SCO2

Gene Information

Official Symbol: SCO2
Official Name: synthesis of cytochrome C oxidase 2
Aliases and Previous Symbols: N/A
Entrez ID: 9997
UniProt: O43819
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Cytochrome c oxidase (COX) catalyzes the transfer of electrons from cytochrome c to molecular oxygen, which helps to maintain the proton gradient across the inner mitochondrial membrane that is necessary for aerobic ATP production. Human COX is a multimeric protein complex that requires several assembly factors; this gene encodes one of the COX assembly factors. The encoded protein is a metallochaperone that is involved in the biogenesis of cytochrome c oxidase subunit II. Mutations in this gene are associated with fatal infantile encephalocardiomyopathy and myopia 6. [provided by RefSeq, Oct 2014].
UniProt Summary: Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2).

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Golgicide-A 4μM R03 exp122	-2.48
39°C R06 exp303	-2.41
Metformin 40μM R03 exp132	-2.3
Cycloheximide 0.2μM R00 exp15	-2.28
2-Deoxy-D-glucose 800μM R05 exp214	-2.25
Betulinic acid 10 to 15μM on day4 R05 exp222	-2.22
UM0011500 5μM R05 exp245	-2.08
UM0011500 10μM R05 exp246	-2.07
HMS-I2 10μM R06 exp288	-2.06
Nifuroxazide 1μM R01 exp51	-1.96
BI-2536 0.001μM R01 exp41	-1.94
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-1.93
HMS-I2 1μM R06 exp286	-1.83
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	-1.8
GSK-LSD1 10μM R03 exp123	-1.79
IU1-47 25μM R04 exp182	-1.79
Nicotinamide 1000μM R03 exp101	-1.79
UNC2400 2μM R03 exp156	-1.76
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	-1.75
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-1.72
Thimerosal 0.85μM R08 exp529	1.71
Genistein 15μM R07 exp360	1.75
PU-H71 1μM R08 exp515	1.76
TIC10 10μM R08 exp532	1.8
iCRT14 30μM R08 exp492	1.81
CFI-400945 25μM R08 exp469	1.83
Hippuristanol 0.12μM R08 exp488	1.83
Pterostilbene 16μM R02 exp78	1.84
Tanespimycin 14μM R08 exp527	1.88
Amiloride 100μM R08 exp447	1.89
Ribavirin 10 to 15μM on day4 R04 exp160	1.91
Arsenate 40μM R06 exp264	1.92
UM0125461 0.74μM R02 exp84	1.94
MK2206 4μM R08 exp504	1.97
Monensin 0.3μM R08 exp507	2.15
Hydroxyurea 100μM R07 exp329	2.43

