POLR2J3

Gene Information

Official Symbol: POLR2J3
Official Name: RNA polymerase II subunit J3
Aliases and Previous Symbols: N/A
Entrez ID: 548644
UniProt: Q9H1A7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: N/A

Function Summary

Entrez Summary: N/A
UniProt Summary: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bortezomib 0.05μM R00 exp7	-3.28
Rotenone 20μM R00 exp34	-2.88
Etoposide 10μM R00 exp20	-2.2
Pterostilbene 16μM R02 exp78	-2.06
MLN-4924 2μM R00 exp22	-2.02
Pimelic-diphenylamide-106 5μM R00 exp28	-1.84
Brefeldin A 0.02μM R00 exp8	-1.8
BI-2536 0.001μM R01 exp41	1.71
UMK57 1μM R01 exp59	1.79
3-Bromopyruvate 7μM R04 exp175	1.97
Nocodazole 0.1μM R03 exp94	2.09
IU1-C 25μM R04 exp183	2.15
Taxol 0.002μM R01 exp54	2.38
Apcin 25μM plus proTAME 2μM R04 exp177	2.47

Gene	Correlation
GOLGA6L1	0.739
TYMS	0.712
TBC1D3H	0.668
ATP6V0C	0.644
TSPY8	0.633
AATF	0.63
TBC1D3F	0.63
TICRR	0.617
RPL17	0.611
RPL35	0.606
TTC31	0.606
ATP6V1A	0.601
TAF1	0.601
SLC4A1	0.6
MDN1	0.591
TRAIP	0.588
PSMB4	0.586
TBC1D3G	0.586
RRP7A	0.584
TCEB3CL2	0.583
TBC1D3E	0.583
TBC1D3L	0.583
TBC1D3K	0.583
TBC1D3I	0.583
EXOSC5	0.58
TBC1D3C	0.579
TIMELESS	0.579
NARFL	0.579
TWISTNB	0.579
SUPT6H	0.579
HINFP	0.577
C14orf93	0.576
RRP1	0.576
TCEB3C	0.574
UNC45B	0.574
HIST2H3A	0.574
HIST2H3C	0.573
CDCA3	0.573
FAM231A	0.572
TCEB3CL	0.572
FAM231C	0.571
SF3A2	0.569
PRPF6	0.567
COX7A2L	0.564
CASC5	0.563
KIF3C	0.56
VPS52	0.559
VPS28	0.557
NOL12	0.555
TPX2	0.554
SSH2	0.554
KRT78	0.553
ZNF583	0.553
ACO2	0.552
GLTSCR2	0.552
OSBP	0.551
AKIRIN2	0.55
FAM20A	0.55
MCOLN1	0.548
CA5A	0.547
EP300	0.547
SMTN	0.546
CHMP4B	0.545
HIVEP3	0.544
TMEM199	0.541
AGAP5	0.54
MMS22L	0.537
CXCR3	0.536
PEX5	0.534
CEBPZ	0.533
ARRDC2	0.532
MGME1	0.531
TP53TG3D	0.53
ARL5C	0.53
NFYA	0.53
OR10H5	0.529
RILPL2	0.528
GJC3	0.528
CCDC94	0.527
INTS6	0.527
PLA2G6	0.527
C1QTNF9B	0.527
PSAP	0.526
TSPY1	0.526
GOLGA6L3	0.525
RBP4	0.525
RAD51	0.525
AQR	0.525
ARHGAP31	0.525
IGFN1	0.524
ISCU	0.524
PSMC4	0.524
TBC1D3	0.523
CDC45	0.522
UPF1	0.522
GNL3L	0.521
PSMB1	0.521
ATP6V0B	0.521
B4GALNT4	0.521
MT1E	0.52
CACNA1E	0.52
EXOSC8	0.519
YTHDC1	0.519
COPG1	0.518
RFXANK	0.517
NARF	0.517
POLR2D	0.517
SUPT5H	0.516
NUP153	0.516
OGFR	0.515
PCDHGA5	0.514
ATP6V0D1	0.514
PREX2	0.514
AURKA	0.513
MED29	0.513
DGCR14	0.512
RANGAP1	0.512
DAND5	0.512
PHF12	0.51
MPHOSPH10	0.51
POLE	0.51
NUPL1	0.51
CDH24	0.509
MRS2	0.509
MDM2	0.509
REEP1	0.507
CHD4	0.506
RPL9	0.506
MED14	0.505
WAPAL	0.504
SNRPA1	0.504
NCKAP1L	0.504
RPL6	0.504
FBL	0.503
FAM25B	0.503
UNC5C	0.503
SART1	0.5
COPB1	0.499
PLK1	0.499
FCN2	0.498
SNRPB	0.498
TCP11X2	0.497
