PRIM1

Gene Information

Official Symbol: PRIM1
Official Name: DNA primase subunit 1
Aliases and Previous Symbols: N/A
Entrez ID: 5557
UniProt: P49642
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MLN-4924 2μM R00 exp22	-2.56
DABN 20μM R00 exp17	-2.51
Pimelic-diphenylamide-106 5μM R00 exp28	-2.01
Nocodazole 0.2μM R00 exp24	-1.75
DABN 2μM R00 exp16	1.71
KU-0063794 3.8μM R02 exp71	1.73
INK128 0.2μM R02 exp70	1.79
Deguelin 0.05μM R02 exp69	2.35

Gene	Correlation
ATP6V0B	0.648
FBL	0.62
WDR75	0.616
NXPE3	0.605
ZNF783	0.602
TRIM50	0.601
EP300	0.596
KIAA1211	0.593
DIDO1	0.592
COPB1	0.589
UPF1	0.588
ATP6V0A2	0.583
TICRR	0.579
NAALADL2	0.578
PSMB2	0.577
AATF	0.575
XAB2	0.575
GCOM1	0.573
MYZAP	0.573
TYMS	0.571
SUPT16H	0.569
SF3A2	0.569
SOCS1	0.567
CMA1	0.565
NUP153	0.564
TRAPPC8	0.563
GOLGA6L1	0.562
ATP6V1A	0.559
SPPL3	0.559
ATP6V1C2	0.556
ATP6V1B2	0.555
EXOSC6	0.554
CCDC108	0.553
COL2A1	0.551
CTAGE4	0.551
TMEM161A	0.55
MFSD3	0.55
TWISTNB	0.547
DAPK3	0.546
AQR	0.545
PSMB4	0.543
POLE	0.54
ATP6V1C1	0.54
PIGS	0.539
SLC2A11	0.539
GID4	0.538
NUP160	0.537
MIEF1	0.537
SOCS2	0.536
ZNF805	0.536
COL25A1	0.534
SLC4A1	0.531
MED17	0.531
OSBP	0.53
METTL1	0.53
BUD31	0.529
SCFD2	0.528
UTP6	0.528
TCP11X2	0.528
TSPY1	0.524
DDX3X	0.524
NPPC	0.519
EPB41	0.519
MAP1LC3B	0.518
KRI1	0.518
NPIPB5	0.516
PTGDR	0.516
RAD21	0.516
NBPF10	0.515
COG1	0.514
EIF4A3	0.514
SPATA31A7	0.513
S1PR4	0.513
ANKMY1	0.513
GP6	0.513
KIAA1244	0.513
UBR7	0.512
GAR1	0.509
AGPS	0.508
S100A9	0.506
RUVBL1	0.505
RPA1	0.503
PPFIA3	0.503
SCML1	0.503
C14orf93	0.503
PALM3	0.503
NOL10	0.502
SLC25A36	0.502
ISY1	0.501
TAF1	0.501
RPL35	0.501
PDCD1	0.5
BID	0.5
VPS37D	0.5
RASIP1	0.499
COPB2	0.498
RPL19	0.498
NFATC4	0.497
AADACL2	0.497
RPS11	0.495
C1orf68	0.494
TBL3	0.494
UBAP2L	0.494
NDUFAF3	0.494
RPS3A	0.493
MUC2	0.493
MSTN	0.492
CHD4	0.491
ZNF655	0.491
ZNF574	0.49
POLA2	0.49
BARX1	0.489
SLC25A51	0.489
SF3B2	0.489
CDC40	0.489
SMAD2	0.489
NOB1	0.489
S100A4	0.487
POTEE	0.487
DNAJC11	0.486
ATP6V0C	0.486
EXOSC1	0.485
NFKBID	0.484
GOLGA8O	0.48
INTS5	0.48
PPP1R8	0.48
STXBP2	0.48
TPX2	0.48
ZC2HC1C	0.479
ITGAM	0.479
COLGALT1	0.479
TOPBP1	0.478
ERMP1	0.478
COPZ1	0.478
RPS8	0.478
PMAIP1	0.477
TBC1D17	0.477
TSPY2	0.476
DONSON	0.476
TUBA8	0.476
YY1	0.475
MADCAM1	0.474
COG8	0.473
PIP4K2B	0.472
POLR2J	0.47
COPG1	0.47
MGRN1	0.47
NELFCD	0.47
FAM194B	0.47
RNF113A	0.47
MDM2	0.469
SF3A3	0.468
MCRS1	0.468
HIST1H2BF	0.468
CHAF1A	0.468
KRT36	0.468
