PSMB4

Gene Information

Official Symbol: PSMB4
Official Name: proteasome 20S subunit beta 4
Aliases and Previous Symbols: N/A
Entrez ID: 5692
UniProt: P28070
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. {ECO:0000269|PubMed:12097147, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
DABN 20μM R00 exp17	-2.67
PU-H71 1μM R08 exp515	-2.52
Nocodazole 0.2μM R00 exp24	-2.42
Etoposide 1μM R00 exp19	-2.35
SNS-032 25μM R07 exp401	-2.17
Bortezomib 0.05μM R00 exp7	-2.14
Etoposide 0.3μM R05 exp199	-2.12
Hinokiflavone 12μM R08 exp487	-1.98
Rotenone 20μM R00 exp34	-1.95
Rotenone 2μM R00 exp33	-1.94
Pimelic-diphenylamide-106 5μM R00 exp28	-1.93
RO-3307 4.7μM R02 exp80	-1.91
Oligomycin-A 20μM R00 exp26	-1.88
Actinomycin-D 0.001μM R00 exp3	-1.85
BI-6727 0.04μM R03 exp98	-1.82
Bortezomib 0.005μM R00 exp6	-1.73
HMS-I1 10μM R06 exp256	-1.71
CB-839 10μM R05 exp224	1.7
Chlorpromazine 10μM R07 exp344	1.7
Ibrutinib 1μM R07 exp372	1.71
BI-6727 0.001μM R01 exp42	1.73
Rifampicin 1μM R00 exp31	1.73
Asunaprenir 3μM R07 exp336	1.78
VE-822 0.04μM R06 exp300	1.78
Glyphosate 1000μM R06 exp283	1.86
NFN1 0.1μM R01 exp49	1.88
Vinorelbine 0.001μM R05 exp249	1.88
Citral 50μM R06 exp274	1.95
UM131593 0.1μM R01 exp58	1.95
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	1.97
Geldanamycin 0.01μM R05 exp235	2
Aphidicolin 0.04μM R06 exp263	2.01
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	2.02
Cisplatin 0.35μM R06 exp273	2.03
Resminostat 0.5μM R07 exp393	2.03
UM0131023 0.05μM R05 exp248	2.04
THZ531 0.11μM R07 exp409	2.13
2-Methoxyestradiol 0.2μM R01 exp40	2.23
ABT-702 5μM R07 exp318	2.23
CCT251545 0.2μM R06 exp271	2.23
All-trans-Retinoic-Acid 8μM R07 exp333	2.27
HMS-I2 1μM R06 exp286	2.28
Cidofovir 10μM R07 exp345	2.32
D-Fructose 10000μM R06 exp279	2.39
ABT-702 0.1μM R06 exp260	2.45
Nifuroxazide 1μM R01 exp51	2.68
Pyronaridine 1μM R06 exp295	2.8
CCCP 1μM R00 exp11	2.86
ABT-702 5μM R06 exp261	3.78

