PMM2

Gene Information

Official Symbol: PMM2
Official Name: phosphomannomutase 2
Aliases and Previous Symbols: N/A
Entrez ID: 5373
UniProt: O15305
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate, which is a precursor to GDP-mannose necessary for the synthesis of dolichol-P-oligosaccharides. Mutations in this gene have been shown to cause defects in glycoprotein biosynthesis, which manifests as carbohydrate-deficient glycoprotein syndrome type I. [provided by RefSeq, Jul 2008].
UniProt Summary: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
2-Deoxy-D-glucose 800μM R05 exp214	-3.4
Apcin 50 to 100μM on day4 R04 exp176	-2.36
Golgicide-A 4μM R03 exp122	-2.11
Mubritinib 0.2μM R01 exp48	-2.1
GSK2606414 1μM R05 exp236	-2.07
UM0011500 5μM R05 exp245	-2.07
VHL-ligand-1 20μM R07 exp421	-2.06
Pimelic-diphenylamide-106 0.5μM R00 exp27	-2.05
A-366 10μM R03 exp115	-2.03
Lapatinib 5μM R01 exp47	-2.02
Taxol 0.002μM R01 exp54	-2.02
MS094 2μM R03 exp136	-1.99
Hypoxia 5%O2 R04 exp191	-1.98
Lenalidomide 20μM R07 exp375	-1.94
Vinorelbine 0.001μM R05 exp249	-1.93
proTAME 5μM R04 exp187	-1.91
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-1.9
NFN1 1μM R03 exp100	-1.9
JQ1 0.01μM R03 exp130	-1.89
UM0131023 0.05μM R05 exp248	-1.87
Ethanol 0.01 R05 exp234	-1.86
Cabazitaxel 0.001μM R05 exp223	-1.85
Chloramphenicol 2μM R00 exp12	-1.85
CCCP 0.1μM R00 exp10	-1.82
EPZ-5676 30μM R05 exp233	-1.81
UM131593 0.1μM R01 exp58	-1.81
Phenformin 20μM R03 exp143	-1.77
Tenofovir 10μM R07 exp405	-1.77
OICR-9429 10μM R03 exp142	-1.73
LB-100 2μM R05 exp210	-1.72
Doxycycline 10μM R00 exp18	-1.7
THZ1 0.06μM R08 exp531	1.72
Doxorubicin 0.02μM R08 exp478	1.73
Torin1 0.08μM R02 exp82	1.73
Nocodazole 0.1μM R03 exp94	1.75
CFI-400945 25μM R08 exp469	1.82
ONC212 0.15μM R08 exp513	1.82
JQ1 0.8μM R08 exp435	1.86
SNS-032 15μM R08 exp443	1.91
Benzoate 20000μM R08 exp456	1.99
Actinomycin-D 0.001μM R00 exp3	2.01
Nocodazole 0.2μM R02 exp64	2.04
6-Thio-2-deoxyguanosine 2μM R06 exp259	2.13
PU-H71 1μM R08 exp515	2.14
DABN racemic mixture R03 exp93	2.17
Bleomycin 5μM R08 exp459	2.2
MLN-4924 2μM R00 exp22	2.22
CI-1040 9.5μM R08 exp472	2.26
Brefeldin A 0.02μM R00 exp8	2.29
GSK461364A 0.1μM R03 exp126	2.31
BI-6727 0.04μM R03 exp98	2.34
BI-2536 0.02μM R03 exp96	2.35
Tanespimycin 14μM R08 exp527	2.35
42°C R08 exp539	2.73
5-Fluorouracil 20μM R00 exp2	2.88