DDX47	0.468
PCNA	0.466
KRT78	0.466
SUPT5H	0.466
COX7A2L	0.465
OR4B1	0.465
PRKACB	0.464
NDUFS8	0.464
SMPD4	0.463
DNTTIP2	0.463
PDE9A	0.462
ZNF254	0.462
STRN	0.461
STX6	0.46
CDK6	0.46
TCEB3C	0.46
ABCC10	0.459
RILPL2	0.459
RPL27	0.458
EXOSC5	0.457
GPRC5B	0.457
PEPD	0.457
MYB	0.457
ROBO4	0.456
RILPL1	0.456
LMAN1	0.456
PI4KB	0.456
POLR2J3	0.456
ATP2B4	0.455
PANK2	0.455
CA8	0.454
STARD7	0.454
TCF20	0.454
MT1E	0.453
RPL13A	0.453
RPL23	0.453
CCND3	0.453
TRDN	0.452
TBC1D3H	0.452
RIOK2	0.452
UTP20	0.452
RPL15	0.452
ING2	0.452
IFITM1	0.451
RPS9	0.451
ENPP3	0.451
PAN3	0.45
SYF2	0.45
TBC1D3F	0.45
SNRPA1	0.449
RANBP2	0.449
ALS2CL	0.449
POLR2C	0.448
GNA15	0.447
NDUFV2	0.447
PKIB	0.447
SRM	0.446
DHX8	0.446
ERAS	0.446
WDR74	0.446
CTAGE9	0.446
ARMC9	0.446
C12orf68	0.446
RPS19	0.446
SULT2B1	0.445
ARCN1	0.445
HEXIM1	0.445
NHLRC3	0.445
COG4	0.445
ACTL9	0.445
RCL1	0.445
THADA	0.445
PPM1F	0.444
KIR2DL1	0.444
ATP6V1E1	0.444
GPT	0.443
OR5W2	0.443
DPEP3	0.443
CKAP5	0.442
SLCO4C1	0.442
TMCC2	0.442
ALDH1B1	0.442
SCAF1	0.441
EXD1	0.441
ATP6V1D	0.441
INTS6	0.441
FBXO5	0.441
KANSL1	0.44
SRSF8	0.44
CHRNA2	0.44
PDS5A	0.44
ZCCHC9	0.44
ZNF541	0.439
RPL12	0.439
EMC7	0.439
NLN	0.439
SLC9A1	0.439
AURKAIP1	0.438
NUBPL	0.438
MPHOSPH10	0.438
RRP36	0.438
KMO	0.438
MED14	0.437
EPS15L1	0.437
CACNA2D4	0.437
SDAD1	0.437
CNIH1	0.437
LAD1	0.436
TSNAXIP1	0.436
BCAS2	0.435
KCNJ12	0.435
PCCA	0.435
HEATR1	0.435
TBKBP1	0.435
KIAA0947	0.434
IGLON5	0.433
TCEB3CL	0.433
KRT82	0.433
SF3B3	0.433
ZNF454	0.432
COG3	0.432
SMG1	0.432
POC1A	0.432
RRP7A	0.431
CLN8	0.431
COPA	0.431
TIMELESS	0.431
RMDN3	0.431
ABI3BP	0.431
PTMA	0.43
CCDC64	0.43
SMCO3	0.43
CDH13	0.43
MDH2	0.43
SRGAP1	0.429
PSMA6	0.429
METTL24	0.429
PIF1	0.429
SNIP1	0.429
SUPT6H	0.429
GOLGA6L3	0.428
CD6	0.428
NUP214	0.428
CCDC86	0.427
ZNF442	0.427
DNAJC17	0.426
SH3BP1	0.426
NSUN4	0.425
SF3B5	0.425
MDC1	0.425
BCAS3	0.425
NELFA	0.425
MCAT	0.425
SNX11	0.425
DCPS	0.424
ARHGEF37	0.424
B3GALT5	0.423
VPS52	0.423
PBXIP1	0.423
ABHD17A	0.423
STON2	0.423
PWP2	0.422
RPS2	0.422
RBMS1	0.422
ACAD9	0.422
CHEK1	0.422
BRMS1	0.422
TBC1D4	0.422
NUP93	0.421
FAM111A	0.421
ZBTB7A	0.421
LEFTY1	0.421
SEC22C	0.42
ZNF687	0.42
AAMP	0.419
NFYA	0.419
ADAMTS18	0.419
RPA2	0.419
ATP6AP1	0.419
RAP1GAP2	0.419
NR2C2AP	0.418
PHF2	0.418
RPS12	0.418
LAMA2	0.418
MTCH2	0.418
POLR1A	0.418
BRCA1	0.417
GOLGA2	0.417
GLRX	0.417
FZD1	0.417
ZNF652	0.416
DCP1B	0.416
TFRC	0.415
ZFAT	0.415
DIEXF	0.415
CLSTN1	0.415
EXOSC7	0.415
WARS2	0.415
VPS28	0.415
ANKRD7	0.415
TRAIP	0.415
LDHD	0.414
HNRNPCL1	0.414
DPY19L3	0.414
PCF11	0.414
GPX4	0.414
STAU2	0.413
PCDHGA2	0.413
TBC1D3	0.413
MOV10L1	0.413
MAP1LC3C	0.412
SART1	0.412
XKR4	0.412
RPL10A	0.412
HINFP	0.412
LRRC46	0.412
FXYD1	0.411
ARL6IP1	0.411
NOL6	0.411
ZKSCAN4	0.411
EMC9	0.411
TRIM38	0.411
SYS1	0.41
AKT1S1	0.41
GOLGA8N	0.41
AGAP5	0.41
GNLY	0.41
OR9Q2	0.41
RGS4	0.41
CHDH	0.409
ZMAT4	0.409
HCFC1	0.409
IGFN1	0.409
SNRPB	0.409
AQP5	0.409
TIMMDC1	0.409
WDR7	0.408
DDX49	0.408
CYB561A3	0.408
KIAA0556	0.407
DNAAF2	0.407
RPS7	0.407
EMCN	0.407
POLR2B	0.407
NEDD4	0.407
COPE	0.407
VWA7	0.407
POLA1	0.407
GNAT1	0.406
GOLT1A	0.406
PNMA1	0.406
GANC	0.406
PRAP1	0.406
VWA2	0.405
ZNF148	0.405
DGKE	0.404
TOX3	0.404
MYOCD	0.404
VPS54	0.404
RHEBL1	0.403
RBM22	0.403
SOAT2	0.403
TFIP11	0.403
RPAP1	0.403
ARHGEF11	0.403
NANOS2	0.403
GDF9	0.403
SOX17	0.402
FGF23	0.402
SULT1A3	0.402
NUPL1	0.402
DUSP5	0.402
BRD4	0.402
NUP62	0.402
RHBDD3	0.402
SULT1A4	0.402
NUDT1	0.402
DKK1	0.401
DPH5	0.401
NPIPA8	0.401
C3orf22	0.401
ODF3	0.401
FAM114A1	0.401
SLITRK5	0.4
ATP6AP2	0.4
NPIPA7	0.4
NOC4L	0.4
RPS3	0.4
TCEB3CL2	0.4
ZZEF1	0.4

Global Fraction of Cell Lines Where Essential: 729/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	31/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	19/21
liver	19/20
lung	74/75
lymphocyte	16/16
ovary	25/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	23/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 160
Expression level (log2 read counts): 5.56

Expression Distribution

DNA primase activity
alpha DNA polymerase:primase complex
DNA replication, synthesis of RNA primer
telomere maintenance via semi-conservative replication
DNA replication initiation
nuclear DNA replication
cell cycle DNA replication
telomere maintenance
telomere organization
single-stranded DNA binding
G1/S transition of mitotic cell cycle
cell cycle G1/S phase transition
DNA-dependent DNA replication
DNA replication
mitotic cell cycle phase transition
cell cycle phase transition
anatomical structure homeostasis
mitotic cell cycle process
RNA biosynthetic process
mitotic cell cycle
DNA metabolic process
cellular homeostasis
cell cycle process
chromosome organization
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
cell cycle
cellular nitrogen compound biosynthetic process
homeostatic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
membrane