GFPT1

Gene Information

Official Symbol: GFPT1
Official Name: glutamine–fructose-6-phosphate transaminase 1
Aliases and Previous Symbols: N/A
Entrez ID: 2673
UniProt: Q06210
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes the first and rate-limiting enzyme of the hexosamine pathway and controls the flux of glucose into the hexosamine pathway. The product of this gene catalyzes the formation of glucosamine 6-phosphate. [provided by RefSeq, Sep 2008].
UniProt Summary: Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes ARNTL/BMAL1 and CRY1.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Pterostilbene 16μM R02 exp78	-2.28
Pimelic-diphenylamide-106 0.5μM R00 exp27	-2.23
Azithromycin 100μM R08 exp452	-2.18
Sucrose 20000μM R06 exp298	-2.03
All-trans-Retinoic-Acid 40μM R07 exp334	-2
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-1.99
PFI-2 4μM R05 exp239	-1.99
UM0011500 10μM R05 exp246	-1.97
THZ531 0.11 to 0.175μM on day4 R07 exp413	-1.92
Alpha-Amanitin 0.5μM R00 exp5	-1.9
FTY720 3μM R08 exp483	-1.82
Calcium Ionophore 0.4μM R07 exp342	-1.81
Fluvastatin 2.2μM R06 exp282	-1.8
IU1-47 25μM R04 exp182	-1.8
Nicotinate 1000μM R03 exp140	-1.8
Tunicamycin 0.04μM R07 exp418	-1.75
Thapsigargin 0.005μM R07 exp407	-1.74
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-1.72
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	-1.72
GSK-J4 1.5μM R08 exp441	1.72
DABN 20μM R00 exp17	1.89
5-Fluorouracil 20μM R00 exp2	1.9
Etoposide 0.3μM R05 exp199	1.9
Actinomycin-D 0.001μM R00 exp3	1.92
Rotenone 20μM R00 exp34	1.92
THZ1 0.06μM R08 exp531	1.99
DABN racemic mixture R03 exp93	2
Ammonium tetrathiomolybdate 10μM R08 exp448	2.07
Tanespimycin 14μM R08 exp527	2.09
BI-6727 0.04μM R03 exp98	2.12
MLN-4924 2μM R00 exp22	2.17
Aphidicolin 0.4μM R08 exp440	2.18
TIC10 10μM R08 exp532	2.35
CI-1040 9.5μM R08 exp472	2.38
Mitomycin-C 0.06μM R08 exp503	2.43
GSK461364A 0.1μM R03 exp126	2.45
Pimelic-diphenylamide-106 5μM R00 exp28	2.56
Benzoate 20000μM R08 exp456	2.62
Vinblastine 0.2μM R03 exp108	2.92
Doxorubicin 0.02μM R08 exp478	3.1