Gene	Correlation
SELRC1	0.77
HSD17B10	0.755
YARS2	0.733
TARS2	0.726
BCS1L	0.71
NARS2	0.704
COX16	0.698
GFM1	0.694
EARS2	0.691
QRSL1	0.689
MRPS6	0.689
MRPL21	0.685
COA3	0.679
DAP3	0.676
MRPS16	0.676
MRPS34	0.673
DARS2	0.668
VARS2	0.668
MRPS14	0.666
PARS2	0.665
FASTKD5	0.659
COX11	0.655
RPUSD4	0.645
MRPS21	0.643
LARS2	0.638
MRPL47	0.636
C10orf2	0.633
AARS2	0.633
MRPS26	0.629
MRPL23	0.626
RBFA	0.625
COX15	0.623
MRPL53	0.623
MRPS25	0.618
GTPBP10	0.617
MRPS5	0.616
MRP63	0.614
MRPS2	0.614
SUPV3L1	0.614
PET112	0.612
FARS2	0.612
HARS2	0.61
MTG2	0.608
COA6	0.608
POLG2	0.602
PET117	0.6
SARS2	0.6
RARS2	0.599
GFM2	0.598
RNASEH1	0.597
MRPL45	0.595
NDUFAF7	0.594
WARS2	0.592
COX7B	0.591
C12orf65	0.588
KIAA0391	0.588
TUFM	0.584
MRPS18A	0.583
NDUFA3	0.581
GATC	0.578
PGM3	0.576
SLC25A26	0.573
MARS2	0.572
AIFM1	0.572
METTL17	0.567
MRPL15	0.566
ATP5C1	0.555
DHRSX	0.555
NDUFB11	0.552
MRPS24	0.548
PNPT1	0.544
MTPAP	0.542
WBSCR16	0.537
TMEM242	0.537
COQ2	0.536
MRPS22	0.535
TEFM	0.534
MRPL12	0.533
FTSJ2	0.532
MRPL36	0.53
MRPS11	0.527
NDUFA2	0.527
MRPS23	0.527
COX17	0.526
MRPS12	0.525
MTG1	0.525
PET100	0.523
MRPL20	0.522
COX20	0.52
COX6C	0.52
MRPS9	0.52
MTRF1L	0.517
POLG	0.517
TOMM20	0.516
TRUB2	0.516
ATP5A1	0.514
MRPL44	0.513
HIGD2A	0.512
DNLZ	0.511
C17orf89	0.508
MRPS33	0.507
POLRMT	0.503
MRPL11	0.501
NDUFB5	0.5
UQCRC2	0.499
MRPL18	0.499
RPIA	0.499
MRPL3	0.498
ATP5D	0.498
NDUFS2	0.494
MRPL4	0.494
MRPL42	0.493
MRPL55	0.49
UQCR10	0.489
MRPS10	0.487
MTERFD2	0.487
TIMM8B	0.487
COQ7	0.485
MRPL34	0.483
PDSS1	0.482
IBA57	0.481
FH	0.479
CARS2	0.479
COA5	0.477
MTIF3	0.476
SLC25A3	0.476
NDUFAF3	0.473
TRIAP1	0.473
MRPL43	0.471
LRPPRC	0.469
CHCHD4	0.468
COX6B1	0.468
MRPS35	0.466
MRPL2	0.466
NDUFC2	0.465
COQ5	0.464
MRPL39	0.463
AASDHPPT	0.461
RPUSD3	0.46
LSM10	0.459
NDUFA1	0.457
ATP5B	0.456
MRPS27	0.455
ELAC2	0.451
MALSU1	0.45
ECSIT	0.45
NFU1	0.45
NDUFB6	0.45
HCCS	0.449
MIPEP	0.447
MRPL27	0.446
COQ4	0.446
ATP5O	0.445
MRPL37	0.445
TPK1	0.445
TRMT61A	0.444
CHCHD1	0.443
DHX30	0.443
MRPL33	0.443
TFAM	0.442
DDX28	0.442
TMEM126B	0.441
PTCD3	0.441
C11orf57	0.44
RPE	0.438
ATIC	0.438
NDUFA10	0.437
NDUFV1	0.437
MRPL35	0.436
ATP5L	0.435
TFB1M	0.435
PMVK	0.434
COX10	0.433
MRPL13	0.431
SCO1	0.431
MRPS7	0.431
UQCRQ	0.431
NDUFB3	0.431
MRPL22	0.429
RTN4IP1	0.429
PMM2	0.429
COQ3	0.428
MRPL52	0.428
COQ6	0.427
GTPBP6	0.424
NDUFAF4	0.424
TAMM41	0.423
ALG8	0.423
PPCS	0.423
NUBPL	0.42
NDUFA11	0.42
COX5A	0.419
NDUFS7	0.417
TOMM6	0.417
ATP5E	0.416
MRPL1	0.415
ZCRB1	0.413
UQCC2	0.413
TOMM40	0.413
OPA1	0.412
ERAL1	0.411
NDUFB9	0.411
ALDH18A1	0.411
TBRG4	0.41
GRSF1	0.41
UAP1	0.41
COX4I1	0.409
ATP5J	0.408
MTERFD1	0.407
ACAD9	0.406
MRPS17	0.405
RNMTL1	0.405
COX7C	0.404
ATP5H	0.403
MRPL17	0.403
ATXN10	0.403
ATP5SL	0.402
UQCRC1	0.401
PPCDC	0.401
SDHA	0.4

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1714
Expression level (log2 read counts): 3.8

Expression Distribution

transferase activity, transferring pentosyl groups
phosphorylase activity
cellular copper ion homeostasis
copper ion homeostasis
copper ion transport
mitochondrial respiratory chain complex IV assembly
protein disulfide oxidoreductase activity
pyrimidine nucleobase metabolic process
respiratory chain complex IV assembly
myofibril
cytochrome complex assembly
integral component of mitochondrial inner membrane
pyrimidine nucleoside metabolic process
nucleobase metabolic process
copper ion binding
cell redox homeostasis
mitochondrial respiratory chain complex assembly
pyrimidine-containing compound metabolic process
cellular transition metal ion homeostasis
nucleoside metabolic process
transition metal ion transport
transition metal ion homeostasis
glycosyl compound metabolic process
eye development
visual system development
sensory system development
mitochondrial matrix
mitochondrial inner membrane
mitochondrion organization
nucleobase-containing small molecule metabolic process
sensory organ development
cellular metal ion homeostasis
metal ion homeostasis
cellular cation homeostasis
metal ion transport
cellular ion homeostasis
cation homeostasis
inorganic ion homeostasis
cellular chemical homeostasis
ion homeostasis