HSD17B10

Gene Information

Official Symbol: HSD17B10
Official Name: hydroxysteroid 17-beta dehydrogenase 10
Aliases and Previous Symbols: N/A
Entrez ID: 3028
UniProt: Q99714
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids and steroids, and is a subunit of mitochondrial ribonuclease P, which is involved in tRNA maturation. The protein has been implicated in the development of Alzheimer disease, and mutations in the gene are the cause of 17beta-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Aug 2014].
UniProt Summary: Mitochondrial dehydrogenase that catalyzes the beta- oxidation at position 17 of androgens and estrogens and has 3- alpha-hydroxysteroid dehydrogenase activity with androsterone (PubMed:9553139, PubMed:23042678, PubMed:12917011, PubMed:18996107, PubMed:25925575, PubMed:28888424). Catalyzes the third step in the beta-oxidation of fatty acids (PubMed:9553139, PubMed:12917011, PubMed:18996107, PubMed:25925575, PubMed:28888424). Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids (PubMed:12917011). Also exhibits 20-beta- OH and 21-OH dehydrogenase activities with C21 steroids (PubMed:12917011). By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD) (PubMed:9338779). Essential for structural and functional integrity of mitochondria (PubMed:20077426). {ECO:0000269|PubMed:12917011, ECO:0000269|PubMed:18996107, ECO:0000269|PubMed:20077426, ECO:0000269|PubMed:23042678, ECO:0000269|PubMed:25925575, ECO:0000269|PubMed:26950678, ECO:0000269|PubMed:28888424, ECO:0000269|PubMed:9338779, ECO:0000269|PubMed:9553139}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Benzoate 10000μM R08 exp455	-2.52
Lapatinib 5μM R01 exp47	-2.16
CVT-10216 0.1μM R06 exp278	-2.06
Dynasore 10μM R04 exp180	-1.83
NFN1 0.4μM R03 exp99	-1.83
GSK2606414 1μM R05 exp236	-1.77
Daidzin 10μM R06 exp280	-1.74
Nicotinamide 1000μM R03 exp101	-1.73
YM155 0.0002μM R01 exp61	-1.72
ZLN024 50μM R08 exp538	-1.7
LLY-283 2.6μM R06 exp290	1.75
Calcium Ionophore 0.4μM R07 exp342	1.78
Hippuristanol 0.12μM R08 exp488	1.78
AICAR 240μM R05 exp211	1.79
Amiloride 100μM R08 exp447	1.79
WYE-354 6μM R02 exp90	1.79
Monensin 0.3μM R08 exp507	1.86
CFI-400945 25μM R08 exp469	1.89
Hinokiflavone 12μM R08 exp487	1.91
Atovaquone 15μM R08 exp451	1.95
MK2206 4μM R08 exp504	1.95
CR131-b 0.005μM R08 exp474	1.98
PU-H71 1μM R08 exp515	2.08
Mitomycin-C 0.06μM R08 exp503	2.16
Deferoxamine 11μM R07 exp350	2.18
Vemurafenib 6.6μM R02 exp89	2.23
Mubritinib 0.2μM R02 exp65	2.24
CoCl2 18μM R07 exp346	2.31
Pterostilbene 16μM R02 exp78	2.31
ONC212 0.15μM R08 exp513	2.37
TIC10 10μM R08 exp532	2.38
Aphidicolin 0.4μM R08 exp440	2.43
BI-D1870 3.15μM R02 exp66	2.43
Tanespimycin 14μM R08 exp527	2.44
Thimerosal 0.85μM R08 exp529	2.49
iCRT14 30μM R08 exp492	2.7
Mubritinib 0.2μM R01 exp48	2.82
Hydroxyurea 100μM R07 exp329	2.99
Oligomycin-A 2μM R00 exp25	3.04
UM0125461 0.74μM R02 exp84	3.21
GSK-J4 1.5μM R08 exp441	4.1