Gene	Correlation
TCEB3CL2	0.655
TCEB3C	0.651
PSMA6	0.635
TCEB3CL	0.634
CHD4	0.632
RPL35	0.625
NPIPB5	0.618
RPS2	0.604
NUP160	0.593
NUPL1	0.593
PSMB3	0.592
VPS28	0.59
PSMB1	0.588
POLR2J3	0.586
PSMA7	0.586
COPG1	0.582
MYB	0.581
CCNA2	0.581
EXOSC5	0.58
PSMB2	0.58
AATF	0.578
ATP6V1C1	0.576
UPF1	0.574
CDC45	0.571
SUPT5H	0.571
CHAF1A	0.57
CBWD3	0.568
PAF1	0.567
BRD2	0.566
GOLGA6L3	0.565
TSG101	0.565
RRP7A	0.564
CDC73	0.56
CBWD5	0.559
HAP1	0.558
RPL6	0.557
CACTIN	0.557
NARFL	0.556
ATP6V0C	0.555
ISCU	0.555
ZNF830	0.552
SNRPA1	0.552
AAMP	0.55
TBC1D3H	0.549
TWISTNB	0.547
LAD1	0.546
PSMC2	0.545
KCTD17	0.544
IK	0.543
PRIM1	0.543
ORC1	0.542
POLA1	0.541
C1QTNF9B	0.541
EXOSC9	0.54
CEP192	0.539
PSMC6	0.539
CBWD6	0.539
ANKLE2	0.538
RBBP5	0.536
HIST2H3C	0.536
HIST2H3A	0.536
TICRR	0.536
SSH2	0.535
SF3A1	0.533
PSMA1	0.533
PSMD1	0.532
COL2A1	0.532
GOLGA6L1	0.531
INTS5	0.531
TBC1D3G	0.53
VASN	0.528
EXOSC6	0.528
SUPT6H	0.527
WDR75	0.527
POLE	0.527
TYMS	0.527
ATP6V1A	0.527
ARCN1	0.526
GOLGA8O	0.525
HIST1H2BE	0.525
EIF4A3	0.524
RPS9	0.523
SLC4A1	0.523
CDC6	0.522
TP53TG3B	0.522
SEC13	0.522
C14orf93	0.522
CDT1	0.521
TP53TG3	0.521
RPS5	0.52
TP53TG3C	0.52
TBC1D3F	0.519
TFIP11	0.518
RANBP2	0.518
MT1E	0.517
PSMC1	0.517
GOLGA6L4	0.516
BYSL	0.516
STIL	0.516
PSMD2	0.515
TAF1	0.515
RPS12	0.515
OSBP	0.513
POLR2F	0.512
POLA2	0.512
RRN3	0.512
CDCA3	0.511
DNTTIP2	0.51
TP53TG3D	0.51
RBM39	0.509
TSPY8	0.509
PSMD11	0.508
ZNF655	0.508
PAN3	0.507
CKAP5	0.506
MED14	0.506
SNRNP70	0.506
FAM25B	0.506
DTL	0.506
DDTL	0.504
TBC1D3C	0.504
COX7A2L	0.504
ZFAND5	0.503
UTP3	0.503
SMTN	0.502
KRT78	0.501
RRP15	0.501
CTAGE4	0.5
CEBPZ	0.5
DHX38	0.499
NSF	0.499
RPS19BP1	0.498
DISP2	0.497
GID4	0.496
RAD21	0.496
AQR	0.496
VPS54	0.496
SMG1	0.496
ORC6	0.495
NFATC4	0.495
IGFN1	0.493
COPB1	0.493
SLC38A7	0.493
COPA	0.493
CCDC116	0.492
RPS19	0.492
TSPY1	0.492
ATP6V1B2	0.492
PSAP	0.491
OR10G3	0.491
XAB2	0.491
POLR2D	0.489
PRPF19	0.489
RAD51	0.488
PSMD3	0.488
RNPC3	0.487
RPL30	0.487
DIDO1	0.487
DDX56	0.487
GOLGA6L6	0.487
LRR1	0.486
ATP6AP1	0.486
PSMD14	0.485
CGB2	0.485
SRSF3	0.485
RNF113A	0.485
ATP6V0B	0.484
TOP1MT	0.483
SART1	0.483
EXOSC4	0.483
KIAA0947	0.482
NOP16	0.482
PSMD7	0.481
AKAP1	0.481
COPE	0.481
RPS3A	0.481
XYLT2	0.48
RPL34	0.48
ACSF2	0.479
NUP153	0.478
GOLGA8J	0.478
TBC1D3I	0.477
TBC1D3E	0.477
TBC1D3L	0.477
TBC1D3K	0.477
RIOK2	0.476
MED17	0.476
NOL10	0.475
TSPY2	0.475
DDT	0.475
SNRNP200	0.474
CHMP4B	0.474
FAM231A	0.474
SYT9	0.474
FAM231C	0.474
SAP30BP	0.472
POLR1A	0.472
TGFBRAP1	0.471
RPS28	0.471
SNIP1	0.47
COPZ1	0.469
NOL9	0.469
CDC5L	0.469
CTAGE9	0.469
TBC1D3	0.468
RPS20	0.468
AHCTF1	0.468
S1PR4	0.467
ANKLE1	0.467
MFSD12	0.466
CCDC94	0.466
AKIRIN2	0.465
NCAPG	0.465
ATP13A1	0.465
MTCH2	0.464
FBXW9	0.463
RPL38	0.463
CDH24	0.463
NAPA	0.462
CWC22	0.462
GOSR2	0.462
NGDN	0.461
SF3A3	0.461
PSMC5	0.461
PAN2	0.46
SCGB1C1	0.459
SLC6A17	0.459
SKIV2L2	0.458
FANCM	0.457
TIMELESS	0.456
CACNA1A	0.456
TRAIP	0.456
NOL12	0.454
SF3B2	0.454
ZNF106	0.454
RPS7	0.454
TUBA8	0.453
EXOSC8	0.453
POLR2I	0.452
RPS11	0.451
RILPL2	0.451
UTP20	0.45
EGR2	0.45
POLE2	0.45
NUP98	0.45
NCL	0.449
EXOSC3	0.449
NBPF16	0.448
NIPBL	0.448
TPX2	0.448
SCAF1	0.448
PPM1D	0.448
PSMC3	0.448
HINFP	0.448
MDM2	0.448
ACBD4	0.447
NUP133	0.447
PLEKHA4	0.447
DOCK6	0.447
PDE4DIP	0.445
UBE2Q2L	0.445
PARP3	0.445
MBTD1	0.443
MYO1H	0.443
PSMC4	0.443
GPRIN2	0.442
PSMD6	0.442
RPSA	0.442
BRIX1	0.442
TAF15	0.441
RPL9	0.441
CHMP2A	0.44
FCN2	0.44
EBNA1BP2	0.44
CTR9	0.44
CNOT1	0.44
OGFR	0.44
ADRM1	0.44
RPL8	0.438
PLRG1	0.437
DDX41	0.437
PCF11	0.436
NPIPB8	0.436
FAM86B2	0.436
GLTSCR2	0.435
CHCHD3	0.435
ART5	0.434
SEMA6B	0.434
TONSL	0.434
RANGAP1	0.434
TTC31	0.434
PWP2	0.434
WDR87	0.433
HNRNPA1	0.433
CLN6	0.432
SF3A2	0.432
AGAP5	0.432
TERF1	0.431
NELFCD	0.431
ALDH1B1	0.431
NAALADL1	0.431
KPNB1	0.431
NOL8	0.431
KIF3C	0.429
SULT1A3	0.429
RPS14	0.429
RPS3	0.428
SULT1A4	0.428
DDX3X	0.428
NELFA	0.428
GAR1	0.427
MYO18A	0.427
NBPF10	0.427
MCOLN1	0.426
SMG7	0.426
SF3B1	0.426
INTS6	0.426
PDCD11	0.425
RPL15	0.425
HIST2H2BF	0.425
PSMD8	0.425
ZNF541	0.425
NIP7	0.425
RRP1	0.424
MKI67IP	0.424
KIN	0.424
RPA2	0.424
RPL12	0.424
NUP205	0.423
RFC1	0.423
VPS51	0.423
NBPF1	0.423
TAGLN	0.423
HIST1H4B	0.423
RPL17	0.422
POLD1	0.422
SF3B3	0.422
FBN1	0.421
POLR2A	0.421
MYH2	0.421
EIF3A	0.421
USP35	0.42
RPL14	0.42
ZNF574	0.419
GOLGA6A	0.419
FAM160A1	0.418
COG4	0.418
CMYA5	0.418
SPECC1L	0.418
TERF2	0.417
EIF3G	0.417
KRT2	0.416
DDX21	0.415
TTK	0.415
FAM20A	0.414
SNRPB	0.414
RPS10	0.414
RRP12	0.414
INTS1	0.413
UBA52	0.412
NUFIP2	0.411
CYB561A3	0.411
GGA3	0.41
DDX47	0.41
MED29	0.41
TINF2	0.41
PSMA3	0.409
RRM1	0.409
BUD31	0.409
DAND5	0.409
SMG5	0.409
MADCAM1	0.408
GON4L	0.408
HIVEP3	0.408
ESF1	0.408
PDS5B	0.407
TRIM52	0.406
ITGA2B	0.406
WDR43	0.406
BID	0.406
PLK4	0.406
SETD1A	0.406
PPIE	0.406
FBXO5	0.405
ZNF687	0.405
KRT36	0.404
SF3B4	0.404
RILPL1	0.403
MYT1L	0.403
RNF121	0.403
CIAPIN1	0.403
SH3BP1	0.402
MYH7B	0.402
RPLP2	0.402
NHP2L1	0.401
GPX4	0.401
NOB1	0.401
C2orf27B	0.4

