ALG1

Gene Information

Official Symbol: ALG1
Official Name: ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase
Aliases and Previous Symbols: N/A
Entrez ID: 56052
UniProt: Q9BT22
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The enzyme encoded by this gene catalyzes the first mannosylation step in the biosynthesis of lipid-linked oligosaccharides. This gene is mutated in congenital disorder of glycosylation type Ik. [provided by RefSeq, Dec 2008].
UniProt Summary: Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER. {ECO:0000269|PubMed:10704531, ECO:0000269|PubMed:26931382}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Epothilone-B 0.0015μM R05 exp231	-2.04
Aminopterin 0.005μM R07 exp335	-1.95
Rifampicin 30μM R08 exp430	-1.94
SGC2043 10μM R03 exp152	-1.91
YM155 0.001μM R08 exp432	-1.9
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-1.79
OICR-9429 10μM R03 exp142	-1.79
A-395 10μM R05 exp218	-1.74
IL-3 9ng/ml R08 exp493	-1.74
UM0130462 0.025 to 0.035μM day4 R05 exp247	-1.71
Nocodazole 0.1μM R03 exp94	1.87
DABN racemic mixture R03 exp93	1.91
BI-6727 0.04μM R03 exp98	1.93
BI-2536 0.02μM R03 exp96	2
Atovaquone 15μM R08 exp451	2.02
6-Thio-2-deoxyguanosine 2μM R06 exp259	2.16