Gene	Correlation
UAP1	0.747
DPAGT1	0.736
THG1L	0.711
GMPPB	0.703
RTCB	0.69
PMM2	0.69
RPTOR	0.66
ALG1	0.656
DOHH	0.649
TRIAP1	0.648
RNMT	0.646
HSPD1	0.643
GNB1L	0.629
ATP5J	0.625
ENY2	0.623
NAE1	0.619
HARS	0.617
CSNK2B	0.616
ATXN10	0.612
ALG13	0.609
ORAOV1	0.607
ALG5	0.604
MTOR	0.591
PLAA	0.59
UBE2K	0.581
TSEN54	0.581
HCCS	0.577
UHRF1	0.576
EIF4E	0.574
RPP21	0.574
ALG2	0.573
CTDNEP1	0.572
MED16	0.571
GTF3C3	0.569
SRP14	0.567
CCDC101	0.563
TSEN34	0.56
BAP1	0.557
CASP9	0.557
PELO	0.557
DAD1	0.551
GTF3C4	0.551
TTI2	0.549
CBFB	0.548
PPA2	0.548
EXOC4	0.544
ADSL	0.542
CYCS	0.539
DOLK	0.538
UBE2G2	0.537
APAF1	0.535
AARS	0.531
MARS	0.531
TBCA	0.531
ATP5B	0.53
TAMM41	0.528
TMEM41B	0.527
DHDDS	0.526
VEZT	0.525
DHPS	0.524
GTF3C6	0.523
UBQLN1	0.523
PPCS	0.522
BAK1	0.522
ATP5O	0.519
GTF3C2	0.519
VMP1	0.518
TRNT1	0.516
MEAF6	0.516
NARS	0.515
PAM16	0.513
FAF2	0.513
OSGEP	0.513
NXT1	0.511
TIMM13	0.511
MBTPS2	0.51
PPP2R3C	0.509
KDSR	0.507
POLR3H	0.507
NSMCE1	0.507
LAMTOR5	0.505
TTI1	0.505
ALG14	0.504
TELO2	0.503
TBP	0.503
RPN1	0.502
SLC25A26	0.502
WDR24	0.5
DPF2	0.499
SRP72	0.499
NSD1	0.498
TAZ	0.498
RPE	0.497
WDR59	0.496
MLLT1	0.494
UTP23	0.492
ALG6	0.492
THOC6	0.491
UBA3	0.488
ATP2A2	0.488
TRMT5	0.488
DR1	0.486
ROMO1	0.485
GTF3A	0.485
TRMT10A	0.484
YARS	0.482
VHL	0.482
CARS	0.481
CEPT1	0.481
MED4	0.481
ELAC2	0.48
GFER	0.477
USO1	0.476
GEMIN5	0.476
PPP4C	0.474
DDX55	0.473
CCT7	0.473
SSB	0.473
DDX20	0.472
ZNF259	0.472
CRLS1	0.472
UXT	0.472
LSM11	0.471
SERF2	0.471
ATP5A1	0.468
EIF3F	0.467
DDX1	0.466
TIMM22	0.466
ENO1	0.465
SLC25A19	0.463
OTUD5	0.462
ZRSR2	0.461
TGS1	0.46
EXOC3	0.459
SEC16A	0.459
HAUS8	0.459
DHRSX	0.456
SLC35B1	0.456
SRPRB	0.456
ATP5I	0.456
ATP5D	0.456
NUP50	0.455
SRP68	0.455
RFT1	0.455
TBCB	0.455
SEC62	0.454
SPCS3	0.454
LSM10	0.453
LSMD1	0.452
THOC3	0.452
WDR1	0.451
EPRS	0.45
TTC4	0.45
TMED10	0.45
SUPV3L1	0.449
RAD1	0.448
MFN1	0.447
ZNF608	0.447
VDAC2	0.446
DDOST	0.446
MARCH5	0.443
OIP5	0.442
GEMIN8	0.441
NUPL2	0.44
CHCHD4	0.44
VRK1	0.439
RABGGTB	0.439
DIABLO	0.439
FH	0.439
DNAJC3	0.438
TRIM28	0.437
MED23	0.437
ELP3	0.437
CRCP	0.436
PGGT1B	0.436
KIAA0391	0.436
PISD	0.435
LAMTOR4	0.435
SEC61G	0.435
SPCS2	0.435
GABPA	0.435
CHORDC1	0.434
TUFM	0.433
RPIA	0.431
ATP5H	0.431
BTAF1	0.431
URM1	0.431
MED25	0.431
QARS	0.429
TEN1	0.428
SEH1L	0.428
POLR3B	0.427
FBXO11	0.427
ATIC	0.427
SRD5A3	0.427
ZBTB11	0.426
UQCRC2	0.424
RBM14	0.423
UBA5	0.423
CEP57	0.422
BCS1L	0.421
FNTA	0.42
OPA1	0.42
PDAP1	0.419
TPRKB	0.419
MRPS14	0.418
PPP6C	0.418
SEC63	0.417
AASDHPPT	0.417
PIK3R4	0.416
TXNL4B	0.416
GTF2A2	0.415
DHX29	0.413
PGM3	0.413
C10orf2	0.413
TSEN2	0.413
CMTR1	0.411
MIS18A	0.411
CDIPT	0.41
WDR82	0.41
GEMIN7	0.407
SARS2	0.407
UBE2M	0.407
PCBP2	0.406
MBTPS1	0.406
WDR92	0.406
MAPK14	0.404
XPO5	0.404
SDHA	0.404
TXNRD1	0.403
GPN2	0.402
TOMM40	0.401
YARS2	0.401
PYROXD1	0.401

Global Fraction of Cell Lines Where Essential: 33/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	4/28
blood	4/28
bone	0/25
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	1/13
fibroblast	0/1
gastric	0/15
kidney	4/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	1/26
pancreas	3/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	1/22
urinary tract	2/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1006
Expression level (log2 read counts): 6.46

Expression Distribution

GATase 2
SIS

carbohydrate derivative binding
glutamine-fructose-6-phosphate transaminase (isomerizing) activity
fructose 6-phosphate metabolic process
UDP-N-acetylglucosamine biosynthetic process
amino sugar biosynthetic process
UDP-N-acetylglucosamine metabolic process
glutamine metabolic process
nucleotide-sugar biosynthetic process
nucleotide-sugar metabolic process
amino sugar metabolic process
IRE1-mediated unfolded protein response
circadian regulation of gene expression
energy reserve metabolic process
glutamine family amino acid metabolic process
protein N-linked glycosylation
endoplasmic reticulum unfolded protein response
cellular response to unfolded protein
circadian rhythm
cellular response to topologically incorrect protein
response to unfolded protein
response to topologically incorrect protein
alpha-amino acid metabolic process
energy derivation by oxidation of organic compounds
protein glycosylation
macromolecule glycosylation
response to endoplasmic reticulum stress
glycosylation
rhythmic process
cellular amino acid metabolic process
glycoprotein biosynthetic process
glycoprotein metabolic process
generation of precursor metabolites and energy
nucleobase-containing small molecule metabolic process
carbohydrate derivative biosynthetic process
organophosphate metabolic process
carboxylic acid metabolic process
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process
carbohydrate derivative metabolic process