TRIAP1

Gene Information

Official Symbol: TRIAP1
Official Name: TP53 regulated inhibitor of apoptosis 1
Aliases and Previous Symbols: N/A
Entrez ID: 51499
UniProt: O43715
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (PubMed:23931759). Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo) (PubMed:26071602). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (PubMed:15735003). {ECO:0000269|PubMed:15735003, ECO:0000269|PubMed:23931759}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
PT-1 25μM R07 exp392	-2.14
Fas-L 44ng/ml R08 exp482	-2.06
TGF-beta1 44ng/ml R08 exp528	-2.01
All-trans-Retinoic-Acid 8μM R07 exp333	-1.98
Momordin-Ic 10μM R08 exp506	-1.95
CCCP 1μM R00 exp11	-1.94
Bisphenol S 100μM R08 exp458	-1.93
Asunaprenir 3μM R07 exp336	-1.92
A-769662 20μM R07 exp331	-1.9
All-trans-Retinoic-Acid 40μM R07 exp334	-1.89
Lenalidomide 20μM R07 exp375	-1.89
Salubrinal 20μM R07 exp399	-1.83
FK-506 5μM R07 exp358	-1.81
Doxycycline 10μM R00 exp18	-1.8
Geldanamycin 0.01μM R05 exp235	-1.76
BI-2536 0.0042μM R03 exp95	-1.74
Cincreasin 100μM R08 exp473	-1.73
UM0130462 0.025 to 0.035μM day4 R05 exp247	-1.71
UM0131023 0.05μM R05 exp248	-1.71
Hippuristanol 0.12μM R08 exp488	1.73
RO-3307 4.7μM R02 exp80	1.74
ONC212 0.15μM R08 exp513	1.79
Dinaciclib 0.007μM R07 exp355	1.85
WYE-354 6μM R02 exp90	1.86
Hinokiflavone 12μM R08 exp487	1.87
Nocodazole 0.1μM R03 exp94	1.87
BI-D1870 3.15μM R02 exp66	1.88
KU-0063794 3.8μM R02 exp71	1.92
LLY-283 2.6μM R06 exp290	1.94
6-Thio-2-deoxyguanosine 2μM R06 exp259	1.95
Mitomycin-C 0.06μM R08 exp503	1.95
Pimelic-diphenylamide-106 5μM R00 exp28	1.96
CB-5083 0.4μM R08 exp468	2
Staurosporine 0.02μM R08 exp524	2.01
Ammonium tetrathiomolybdate 10μM R08 exp448	2.03
Etoposide 0.3μM R05 exp199	2.03
Atovaquone 15μM R08 exp451	2.05
BI-6727 0.04μM R03 exp98	2.05
R-DABN 8μM R03 exp111	2.08
Rotenone 2μM R00 exp33	2.08
INK128 0.2μM R02 exp70	2.1
JQ1 0.8μM R08 exp435	2.13
DABN 20μM R00 exp17	2.22
Monensin 0.3μM R08 exp507	2.22
Vinblastine 0.2μM R03 exp108	2.23
UM131593 0.2μM R03 exp106	2.26
SNS-032 15μM R08 exp443	2.35
Benzoate 20000μM R08 exp456	2.39
Aphidicolin 0.4μM R08 exp440	2.44
GSK461364A 0.1μM R03 exp126	2.52
DABN racemic mixture R03 exp93	2.54
Actinomycin-D 0.001μM R00 exp3	2.55
5-Fluorouracil 20μM R00 exp2	2.6
42°C R08 exp539	2.62
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.65
Doxorubicin 0.02μM R08 exp478	2.7
Bleomycin 5μM R08 exp459	2.85
PU-H71 1μM R08 exp515	2.9
Rotenone 20μM R00 exp34	2.96
CFI-400945 25μM R08 exp469	3.07
Etoposide 1μM R00 exp19	3.11
MS023 7μM R03 exp135	3.18