Global Fraction of Cell Lines Where Essential: 738/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	32/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 330
Expression level (log2 read counts): 6.98

Expression Distribution

proteasome core complex, beta-subunit complex
negative regulation of inflammatory response to antigenic stimulus
proteasome core complex
threonine-type endopeptidase activity
regulation of inflammatory response to antigenic stimulus
proteasomal ubiquitin-independent protein catabolic process
lipopolysaccharide binding
proteasome complex
regulation of cellular amino acid metabolic process
regulation of hematopoietic stem cell differentiation
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
endopeptidase activity
regulation of transcription from RNA polymerase II promoter in response to hypoxia
antigen processing and presentation of exogenous peptide antigen via MHC class I
NIK/NF-kappaB signaling
regulation of cellular amine metabolic process
anaphase-promoting complex-dependent catabolic process
regulation of hematopoietic progenitor cell differentiation
negative regulation of G2/M transition of mitotic cell cycle
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
interleukin-1-mediated signaling pathway
Wnt signaling pathway, planar cell polarity pathway
antigen processing and presentation of peptide antigen via MHC class I
negative regulation of cell cycle G2/M phase transition
regulation of establishment of planar polarity
stimulatory C-type lectin receptor signaling pathway
innate immune response activating cell surface receptor signaling pathway
regulation of stem cell differentiation
tumor necrosis factor-mediated signaling pathway
regulation of transcription from RNA polymerase II promoter in response to stress
regulation of DNA-templated transcription in response to stress
non-canonical Wnt signaling pathway
negative regulation of inflammatory response
positive regulation of canonical Wnt signaling pathway
negative regulation of immune response
regulation of cellular ketone metabolic process
Fc-epsilon receptor signaling pathway
cellular response to interleukin-1
negative regulation of canonical Wnt signaling pathway
T cell receptor signaling pathway