Gene	Correlation
DARS2	0.783
TARS2	0.782
MRPL21	0.772
YARS2	0.771
GFM1	0.763
MRPS34	0.757
SCO2	0.755
MRPS6	0.754
SELRC1	0.754
DAP3	0.75
QRSL1	0.749
MRPS21	0.745
PARS2	0.744
MRPS16	0.741
MRPS14	0.738
MRPL23	0.735
NARS2	0.73
MRP63	0.728
RARS2	0.722
COX16	0.721
BCS1L	0.706
VARS2	0.705
MRPL53	0.704
RPUSD4	0.701
SUPV3L1	0.7
MRPS5	0.699
MRPS26	0.693
MRPS2	0.693
TUFM	0.691
MARS2	0.688
LARS2	0.685
WBSCR16	0.681
EARS2	0.681
C10orf2	0.68
HARS2	0.675
MRPS18A	0.673
RBFA	0.672
FASTKD5	0.667
MRPL47	0.664
KIAA0391	0.661
COA3	0.661
SARS2	0.657
AARS2	0.656
MRPS9	0.653
FARS2	0.648
NDUFA3	0.648
RNASEH1	0.647
MRPS25	0.644
GFM2	0.643
NDUFB11	0.641
GTPBP10	0.641
COX11	0.641
MRPL15	0.639
MRPL20	0.635
MRPL3	0.634
MTG2	0.633
MRPL45	0.632
AIFM1	0.627
GATC	0.627
C12orf65	0.626
FTSJ2	0.622
MRPS33	0.622
MRPS24	0.62
COX17	0.619
COX7B	0.616
PET112	0.614
NDUFAF7	0.613
POLG2	0.612
SLC25A26	0.611
ATP5D	0.609
MRPL55	0.609
MRPS12	0.609
MTPAP	0.608
TRUB2	0.608
PET117	0.602
MRPL12	0.6
COA6	0.595
ELAC2	0.593
PGM3	0.593
TEFM	0.592
MRPS23	0.591
MRPL11	0.591
PNPT1	0.587
MRPS10	0.586
POLG	0.585
MTRF1L	0.584
COX6C	0.584
MRPL42	0.584
UQCRC2	0.582
ATP5A1	0.579
POLRMT	0.579
ATP5C1	0.578
MRPS11	0.577
METTL17	0.576
NDUFA2	0.574
TOMM20	0.574
MRPL43	0.573
RPUSD3	0.573
PDSS1	0.568
MRPL36	0.567
DHRSX	0.562
COX15	0.562
NDUFC2	0.562
NDUFA1	0.561
RPIA	0.56
C17orf89	0.558
MRPL4	0.557
LSM10	0.556
MRPL39	0.553
NDUFB5	0.551
MRPS35	0.55
FH	0.548
WARS2	0.548
COA5	0.547
MRPS22	0.545
TFAM	0.543
MRPL44	0.543
MTG1	0.542
DNLZ	0.542
NDUFAF3	0.539
NDUFB6	0.539
TMEM242	0.538
NDUFS2	0.537
HCCS	0.537
CHCHD4	0.536
PPA2	0.536
TRIAP1	0.534
ATP5SL	0.534
UQCR10	0.531
ATP5B	0.53
MRPL33	0.53
MALSU1	0.53
RTN4IP1	0.527
MRPL18	0.526
MRPL27	0.526
TFB1M	0.521
NDUFAF4	0.52
RNMTL1	0.519
MRPS7	0.516
COX5A	0.515
MRPS27	0.514
ATXN10	0.511
CHCHD1	0.511
MRPL22	0.511
DHX30	0.51
MTERFD1	0.509
ECSIT	0.508
MRPL52	0.507
MRPL17	0.503
MRPL28	0.503
CARS2	0.502
NDUFB3	0.5
ALG6	0.497
VEZT	0.495
AASDHPPT	0.495
COX6B1	0.494
ATP5H	0.494
IBA57	0.493
NDUFA10	0.493
UQCRQ	0.492
ALG8	0.492
MRPL34	0.492
MIPEP	0.491
PPCS	0.49
MRPL13	0.489
MRPS17	0.487
DPAGT1	0.487
NDUFV1	0.486
ATP5J	0.485
NDUFA11	0.485
TOMM6	0.484
COQ2	0.483
SRD5A3	0.481
TIMM8B	0.481
ACAD9	0.481
OPA1	0.481
MTERFD2	0.48
ATP5O	0.48
NDUFS7	0.479
MRPL41	0.478
ATIC	0.477
DOLK	0.477
MRPL37	0.477
PTCD3	0.475
PMM2	0.475
PET100	0.474
HMGXB3	0.473
COQ3	0.473
UQCRC1	0.472
GTPBP8	0.472
SLC25A19	0.472
TRMT61A	0.471
SDHA	0.47
NDUFB1	0.47
NDUFB9	0.467
TPK1	0.466
GRSF1	0.465
UQCC2	0.465
CRLS1	0.463
MRPL49	0.462
MRPL2	0.462
CYCS	0.462
TAMM41	0.461
TMEM261	0.461
COQ7	0.46
SSB	0.46
TFB2M	0.46
SSBP1	0.459
HIGD2A	0.459
NFU1	0.458
MRPS28	0.458
COQ4	0.458
TOMM40	0.457
DDX28	0.456
MRPL46	0.456
UAP1	0.454
TRMT10C	0.454
LRPPRC	0.454
MRPL35	0.453
COQ6	0.453
THG1L	0.453
MRPL38	0.452
SCO1	0.448
MTIF3	0.447
COX19	0.444
SLC25A3	0.443
COX20	0.442
UHRF1	0.442
MRPL51	0.441
ALG1	0.44
PPCDC	0.44
PITRM1	0.439
ATP5E	0.439
COQ5	0.438
ERAL1	0.438
TTC4	0.437
MRPL32	0.437
GARS	0.433
MCAT	0.432
GFER	0.431
NDUFAF5	0.431
RFT1	0.431
SLC25A52	0.43
TOMM22	0.429
CLPP	0.428
PMVK	0.427
RPE	0.426
DDX39A	0.426
ALG13	0.425
MTO1	0.421
ATP5F1	0.421
TAZ	0.42
TIMMDC1	0.42
C11orf57	0.419
MRPL9	0.419
DOHH	0.418
NDUFS5	0.417
MRPS18B	0.415
ATP5L	0.414
ALDH18A1	0.413
NUBPL	0.413
RFK	0.413
ZRSR2	0.411
GTPBP6	0.411
TEN1	0.408
KDSR	0.407
NDUFAF6	0.406
FASTKD2	0.406
SRP14	0.405
ALG5	0.403
NDUFC1	0.402
PRKRIR	0.401
UQCRFS1	0.401
FASTKD1	0.4
CBX3	0.4

