RPE

Gene Information

Official Symbol: RPE
Official Name: ribulose-5-phosphate-3-epimerase
Aliases and Previous Symbols: N/A
Entrez ID: 6120
UniProt: Q96AT9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Parthenolide 2.5μM R05 exp238	-2.57
Betulinic acid 10 to 15μM on day4 R05 exp222	-2.48
A-395 10μM R05 exp218	-2.45
HMS-I2 1μM R06 exp286	-2.42
GSK-J4 1μM R07 exp362	-2.36
UM0011500 5μM R05 exp245	-2.27
IL-3 9ng/ml R08 exp493	-2.23
QNZ 0.01μM R05 exp241	-2.23
Asunaprenir 3μM R07 exp336	-2.08
VHL-ligand-1 20μM R07 exp421	-2.08
Pimelic-diphenylamide-106 0.5μM R00 exp27	-2.07
SGC0946 7μM R03 exp151	-2.06
GSK-J4 1-1.25μM to day4 R07 exp363	-2.05
CCCP 0.1μM R00 exp10	-2.02
PNU96415E 10μM R03 exp145	-1.97
Pomalidomide 20μM R07 exp391	-1.97
THZ531 0.11 to 0.125μM on day4 R07 exp410	-1.97
Cyclosporin-A 0.8μM R07 exp347	-1.96
WNT3A 44ng/ml R08 exp537	-1.96
Oligomycin-A 2μM R00 exp25	-1.94
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-1.91
GSK343 3μM R03 exp124	-1.91
JQ1 0.01μM R03 exp130	-1.89
RS-1 10μM R08 exp519	-1.89
MKC9989 10μM R03 exp133	-1.88
Phenformin 20μM R05 exp212	-1.85
PT-1 25μM R07 exp392	-1.85
Geldanamycin 0.01μM R05 exp235	-1.8
Wortmannin 0.5μM R00 exp37	-1.76
Nifuroxazide 5μM R03 exp102	-1.74
Milciclib 2μM R08 exp502	1.7
Doxorubicin 0.02μM R08 exp478	1.71
Tanespimycin 14μM R08 exp527	1.72
5-Fluorouracil 20μM R00 exp2	1.79
Latrunculin-B 10μM R07 exp374	1.8
CI-1040 9.5μM R08 exp472	1.84
Brefeldin A 0.02μM R00 exp8	1.85
Nocodazole 0.2μM R00 exp24	1.85
Artemisinin 50μM R08 exp450	1.87
BI-D1870 3.15μM R02 exp66	1.91
JQ1 0.8μM R08 exp435	1.92
PU-H71 1μM R08 exp515	2.01
Ammonium tetrathiomolybdate 10μM R08 exp448	2.02
Atovaquone 15μM R08 exp451	2.02
Salinomycin 3.5μM R08 exp521	2.13
THZ1 0.06μM R08 exp531	2.21
Benzoate 20000μM R08 exp456	2.22
Hippuristanol 0.12μM R08 exp488	2.25
MK2206 4μM R08 exp504	2.32
42°C R08 exp539	2.33
Cytochalasin-B 5μM R07 exp349	2.33
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.45
UM0125461 0.74μM R02 exp84	2.51
Arsenate 40μM R06 exp264	2.53
Bleomycin 5μM R08 exp459	2.55
CFI-400945 25μM R08 exp469	2.57
SNS-032 25μM R07 exp401	2.61
INK128 0.2μM R02 exp70	2.63
MLN-4924 2μM R00 exp22	2.72
Q15 2.7μM R02 exp79	3.16

