UHRF1

Gene Information

Official Symbol: UHRF1
Official Name: ubiquitin like with PHD and ring finger domains 1
Aliases and Previous Symbols: N/A
Entrez ID: 29128
UniProt: Q96T88
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dimethyloxaloylglycine 11μM R07 exp314	-2.68
GSK-J5 1.5μM R08 exp484	-2.67
S-trityl-L-cysteine 0.5μM R05 exp243	-2.6
Nicotinamide Riboside 100μM R03 exp139	-2.57
2-Methoxyestradiol 0.55μM R07 exp310	-2.48
Calcipotriol 5μM R08 exp464	-2.39
Hydroxychloroquine 30μM R08 exp490	-2.38
Trametinib 10μM R02 exp83	-2.36
Trichostatin-A 0.06μM R07 exp415	-2.36
BH1 1μM R04 exp169	-2.35
UM0131023 0.05μM R05 exp248	-2.22
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-2.19
Ibrutinib 1μM R07 exp372	-2.19
PFI-3 10μM R03 exp144	-2.19
Taxol 0.002μM R01 exp54	-2.11
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-2.11
PNU96415E 10μM R03 exp145	-2.1
GSK-J4 1μM R07 exp362	-2.09
2-Methoxyestradiol 0.2μM R01 exp40	-2.08
VHL-ligand-1 20μM R07 exp421	-2.08
Chloroquine 32μM R08 exp470	-2.07
LY2090314 0.003μM R08 exp500 no dilution day6	-2.07
A-196 10μM R03 exp114	-2.06
Hydroxyurea 15μM R06 exp289	-2.05
Cadmium 60μM R08 exp462	-2.04
Dihydrosphingosine 8μM R08 exp476	-2.04
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	-2.01
Docosahexaenoic-acid 50μM R07 exp356	-2.01
GW501516 25μM R06 exp285	-2
HMS-I2 1μM R06 exp286	-2
Cyclosporin-A 3μM R07 exp348	-1.95
UNC2400 2μM R03 exp156	-1.93
Vinblastine 0.002μM R01 exp60	-1.91
Chlorpromazine 10μM R07 exp344	-1.9
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-1.9
NFN1 1μM R03 exp100	-1.9
Hypoxia 5%O2 R04 exp191	-1.89
UNC1999 2μM R03 exp155	-1.89
CVT-10216 0.1μM R06 exp278	-1.88
OICR-9429 10μM R03 exp142	-1.88
Resminostat 0.5μM R07 exp393	-1.88
Apcin 25μM plus proTAME 2μM R04 exp177	-1.87
Rucaparib 6.5μM R08 exp520	-1.85
Bisphenol A 100μM R06 exp269	-1.83
PT-1 25μM R07 exp392	-1.83
Latrunculin-B 10μM R07 exp374	-1.82
Beta-Estradiol 0.55μM R07 exp425	-1.8
LLY-284 2.6μM R06 exp291	-1.79
Trimetrexate 0.03μM R08 exp535	-1.79
Salubrinal 20μM R07 exp399	-1.78
JQ1 0.01μM R03 exp130	-1.77
I-BRD9 4μM R07 exp365	-1.76
Caffeine 2600μM R08 exp463	-1.75
Citral 50μM R06 exp274	-1.73
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-1.73
Benzoate 10000μM R08 exp455	-1.72
Zebularine 20μM R07 exp423	-1.72
MKC9989 10μM R03 exp133	-1.71
Pomalidomide 20μM R07 exp391	-1.71
Tenofovir 10μM R07 exp405	-1.7
BI-D1870 3.15μM R02 exp66	1.71
MLN-4924 2μM R00 exp22	1.71
JQ1 0.8μM R08 exp435	1.72
Monensin 0.3μM R08 exp507	1.75
Atovaquone 15μM R08 exp451	1.79
BI-2536 0.02μM R03 exp96	1.81
6-Thio-2-deoxyguanosine 2μM R06 exp259	1.83
DABN racemic mixture R03 exp93	2.08
TIC10 10μM R08 exp532	2.13
Salinomycin 3.5μM R08 exp521	2.16
ONC212 0.15μM R08 exp513	2.87
Mitomycin-C 0.06μM R08 exp503	3.03