Gene	Correlation
PMM2	0.754
CRLS1	0.717
THG1L	0.715
DPAGT1	0.7
ROMO1	0.7
SLC25A26	0.698
ALG1	0.693
UAP1	0.681
TAZ	0.676
RPE	0.673
TAMM41	0.661
GMPPB	0.651
GFPT1	0.648
HCCS	0.646
DOHH	0.642
SRP14	0.634
RPTOR	0.63
ATXN10	0.628
RTCB	0.626
HSPD1	0.62
VEZT	0.615
RNMT	0.607
TIMM13	0.599
TRNT1	0.597
SUPV3L1	0.597
CASP9	0.596
PAM16	0.591
ALG5	0.59
ALG13	0.59
DHPS	0.587
NAE1	0.586
OPA1	0.585
ATP5B	0.584
ATP5O	0.582
PELO	0.582
ADSL	0.581
CYCS	0.581
DNLZ	0.581
PPA2	0.578
PLAA	0.577
AASDHPPT	0.576
UTP23	0.573
APAF1	0.572
UHRF1	0.565
ATP5J	0.565
RPIA	0.564
CHCHD4	0.564
ENY2	0.564
ALG6	0.56
AARS	0.559
MRPS34	0.556
EXOC4	0.555
CBFB	0.555
ATP5A1	0.555
BAP1	0.553
MRPS14	0.552
TRMT10A	0.545
TMEM41B	0.542
MEAF6	0.541
DAP3	0.54
HARS	0.54
GTF3C6	0.54
PPCS	0.538
MRPS16	0.538
ATP5H	0.537
BAK1	0.535
UBE2G2	0.535
WDR24	0.535
TRMT5	0.534
HSD17B10	0.534
LSM10	0.533
ALG14	0.532
CSNK2B	0.532
COX16	0.532
ATIC	0.532
MED16	0.532
DAD1	0.531
KDSR	0.529
ZRSR2	0.527
PDSS1	0.527
GTF3C2	0.526
YARS2	0.525
CEP57	0.524
MRPL21	0.523
SEC61G	0.523
DHRSX	0.523
GTF3C3	0.521
SEC62	0.52
BCS1L	0.52
PGM3	0.52
MRPS11	0.519
ENO1	0.518
KIAA0391	0.518
ATP5D	0.515
RPP21	0.515
TBCA	0.514
MTOR	0.514
ALG2	0.514
TEN1	0.514
ORAOV1	0.513
DOLK	0.513
FH	0.513
PPP2R3C	0.513
DPF2	0.511
TXNL4B	0.509
TSEN54	0.508
UBA3	0.508
ELAC2	0.508
MRPS18A	0.507
MRPS6	0.503
SSB	0.503
MFN1	0.502
MRPL23	0.501
TUFM	0.5
SDHA	0.499
CCT7	0.498
GTF3C4	0.498
THOC6	0.498
HAUS8	0.497
VDAC2	0.497
UQCRC2	0.497
NSD1	0.497
PGGT1B	0.497
DDX55	0.497
TTI2	0.496
TOMM22	0.494
DARS2	0.493
MRPL15	0.493
ATP5F1	0.493
EIF3F	0.491
DDX20	0.491
UBE2M	0.489
PGS1	0.488
SRD5A3	0.488
GFER	0.487
SERF2	0.486
YARS	0.486
RPUSD4	0.485
TXNRD1	0.485
MRPS2	0.485
RPN1	0.483
SARS2	0.481
UBE2K	0.481
TMEM242	0.48
GEMIN8	0.48
TKT	0.479
ATP2A2	0.479
GFM1	0.478
TPRKB	0.478
PPP5C	0.477
TRMT61A	0.477
RAD1	0.477
NUPL2	0.476
FNTA	0.475
MRPL47	0.475
RNASEH1	0.475
FAF2	0.474
OIP5	0.474
MRPL20	0.474
RFT1	0.474
SCO2	0.473
GEMIN7	0.473
BRWD1	0.473
GEMIN5	0.472
VRK1	0.472
NSMCE1	0.471
MRPS33	0.471
PARL	0.47
WDR59	0.47
POLR3H	0.47
PIK3R4	0.47
COQ3	0.467
EIF4E	0.467
EXOC3	0.467
TELO2	0.466
DDOST	0.466
GNB1L	0.466
CCDC101	0.466
UBQLN1	0.466
GEMIN6	0.465
SLC35B1	0.465
MRP63	0.465
VMP1	0.464
C17orf89	0.464
ATP5L	0.464
MBTPS2	0.464
TTC4	0.464
RBFA	0.462
HARS2	0.462
TGS1	0.462
CBX3	0.461
MED23	0.461
MRPS9	0.46
ATP5C1	0.458
DR1	0.457
MRPS5	0.457
MARCH5	0.457
VARS2	0.456
COQ5	0.456
PHB	0.455
FASTKD5	0.455
CTDNEP1	0.455
TIMM23B	0.454
MRPS26	0.454
RBMX2	0.454
LSM11	0.454
C11orf57	0.453
UQCRQ	0.452
RABGGTB	0.451
PNPT1	0.451
TBCB	0.451
KCTD5	0.45
LAMTOR5	0.45
TIMM22	0.449
SLC25A19	0.449
GTF2A2	0.449
TARS2	0.448
SELRC1	0.447
UXT	0.447
MRPL53	0.447
TIMM8B	0.447
GATC	0.446
ATP5I	0.446
NARS	0.446
GFM2	0.445
NUP50	0.444
EPRS	0.443
TOMM40	0.443
OTUD5	0.443
LONP1	0.443
WBSCR16	0.443
PARS2	0.442
COX7B	0.441
TTI1	0.44
MIS18A	0.439
C12orf65	0.439
MED4	0.439
EARS2	0.438
LAMTOR4	0.438
METAP2	0.438
TOP3A	0.437
MRPL27	0.436
PISD	0.436
STT3A	0.434
TBP	0.434
ELF2	0.432
COX17	0.432
MAPK14	0.432
RARS2	0.431
WDR1	0.431
GABPA	0.431
ZFP91	0.431
SEC16A	0.431
GTF3A	0.43
MRPS21	0.43
C10orf2	0.429
PPP4C	0.429
TMED10	0.428
NBN	0.428
DIABLO	0.426
SEC63	0.426
DHX30	0.425
UBE2J1	0.425
TSEN34	0.425
MLLT1	0.424
HIST1H4I	0.424
NXT1	0.424
DUSP12	0.422
SRP68	0.421
DDX1	0.421
EEF1E1	0.42
MRPL36	0.419
ASXL2	0.419
CARS	0.418
TPK1	0.417
ELP3	0.417
SRP72	0.416
URM1	0.416
TRIM28	0.416
FBXO11	0.415
MARS	0.415
ALG8	0.415
TEFM	0.415
IRF2BP2	0.414
WDR92	0.414
BTF3	0.413
MRPS23	0.412
DNAJC3	0.412
RFK	0.411
GTPBP10	0.41
CHORDC1	0.409
UQCR10	0.408
UBA5	0.407
NDUFAF4	0.407
PDAP1	0.406
TPI1	0.406
NDUFB5	0.406
CTC1	0.406
ELP2	0.405
SPCS2	0.404
OSGEP	0.404
TAF1A	0.404
TMEM126B	0.403
PYROXD1	0.403
CDIPT	0.403
SLMO2	0.403
DHX29	0.402
MRPL34	0.402
ZFX	0.401
GLMN	0.401
POLR3B	0.401
PDPK1	0.401