ATP6V1B2	0.496
CHMP3	0.495
BCAS2	0.495
RPS5	0.495
SNRNP200	0.494
GOLGA8A	0.494
ART5	0.494
PSMC2	0.493
FCRLB	0.493
DDX47	0.493
GAGE10	0.492
NRF1	0.492
VPS54	0.491
POLR2G	0.49
HEATR1	0.49
TSPY2	0.49
CLN6	0.49
HIP1	0.49
LAD1	0.489
PSMA6	0.488
DIEXF	0.488
MED10	0.487
C14orf183	0.487
NSF	0.486
IK	0.486
SYT9	0.486
SPG7	0.486
BCOR	0.485
RPL10A	0.485
RPS14	0.485
PSMD8	0.484
KIAA1683	0.484
XAB2	0.484
RPL13	0.484
MFAP1	0.483
ZNF541	0.483
ORC6	0.483
TRAPPC8	0.483
HAP1	0.483
RPS19BP1	0.483
GOLGA8B	0.483
PIAS3	0.483
ATP6AP2	0.483
CDCA5	0.483
PHF2	0.483
TMC7	0.482
LRRC56	0.482
ANKLE2	0.481
MYB	0.481
CCNA2	0.481
COL2A1	0.481
CHAF1A	0.48
DIDO1	0.48
RPS2	0.48
TBL3	0.479
NFATC4	0.479
SNIP1	0.479
PIGS	0.479
NAALADL1	0.478
POLR2L	0.478
NELFCD	0.477
EXOC3L2	0.477
MUL1	0.477
OGDH	0.476
RPS7	0.476
REG3G	0.476
DHX38	0.476
PSMB2	0.476
DTL	0.475
RPL15	0.474
CACNA1A	0.474
AKT1S1	0.474
CWC15	0.474
TAPBPL	0.474
MAT2A	0.473
PEX26	0.473
LIPE	0.473
GRAMD1A	0.472
GOLGA6L4	0.471
POLR2A	0.471
BID	0.47
RBM48	0.47
ARFRP1	0.47
SHMT2	0.47
CCND3	0.47
NIT2	0.47
SLC25A36	0.469
PSMD2	0.469
NEK5	0.468
GPRIN2	0.468
SLC38A7	0.467
PSMD1	0.467
SEC13	0.467
CELF6	0.467
MCF2L	0.466
HPR	0.466
MED17	0.466
MBTD1	0.466
SPRR2B	0.465
GAGE12H	0.465
RPL34	0.464
CCDC116	0.464
PSMD7	0.463
TFIP11	0.463
FAM25C	0.463
HSPA5	0.462
UTP18	0.462
SKI	0.462
TNFRSF10A	0.461
PHC3	0.461
NPIPB5	0.461
SF3A1	0.46
PPP2R5B	0.46
POLA2	0.46
POLR1C	0.46
POLR2C	0.459
NIP7	0.458
ZFAND5	0.458
POP7	0.457
OR9Q1	0.456
PRIM1	0.456
SF3B5	0.455
APC2	0.455
RHBDD3	0.455
FBXO21	0.454
SH3BP1	0.454
TONSL	0.453
WDR18	0.453
TPM2	0.453
RPL26	0.453
PSMD3	0.452
RAD21	0.452
FBXL19	0.452
KCTD17	0.452
EBNA1BP2	0.452
PWP2	0.451
COPZ1	0.451
PRPF3	0.451
FLRT1	0.45
SF3B1	0.449
RBM22	0.449
BPIFA1	0.449
ATP1A2	0.447
CCDC28B	0.447
PAF1	0.447
CTDP1	0.447
PIGZ	0.447
POLR1A	0.447
RRN3	0.446
EXD1	0.446
MED1	0.446
REG1B	0.446
C11orf88	0.446
CLEC11A	0.446
ACSS2	0.445
CLASP1	0.445
EXOSC6	0.445
TBR1	0.444
PI4KB	0.444
RIOK1	0.444
COG4	0.444
ABHD8	0.444
ANXA9	0.444
CHRM3	0.443
PRPF8	0.443
UBE2Q2L	0.443
ATP6V1C1	0.442
PIP4K2B	0.441
PSMB3	0.441
ORC1	0.44
HIST2H2BF	0.44
ZNF655	0.439
NPIPA8	0.439
NPIPA7	0.439
CACTIN	0.439
RIOK2	0.439
GTPBP4	0.439
ACSF2	0.439
ATP1A3	0.438
PSMC1	0.438
COL19A1	0.438
RNF157	0.437
RPS19	0.437
NCAPG	0.437
CNOT3	0.436
RPS4X	0.436
MARCH4	0.436
TP53TG3B	0.435
MCM10	0.435
ISG15	0.435
POP1	0.435
PBRM1	0.435
RNASE3	0.435
MAN2B1	0.435
RUNDC3A	0.435
COL4A2	0.435
C8orf34	0.435
C19orf18	0.435
TP53TG3	0.434
RPS15A	0.434
TBC1D29	0.434
PRKX	0.434
TUBB2A	0.433
TP53TG3C	0.433
IKBKG	0.433
KCNJ12	0.432
VPS11	0.432
UQCRH	0.432
