TCEB3CL

Gene Information

Official Symbol: ELOA3B
Official Name: elongin A3 family member B
Aliases and Previous Symbols: N/A
Entrez ID: 728929
UniProt: Q3SY89
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: N/A

Function Summary

Entrez Summary: N/A
UniProt Summary: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). {ECO:0000250|UniProtKB:Q63187}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Gene	Correlation
PSMB4	0.634
TBC1D3H	0.61
NPIPB5	0.609
RPS2	0.607
C1QTNF9B	0.605
TICRR	0.604
PSMB2	0.601
PSMA6	0.6
TBC1D3G	0.599
RRP7A	0.594
TBC1D3F	0.586
ORC1	0.584
UPF1	0.577
POLR2J3	0.572
SLC6A17	0.57
CHD4	0.568
TBC1D3C	0.567
GOLGA6L1	0.567
AATF	0.564
TBC1D3	0.559
DDTL	0.556
RPL35	0.554
RPS12	0.554
VPS28	0.553
TBC1D3E	0.553
TBC1D3K	0.553
TBC1D3I	0.553
TBC1D3L	0.553
CHAF1A	0.549
COPG1	0.549
CCNA2	0.548
CACTIN	0.548
TYMS	0.548
UTP3	0.546
SUPT5H	0.546
TSPY8	0.545
SLC4A1	0.543
VASN	0.543
CBWD3	0.543
RRN3	0.542
IGFN1	0.542
WDR87	0.541
MT1E	0.539
CBWD5	0.539
NUPL1	0.535
PSMD3	0.534
DTL	0.534
AQR	0.531
NUP160	0.528
PSMC1	0.527
LRR1	0.527
POLE	0.526
IK	0.526
CDCA3	0.526
GOLGA6L3	0.526
TIMELESS	0.525
RAD51	0.524
HIVEP3	0.524
COL2A1	0.522
PSMD14	0.522
ATP6V1A	0.521
ANKLE2	0.521
PSMA7	0.52
GOLGA6L4	0.52
CDC6	0.519
CCDC94	0.519
AAMP	0.519
ORC6	0.519
TP53TG3B	0.518
TP53TG3	0.517
TP53TG3C	0.517
C14orf93	0.516
NARFL	0.515
EXOSC9	0.515
KRT78	0.514
AKIRIN2	0.513
XYLT2	0.513
SNRPA1	0.512
PSMC2	0.512
KCTD17	0.512
TFIP11	0.511
FAM25B	0.511
SUPT6H	0.51
CDC73	0.51
NOL12	0.509
PSMB1	0.509
MYB	0.509
TWISTNB	0.505
GOLGA6L6	0.504
RPS19BP1	0.503
BYSL	0.503
PWP2	0.502
PCF11	0.501
PIGS	0.501
SF3A1	0.499
CBWD6	0.499
RPL6	0.499
CMYA5	0.499
RPL30	0.499
WDR75	0.498
HAP1	0.498
HIST2H3A	0.498
HIST2H3C	0.498
COPE	0.498
SLC38A7	0.497
GOLGA6A	0.497
INTS5	0.497
PSMC6	0.496
DOCK6	0.496
ATP6V1C1	0.495
SCGB1C1	0.494
FCN2	0.494
PAF1	0.493
TSG101	0.493
MPHOSPH10	0.492
TAF1	0.491
EXD1	0.491
DDT	0.491
NUP153	0.491
PSMD1	0.49
CEP192	0.488
RBM39	0.487
MADCAM1	0.487
POLR2D	0.486
NPIPB8	0.486
MCOLN1	0.485
ATP6AP1	0.483
ZNF830	0.483
COX7A2L	0.483
CDC45	0.482
FAM231A	0.482
FAM231C	0.482
DISP2	0.481
WDR43	0.481
PSMC5	0.481
CLN6	0.476
PNO1	0.476
GOLGA8O	0.475
SEC13	0.475
PHF2	0.475
NAPA	0.475
RNF113A	0.475
ARHGEF35	0.474
CCDC116	0.474
SH3BP1	0.473
MYO1H	0.473
RBBP5	0.472
COPB1	0.472
UTP20	0.472
SEMA6B	0.471
S1PR4	0.471
POLA2	0.471
PSMD11	0.47
RPL8	0.469
ISCU	0.469
NOL10	0.469
STRN	0.469
PLA2G4F	0.468
ATP1A3	0.468
RRP9	0.468
RNPC3	0.468
POLA1	0.467
PAN2	0.467
CTAGE4	0.467
RRP15	0.467
SMTN	0.467
AKT1S1	0.466
TERF2	0.466
ATP6V1B2	0.465
SSH2	0.465
KPNB1	0.465
RPS9	0.465
SCAF1	0.465
NAALADL1	0.464
INTS6	0.464
POLR2A	0.464
EXOSC5	0.464
