TCEB3CL2

Gene Information

Official Symbol: ELOA3D
Official Name: elongin A3 family member D
Aliases and Previous Symbols: N/A
Entrez ID: 100506888
UniProt: A6NLF2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: N/A

Function Summary

Entrez Summary: N/A
UniProt Summary: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). {ECO:0000250|UniProtKB:Q63187}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Gene	Correlation
PSMB4	0.655
C1QTNF9B	0.635
TBC1D3H	0.633
TBC1D3G	0.619
DDTL	0.618
RPS2	0.613
PSMA6	0.612
TICRR	0.61
PSMB2	0.609
NPIPB5	0.6
TBC1D3F	0.6
ORC1	0.595
RRP7A	0.592
UPF1	0.592
TBC1D3C	0.587
C14orf93	0.587
VASN	0.585
COPG1	0.584
POLR2J3	0.583
CHD4	0.583
TBC1D3L	0.58
TBC1D3K	0.579
TBC1D3E	0.579
TBC1D3I	0.579
CBWD3	0.578
CBWD5	0.574
NUPL1	0.574
RPS12	0.574
TBC1D3	0.574
MT1E	0.571
KCTD17	0.567
CDC6	0.565
RPL35	0.559
CCNA2	0.558
COPE	0.558
CCDC94	0.557
GOLGA6L1	0.556
PSMD14	0.555
AKIRIN2	0.553
IGFN1	0.552
EXOSC9	0.551
CHAF1A	0.55
PCF11	0.55
TFIP11	0.549
VPS28	0.547
CACTIN	0.547
SLC6A17	0.547
HIVEP3	0.545
ISCU	0.544
PAF1	0.543
KRT78	0.543
TIMELESS	0.543
CDCA3	0.542
AAMP	0.542
TYMS	0.541
TWISTNB	0.541
ANKLE2	0.541
PSMD3	0.539
BYSL	0.538
FCN2	0.538
WDR87	0.537
PSMB1	0.537
SLC4A1	0.536
SNRPA1	0.536
PSMA7	0.536
SF3A1	0.535
SUPT6H	0.535
GOLGA6L3	0.535
HAP1	0.533
RAD51	0.532
SUPT5H	0.532
PSMC1	0.532
GOLGA6L4	0.531
NPIPB8	0.53
EXOSC5	0.53
NUP160	0.529
PSMC2	0.528
DTL	0.527
WDR75	0.527
CDC73	0.527
LRR1	0.526
GOLGA8O	0.526
CBWD6	0.526
RPL6	0.525
PWP2	0.524
HIST2H3C	0.524
PSMD11	0.524
PSMD1	0.524
HIST2H3A	0.523
DDT	0.523
MYB	0.521
SSH2	0.52
NARFL	0.519
TP53TG3B	0.518
AQR	0.518
PSMC6	0.517
GOLGA6L6	0.517
CCDC116	0.517
TP53TG3	0.517
EXD1	0.517
IK	0.516
TP53TG3C	0.516
UTP3	0.515
SLC38A7	0.515
MADCAM1	0.515
NAALADL1	0.513
ATP6V1A	0.513
RPS9	0.512
RBBP5	0.511
RNPC3	0.511
XYLT2	0.511
RRN3	0.511
RPL30	0.51
TSPY8	0.508
RPL34	0.508
COL2A1	0.508
POLA2	0.507
RBM39	0.507
INTS5	0.506
MYO1H	0.506
FAM25B	0.505
POLE	0.505
MDM2	0.504
POLR2D	0.503
KIF3C	0.503
NOL12	0.503
ZFAND5	0.503
SYT9	0.502
UTP20	0.502
ORC6	0.502
CDC45	0.5
S1PR4	0.5
AATF	0.5
MYT1L	0.498
PPFIA4	0.495
GOLGA6A	0.495
NAPA	0.495
RPS5	0.494
FAM231A	0.494
POLA1	0.494
CCDC64B	0.494
FAM231C	0.493
MCOLN1	0.492
CMYA5	0.491
GPRIN2	0.491
PSMB3	0.49
HIST1H2BE	0.489
DOCK6	0.489
RPS28	0.489
NOL10	0.489
WDR43	0.488
PSMC5	0.488
DISP2	0.487
CGB2	0.487
SH3BP1	0.487
PNO1	0.487
ATP6V0C	0.486
ZNF219	0.486
DIDO1	0.485
POLR2F	0.485
OGFR	0.485
TSG101	0.485
MED17	0.484
ATP13A1	0.483
ADRA1D	0.483
KPNB1	0.482
INTS6	0.482
NUP54	0.482
EBNA1BP2	0.481
RNF113A	0.481
TRAIP	0.481
SMG7	0.48
PSMD6	0.48
ATP1A3	0.48
ARHGEF35	0.48
ACSF2	0.48
RPS7	0.479
COPB1	0.479
SCGB1C1	0.479
COPA	0.478
EIF4A3	0.478
EGR2	0.478
MED29	0.477
RPS19BP1	0.476
TAF1	0.476
ZNF830	0.476
SEL1L	0.476
NSF	0.475
SEC13	0.474
KIAA0947	0.474
ATP6V1C1	0.474
DNM2	0.473
PSMD7	0.473
ATP6AP1	0.473
CWC22	0.473
RFFL	0.472
PLK1	0.472
RRP9	0.471
NUP153	0.47
NOP16	0.47
NCAPG	0.47
CNOT1	0.47
MPHOSPH10	0.469
SCAF1	0.469
NFATC4	0.469