Gene	Correlation
TKT	0.77
TRIAP1	0.673
PMM2	0.645
SLC25A26	0.614
DPAGT1	0.594
SRP14	0.593
CRLS1	0.584
ALG1	0.582
ROMO1	0.581
AASDHPPT	0.571
ENO1	0.57
THG1L	0.569
TAMM41	0.566
UAP1	0.557
HARS	0.554
ADSL	0.54
ATXN10	0.538
TAZ	0.538
RPTOR	0.537
GMPPB	0.537
RTCB	0.536
RPIA	0.533
UTP23	0.532
GTF3C3	0.528
ALG5	0.527
RPP21	0.523
EXOC4	0.523
DOHH	0.514
GTF3C6	0.513
RAD1	0.513
TPI1	0.502
SUPV3L1	0.501
HAUS8	0.5
BCS1L	0.499
ATIC	0.498
GFPT1	0.497
DHRSX	0.497
URM1	0.496
TMEM41B	0.493
PGP	0.493
DHPS	0.493
VEZT	0.491
UHRF1	0.49
VRK1	0.487
RBMX2	0.487
DPF2	0.484
TRMT5	0.483
ALG13	0.482
NSMCE1	0.48
ELP3	0.48
ENY2	0.478
PGM3	0.475
CHCHD4	0.474
ALG6	0.471
ZRSR2	0.471
TIMM13	0.471
DDX20	0.471
PGLS	0.471
UBE2J1	0.47
PKM	0.469
TXNL4B	0.467
TIMM8B	0.464
PPCS	0.464
HSPD1	0.463
TBCA	0.463
PGK1	0.462
GEMIN8	0.46
PPP4C	0.46
TTI2	0.459
TGS1	0.459
PPP2R3C	0.458
SEC62	0.458
EPRS	0.458
HCCS	0.457
GNB1L	0.457
GTF3C2	0.456
LSM10	0.456
OPA1	0.455
CCT7	0.454
ALG2	0.454
DHX30	0.454
GEMIN6	0.454
ELAC2	0.453
RABGGTB	0.452
GTF3C4	0.452
ALG14	0.451
PELO	0.45
EIF3F	0.45
DNLZ	0.449
CBX3	0.449
TSEN54	0.449
TUFM	0.448
AARS	0.447
MRPS14	0.445
GEMIN5	0.444
RNMT	0.443
YARS2	0.442
MRPS11	0.44
CASP9	0.439
SCO2	0.438
C11orf57	0.438
PLAA	0.438
ATP5J	0.436
PAM16	0.434
NAE1	0.432
MAPK14	0.432
SSB	0.432
TEN1	0.432
UXT	0.431
YARS	0.431
DDX55	0.431
OTUD5	0.43
CTC1	0.429
GEMIN7	0.429
SARS2	0.428
EIF4E	0.428
MRPS34	0.427
PDSS1	0.427
HSD17B10	0.426
COPS8	0.425
WDR24	0.424
BAP1	0.424
TRMT10A	0.423
ATP5A1	0.422
KDM8	0.422
DNAJB6	0.421
CSNK2B	0.421
TPRKB	0.421
COQ3	0.42
PGGT1B	0.419
RBFA	0.418
TMEM208	0.418
KCTD5	0.418
OSGEP	0.417
RNASEH1	0.417
FH	0.417
MRPS18A	0.415
SEC61G	0.413
KIAA0391	0.413
MRPL21	0.413
UBE2G2	0.413
RPUSD4	0.412
LAMTOR5	0.412
LAMTOR4	0.411
PRKRIP1	0.411
HIST1H4I	0.411
CYCS	0.411
BAK1	0.411
C17orf89	0.41
NAA20	0.41
BRWD1	0.407
GFM2	0.407
EXOC3	0.407
DAD1	0.405
ORAOV1	0.405
SERF2	0.405
ZNHIT1	0.404
MRPS6	0.404
NAF1	0.404
SPR	0.403
CEP57	0.403
CMTR2	0.403
TBCD	0.4
UBE2K	0.4

Global Fraction of Cell Lines Where Essential: 377/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	12/28
blood	11/28
bone	10/26
breast	20/33
central nervous system	24/56
cervix	2/4
colorectal	6/17
esophagus	10/13
fibroblast	0/1
gastric	8/16
kidney	17/21
liver	8/20
lung	39/75
lymphocyte	7/16
ovary	9/26
pancreas	13/24
peripheral nervous system	10/16
plasma cell	7/15
prostate	0/1
skin	18/24
soft tissue	4/9
thyroid	1/2
upper aerodigestive	8/22
urinary tract	13/29
uterus	2/5

Essentiality in NALM6

Essentiality Rank: 2503
Expression level (log2 read counts): 5.37

Expression Distribution