MRPL21

Gene Information

Official Symbol: MRPL21
Official Name: mitochondrial ribosomal protein L21
Aliases and Previous Symbols: N/A
Entrez ID: 219927
UniProt: Q7Z2W9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
3-Bromopyruvate 7μM R04 exp175	-1.99
Hypoxia 5%O2 R04 exp191	-1.95
Lenalidomide 20μM R07 exp375	-1.8
2-Deoxy-D-glucose 800μM R05 exp214	-1.78
Glyphosate 1000μM R06 exp283	-1.72
Oligomycin-A 2μM R00 exp25	1.75
Aphidicolin 0.4μM R08 exp440	1.78
Genistein 15μM R07 exp360	1.8
Thimerosal 0.85μM R08 exp529	1.8
CI-1040 9.5μM R08 exp472	1.81
Hinokiflavone 12μM R08 exp487	1.86
QNZ 0.01μM R05 exp241	1.94
QNZ 0.01μM R08 exp439	1.95
CR131-b 0.005μM R08 exp474	1.97
Tanespimycin 14μM R08 exp527	2.05
Deferoxamine 11μM R07 exp350	2.1
Atovaquone 15μM R08 exp451	2.14
Dorsomorphin 5μM R07 exp357	2.14
TIC10 10μM R08 exp532	2.16
ONC212 0.15μM R08 exp513	2.44
Hydroxyurea 100μM R07 exp329	2.63
GSK-J4 1.5μM R08 exp441	2.9