Gene	Correlation
ALG1	0.661
THG1L	0.647
PMM2	0.631
DPAGT1	0.603
RPTOR	0.603
UAP1	0.599
HARS	0.582
RTCB	0.581
RNMT	0.577
GFPT1	0.576
TRIAP1	0.565
GTF3C6	0.562
YARS	0.56
RPP21	0.56
ATXN10	0.559
GMPPB	0.558
VEZT	0.557
FH	0.554
ALG13	0.553
DOHH	0.552
SRP14	0.547
PPCS	0.547
ADSL	0.545
CBFB	0.545
SLC25A26	0.545
LSM10	0.545
DHPS	0.536
GNB1L	0.536
NAE1	0.535
OSGEP	0.534
PPP2R3C	0.533
GEMIN6	0.531
TEN1	0.53
GEMIN8	0.527
TTI1	0.525
WDR24	0.519
PELO	0.517
PPP4C	0.515
TRMT5	0.515
ELAC2	0.51
LSM11	0.509
NBN	0.508
CCDC101	0.505
UTP23	0.498
MED16	0.497
SUPV3L1	0.497
BAP1	0.496
TMEM41B	0.493
RFK	0.492
PPP6C	0.49
UXT	0.49
RPE	0.49
RPIA	0.489
ZRSR2	0.488
CTC1	0.486
GTF3C3	0.485
DDX20	0.484
ENY2	0.483
CHCHD4	0.483
EIF3F	0.483
ROMO1	0.48
CCT7	0.48
ALG5	0.478
MRPS33	0.476
ATP5J	0.474
DOLK	0.473
EXOC4	0.473
TGS1	0.473
TAZ	0.472
ENO1	0.47
WDR59	0.47
GEMIN7	0.47
MRPS14	0.469
THOC6	0.468
MLLT1	0.468
SLC25A19	0.468
HAUS8	0.467
EIF4E	0.467
MED23	0.466
GTF3C4	0.465
MTOR	0.464
GTF3C2	0.464
ATP5O	0.464
UBA3	0.461
POLR3H	0.459
TRNT1	0.459
AASDHPPT	0.459
TBCB	0.457
DR1	0.457
RBMX2	0.456
SNAPC5	0.456
TELO2	0.456
MED4	0.455
MRPS34	0.454
TUFM	0.451
EPRS	0.45
TPRKB	0.449
SSB	0.448
TAMM41	0.448
CBX3	0.448
DDX39A	0.448
TRMT10A	0.447
TTI2	0.446
TSEN54	0.443
HSD17B10	0.442
SARS2	0.442
PPA2	0.441
UBE2G2	0.441
TBCA	0.441
CSNK2B	0.439
PGGT1B	0.438
UQCRC2	0.437
HSPD1	0.436
ALG2	0.436
TXNL4B	0.435
FNTA	0.433
KIAA0391	0.433
DHRSX	0.432
GEMIN5	0.431
MAPK14	0.43
NARS	0.429
C15orf41	0.429
ATP5H	0.428
DHX29	0.428
VMP1	0.427
GPN2	0.426
TAF1A	0.425
RFT1	0.424
LAMTOR5	0.424
TTC4	0.424
DPF2	0.424
TPK1	0.424
KCTD5	0.42
DDX55	0.419
YARS2	0.419
WDR1	0.419
CEP57	0.419
AARS	0.418
CRLS1	0.418
CTDNEP1	0.417
PIK3R4	0.417
C17orf89	0.417
MAML1	0.416
ATP5B	0.416
ZCRB1	0.415
EEF1E1	0.415
TIMM13	0.415
UBE2M	0.414
NSMCE1	0.413
GTF2A2	0.412
WDR82	0.412
TSEN34	0.411
RAD1	0.41
ORC5	0.41
ATIC	0.41
VRK1	0.409
MRPS18A	0.409
ALG6	0.409
EED	0.408
NDUFB1	0.408
PSMG4	0.407
HCCS	0.406
TXNRD1	0.405
XRCC2	0.404
OIP5	0.404
RAD50	0.404
CRCP	0.404
BCS1L	0.402
DARS2	0.401
SRD5A3	0.401
GFM1	0.401
LAMTOR4	0.401

Essentiality in NALM6

Essentiality Rank: 2917
Expression level (log2 read counts): 8.86

Expression Distribution

PHD
ubiquitin
DUF3590
YDG SRA

hemi-methylated DNA-binding
nucleosomal histone binding
regulation of DNA topoisomerase (ATP-hydrolyzing) activity
maintenance of DNA methylation
positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
euchromatin
positive regulation of isomerase activity
regulation of isomerase activity
nuclear heterochromatin
replication fork
heterochromatin
methyl-CpG binding
histone monoubiquitination
proximal promoter sequence-specific DNA binding
histone ubiquitination
positive regulation of ATPase activity
methylated histone binding
protein monoubiquitination
protein autoubiquitination
regulation of ATPase activity
nuclear matrix
histone binding
ubiquitin protein ligase activity
nuclear chromatin
ubiquitin-protein transferase activity
regulation of epithelial cell proliferation
histone modification
covalent chromatin modification
DNA repair
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
protein ubiquitination
chromatin organization
DNA metabolic process
positive regulation of hydrolase activity
protein modification by small protein conjugation