Global Fraction of Cell Lines Where Essential: 700/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	26/28
blood	27/28
bone	25/26
breast	29/33
central nervous system	55/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	15/16
kidney	20/21
liver	19/20
lung	74/75
lymphocyte	16/16
ovary	25/26
pancreas	24/24
peripheral nervous system	12/16
plasma cell	14/15
prostate	1/1
skin	22/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	28/29
uterus	3/5

Essentiality in NALM6

Essentiality Rank: 1713
Expression level (log2 read counts): 5.18

Expression Distribution

phosphatidic acid transfer activity
positive regulation of phospholipid transport
regulation of phospholipid transport
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
negative regulation of release of cytochrome c from mitochondria
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
regulation of intrinsic apoptotic signaling pathway by p53 class mediator
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of signal transduction by p53 class mediator
regulation of intrinsic apoptotic signaling pathway in response to DNA damage
regulation of release of cytochrome c from mitochondria
positive regulation of anion transport
regulation of membrane lipid distribution
negative regulation of mitochondrion organization
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
signal transduction involved in mitotic cell cycle checkpoint
signal transduction involved in mitotic G1 DNA damage checkpoint
signal transduction involved in mitotic DNA damage checkpoint
intracellular signal transduction involved in G1 DNA damage checkpoint
signal transduction involved in mitotic DNA integrity checkpoint
positive regulation of lipid transport
mitotic G1 DNA damage checkpoint
mitotic G1/S transition checkpoint
G1 DNA damage checkpoint
p53 binding
signal transduction involved in DNA integrity checkpoint
signal transduction involved in DNA damage checkpoint
signal transduction involved in cell cycle checkpoint
mitochondrial intermembrane space
DNA damage response, signal transduction by p53 class mediator
positive regulation of cell cycle arrest
negative regulation of response to DNA damage stimulus
positive regulation of lipid localization
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
cellular response to UV
negative regulation of cysteine-type endopeptidase activity
phospholipid transport
mitotic DNA damage checkpoint
negative regulation of intrinsic apoptotic signaling pathway