Global Fraction of Cell Lines Where Essential: 154/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	5/28
blood	6/26
bone	7/26
breast	5/30
central nervous system	3/49
cervix	1/4
colorectal	1/17
esophagus	7/11
fibroblast	0/1
gastric	3/14
kidney	4/18
liver	7/19
lung	19/72
lymphocyte	3/16
ovary	1/25
pancreas	5/22
peripheral nervous system	2/15
plasma cell	1/12
prostate	0/1
skin	2/20
soft tissue	2/9
thyroid	0/2
upper aerodigestive	13/22
urinary tract	8/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 32
Expression level (log2 read counts): 5.86

Expression Distribution

KR
adh short

cholate 7-alpha-dehydrogenase activity
3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity
dihydrotestosterone 17-beta-dehydrogenase activity
testosterone dehydrogenase [NAD(P)] activity
mitochondrial tRNA 5-end processing
mitochondrial tRNA 3-end processing
mitochondrial ribonuclease P complex
mitochondrial RNA 5-end processing
mitochondrial tRNA methylation
mitochondrial RNA 3-end processing
3-hydroxyacyl-CoA dehydrogenase activity
tRNA 3-end processing
mitochondrial tRNA modification
mitochondrial RNA modification
mitochondrial tRNA processing
tRNA 5-end processing
tRNA threonylcarbamoyladenosine metabolic process
mitochondrial RNA processing
ncRNA 5-end processing
RNA 5-end processing
branched-chain amino acid catabolic process
branched-chain amino acid metabolic process
tRNA methylation
mitochondrial RNA metabolic process
ncRNA 3-end processing
tRNA binding
RNA methylation
tRNA modification
protein homotetramerization
cellular amino acid catabolic process
tRNA processing
RNA 3-end processing
mitochondrial gene expression
protein tetramerization
RNA modification
tRNA metabolic process
macromolecule methylation
organic acid catabolic process
carboxylic acid catabolic process
cellular amino acid metabolic process