TCEB3C
Gene Information
- Official Symbol: ELOA3
- Official Name: elongin A3
- Aliases and Previous Symbols: N/A
- Entrez ID: 162699
- UniProt: Q8NG57
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: N/A
Function Summary
- Entrez Summary: The SIII (or elongin) transcription elongation factor complex stimulates the rate of transcription elongation by RNA polymerase II by suppressing the transient pausing of the polymerase at many sites along the DNA template. This complex is a heterotrimer, composed of the transcriptionally active subunit A, A2 or A3 (or elongin A, A2 or A3) and two regulatory subunits, B and C (or elongin B and C). This gene encodes subunit A3. A3 and A are ubiquitously expressed, whereas A2 is specifically expressed in the testis. [provided by RefSeq, Mar 2010].
- UniProt Summary: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A3 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). {ECO:0000269|PubMed:11994304}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 558
- Expression level (log2 read counts): -4.01
TCEB3C Expression in NALM6 Cells: -4.01
