 6.6μM R08 exp434	2.04
Phenformin 20μM R05 exp212	2.16
Chloroquine 32μM R08 exp470	2.17
Cannabidiol 20μM R08 exp466	2.23
Tanespimycin 14μM R08 exp527	2.26
CR131-b 0.005μM R08 exp474	2.29
Trimetrexate 0.03μM R08 exp535	2.38
QNZ 0.01μM R08 exp439	2.39
iCRT14 30μM R08 exp492	2.48
UM0125461 0.74μM R02 exp84	2.58
Thimerosal 0.85μM R08 exp529	2.84

Gene	Correlation
SCO2	0.77
NARS2	0.756
HSD17B10	0.754
EARS2	0.746
YARS2	0.736
TARS2	0.733
MRPL21	0.73
RPUSD4	0.729
COA3	0.724
QRSL1	0.721
FASTKD5	0.718
PARS2	0.714
MRPS6	0.71
DAP3	0.708
BCS1L	0.692
LARS2	0.692
MRPS21	0.683
VARS2	0.682
MRPS16	0.682
COX16	0.681
COA6	0.675
RNASEH1	0.671
PET117	0.668
MRPS34	0.665
SARS2	0.662
MRPS5	0.657
GFM1	0.657
COX11	0.656
RBFA	0.65
RARS2	0.65
KIAA0391	0.647
AARS2	0.646
MRPL23	0.645
HARS2	0.644
MRPS14	0.641
PET112	0.638
COX15	0.637
DARS2	0.632
MRPS18A	0.63
POLG2	0.627
MRPS25	0.626
NDUFAF7	0.625
MRP63	0.622
GATC	0.621
GFM2	0.62
MRPL53	0.62
C10orf2	0.618
MRPS26	0.617
C12orf65	0.613
GTPBP10	0.61
MRPS24	0.61
SUPV3L1	0.607
MTG2	0.606
MARS2	0.603
COX7B	0.602
MRPL47	0.602
MRPL12	0.601
FTSJ2	0.598
WARS2	0.595
TMEM242	0.594
AIFM1	0.593
MTRF1L	0.591
FARS2	0.588
NDUFB11	0.586
MRPS2	0.586
ATP5C1	0.581
CARS2	0.581
NDUFA3	0.578
MRPL45	0.57
MRPS10	0.568
WBSCR16	0.566
PDSS1	0.565
PNPT1	0.565
MTPAP	0.564
MRPL20	0.563
MTIF3	0.563
METTL17	0.562
COX6C	0.559
NDUFA2	0.558
MTG1	0.558
MRPS12	0.554
TEFM	0.554
SLC25A26	0.547
COX17	0.545
TUFM	0.544
POLG	0.544
PGM3	0.543
RPUSD3	0.542
MRPL15	0.542
MALSU1	0.541
MRPL44	0.541
ATP5D	0.541
UQCRC2	0.54
MRPS9	0.54
COQ2	0.536
HIGD2A	0.534
C17orf89	0.533
TRUB2	0.533
UQCR10	0.527
COX20	0.527
LRPPRC	0.526
MRPS23	0.525
MRPL55	0.523
MRPL4	0.523
MRPS35	0.518
DHRSX	0.516
NDUFB5	0.514
TMEM126B	0.514
POLRMT	0.513
MRPL42	0.513
MRPL36	0.512
MRPS33	0.511
COA5	0.51
NDUFS2	0.508
NDUFAF3	0.507
MRPL18	0.506
LSM10	0.504
TOMM20	0.504
MRPS11	0.503
MTERFD2	0.503
MINOS1	0.502
MRPL11	0.499
DNLZ	0.498
MRPS27	0.498
NDUFC2	0.497
MRPL22	0.496
MRPL27	0.495
DHX30	0.495
NDUFA1	0.495
COX6B1	0.494
MRPL3	0.493
ATP5B	0.493
NDUFB6	0.489
ELAC2	0.489
RPIA	0.489
PET100	0.487
TMEM261	0.486
MRPL2	0.485
ATP5A1	0.484
NDUFAF4	0.482
MRPL43	0.481
PMVK	0.48
FH	0.477
GTPBP6	0.475
ECSIT	0.473
ATP5SL	0.473
COX5A	0.473
NDUFV1	0.471
SCO1	0.471
NDUFS7	0.47
MIPEP	0.47
COQ7	0.469
MRPL51	0.467
MRPS22	0.466
COQ3	0.466
MRPL34	0.465
MRPL33	0.464
MTERFD1	0.463
MRPL49	0.462
SLC25A3	0.461
CHCHD1	0.461
HCCS	0.461
RTN4IP1	0.461
PTRHD1	0.461
MRPL35	0.457
MCAT	0.457
FASTKD1	0.457
MRPS7	0.453
CHCHD4	0.451
TFB1M	0.451
TIMM8B	0.451
PITRM1	0.45
MRPS28	0.449
ALG8	0.449
DDX28	0.448
ACAD9	0.448
TRIAP1	0.447
MTIF2	0.446
TBRG4	0.445
COX4I1	0.444
MRPL41	0.444
UQCC2	0.443
HMGXB3	0.442
NDUFA11	0.441
TOMM6	0.441
MTRF1	0.439
PTCD3	0.438
C11orf57	0.437
ATP5O	0.437
PTCD1	0.436
IBA57	0.435
TPK1	0.434
MRPL39	0.434
COQ4	0.432
TRMT61A	0.432
MRPL52	0.432
ALDH18A1	0.431
MRPL17	0.431
SSBP1	0.43
ERAL1	0.43
MRPL13	0.43
TIMMDC1	0.43
RNMTL1	0.429
TFAM	0.428
NDUFB9	0.428
ALAS1	0.428
GRSF1	0.427
TOMM22	0.426
NDUFAF5	0.426
TOMM40	0.423
CLPP	0.423
ATP5H	0.422
UQCRC1	0.422
NDUFB1	0.422
MRPL38	0.421
PPCDC	0.421
NDUFA10	0.419
UQCRQ	0.419
MTO1	0.418
COQ5	0.418
COX19	0.417
COX10	0.415
SSB	0.415
MRPL46	0.415
COX7C	0.415
PPCS	0.414
CYCS	0.414
NDUFC1	0.412
FASTKD2	0.411
ATP5J	0.408
ADAT2	0.407
TEN1	0.407
COQ6	0.406
MRPL28	0.405
TFB2M	0.404
NDUFB3	0.404
PPA2	0.404
ZCRB1	0.404
MRPL37	0.403
NUBPL	0.402
MRPS17	0.402
NDUFS5	0.402
NDUFB2	0.402
GARS	0.401
AASDHPPT	0.401
NDUFAF6	0.4
CRLS1	0.4

Global Fraction of Cell Lines Where Essential: 100/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	4/28
blood	6/28
bone	3/26
breast	3/33
central nervous system	5/56
cervix	1/4
colorectal	2/17
esophagus	2/13
fibroblast	0/1
gastric	2/16
kidney	2/21
liver	6/20
lung	11/75
lymphocyte	2/16
ovary	1/26
pancreas	2/24
peripheral nervous system	1/16
plasma cell	2/15
prostate	0/1
skin	7/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	3/22
urinary tract	4/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1774
Expression level (log2 read counts): 6.61

Expression Distribution

mitochondrial intermembrane space
mitochondrion