TCF4
Gene Information
- Official Symbol: TCF4
- Official Name: transcription factor 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 6925
- UniProt: P15884
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs endothelial corneal dystrophy. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq, Jul 2016].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| HLH |
GO Terms
| beta-catenin-TCF7L2 complex |
| TFIIB-class transcription factor binding |
| beta-catenin-TCF complex |
| bHLH transcription factor binding |
| E-box binding |
| transcription initiation from RNA polymerase II promoter |
| protein C-terminus binding |
| protein-DNA complex assembly |
| transcription factor complex |
| DNA-templated transcription, initiation |
| nuclear chromatin |
| protein-DNA complex subunit organization |
| positive regulation of neuron differentiation |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| positive regulation of neurogenesis |
| transcription by RNA polymerase II |
| protein heterodimerization activity |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| positive regulation of nervous system development |
| positive regulation of cell development |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| regulation of neuron differentiation |
| DNA-binding transcription factor activity |
| regulation of neurogenesis |
| cellular protein-containing complex assembly |
| protein homodimerization activity |
| regulation of nervous system development |
| regulation of cell development |
| positive regulation of cell differentiation |
| identical protein binding |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| positive regulation of transcription by RNA polymerase II |
| organic cyclic compound biosynthetic process |
| positive regulation of developmental process |
| DNA binding |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| protein-containing complex assembly |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| macromolecule biosynthetic process |
| regulation of cell differentiation |
| protein-containing complex subunit organization |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 9537
- Expression level (log2 read counts): 9.35
Expression Distribution
TCF4 Expression in NALM6 Cells: 9.35