Gene	Correlation
HSD17B10	0.772
DAP3	0.758
RPUSD4	0.738
MRPS21	0.735
MRPL23	0.733
YARS2	0.731
SELRC1	0.73
MRPS6	0.73
EARS2	0.725
NARS2	0.725
QRSL1	0.717
MRPS34	0.717
COX16	0.713
SUPV3L1	0.708
MRP63	0.705
MRPS5	0.699
TARS2	0.697
DARS2	0.695
MRPS14	0.693
GFM1	0.692
LARS2	0.691
TUFM	0.69
MRPS18A	0.686
KIAA0391	0.685
SCO2	0.685
MRPL47	0.683
GTPBP10	0.676
PARS2	0.676
MRPS16	0.676
FASTKD5	0.674
BCS1L	0.674
NDUFA3	0.669
MTG2	0.659
WBSCR16	0.654
SLC25A26	0.652
MRPS26	0.651
VARS2	0.648
MRPL53	0.646
RARS2	0.646
HARS2	0.639
FTSJ2	0.639
RBFA	0.639
TRUB2	0.637
PNPT1	0.632
SARS2	0.629
NDUFB11	0.625
RNASEH1	0.622
GFM2	0.622
MRPS9	0.616
MRPS25	0.615
MTPAP	0.614
GATC	0.613
C12orf65	0.611
MRPS2	0.607
MRPL12	0.605
TEFM	0.605
NDUFAF7	0.604
PET112	0.601
TMEM242	0.601
MRPS12	0.599
MRPL15	0.597
MTG1	0.596
MRPL20	0.595
ATP5C1	0.595
MRPL45	0.593
MRPL44	0.592
COA3	0.59
MRPS10	0.59
C10orf2	0.589
MARS2	0.588
COX7B	0.587
MTRF1L	0.586
MRPS23	0.586
ATP5D	0.585
C17orf89	0.583
FARS2	0.582
TOMM20	0.582
AARS2	0.582
UQCRC2	0.582
NDUFC2	0.582
MRPS11	0.582
MRPL42	0.582
PGM3	0.58
MRPL55	0.579
ATP5A1	0.578
RPUSD3	0.577
MRPS24	0.573
MRPL3	0.571
CHCHD1	0.569
DHRSX	0.567
PDSS1	0.566
UQCR10	0.566
PET117	0.565
METTL17	0.565
COX11	0.562
NDUFB5	0.562
MRPL33	0.561
NDUFA1	0.56
COX15	0.558
ELAC2	0.556
COQ3	0.553
CHCHD4	0.553
MRPS35	0.553
COQ2	0.551
MIPEP	0.55
MRPL43	0.55
MRPS33	0.549
ATP5B	0.549
COX17	0.548
NDUFA2	0.547
NDUFB6	0.546
AASDHPPT	0.545
MRPL39	0.541
POLG2	0.54
POLG	0.54
POLRMT	0.539
TFAM	0.536
IBA57	0.532
MRPL27	0.531
FH	0.531
DNLZ	0.53
AIFM1	0.529
COQ7	0.528
MRPL18	0.528
COA6	0.528
MRPL4	0.527
MRPS22	0.527
NDUFAF4	0.526
TRIAP1	0.523
MRPS17	0.523
RNMTL1	0.522
TOMM22	0.522
CLPP	0.521
MRPL36	0.521
NDUFB9	0.521
NDUFB3	0.52
CARS2	0.519
MRPL41	0.519
DHX30	0.518
ATP5SL	0.517
NDUFS2	0.517
UQCC2	0.515
RPIA	0.513
NDUFV1	0.513
MRPL46	0.513
MRPL22	0.512
NDUFAF3	0.512
NDUFA11	0.509
MRPL34	0.508
COX6B1	0.507
OPA1	0.506
MTERFD2	0.506
RTN4IP1	0.506
COA5	0.506
ACAD9	0.505
MTERFD1	0.505
COQ4	0.502
ATP5O	0.502
HIGD2A	0.502
DDX28	0.501
MRPS7	0.5
MRPL13	0.499
HCCS	0.499
MRPS28	0.499
PPA2	0.497
SSBP1	0.493
TOMM6	0.492
GTPBP6	0.489
MRPL11	0.487
MRPL52	0.486
MTIF3	0.485
TAMM41	0.485
TFB1M	0.483
LRPPRC	0.482
WARS2	0.481
LSM10	0.481
TIMM8B	0.481
NDUFS7	0.48
CRLS1	0.477
PPCS	0.477
MRPL49	0.474
COX5A	0.473
MALSU1	0.473
COX6C	0.472
MTIF2	0.471
PMVK	0.471
TPK1	0.47
PET100	0.469
COQ6	0.469
SLC25A3	0.469
UQCRC1	0.467
UQCRQ	0.467
NDUFB1	0.467
TIMMDC1	0.467
NDUFS1	0.464
TRMT61A	0.463
GLRX5	0.463
COX20	0.462
ICT1	0.461
ATP5J	0.459
ECSIT	0.458
ATP5F1	0.458
TIMM17A	0.458
CYCS	0.457
MRPL24	0.457
HMGXB3	0.455
PTCD1	0.455
TRMT10C	0.454
PPCDC	0.453
FASTKD2	0.452
MRPL1	0.451
TOMM40	0.45
G6PD	0.449
ROMO1	0.447
TAZ	0.447
ATP5E	0.447
NFU1	0.447
MRPS27	0.446
UAP1	0.446
ALAS1	0.444
GRSF1	0.443
NDUFA8	0.443
NDUFAF5	0.443
PMM2	0.443
TMEM261	0.442
PITRM1	0.442
PTPMT1	0.44
MRPL51	0.44
GTPBP8	0.439
ATXN10	0.439
NDUFAF1	0.439
ALG6	0.439
FECH	0.438
MRPL38	0.438
SLC25A19	0.436
ATIC	0.436
COX19	0.435
MRPL35	0.435
NUBPL	0.434
NDUFC1	0.434
MRPL2	0.433
TFB2M	0.432
MINOS1	0.432
FASTKD1	0.431
VEZT	0.43
ATP5H	0.429
SRD5A3	0.429
MRPL32	0.429
DOHH	0.428
MTRF1	0.427
NDUFA10	0.426
THG1L	0.426
COQ5	0.425
MTO1	0.424
C1QBP	0.423
MRPL37	0.422
NDUFS5	0.422
TOMM7	0.419
SLC25A52	0.419
ALG8	0.417
TMEM126B	0.417
MRPL17	0.416
MCAT	0.416
MRPL19	0.415
MRPL28	0.415
SSB	0.413
RPE	0.413
NDUFAF6	0.412
PTDSS1	0.411
ALDH18A1	0.41
KDSR	0.41
PTCD3	0.409
GEMIN7	0.408
ERAL1	0.407
TBRG4	0.406
TTC4	0.406
ATP5L	0.405
MRPL9	0.405
ZRSR2	0.405
NDUFA6	0.404
COX7C	0.403
NDUFB7	0.403
NDUFB2	0.403
NDUFB4	0.402
GTF3C6	0.401
COX10	0.401

Global Fraction of Cell Lines Where Essential: 597/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	23/28
blood	24/28
bone	18/26
breast	27/33
central nervous system	45/56
cervix	4/4
colorectal	15/17
esophagus	13/13
fibroblast	1/1
gastric	12/16
kidney	12/21
liver	17/20
lung	64/75
lymphocyte	14/16
ovary	21/26
pancreas	16/24
peripheral nervous system	12/16
plasma cell	9/15
prostate	0/1
skin	20/24
soft tissue	7/9
thyroid	2/2
upper aerodigestive	20/22
urinary tract	24/29
uterus	4/5

Essentiality in NALM6

Essentiality Rank: 575
Expression level (log2 read counts): 4.9

Expression Distribution

mitochondrial large ribosomal subunit
mitochondrial translational elongation
mitochondrial translational termination
translational termination
mitochondrial translation
translational elongation
cellular protein complex disassembly
mitochondrial gene expression
structural constituent of ribosome
protein-containing complex disassembly
translation
mitochondrial inner membrane
cellular component disassembly
peptide biosynthetic process
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
mitochondrion
RNA binding
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
protein-containing complex subunit organization
gene expression