UAP1

Gene Information

Official Symbol: UAP1
Official Name: UDP-N-acetylglucosamine pyrophosphorylase 1
Aliases and Previous Symbols: N/A
Entrez ID: 6675
UniProt: Q16222
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Converts UTP and GlcNAc-1-P into UDP-GlcNAc, and UTP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Doxycycline 10μM R00 exp18	-1.9
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-1.84
Mitomycin-C 0.06μM R08 exp503	1.72
Nocodazole 0.1μM R03 exp94	1.76
Etoposide 1μM R00 exp19	1.78
Benzoate 20000μM R08 exp456	1.82
Deferoxamine 11μM R07 exp350	1.89
5-Fluorouracil 20μM R00 exp2	2.13
DABN racemic mixture R03 exp93	2.3

Gene	Correlation
GFPT1	0.747
THG1L	0.72
DPAGT1	0.708
PMM2	0.695
ALG1	0.682
TRIAP1	0.681
GMPPB	0.671
DOHH	0.663
RTCB	0.658
RPTOR	0.63
HCCS	0.622
ALG13	0.619
ATXN10	0.615
HSPD1	0.607
GTF3C3	0.605
TSEN54	0.605
UHRF1	0.599
EXOC4	0.598
ALG2	0.597
RPP21	0.595
HARS	0.593
SRP14	0.593
ATP5J	0.588
GTF3C6	0.585
ROMO1	0.583
NAE1	0.581
ALG5	0.579
ORAOV1	0.578
RNMT	0.577
TAMM41	0.577
ENY2	0.572
ADSL	0.569
PPCS	0.567
DHPS	0.567
VEZT	0.566
EIF4E	0.56
RPE	0.557
APAF1	0.554
DHRSX	0.554
TRNT1	0.552
CASP9	0.552
PELO	0.547
DOLK	0.547
GNB1L	0.546
TTC4	0.544
PGM3	0.544
LSM11	0.542
CSNK2B	0.542
BAK1	0.541
PLAA	0.539
TBCA	0.536
UBE2G2	0.534
MBTPS2	0.531
SLC25A26	0.53
TAZ	0.53
CBFB	0.529
PPA2	0.528
TMEM41B	0.527
FH	0.527
SEC62	0.527
BAP1	0.524
DR1	0.522
TRMT5	0.521
CHCHD4	0.52
DPF2	0.519
TSEN34	0.518
GTF3C4	0.517
TTI2	0.516
CYCS	0.516
RPIA	0.515
PDAP1	0.515
TEN1	0.514
MTOR	0.514
CRLS1	0.513
RABGGTB	0.513
SUPV3L1	0.51
UXT	0.509
UTP23	0.509
ATP5O	0.508
PPP4C	0.508
OSGEP	0.507
ALG6	0.507
EIF3F	0.505
PAM16	0.505
GTF3C2	0.505
GEMIN6	0.504
URM1	0.504
AARS	0.504
ATP5B	0.503
POLR3H	0.502
PPP6C	0.501
VRK1	0.5
NSMCE1	0.499
ATP5A1	0.499
THOC6	0.499
LSM10	0.498
MED16	0.496
CCDC101	0.495
PPP2R3C	0.495
FAF2	0.494
DDX20	0.494
GEMIN8	0.493
ATIC	0.493
TELO2	0.492
UBQLN1	0.491
DHDDS	0.491
SSB	0.491
NSD1	0.49
RPN1	0.489
CTC1	0.489
ELAC2	0.489
BCS1L	0.489
TBCB	0.488
HAUS8	0.488
GEMIN7	0.486
TXNL4B	0.485
CTDNEP1	0.483
ATP2A2	0.483
UBA3	0.481
DAD1	0.479
GTF3A	0.479
NARS	0.479
OTUD5	0.478
KDSR	0.477
CEP57	0.477
KIAA0391	0.477
DDX1	0.476
SRD5A3	0.476
RFT1	0.476
YARS	0.475
TIMM13	0.471
OIP5	0.471
UBE2K	0.47
CCT7	0.47
VDAC2	0.469
TTI1	0.468
ELP2	0.468
ALG14	0.467
TPRKB	0.465
CEPT1	0.465
LAMTOR5	0.464
WDR59	0.463
UQCR10	0.463
FNTA	0.462
DNLZ	0.462