LRRC45	0.432
TMEM160	0.432
RPL13A	0.431
SLC25A33	0.431
UBALD1	0.43
PSENEN	0.43
KIAA1407	0.429
UBE4A	0.429
FSTL4	0.429
FANCM	0.429
CPLX2	0.429
C16orf71	0.428
BTBD18	0.428
SLCO4C1	0.428
RANBP2	0.428
EGR2	0.428
RPA2	0.428
TAF8	0.427
HAUS1	0.427
TTK	0.427
MAP2K7	0.426
SPRR2A	0.426
SNX11	0.426
NOC3L	0.426
ASTN2	0.426
CDC6	0.426
DHRS7C	0.426
VPS16	0.425
S1PR4	0.425
FKBP8	0.425
PAK1IP1	0.425
RRP15	0.425
SSRP1	0.425
RAB32	0.425
C14orf119	0.424
FAM212A	0.424
VWA7	0.423
NOP16	0.423
PSMD6	0.423
UPB1	0.423
SEL1L	0.423
PPP1R36	0.423
NPIPB8	0.423
PBXIP1	0.423
PRPF19	0.423
SERPINE1	0.422
USP8	0.422
ELL	0.422
ACD	0.422
DEF6	0.422
WEE1	0.421
ZNF687	0.421
CCDC12	0.421
ILDR2	0.421
C9orf114	0.421
EIF4A3	0.421
PTPRB	0.42
RPL32	0.42
RNF121	0.42
KIN	0.42
ATP13A1	0.42
RGL1	0.42
NUP98	0.42
NDC80	0.42
MED12	0.419
SORCS3	0.419
NUP160	0.419
PPP1R1A	0.419
NUP93	0.419
RAB33A	0.419
DOC2A	0.418
BRD7	0.418
FCRL1	0.418
SYP	0.418
UTP3	0.418
PLK5	0.418
NBPF1	0.418
MYO18A	0.418
CTNNA2	0.417
HMGCR	0.417
GOLGA6L10	0.417
STRN	0.417
CD109	0.416
ZNF124	0.416
SKAP1	0.416
RUVBL2	0.416
POLR2B	0.416
KRI1	0.415
PSMA7	0.414
AAMP	0.414
PSMC6	0.414
NUP43	0.414
RPS9	0.414
TRPC5	0.414
UTP20	0.414
SKIV2L2	0.414
SULT1A3	0.414
NPM1	0.414
F2RL3	0.414
SULT1A4	0.413
OR4C3	0.413
FTSJ3	0.413
CANT1	0.413
DHFR	0.413
NUP155	0.412
ATP6V1D	0.412
NUP107	0.412
FNDC3A	0.412
PPAN	0.412
SLC3A1	0.412
SMG1	0.412
MINA	0.411
GNPAT	0.411
LTA4H	0.411
NPIPB15	0.411
COMMD4	0.411
RPL23A	0.41
TAF7	0.41
VPS51	0.41
C3orf17	0.41
CD4	0.41
CDK9	0.41
FBXO4	0.41
CXXC1	0.409
NOTCH2	0.409
MED15	0.409
C19orf43	0.409
PDE4DIP	0.409
BRD4	0.408
ANKLE1	0.408
MAP7D1	0.408
BYSL	0.408
CEP192	0.408
POLA1	0.408
PRR5L	0.408
NUP62	0.408
FAM86B2	0.408
TTC1	0.407
ETV3	0.406
OR51G1	0.406
ADD2	0.406
PEX13	0.406
HIST1H4B	0.406
TMEM2	0.406
SEMA5A	0.406
ACAP3	0.405
UFD1L	0.405
TCF7	0.405
DNTTIP2	0.405
DDX18	0.405
TGFBRAP1	0.405
ITGA11	0.405
PZP	0.404
RAC2	0.404
NBPF10	0.403
ACSM2B	0.403
KIF11	0.403
FCGR2B	0.403
PHLDB3	0.403
VASN	0.402
GP1BB	0.402
ZNF48	0.402
LTV1	0.402
TTC32	0.402
BRD2	0.402
PAN3	0.402
KRT31	0.402
TCF15	0.402
TMEM161A	0.401
TAF6	0.401
PCDHGB4	0.401
RPL12	0.401
SCNN1B	0.401
CDH20	0.401
EFCAB6	0.401
TEAD4	0.4
RPS12	0.4
PSMA5	0.4
TRIM2	0.4
NUP85	0.4

Essentiality in NALM6

Essentiality Rank: 166
Expression level (log2 read counts): 7.79

Expression Distribution

RNA polymerase II activity
RNA polymerase II, core complex
DNA-directed 5-3 RNA polymerase activity
protein dimerization activity
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
DNA binding
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression