CCDC101

Gene Information

Official Symbol: SGF29
Official Name: SAGA complex associated factor 29
Aliases and Previous Symbols: N/A
Entrez ID: 112869
UniProt: Q96ES7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (PubMed:19103755, PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293). SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (PubMed:20850016). Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (PubMed:23894581). {ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:21685874, ECO:0000269|PubMed:23894581, ECO:0000269|PubMed:26421618, ECO:0000269|PubMed:26578293}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rapamycin 0.001μM R08 exp429	-3.18
Dihydrosphingosine 8μM R08 exp476	-2.64
Nicotinamide Riboside 100μM R03 exp139	-2.34
Erlotinib 10μM R05 exp216	-2.25
Rapamycin 10μM R00 exp30	-2.25
Dimethyloxaloylglycine 100μM R05 exp229	-2.21
Resminostat 0.5μM R07 exp393	-2.19
Rapamycin 2μM R07 exp306	-2.16
MK-1775 0.32μM R02 exp75	-2.07
Temozolomide 200μM R04 exp189	-2.07
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	-2.05
NMS-873 0.07μM R07 exp380	-2
LJH685 5μM R02 exp73	-1.97
Caffeine 2600μM R08 exp463	-1.94
ETC-159 50μM R08 exp480	-1.91
Aphidicolin 0.04μM R06 exp263	-1.89
5-Azacytidine 2μM R07 exp330	-1.88
Trametinib 10μM R02 exp83	-1.88
RO-3306 3 to 4μM on day4 R04 exp165	-1.85
Milciclib 2μM R08 exp502	-1.81
Pifithrin-alpha 20μM R07 exp390	-1.81
I-BRD9 4μM R07 exp365	-1.79
Rapamycin 1μM R00 exp29	-1.77
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	-1.74
IU1-47 25μM R04 exp182	-1.73
Benzoate 20000μM R08 exp456	1.73
Etoposide 1μM R00 exp19	1.81
Deferoxamine 11μM R07 exp350	1.83
MLN-4924 0.2μM R00 exp21	1.84
6-Thio-2-deoxyguanosine 2μM R06 exp259	1.96
Vinblastine 0.2μM R03 exp108	2.01
Ammonium tetrathiomolybdate 10μM R08 exp448	2.13
BI-6727 0.04μM R03 exp98	2.15
GSK461364A 0.1μM R03 exp126	2.25
Rotenone 20μM R00 exp34	2.37
CI-1040 9.5μM R08 exp472	2.49
BI-2536 0.02μM R03 exp96	2.5
SNS-032 15μM R08 exp443	2.54
3-Bromopyruvate 7μM R04 exp175	2.64
Hinokiflavone 12μM R08 exp487	2.83
UM131593 0.2μM R03 exp106	2.99
42°C R08 exp539	3.22

Gene	Correlation
RPTOR	0.664
MED16	0.655
MLLT1	0.652
TLE4	0.623
MED23	0.622
GNB1L	0.622
TAF5L	0.622
AARS	0.62
DPAGT1	0.613
TADA1	0.61
GMPPB	0.608
TAF6L	0.604
ID3	0.601
RNMT	0.597
MTOR	0.594
TTI2	0.593
RTCB	0.589
WDR24	0.577
DOHH	0.572
PELO	0.569
PMM2	0.568
GFPT1	0.563
MAPK14	0.562
TTI1	0.56
SUPT7L	0.558
EIF4E	0.55
CSNK2B	0.546
THOC6	0.545
OTUD5	0.542
THG1L	0.538
FLI1	0.536
UBE2L3	0.534
ALG2	0.532
TADA3	0.532
CBFB	0.527
ALG1	0.526
GTF3C2	0.526
MED25	0.517
BAP1	0.516
ALG5	0.515
HSPD1	0.513
GTF3C3	0.508
UHRF1	0.505
USP22	0.505
GTF3C4	0.505
MEAF6	0.502
TRIM28	0.502
MAML1	0.501
VMP1	0.499
VHL	0.498
WDR59	0.498
TELO2	0.497
TADA2B	0.496
DERL2	0.496
UAP1	0.495
BRPF1	0.495
TMEM41B	0.493
LMO2	0.492
LAMTOR5	0.492
NSD1	0.49
POLR3H	0.489
UBE2G2	0.488
SPCS3	0.486
EXOC4	0.485
TMED10	0.485
IRF2BP2	0.484
MED4	0.483
ZNF592	0.483
MAX	0.481
RPP21	0.48
CBX3	0.477
EPRS	0.477
NARS	0.476
DNAJC3	0.475
DHX29	0.474
PAM16	0.474
SUPT20H	0.473
PAX5	0.473
ENY2	0.473
HARS	0.471
ALG14	0.47
YARS	0.47
NAE1	0.468
ATF7IP	0.468
LAMTOR4	0.467
TRIAP1	0.466
ATP5J	0.465
BRD9	0.463
ADSL	0.46
TSEN54	0.46
UBE3A	0.457
MED13	0.457
ALG13	0.457
CCT7	0.456
TRMT5	0.456
SSBP2	0.455
SLC35B1	0.454
DDOST	0.454
OSGEP	0.45
TSEN34	0.45
SMARCD1	0.45
DPF2	0.447
XPO6	0.447
SRP68	0.446
SPCS2	0.445
PPP2R3C	0.445
DHDDS	0.445
ARIH1	0.445
SOX7	0.444
GPN2	0.443
ZNF259	0.442
NXT1	0.442
ZFX	0.441
ASXL2	0.441
HHEX	0.44
POLR3B	0.44
CRCP	0.44
ZNF608	0.439
RPN1	0.439
SEH1L	0.439
DHPS	0.439
GTF2A2	0.438
LSMD1	0.438
LDB1	0.438
UXT	0.438
SRP72	0.437
BTAF1	0.436
VRK1	0.436
FBXO11	0.435
SCAF8	0.434
ORAOV1	0.434
ZBTB11	0.434
ATXN10	0.433
UBR5	0.433
ZBTB44	0.431
ASB7	0.431
DAD1	0.43
MED18	0.43
SRP14	0.43
DCAF5	0.429
VCPIP1	0.426
HSPA9	0.426
ZNF410	0.425
UTP23	0.425
UBE2J1	0.423
TRIM33	0.423
TRNT1	0.422
TCEB3	0.42
TRMT10A	0.416
LSM11	0.416
PRKAR1A	0.415
CARS	0.415
ERG	0.415
WARS	0.414
RUNX1	0.414
TBCB	0.414
ERCC2	0.413
MED13L	0.411
EEF1E1	0.409
GTF3C6	0.409
SETDB1	0.408
TXNRD1	0.407
C21orf59	0.404
PGGT1B	0.403
AGO2	0.403
ALG11	0.403
TBCA	0.402
ATP5O	0.401
CTDNEP1	0.401
TRIP12	0.4

Global Fraction of Cell Lines Where Essential: 173/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	4/28
blood	10/28
bone	6/25
breast	13/33
central nervous system	6/56
cervix	1/4
colorectal	5/17
esophagus	6/13
fibroblast	0/1
gastric	4/15
kidney	2/21
liver	4/20
lung	19/75
lymphocyte	4/14
ovary	5/26
pancreas	4/24
peripheral nervous system	4/16
plasma cell	9/15
prostate	1/1
skin	10/24
soft tissue	2/7
thyroid	1/2
upper aerodigestive	3/22
urinary tract	3/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 1129
Expression level (log2 read counts): 3.93

Expression Distribution

RNA polymerase II transcription regulator recruiting activity
SAGA-type complex
establishment of protein localization to chromatin
RNA polymerase II preinitiation complex assembly
establishment of protein localization to chromosome
Ada2/Gcn5/Ada3 transcription activator complex
SAGA complex
protein localization to chromatin
transcription preinitiation complex assembly
histone H3 acetylation
methylated histone binding
protein localization to chromosome
protein N-terminus binding
histone acetylation
internal peptidyl-lysine acetylation
peptidyl-lysine acetylation
internal protein amino acid acetylation
protein acetylation
transcription initiation from RNA polymerase II promoter
protein acylation
protein-DNA complex assembly
DNA-templated transcription, initiation
protein-DNA complex subunit organization
peptidyl-lysine modification
enzyme binding
histone modification
covalent chromatin modification
establishment of protein localization to organelle
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
chromatin organization
protein localization to organelle
cellular protein-containing complex assembly
peptidyl-amino acid modification
chromosome organization
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process