SARS2	0.461
PIK3R4	0.461
MARS	0.46
SLC25A19	0.46
MED4	0.459
SEC61G	0.458
DDX55	0.457
ATP5D	0.456
RBM14	0.456
HSD17B10	0.454
PGGT1B	0.453
ELP3	0.453
UBA5	0.453
TRMT10A	0.452
GEMIN5	0.452
MEAF6	0.451
TPI1	0.451
CHORDC1	0.451
EPRS	0.45
SEC63	0.45
MARCH5	0.45
VHL	0.449
RAD1	0.449
SEC16A	0.449
CDIPT	0.448
TGS1	0.447
PYROXD1	0.446
DDOST	0.446
MRPL21	0.446
TMED10	0.446
PISD	0.446
MRPS14	0.444
MLLT1	0.444
ENO1	0.444
TBP	0.443
TRMT61A	0.442
YARS2	0.441
TMEM242	0.441
SERF2	0.441
WDR24	0.441
C15orf41	0.441
TUFM	0.44
ZNHIT1	0.439
NXT1	0.437
OPA1	0.437
BUB3	0.436
POLR3B	0.435
SLC35B1	0.435
GTF2A2	0.434
USO1	0.434
MRPS2	0.433
WDR1	0.432
C11orf57	0.432
TKT	0.432
DNAJC3	0.431
KDM8	0.431
SPCS3	0.431
DHX29	0.43
MFN1	0.43
VMP1	0.429
TXNRD1	0.428
EEF1E1	0.427
SRP68	0.426
DIABLO	0.425
SNAPC5	0.425
UQCRQ	0.424
ELF2	0.424
MRPS34	0.423
SDHA	0.423
MSTO1	0.423
CRCP	0.422
PTDSS1	0.422
N6AMT1	0.421
NBN	0.421
TRIM28	0.419
WDR82	0.419
TP53	0.419
MRPS6	0.418
TOMM40	0.418
EXOC3	0.417
CMTR1	0.417
SRP72	0.416
SRPRB	0.416
AASDHPPT	0.415
MRPL23	0.415
IRF2BP2	0.415
SNF8	0.412
FNTB	0.411
C17orf89	0.411
MRPS18A	0.41
SCO2	0.41
MED23	0.41
UBE2M	0.41
RFK	0.409
ALG8	0.408
COX16	0.408
STT3A	0.408
SPCS2	0.408
UQCRC2	0.408
ZRSR2	0.406
ID3	0.406
DDX39A	0.406
NHLRC2	0.405
PDCD6IP	0.405
DARS2	0.404
TIMM22	0.404
BRWD1	0.404
C14orf80	0.404
OBFC1	0.403
DAP3	0.403
C14orf166	0.403
TSEN2	0.402
ATP5I	0.402
TPK1	0.4
CARS	0.4

Global Fraction of Cell Lines Where Essential: 22/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	1/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	2/21
liver	2/20
lung	2/75
lymphocyte	0/16
ovary	3/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	2/5

Essentiality in NALM6

Essentiality Rank: 1757
Expression level (log2 read counts): 5.09

Expression Distribution

UDP-N-acetylglucosamine diphosphorylase activity
UDP-N-acetylglucosamine biosynthetic process
amino sugar biosynthetic process
UDP-N-acetylglucosamine metabolic process
nucleotide-sugar biosynthetic process
nucleotide-sugar metabolic process
amino sugar metabolic process
carbohydrate binding
nucleobase-containing small molecule metabolic process
carbohydrate derivative biosynthetic process
carbohydrate derivative metabolic process
identical protein binding
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
cellular nitrogen compound biosynthetic process
small molecule metabolic process