Gene	Correlation
DPAGT1	0.763
TRIAP1	0.754
THG1L	0.754
ALG1	0.751
GMPPB	0.746
UAP1	0.695
GFPT1	0.69
ALG2	0.686
RNMT	0.674
ATXN10	0.661
TAMM41	0.653
RPE	0.645
RPTOR	0.644
ALG5	0.642
SLC25A26	0.642
SRP14	0.641
TRMT5	0.64
ALG13	0.637
ROMO1	0.635
UHRF1	0.631
DOHH	0.623
RPP21	0.619
TAZ	0.614
RTCB	0.614
GTF3C3	0.613
CRLS1	0.613
DAD1	0.607
HARS	0.607
PELO	0.607
NAE1	0.604
UTP23	0.604
ENY2	0.603
GNB1L	0.601
VEZT	0.6
MED16	0.597
ALG14	0.588
RPIA	0.588
ALG6	0.587
ORAOV1	0.581
GTF3C4	0.581
ADSL	0.578
TSEN54	0.578
AASDHPPT	0.576
EXOC4	0.573
HSPD1	0.571
ATP5J	0.571
CCDC101	0.568
HAUS8	0.568
AARS	0.565
GEMIN8	0.56
TTI1	0.558
TTI2	0.557
GTF3C2	0.557
TBCA	0.557
OPA1	0.556
UBE2G2	0.556
EPRS	0.553
CBFB	0.552
SUPV3L1	0.551
LSM10	0.551
BAP1	0.55
TRMT10A	0.549
PAM16	0.549
PPCS	0.547
TRNT1	0.547
TTC4	0.546
PPP2R3C	0.545
ZRSR2	0.545
NSMCE1	0.545
WDR24	0.543
DDOST	0.541
DHPS	0.541
TMEM41B	0.541
CSNK2B	0.541
ATP5O	0.54
HCCS	0.54
MTOR	0.538
CHCHD4	0.536
PGGT1B	0.536
THOC6	0.535
TXNRD1	0.532
ATP5B	0.531
GEMIN5	0.53
PPA2	0.529
GTF2A2	0.528
SEC62	0.528
TEN1	0.528
UBA3	0.528
UBE2J1	0.527
DHRSX	0.526
SDHA	0.526
GTF3C6	0.526
DPF2	0.525
ATP2A2	0.522
SRD5A3	0.521
MBTPS2	0.521
DDX20	0.52
DOLK	0.519
GTF3A	0.517
VMP1	0.516
SLC25A19	0.515
TELO2	0.515
ENO1	0.515
TIMM13	0.515
FNTA	0.515
LSM11	0.514
FH	0.513
OSGEP	0.512
RPN1	0.512
ELAC2	0.511
ATP5D	0.511
SRP72	0.51
MAPK14	0.509
PLAA	0.508
YARS	0.503
POLR3H	0.503
ATP5H	0.502
APAF1	0.501
SEC61G	0.5
CASP9	0.5
ATP5A1	0.5
EIF4E	0.499
MARS	0.499
PPP4C	0.496
DNLZ	0.495
UXT	0.495
EIF3F	0.49
DR1	0.49
MLLT1	0.487
TGS1	0.487
ATIC	0.487
RAD1	0.486
CEP57	0.486
NARS	0.486
EXOC3	0.485
MEAF6	0.484
SSB	0.482
GFER	0.482
VRK1	0.481
MED4	0.479
C17orf89	0.479
TMED10	0.478
PDSS1	0.478
CTDNEP1	0.477
TIMM22	0.477
WDR82	0.477
UBE2K	0.477
MRPS14	0.476
CYCS	0.476
HSD17B10	0.475
KIAA0391	0.475
COX16	0.475
DNAJC3	0.475
RABGGTB	0.475
MRPS33	0.473
TSEN34	0.472
TMEM242	0.471
CDIPT	0.471
DDX55	0.47
YARS2	0.47
DDX39A	0.47
TBCB	0.47
MIS18A	0.469
ZNF259	0.468
TRMT61A	0.467
TPK1	0.467
TAF1A	0.467
GEMIN6	0.466
CCT7	0.466
MRPS34	0.465
BCS1L	0.465
NSD1	0.464
PDAP1	0.464
PGM3	0.464
MRPS5	0.464
SRP68	0.463
PISD	0.463
STT3A	0.462
TXNL4B	0.462
TPRKB	0.462
URM1	0.462
WDR59	0.462
IRF2BP2	0.461
SNAPC5	0.461
SARS2	0.459
RPUSD4	0.459
PPP6C	0.458
BAK1	0.458
CBX3	0.458
ELP3	0.457
RFT1	0.457
GPN2	0.457
MRPL23	0.457
MED23	0.455
TUFM	0.455
TBP	0.455
RFK	0.454
EEF1E1	0.454
POLR3B	0.452
MRPL53	0.451
MRPS18A	0.45
ALG8	0.45
SRPRB	0.45
KDSR	0.449
ATP5C1	0.449
TKT	0.449
MRPS6	0.449
DDX6	0.449
POLR3C	0.447
FEV	0.446