NBPF10	0.468
SULT1A3	0.468
ANKLE1	0.468
TERF2	0.467
SULT1A4	0.467
RAD21	0.467
RRP15	0.467
SF3A3	0.466
PIGS	0.465
RPS19	0.465
PHF2	0.464
EXOSC6	0.464
COX7A2L	0.464
MSH5	0.463
XAB2	0.463
SEMA6B	0.463
CEP192	0.463
C2orf27B	0.462
CDH24	0.462
LAD1	0.461
CTR9	0.461
AAAS	0.461
PSMD2	0.461
MYO18A	0.46
CLPTM1	0.46
RPSA	0.46
PLA2G4F	0.46
MDN1	0.46
RPS10	0.46
ABHD8	0.459
TOP1MT	0.459
NOL9	0.459
RIOK2	0.458
RPS3A	0.458
NUFIP2	0.458
PRPF19	0.457
LOC643669	0.457
MED14	0.457
COPB2	0.457
HNRNPA1	0.457
TSPY1	0.456
RILPL1	0.456
PAN2	0.456
RRP1	0.456
CASC3	0.455
AKT1S1	0.455
RFXANK	0.454
NUP205	0.454
ZNF655	0.454
NUP98	0.454
PAN3	0.454
RPS20	0.453
MEPCE	0.453
TRIM52	0.452
FAM20A	0.452
NFYA	0.451
HIST1H4B	0.45
ALDH1B1	0.45
PLK4	0.448
C3orf17	0.448
COPZ1	0.448
TP53TG3D	0.448
DHX38	0.447
OR10G3	0.446
TPX2	0.446
EXOSC3	0.446
AHCTF1	0.446
NUMA1	0.445
CLN6	0.445
CKAP5	0.443
SNIP1	0.443
ATXN1	0.443
NBPF1	0.443
GID4	0.442
LIPE	0.442
GOLGA6B	0.441
SPRR2B	0.441
STRN	0.44
SART1	0.44
FAM160A1	0.44
CTAGE4	0.44
DIEXF	0.439
POLR1A	0.439
ATP6V0B	0.438
DDX47	0.437
NUP155	0.437
CACNA1A	0.437
RPL8	0.436
CLASP1	0.436
SETD1A	0.435
PPM1D	0.435
KRT2	0.434
DDX56	0.434
BRD2	0.434
MFRP	0.434
PSAP	0.434
STIL	0.434
SNRNP70	0.433
ATP6V1B2	0.433
APRT	0.433
BRIX1	0.433
ACBD4	0.432
NDC1	0.432
RNF4	0.432
HNRNPC	0.432
RPS14	0.432
RANBP2	0.431
NBPF16	0.431
SMG1	0.431
RPL38	0.431
NCL	0.43
VPS54	0.429
BCL2L1	0.429
RFC1	0.429
TERF1	0.429
RPL9	0.429
MFSD12	0.428
GON4L	0.428
NOL8	0.427
NUP43	0.427
POLR2A	0.427
NUP85	0.427
CHCHD3	0.426
TRAPPC11	0.426
ZNF106	0.426
ARCN1	0.425
MMS22L	0.425
DNTTIP2	0.424
FBXW9	0.424
RPL10A	0.424
UBE2Q2L	0.424
RFPL3	0.423
SMTN	0.423
APC2	0.422
URB2	0.422
SFPQ	0.421
PSMD13	0.421
VPS52	0.421
TUBA8	0.421
DAND5	0.42
FAM86B2	0.42
ELMOD3	0.42
GAR1	0.42
MYLK3	0.42
TTYH1	0.419
COX8A	0.419
GOLGA8K	0.418
C2orf27A	0.418
DDX54	0.418
MBTD1	0.417
ABT1	0.417
SHPK	0.417
TSPY2	0.417
RPL37A	0.417
EXOSC8	0.417
NOP14	0.416
HIST2H2BF	0.416
GOLGA8J	0.416
SLC22A10	0.415
SNRPB	0.415
RPLP2	0.415
POLD1	0.415
MAT2A	0.414
BID	0.414
OR11H6	0.414
AKAP1	0.413
RILPL2	0.413
RSL1D1	0.413
SF3B2	0.412
ADD2	0.412
RPS3	0.412
CDT1	0.411
PDE4DIP	0.41
HINFP	0.409
RPS6	0.409
ACD	0.409
MCF2L	0.409
TTC31	0.409
ELL	0.409
RPS11	0.409
PBXIP1	0.409
PLEKHA4	0.408
PLRG1	0.408
CWC15	0.408
SULT2B1	0.407
USP35	0.407
PARP3	0.407
DHFR	0.407
ZNF574	0.407
CHMP2A	0.406
SRGAP2C	0.406
POLR2H	0.406
CASC5	0.406
PSMD8	0.405
PRKCZ	0.405
CSNK1A1	0.405
EXOSC4	0.404
POLE2	0.403
ADRM1	0.403
HTATSF1	0.403
GGA3	0.403
MYH7B	0.403
TINF2	0.402
ARHGEF15	0.402
BAGE2	0.402
EIF3G	0.402
CEBPZ	0.401
BAGE	0.401
BAGE4	0.401
TGFBRAP1	0.401
SAP30BP	0.401
BAGE3	0.401
BAGE5	0.401
HGC6.3	0.401
ATP6AP2	0.4
POLD3	0.4
PRPF3	0.4
PRIM1	0.4
SLC5A5	0.4
NUP62	0.4
ANGPTL4	0.4
NDC80	0.4

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1154
Expression level (log2 read counts): -7.68

Expression Distribution

Screen	Score
Hinokiflavone 12μM R08 exp487	-2.16
Ammonium tetrathiomolybdate 10μM R08 exp448	-1.74

Med26
Elongin A