VEZT

Gene Information

Official Symbol: VEZT
Official Name: vezatin, adherens junctions transmembrane protein
Aliases and Previous Symbols: N/A
Entrez ID: 55591
UniProt: Q9HBM0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a transmembrane protein which has been localized to adherens junctions and shown to bind to myosin VIIA. Examination of expression of this gene in gastric cancer tissues have shown that expression is decreased which appears to be related to hypermethylation of the promoter. Expression of this gene may also be inhibited by binding of a specific microRNA to a target sequence in the 3' UTR of the transcripts. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011].
UniProt Summary: Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. In case of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the entry site. {ECO:0000269|PubMed:15090598}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
A-395N 10μM R05 exp219	-2.89
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-2.8
BI-D1870 2μM R04 exp162	-2.78
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	-2.77
Demecolcine 0.03μM R05 exp228	-2.73
NFN1 0.1μM R01 exp49	-2.7
Losmapimod 1μM R07 exp376	-2.67
L-BMAA 500 to 750μM on day4 R04 exp185	-2.61
BI-2536 0.001μM R01 exp41	-2.53
Dimethyloxaloylglycine 11μM R07 exp314	-2.51
Thalidomide 20μM R07 exp406	-2.5
Nifuroxazide 1μM R01 exp51	-2.43
Q15 1 to 2μM on day4 R04 exp164	-2.43
Taxol 0.002μM R01 exp54	-2.43
GSK461364A 0.005μM R03 exp125	-2.33
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-2.33
Ethambutol 25μM R08 exp481	-2.31
CVT-10216 0.1μM R06 exp278	-2.3
YM155 0.0002μM R01 exp61	-2.28
Ribavirin 10μM R01 exp52	-2.25
Bortezomib 0.005μM R00 exp6	-2.22
Asunaprenir 3μM R07 exp336	-2.21
BI-2536 0.0042μM R03 exp95	-2.2
MSC2530818 10μM R07 exp379	-2.18
Resminostat 0.5μM R07 exp393	-2.18
VHL-ligand-1 20μM R07 exp421	-2.17
SGC0946 7μM R03 exp151	-2.15
THZ531 0.11 to 0.175μM on day4 R07 exp413	-2.14
Mdivi-1 15μM R05 exp217	-2.12
Ibrutinib 1μM R07 exp372	-2.07
5-Fluorouracil 2μM R00 exp1	-2.03
IL-3 9ng/ml R08 exp493	-2.03
NFN1 0.4μM R03 exp99	-2.03
Lenalidomide 20μM R07 exp375	-2.02
L-74142 5μM R03 exp131	-1.99
THZ531 0.11 to 0.125μM on day4 R07 exp410	-1.98
Cyclosporin-A 3μM R07 exp348	-1.97
HMS-I2 1μM R06 exp286	-1.93
MS094 2μM R03 exp136	-1.93
LLY-284 2.6μM R06 exp291	-1.92
A-769662 20μM R07 exp331	-1.91
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-1.88
Cadmium 60μM R08 exp462	-1.86
Glyphosate 1000μM R06 exp283	-1.85
Nocodazole 0.02μM R00 exp23	-1.85
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-1.85
Tunicamycin 0.04μM R07 exp418	-1.83
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-1.82
THZ531 0.11μM R07 exp409	-1.82
SGC0649 7μM R03 exp150	-1.77
Alpha-Amanitin 0.5μM R00 exp5	-1.76
CCCP 0.1μM R00 exp10	-1.76
ETC-159 50μM R08 exp480	-1.76
Cidofovir 10μM R07 exp345	-1.74
Ethanol 0.01 R05 exp234	-1.72
Golgicide-A 2μM R03 exp121	-1.72
Cincreasin 100μM R08 exp473	-1.71
MKC9989 10μM R03 exp133	-1.71
SNS-032 15μM R08 exp443	1.75
Artemisinin 50μM R08 exp450	1.81
Atovaquone 15μM R08 exp451	1.86
WYE-354 6μM R02 exp90	1.86
ONC212 0.15μM R08 exp513	1.91
GSK461364A 0.1μM R03 exp126	1.96
Nocodazole 0.2μM R02 exp64	2.15
Mubritinib 0.2μM R02 exp65	2.16
Mitomycin-C 0.06μM R08 exp503	2.3
Hinokiflavone 12μM R08 exp487	2.98

Gene	Correlation
THG1L	0.695
ATXN10	0.671
ALG1	0.643
TRIAP1	0.615
ATIC	0.611
DPAGT1	0.607
RPIA	0.601
PMM2	0.6
RPP21	0.595
GEMIN6	0.588
GEMIN8	0.586
DOHH	0.578
PPCS	0.575
DDX20	0.574
GMPPB	0.572
RNMT	0.568
UAP1	0.566
ZRSR2	0.56
UHRF1	0.557
EXOC4	0.555
TTC4	0.555
FH	0.552
SLC25A26	0.549
TEN1	0.543
GEMIN7	0.543
ALG13	0.536
RFK	0.53
AASDHPPT	0.528
ADSL	0.527
GFPT1	0.525
SLC25A19	0.523
TBCB	0.522
TSEN54	0.521
SRD5A3	0.521
RTCB	0.519
SRP14	0.518
DHPS	0.513
ELAC2	0.512
NAE1	0.511
RABGGTB	0.509
ALG2	0.507
EXOC3	0.506
CEP57	0.506
DOLK	0.505
DDX39A	0.504
PELO	0.503
KDSR	0.502
TRNT1	0.499
GTF3C6	0.499
RFT1	0.497
HSD17B10	0.495
CHCHD4	0.494
GTF3C4	0.493
TRMT61A	0.492
HAUS8	0.492
RPTOR	0.491
RPE	0.491
DARS2	0.49
MRPS11	0.488
DNLZ	0.488
SDHA	0.487
UTP23	0.483
ELP2	0.482
TXNL4B	0.481
ATP5J	0.481
EEF1E1	0.479
DCTN6	0.479
ATP5B	0.478
LSM10	0.478
FNTA	0.478
ROMO1	0.478
DHRSX	0.477
BCS1L	0.477
TRMT5	0.477
TAMM41	0.477
HSPD1	0.476
YARS	0.476
GEMIN5	0.475
BAP1	0.475
ELP3	0.475
MRPS14	0.474
WDR92	0.474
GNB1L	0.474
DDX1	0.474
PPA2	0.473
MRPL15	0.472
PYROXD1	0.472
GTF3C3	0.472
SSB	0.471
URM1	0.471
PPP6C	0.468
CTC1	0.468
TELO2	0.468
C15orf41	0.467
SUPV3L1	0.467
MBTPS2	0.465
PDCD5	0.465
DR1	0.464
OSGEP	0.463
MED16	0.463
ATP5O	0.462
HCCS	0.462
ALG5	0.461
MSTO1	0.46
TXNRD1	0.46
ALG14	0.46
MRPS34	0.458
ENY2	0.458
TRMT10A	0.456
TBCA	0.456
UBA3	0.455
RAD1	0.455
TUFM	0.451
ORAOV1	0.45
HARS	0.45
TTI2	0.449
TSEN34	0.448
GTF3C2	0.447
MRPS33	0.446
PGM3	0.444
GPN2	0.443
ACTR1A	0.441
KDM8	0.441
N6AMT1	0.44
ALG6	0.438
WDR59	0.437
NAA20	0.437
UQCR10	0.437
MIS18A	0.436
MOCS3	0.435
TPK1	0.435
EIF3F	0.435
PPP4C	0.434
TPRKB	0.432
ZCRB1	0.431
C17orf89	0.43
MRPL21	0.43
RBMX2	0.43
EPRS	0.43
CBFB	0.43
SUGT1	0.429
PLAA	0.429
ATP5A1	0.428
NBN	0.426
ATP5H	0.426
OIP5	0.425
SNAPC5	0.424
PGGT1B	0.424
LSM11	0.423
MRPS16	0.423
SARS2	0.422
TGS1	0.422
TMEM41B	0.422
CCT7	0.421
MRPS2	0.42
WDR24	0.42
YARS2	0.419
HIST1H4I	0.419
ATP5D	0.419
TIMM13	0.416
NSMCE1	0.416
TAZ	0.416
SPR	0.414
RNASEH1	0.414
EFTUD1	0.414
KIAA0391	0.413
PDAP1	0.413
MED4	0.412
DDX55	0.412
AARS	0.411
TMEM242	0.411
C11orf57	0.41
ATP5F1	0.41
MRPS18A	0.409
ENO1	0.409
TAF1A	0.408
RPUSD4	0.408
PPP2R3C	0.407
SEC62	0.407
SEC61G	0.406
CBX3	0.406
CASP9	0.406
SRPRB	0.405
TMA16	0.404
UQCRC2	0.403
USO1	0.402
SNF8	0.401
ATP5C1	0.401

Global Fraction of Cell Lines Where Essential: 5/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6836
Expression level (log2 read counts): 6.12

Expression Distribution

stereocilium membrane
stereocilia ankle link complex
myosin binding
adherens junction
acrosomal vesicle
cell-cell adhesion
cell adhesion
biological adhesion