OTUD5	0.445
CTC1	0.445
TOMM40	0.444
DARS2	0.444
SEC16A	0.443
MRPL21	0.443
GATC	0.442
PYROXD1	0.442
SPCS2	0.441
XPO6	0.44
RBM14	0.44
WBSCR16	0.44
CRCP	0.44
UBE2M	0.44
EIF1AX	0.439
KCTD5	0.439
WDR1	0.437
G6PD	0.436
BRWD1	0.436
DDX1	0.436
LAMTOR5	0.436
DAP3	0.435
SUV420H1	0.435
ELP2	0.434
EED	0.433
MRPL36	0.432
FAF2	0.432
TLE4	0.43
GEMIN7	0.43
CARS	0.429
SEC63	0.429
SCO2	0.429
DHX29	0.428
PTCHD3	0.427
MRPS2	0.426
LAMTOR4	0.426
NXT1	0.424
KDM8	0.423
MRPS16	0.423
GFM1	0.423
TRIM28	0.423
SOX7	0.422
CINP	0.422
N6AMT1	0.421
TIMM10	0.421
THOC3	0.421
SLC35B1	0.42
LSMD1	0.42
MFN1	0.419
DCTN6	0.418
SERF2	0.418
UQCRC2	0.418
TPI1	0.418
ZFP91	0.418
DHDDS	0.417
MRPS11	0.416
EFTUD1	0.415
PPP5C	0.414
ORC5	0.414
VHL	0.414
DCP2	0.414
OIP5	0.413
PHB	0.413
TARS2	0.413
ZBTB11	0.413
MLST8	0.412
PIK3R4	0.412
ZNHIT1	0.411
ZNF608	0.411
MRPS9	0.411
FBXO11	0.411
SNF8	0.411
FGFR1OP	0.41
ZZZ3	0.41
BUB3	0.41
SMG9	0.409
TIMM44	0.408
PGK1	0.406
UBQLN1	0.406
PDPK1	0.405
NBN	0.405
NUPL2	0.404
DNAJB11	0.404
NUP50	0.403
TIMM8B	0.402
COPS8	0.401
WSB1	0.401
DPM3	0.4
CHORDC1	0.4
RBFA	0.4

Global Fraction of Cell Lines Where Essential: 24/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	0/21
liver	3/20
lung	3/75
lymphocyte	1/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	2/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 1463
Expression level (log2 read counts): 6.09

Expression Distribution

PMM
Hydrolase 3

phosphomannomutase activity
GDP-mannose biosynthetic process
GDP-mannose metabolic process
mannose metabolic process
nucleotide-sugar biosynthetic process
nucleotide-sugar metabolic process
protein N-linked glycosylation
protein targeting to ER
establishment of protein localization to endoplasmic reticulum
protein localization to endoplasmic reticulum
hexose metabolic process
monosaccharide metabolic process
protein glycosylation
macromolecule glycosylation
glycosylation
glycoprotein biosynthetic process
protein targeting
neuronal cell body
glycoprotein metabolic process
establishment of protein localization to organelle
carbohydrate metabolic process
nucleobase-containing small molecule metabolic process
carbohydrate derivative biosynthetic process
protein localization to organelle
intracellular protein transport
carbohydrate derivative metabolic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
organonitrogen compound biosynthetic process
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
cellular nitrogen compound biosynthetic process
cellular macromolecule biosynthetic process