Gene	Correlation
PMM2	0.751
DPAGT1	0.749
THG1L	0.749
TRIAP1	0.693
ATXN10	0.686
UAP1	0.682
RPTOR	0.671
RNMT	0.67
GMPPB	0.667
UHRF1	0.661
GFPT1	0.656
VEZT	0.643
RPP21	0.642
GTF3C4	0.636
DOLK	0.634
ADSL	0.633
RTCB	0.632
SRP14	0.631
DOHH	0.628
PELO	0.62
ALG13	0.607
MED16	0.601
GEMIN8	0.6
TRMT5	0.599
ALG5	0.595
GNB1L	0.587
ATP5J	0.583
TAMM41	0.582
ALG2	0.582
RPE	0.582
UTP23	0.581
GTF3C6	0.58
ALG6	0.579
NAE1	0.576
GTF3C2	0.574
ROMO1	0.574
EXOC4	0.573
GTF3C3	0.572
PPCS	0.572
DHPS	0.57
SRD5A3	0.568
TRNT1	0.568
SLC25A26	0.567
TSEN54	0.567
DDX20	0.565
HSPD1	0.558
ENY2	0.558
POLR3H	0.557
ORAOV1	0.557
DHRSX	0.557
OSGEP	0.556
CDIPT	0.556
TMEM41B	0.554
TBCB	0.553
PPP2R3C	0.55
UBA3	0.548
DAD1	0.546
SUPV3L1	0.543
DR1	0.543
WDR59	0.542
RPIA	0.542
TRMT10A	0.541
RFK	0.54
TTI2	0.537
AASDHPPT	0.535
TTI1	0.535
BAP1	0.535
UBE2G2	0.534
MBTPS2	0.534
HAUS8	0.533
LSM10	0.533
PAM16	0.531
TEN1	0.531
WDR24	0.531
AARS	0.528
RABGGTB	0.527
NARS	0.526
CCDC101	0.526
TAZ	0.521
TTC4	0.519
SLC25A19	0.518
ENO1	0.517
GEMIN6	0.516
RFT1	0.516
FH	0.516
PPP6C	0.516
EEF1E1	0.516
TELO2	0.515
KDSR	0.515
CSNK2B	0.515
MED4	0.514
CBFB	0.51
DDX55	0.508
ELAC2	0.508
TXNRD1	0.508
DDX1	0.506
ZRSR2	0.503
PLAA	0.503
MTOR	0.503
PPA2	0.503
DDOST	0.503
MEAF6	0.503
ATIC	0.503
YARS	0.502
DPF2	0.502
TPRKB	0.502
ATP5O	0.501
UXT	0.499
PPP4C	0.498
RAD1	0.497
SEC62	0.497
EIF4E	0.497
HCCS	0.496
VMP1	0.493
URM1	0.493
CRLS1	0.491
THOC6	0.491
ATP5B	0.489
TXNL4B	0.489
GEMIN7	0.489
VRK1	0.488
TSEN34	0.488
TBCA	0.487
DNLZ	0.486
RPN1	0.485
TIMM13	0.485
EXOC3	0.484
SSB	0.483
ELP3	0.483
ALG14	0.483
FNTA	0.482
PDAP1	0.482
EPRS	0.482
NSMCE1	0.482
ELP2	0.482
CASP9	0.481
ATP2A2	0.479
HARS	0.479
CCT7	0.478
DNAJC3	0.476
TIMM22	0.476
PGGT1B	0.472
LAMTOR5	0.472
BUB3	0.471
DDX39A	0.47
TPK1	0.47
TBP	0.469
CEP57	0.469
MRPS33	0.468
TKT	0.467
TRMT61A	0.467
CHCHD4	0.466
TGS1	0.465
RBM14	0.465
WDR1	0.464
SRP68	0.46
GTF2A2	0.46
UBE2J1	0.46
C15orf41	0.458
TIMM10	0.458
PGM3	0.457
USO1	0.457
LSM11	0.456
CMTR1	0.456
NBN	0.455
APAF1	0.454
TMED10	0.453
CTC1	0.452
GTF3C5	0.452
SNAPC5	0.452
GTF3A	0.452
MLLT1	0.451
SEC63	0.45
TAF1A	0.45
PYROXD1	0.449
FAF2	0.448
MAPK14	0.448
SLC35B1	0.448
BAK1	0.447
CRCP	0.447
GEMIN5	0.447
CTDNEP1	0.446
SRP72	0.445
FEN1	0.445
ATP5D	0.444
YARS2	0.444
KCTD5	0.443
TMEM242	0.443
UBE2K	0.441
HSD17B10	0.44
UBA5	0.44
ALG8	0.438
KDM8	0.438
OIP5	0.436
ATP5A1	0.435
DARS2	0.435
MSTO1	0.434
MIS18A	0.434
POLR3C	0.432
WDR82	0.432
SDHA	0.431
MED23	0.431
ZBTB11	0.429
MRPL23	0.428
SPR	0.428
DUSP12	0.428
VHL	0.428
POLR3B	0.427
LSMD1	0.427
DCTN6	0.427
PIK3R4	0.426
NDUFB1	0.425
PPCDC	0.425
ZZZ3	0.423
ATP5H	0.423
ZNF259	0.422
PDSS1	0.422
SNF8	0.422
MRPS34	0.421
SEH1L	0.42
PAX5	0.419
XRCC2	0.419
PHB	0.418
NAA20	0.418
SRPRB	0.418
SPCS2	0.417
MRPS2	0.417
DPM3	0.417
RAD50	0.417
WDR92	0.416
SEC61G	0.416
EIF3F	0.415
RBMX2	0.415
LAMTOR4	0.414
UBE2M	0.413
PISD	0.413
FNTB	0.413
VMA21	0.412
DNAJB11	0.412
C14orf166	0.412
THOC3	0.412
GFER	0.412
NSD1	0.411
UFSP2	0.41
CCDC115	0.408
DHDDS	0.408
MRPS14	0.406
DICER1	0.405
SRPK1	0.405
SARS2	0.405
PKM	0.404
TRMT6	0.404
OPA1	0.404
SGOL1	0.404
OTUD5	0.404
C14orf80	0.403
MARS	0.403
C17orf89	0.402
SPCS3	0.401
MRPS18A	0.401
MRPS11	0.401
CBX3	0.401
TUFM	0.4
TOP3A	0.4
C1orf27	0.4
NUP50	0.4

Global Fraction of Cell Lines Where Essential: 469/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	15/28
blood	13/28
bone	12/26
breast	15/33
central nervous system	50/56
cervix	4/4
colorectal	4/17
esophagus	10/13
fibroblast	1/1
gastric	9/16
kidney	15/21
liver	18/20
lung	43/75
lymphocyte	8/16
ovary	18/26
pancreas	14/24
peripheral nervous system	8/16
plasma cell	10/15
prostate	1/1
skin	20/24
soft tissue	5/9
thyroid	2/2
upper aerodigestive	15/22
urinary tract	21/29
uterus	2/5

Essentiality in NALM6

Essentiality Rank: 1612
Expression level (log2 read counts): 5.83

Expression Distribution

chitobiosyldiphosphodolichol beta-mannosyltransferase activity
dolichol-linked oligosaccharide biosynthetic process
oligosaccharide-lipid intermediate biosynthetic process
mannosyltransferase activity
mannosylation
protein N-linked glycosylation
protein glycosylation
macromolecule glycosylation
glycosylation
glycoprotein biosynthetic process
glycoprotein metabolic process
carbohydrate derivative biosynthetic process
endoplasmic reticulum membrane
cellular lipid metabolic process
endoplasmic reticulum
carbohydrate derivative metabolic process
lipid metabolic process
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
membrane