NFATC4	0.462
NCL	0.461
MED29	0.461
DHX38	0.461
HGC6.3	0.461
PPFIA4	0.46
HIST1H2BE	0.46
PSMD6	0.459
DIDO1	0.459
RPS5	0.459
NUP54	0.458
ACSF2	0.458
EIF4A3	0.458
MYT1L	0.458
ATP6V0C	0.457
RPL34	0.457
EXOSC6	0.456
C2orf27B	0.456
ANKLE1	0.456
EGR2	0.455
ATP13A1	0.455
NSF	0.455
KIF3C	0.455
TRAIP	0.454
PSMD7	0.454
EXOSC8	0.454
TSPY1	0.454
PARP3	0.453
EXOSC3	0.453
CGB2	0.453
TPX2	0.452
SF3A3	0.45
SART1	0.45
PRPF19	0.449
SULT1A3	0.448
RAD21	0.448
SULT1A4	0.448
MED17	0.447
RFFL	0.447
EBNA1BP2	0.446
ALDH1B1	0.446
CDH24	0.446
CLPTM1	0.446
TP53TG3D	0.445
COPZ1	0.445
COPA	0.445
RPS7	0.445
KIAA0947	0.445
RPS19	0.445
NUMA1	0.445
OGFR	0.444
MDM2	0.442
PSMB3	0.442
PLK1	0.441
PAN3	0.441
ADRA1D	0.441
SYT9	0.44
SNIP1	0.44
CTR9	0.439
CNOT1	0.439
RPL9	0.439
GOLGA6B	0.439
RPS10	0.438
GPRIN2	0.438
POLR1A	0.438
MDN1	0.437
RPS3A	0.437
PLEKHA4	0.437
FAM160A1	0.436
ZNF655	0.435
CWC22	0.435
MYLK3	0.435
MSH5	0.435
PPM1D	0.434
SFPQ	0.434
LAD1	0.434
PRIM1	0.433
NUP98	0.433
POLD1	0.432
DNM2	0.432
NBPF10	0.432
MED14	0.431
RANBP2	0.431
C3orf17	0.431
SRGAP2C	0.431
NUP205	0.43
MFRP	0.429
FAM20A	0.429
MFSD12	0.429
NFYA	0.429
TOP1MT	0.429
LOC643669	0.429
CCDC64B	0.429
ZFAND5	0.429
CASC3	0.429
ZNF219	0.429
MEPCE	0.428
HNRNPC	0.428
SEL1L	0.428
DNTTIP2	0.428
ATP6V0B	0.427
NUP43	0.427
RRP1	0.427
GON4L	0.426
XAB2	0.426
MBTD1	0.425
POLR2F	0.425
NUP62	0.424
GID4	0.424
C2orf27A	0.424
NUP85	0.424
RPS28	0.424
NOP16	0.423
OR10G3	0.423
FBXW9	0.423
RIOK2	0.423
ZNF106	0.422
CRNKL1	0.422
HNRNPA1	0.422
COPB2	0.422
NUFIP2	0.422
TRAPPC11	0.421
MAT2A	0.421
ADD2	0.42
CLASP1	0.42
HIST1H4B	0.419
SMG1	0.419
ZNF574	0.419
TTC31	0.419
ITGA2B	0.418
ARCN1	0.417
VPS54	0.417
TGM5	0.417
CEBPZ	0.417
EIF3G	0.417
ATXN1	0.417
PSMD8	0.416
RPL37A	0.416
RPS20	0.416
SLC23A3	0.415
CHMP4B	0.415
SULT2B1	0.415
ABHD8	0.415
PPP1R10	0.414
SMG7	0.414
HK1	0.414
SPRR2B	0.413
RILPL1	0.413
DIEXF	0.412
DDX47	0.412
NOL9	0.411
NCAPG	0.41
ATP6AP2	0.41
PSAP	0.409
PSMD2	0.409
ISY1	0.408
RFC1	0.408
MYO18A	0.408
CACNA1A	0.408
NBPF1	0.408
ACBD4	0.407
GAR1	0.407
PSMC4	0.406
CTAGE9	0.406
SHPK	0.406
BID	0.406
RRP12	0.406
RPSA	0.405
MMS22L	0.405
PLK4	0.404
CKAP5	0.404
SNRNP70	0.404
HINFP	0.404
AHCTF1	0.404
RFPL3	0.403
SAP30BP	0.403
VPS52	0.403
POLR2H	0.402
RPL10A	0.401
DHFR	0.401
NOL8	0.401
FBL	0.401
TINF2	0.4
BRD2	0.4
HIST2H2BF	0.4

Global Fraction of Cell Lines Where Essential: 9/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	2/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1133
Expression level (log2 read counts): -5.01

Expression Distribution

Screen	Score
Hinokiflavone 12μM R08 exp487	-1.93
Rotenone 2μM R00 exp33	-1.89
IL-3 9ng/ml R08 exp493	1.85

Med26
Elongin A